keyword
MENU ▼
Read by QxMD icon Read
search

Mixed specifier

keyword
https://www.readbyqxmd.com/read/29786975/a-comparison-of-one-stage-vs-two-stage-individual-patient-data-meta-analysis-methods-a-simulation-study
#1
Evangelos Kontopantelis
BACKGROUND: Individual patient data (IPD) meta-analysis allows for the exploration of heterogeneity and can identify subgroups that most benefit from an intervention (or exposure), much more successfully than meta-analysis of aggregate data. One-stage or two-stage IPD meta-analysis is possible, with the former using mixed-effects regression models and the latter obtaining study-estimates through simpler regression models before aggregating using standard meta-analysis methodology. However, a comprehensive comparison of the two methods, in practice, is lacking...
May 22, 2018: Research Synthesis Methods
https://www.readbyqxmd.com/read/29760119/spring-summer-net-community-production-new-production-particle-export-and-related-water-column-biogeochemical-processes-in-the-marginal-sea-ice-zone-of-the-western-antarctic-peninsula-2012-2014
#2
Hugh W Ducklow, Michael R Stukel, Rachel Eveleth, Scott C Doney, Tim Jickells, Oscar Schofield, Alex R Baker, John Brindle, Rosie Chance, Nicolas Cassar
New production (New P, the rate of net primary production (NPP) supported by exogenously supplied limiting nutrients) and net community production (NCP, gross primary production not consumed by community respiration) are closely related but mechanistically distinct processes. They set the carbon balance in the upper ocean and define an upper limit for export from the system. The relationships, relative magnitudes and variability of New P (from 15 NO3 - uptake), O2  : argon-based NCP and sinking particle export (based on the 238 U : 234 Th disequilibrium) are increasingly well documented but still not clearly understood...
June 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29739725/surgical-outcomes-for-patients-diagnosed-with-dementia-a-coarsened-exact-matching-study
#3
REVIEW
Kimon Bekelis, Symeon Missios, Joel Shu, Todd A MacKenzie, Bruce Mayerson
BACKGROUND: An increasing number of elderly patients with dementia are undergoing surgical operations. Little is known about the differential impact of dementia on surgical outcomes. We investigated whether demented patients undergoing surgical operations have worse outcomes than their non-demented counterparts. METHODS: We performed a cohort study of all patients undergoing a series of surgical operations who were registered in the New York Statewide Planning and Research Cooperative System (SPARCS) database from 2009 to 2013...
May 5, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29735484/effect-of-an-sirna-therapeutic-targeting-pcsk9-on-atherogenic-lipoproteins-pre-specified-secondary-end-points-in-orion-1
#4
Kausik K Ray, Robert M Stoekenbroek, David Kallend, Lawrence A Leiter, Ulf Landmesser, R Scott Wright, Peter Wijngaard, John J Kastelein
Background -The ORION-1 trial demonstrated that inclisiran, a small interfering RNA (siRNA) therapeutic that targets PCSK9 mRNA within hepatocytes, produces significant LDL-C reduction. The effects of inclisiran on other lipids are less well described. Methods -ORION-1 was a phase 2 trial assessing 6 different inclisiran dosing regimens vs placebo. Participants with elevated LDL-C despite receiving maximally tolerated statin therapy received a single- (200, 300 or 500mg) or two-dose starting regimen (100, 200 or 300mg on days 1 and 90) of inclisiran or placebo...
May 7, 2018: Circulation
https://www.readbyqxmd.com/read/29734096/does-recent-mania-affect-response-to-antidepressants-in-bipolar-disorder-a-re-analysis-of-step-bd-data
#5
Zahra Mousavi, Sheri Johnson, Descartes Li
BACKGROUND: One previous study suggested that the presence of a manic episode before bipolar depression is related to worse response to antidepressants. METHOD: To examine this effect in a larger sample, we used data from the large, multi-site STEP-BD study. We hypothesized that among persons treated with antidepressants for bipolar depression, manic or mixed episodes before depression onset (as compared to euthymia) would predict lower rate of recovery, more sustained depressive symptoms and higher rate of switching into mania/hypomania after antidepressant treatment of bipolar depression...
April 22, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29730721/comparing-the-dsm-5-construct-of-disruptive-mood-dysregulation-disorder-and-icd-10-mixed-disorder-of-emotion-and-conduct-in-the-uk-longitudinal-assessment-of-manic-symptoms-uk-lams-study
#6
I Sagar-Ouriaghli, G Milavic, R Barton, N Heaney, F Fiori, K Lievesley, J Singh, Paramala Santosh
It is important to understand new diagnostic entities in classifications of psychopathology such as the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) (code F34.8) construct of Disruptive Mood Dysregulation Disorder (DMDD) and to compare it with possible equivalent disorders in other classificatory systems such as the International Classification of Diseases-10 (ICD-10), which has a category that superficially appears similar, that is, Mixed Disorder of Emotion and Conduct (MDEC) (code F92)...
May 5, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29729378/leveraging-knowledge-engineering-and-machine-learning-for-microbial-bio-manufacturing
#7
REVIEW
Tolutