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https://www.readbyqxmd.com/read/28088837/disease-severity-classification-using-quantitative-magnetic-resonance-imaging-data-of-cartilage-in-femoroacetabular-impingement
#1
Lisa L Henn, John Hughes, Eleena Iisakka, Jutta Ellermann, Shabnam Mortazavi, Connor Ziegler, Mikko J Nissi, Patrick Morgan
Femoroacetabular impingement (FAI) is a condition in which subtle deformities of the femoral head and acetabulum (hip socket) result in pathological abutment during hip motion. FAI is a common cause of hip pain and can lead to acetabular cartilage damage and osteoarthritis. For some patients with FAI, surgical intervention is indicated, and it can improve quality of life and potentially delay the onset of osteoarthritis. For other patients, however, surgery is contraindicated because significant cartilage damage has already occurred...
January 15, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28088836/upregulation-of-long-noncoding-rna-tug1-promotes-cervical-cancer-cell-proliferation-and-migration
#2
Yingying Hu, Xiangwei Sun, Chenchen Mao, Gangqiang Guo, Sisi Ye, Jianfeng Xu, Ruanmin Zou, Jun Chen, Ledan Wang, Ping Duan, Xiangyang Xue
Long noncoding RNAs (lncRNAs), a novel class of transcripts that have critical roles in carcinogenesis and progression, have emerged as important gene expression modulators. Recent evidence indicates that lncRNA taurine-upregulated gene 1 (TUG1) functions as an oncogene in numerous types of human cancers. However, its function in the development of cervical cancer remains unknown. The aim of this research was to investigate the clinical significance and biological functions of TUG1 in cervical cancer. TUG1 was found to be significantly upregulated in cervical cancer tissues and four cervical cancer cell lines by quantitative real-time polymerase chain reaction (qRT-PCR)...
January 15, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28088809/fibroblast-growth-factor-receptor-1-fgfr1-partly-related-to-vascular-endothelial-growth-factor-receptor-2-vegfr2-and-microvessel-density-is-an-independent-prognostic-factor-for-non-small-cell-lung-cancer
#3
Dan Pu, Jiewei Liu, Zhixi Li, Jiang Zhu, Mei Hou
BACKGROUND This study aimed to explore the correlation between FGFR1 and clinical features, including survival analysis and the promotion of angiogenesis by fibroblast growth factor receptor 1 (FGFR1) and vascular endothelial growth factor receptor 2 (VEGFR2). FGFR1 gene amplification has been found in non-small cell lung cancer (NSCLC). However, the prognostic value of FGFR1 and the correlation between FGFR1 and clinical features are still controversial. MATERIAL AND METHODS A total of 92 patients with NSCLC who underwent R0 resection between July 2006 and July 2008 were enrolled in the study...
January 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28088805/a-retrospective-analysis-of-stereoelectroencephalography-and-subdural-electroencephalography-for-preoperative-evaluation-of-intractable-epilepsy
#4
Meihua Yang, Yuanshi Ma, Wei Li, Xianjun Shi, Zhi Hou, Ning An, Chunqing Zhang, Lihong Liu, Hui Yang, Dong Zhang, Shiyong Liu
BACKGROUND: Different methods for intracranial electrode recording have various advantages and disadvantages, and controversy exists regarding the complications of stereoelectroencephalography (SEEG) and subdural EEG. OBJECTIVE: The purpose of this study was to determine the efficacy and safety of SEEG by comparing it with subdural EEG. METHODS: Data from 100 patients who underwent SEEG (n = 48) and subdural EEG (n = 52) to evaluate the epileptogenic zone were collected from June 2011 to June 2015...
January 14, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28088792/impact-of-nudt15-polymorphisms-on-thiopurines-induced-myelotoxicity-and-thiopurines-tolerance-dose
#5
Dandan Yin, Xuyang Xia, Junlong Zhang, Shouyue Zhang, Fei Liao, Ge Zhang, Yan Zhang, Qianqian Hou, Xue Yang, Hong Wang, Zhigui Ma, Heyao Wang, Yiping Zhu, Wei Zhang, Yuelan Wang, Bo Liu, Lanlan Wang, Heng Xu, Yang Shu
Thiopurines are widely used as anticancer and immunosuppressive agents. However, life-threatening myelotoxicity has been noticed and largely explained by genetic variations, including NUDT15 polymorphisms (e.g., rs116855232). In this study, we conduct a meta-analysis to investigate the impact of rs116855232 on thiopurines-induced myelotoxicity susceptibility (1752 patients from 7 independent cohorts), as well as on thiopurines intolerance dose (2745 patients from 13 cohorts). Variant allele of rs116855232 contributes 7...
January 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28088788/dual-syk-jak-inhibition-overcomes-ibrutinib-resistance-in-chronic-lymphocytic-leukemia-cerdulatinib-but-not-ibrutinib-induces-apoptosis-of-tumor-cells-protected-by-the-microenvironment
#6
Ailin Guo, Pin Lu, Greg Coffey, Pamela Conley, Anjali Pandey, Y Lynn Wang
Ibrutinib (BTK inhibitor) has generated remarkable responses in CLL. However, the drug, to a large extent, does not cause cell death directly and does not eradicate CLL malignant clones. Inability to eradicate CLL has fostered resistance generation. Once patients become resistant, they do poorly with a median survival of 3-4 months. Novel therapeutic strategies are needed to prevent resistance, improve treatment outcome and ultimately cure the disease. Herein, we explore dual targeting of the BCR and JAK-STAT pathways with a novel single agent, cerdulatinib, which selectively inhibits both SYK (a BCR component) and JAK kinases...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28088787/hint2-downregulation-promotes-colorectal-carcinoma-migration-and-metastasis
#7
Weihua Li, Shaoxin Cai, Le Wang, Changshun Yang, Biaohuan Zhou, Huan Wang
Histidine triad nucleotide-binding 2 (HINT2), a member of the histidine triad proteins family, sensitizes cells to apoptosis in hepatocellular carcinoma. Here, we showed that HINT2 expression is lower in primary colorectal cancer (CRC) and metastasis tissues than in normal colorectal tissues, and that HINT2 abundance is inversely correlated with CRC tumor stage. Treating CRC cells with 5-aza-2'-deoxycytidine, a demethylating agent, upregulated HINT2, suggesting HINT2 downregulation is caused by methylation of the gene promoter...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28088765/allo-allo-triploid-sphagnum-%C3%A3-falcatulum-single-individuals-contain-most-of-the-holantarctic-diversity-for-ancestrally-indicative-markers
#8
Eric F Karlin, Peter E Smouse
BACKGROUND AND AIMS: Allopolyploids exhibit both different levels and different patterns of genetic variation than are typical of diploids. However, scant attention has been given to the partitioning of allelic information and diversity in allopolyploids, particularly that among homeologous monoploid components of the hologenome. Sphagnum × falcatulum is a double allopolyploid peat moss that spans a considerable portion of the Holantarctic. With monoploid genomes from three ancestral species, this organism exhibits a complex evolutionary history involving serial inter-subgeneric allopolyploidizations...
January 14, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28088758/c5-substituents-of-uridines-and-2-thiouridines-present-at-the-wobble-position-of-trna-determine-the-formation-of-their-keto-enol-or-zwitterionic-forms-a-factor-important-for-accuracy-of-reading-of-guanosine-at-the-3-end-of-the-mrna-codons
#9
Elzbieta Sochacka, Elzbieta Lodyga-Chruscinska, Justyna Pawlak, Marek Cypryk, Paulina Bartos, Katarzyna Ebenryter-Olbinska, Grazyna Leszczynska, Barbara Nawrot
Modified nucleosides present in the wobble position of the tRNA anticodons regulate protein translation through tuning the reading of mRNA codons. Among 40 of such nucleosides, there are modified uridines containing either a sulfur atom at the C2 position and/or a substituent at the C5 position of the nucleobase ring. It is already evidenced that tRNAs with 2-thiouridines at the wobble position preferentially read NNA codons, while the reading mode of the NNG codons by R5U/R5S2U-containing anticodons is still elusive...
January 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28088747/decreased-s100b-serum-levels-after-treatment-in-bipolar-patients-in-a-manic-phase
#10
Meng-Chang Tsai, Tiao-Lai Huang
BACKGROUND: Previous studies have suggested that patients with bipolar disorder might have brain damage. The aim of this study was to investigate the serum levels of brain injury biomarkers and S100A10 in bipolar patients in a manic phase, and evaluate the changes in S100B, neuron specific enolase (NSE), heat shock protein 70 (HSP70) and S100A10 after treatment. METHOD: We consecutively enrolled 17 bipolar inpatients in a manic phase and 30 healthy subjects. Serum brain injury biomarkers and S100A10 were measured with assay kits...
January 3, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28088736/lncrna-ccat2-promotes-tumorigenesis-by-over-expressed-pokemon-in-non-small-cell-lung-cancer
#11
Zhihong Zhao, Ju Wang, Shengfa Wang, Hao Chang, Tiewa Zhang, Junfeng Qu
BACKGROUND: Non-small cell lung cancer (NSCLC) remains one of the most important death-related diseases, with poor effective diagnosis and less therapeutic biomarkers. LncRNA colon cancer-associated transcript 2 (CCAT2) was identified as an oncogenic lncRNA and over-expressed in many tumor cells. The aims of this study were to detect the correlation between CCAT2 and its regulatory genes and then explore the potential mechanism between them in NSCLC. METHODS: In this study, qRT-PCR was used to detect CCAT2, Pokemon and p21 expression...
January 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28088733/long-non-coding-rna-uc001kfo-promotes-hepatocellular-carcinoma-proliferation-and-metastasis-by-targeting-%C3%AE-sma
#12
Yanfeng Pan, Tao Qin, Shenglu Yin, Xianqiang Zhang, Xiaojuan Gao, Lifen Mu
Several long non-coding RNAs (lncRNAs) have been investigated and found to be correlated with the behaviours and prognosis of hepatocellular carcinoma (HCC); Specifically, we revealed that the lncRNA UC001kfo was differentially expressed in HCC tissues compared with normal liver tissues using lncRNA microarrays, but its functional role in cancers, including HCC, has not yet been elucidated. The present study found that the expression of UC001kfo was upregulated in HCC tissues and cell lines in comparison with tumour-adjacent tissues and normal hepatocytes, respectively...
January 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28088722/in-situ-denitrification-and-dnra-rates-in-groundwater-beneath-an-integrated-constructed-wetland
#13
M M R Jahangir, O Fenton, C Müller, R Harrington, P Johnston, K G Richards
Evaluation of the environmental benefits of constructed wetlands (CWs) requires an understanding of their impacts on the groundwater quality under the wetlands. Empirical mass-balance (nitrogen in/nitrogen out) approaches for estimating nitrogen (N) removal in CWs do not characterise the final fate of N; where nitrate (NO3(-)-N) could be reduced to either ammonium (NH4(+)-N) or N2 with the potential for significant production of N2O. Herein, in situ denitrification and DNRA (dissimilatory nitrate reduction to ammonium) rates were measured in groundwater beneath cells of an earthen lined integrated constructed wetland (ICW, used to remove the nutrients from municipal wastewater) using the (15)N-enriched NO3(-)-N push-pull method...
January 7, 2017: Water Research
https://www.readbyqxmd.com/read/28088721/modeling-biosolids-drying-through-a-laminated-hydrophobic-membrane
#14
Solmaz Marzooghi, Chunjian Shi, Steven K Dentel, Paul T Imhoff
The adaptation of the membrane distillation process as a low-cost and sustainable approach to biosolids drying and stabilization is investigated, which may have application in container-based sanitation systems proposed in low-income urban regions. Three-layer laminated, breathable, hydrophobic membranes enclose the biosolids, facilitating drying but preventing transport of contaminants. The membranes used in this process are non-wetting with pore spaces that only allow vapor transport. Water vapor can be expelled due to a moderate vapor pressure gradient...
December 29, 2016: Water Research
https://www.readbyqxmd.com/read/28088718/highly-efficient-inactivation-of-bacteria-found-in-drinking-water-using-chitosan-bentonite-composites-modelling-and-breakthrough-curve-analysis
#15
Sarah C Motshekga, Suprakas Sinha Ray
Disinfection of bacterially-contaminated drinking water requires a robust and effective technique and can be achieved by using an appropriate disinfectant material. The advanced use of nanomaterials is observed as an alternative and effective way for the disinfection process and water treatment as a whole. Hence, the inactivation of Escherichia coli (E. coli) using chitosan-Bentonite (Cts-Bent) composites was studied in a fixed bed column. Cts-Bent composites were synthesized using in situ cross-linking method using Bent-supported silver and zinc oxide nanoparticles...
January 3, 2017: Water Research
https://www.readbyqxmd.com/read/28088717/removal-of-antibiotic-resistance-genes-from-wastewater-treatment-plant-effluent-by-coagulation
#16
Na Li, Guo-Ping Sheng, Yong-Ze Lu, Raymond J Zeng, Han-Qing Yu
Antibiotic resistance genes (ARGs), as emerging environmental contaminants, have become a threat to human health. Recent studies have demonstrated that the effluent from wastewater treatment plants is a significant point source of ARGs released into the environment. In this study, we investigated the effectiveness of coagulation technology in the removal of ARGs from treated wastewater. Specifically, we measured the removal of five ARGs (two sulfonamide resistance genes, sulI and sulII, and three tetracycline resistance genes, tetO, tetW and tetQ) and the class 1 integron intI1 gene via the application of two coagulants: FeCl3 and polyferric chloride (PFC)...
January 4, 2017: Water Research
https://www.readbyqxmd.com/read/28088716/unveiling-the-transformation-and-bioavailability-of-dissolved-organic-matter-in-contrasting-hydrothermal-vents-using-fluorescence-eem-parafac
#17
Liyang Yang, Wan-E Zhuang, Chen-Tung Arthur Chen, Bing-Jye Wang, Fu-Wen Kuo
The submarine hydrothermal systems are extreme environments where active cycling of dissolved organic matter (DOM) may occur. However, little is known about the optical properties and bioavailability of hydrothermal DOM, which could provide valuable insights into its transformation processes and biogeochemical reactivity. The quantity, quality, and bioavailability of DOM were investigated for four very different hydrothermal vents east of Taiwan, using dissolved organic carbon (DOC), absorption spectroscopy, and fluorescence excitation-emission matrices-parallel factor analysis (EEM-PARAFAC)...
January 3, 2017: Water Research
https://www.readbyqxmd.com/read/28088715/micropollutant-induced-tolerance-of-in-situ-periphyton-establishing-causality-in-wastewater-impacted-streams
#18
Ahmed Tlili, Juliane Hollender, Cornelia Kienle, Renata Behra
The overarching aim of this field study was to examine causal links between in-situ exposure to complex mixtures of micropollutants from wastewater treatment plants and effects on freshwater microbial communities in the receiving streams. To reach this goal, we assessed the toxicity of serial dilutions of micropollutant mixtures, extracted from deployed passive samplers at the discharge sites of four Swiss wastewater treatment plants, to in situ periphyton from upstream and downstream of the effluents. On the one hand, comparison of the sensitivities of upstream and downstream periphyton to the micropollutant mixtures indicated that algal and bacterial communities composing the periphyton displayed higher tolerance towards these micropollutants downstream than upstream...
January 7, 2017: Water Research
https://www.readbyqxmd.com/read/28088708/germinal-centers-programmed-for-affinity-maturation-and-antibody-diversification
#19
REVIEW
Oliver Bannard, Jason G Cyster
The seminal discovery by Eisen that antibodies undergo improvements in antigen-binding affinity over the course of an immune response led to a long running search for the underlying mechanism. Germinal centers in lymphoid organs are now recognized to be critically involved in this phenomenon, known as antibody affinity maturation. As well as improving in affinity for specific epitopes, some antibody responses maintain or even increase their breadth of antigen-recognition over time. This has led to another intense line of research aimed at understanding how broadly neutralizing anti-pathogen responses are generated...
January 12, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28088692/evaluation-of-motor-and-cognitive-development-among-infants-exposed-to-hiv
#20
Kaitiana Martins da Silva, Cristina Dos Santos Cardoso de Sá, Raquel Carvalho
This study of a prospective and cross-sectional nature compared the motor and cognitive development of HIV-exposed and unexposed infants in their first 18months of age. 40 infants exposed to HIV and antiretroviral therapy (Experimental Group - EG) and 40 unexposed infants (Control Group - CG) participated in the study. They were divided into four age groups of 4, 8, 12 and 18months old, with 10 infants from EG and 10 from CG in each group. The infants were evaluated once on motor and cognitive development by the Bayley Scale of Infant and Toddler Development...
January 12, 2017: Early Human Development
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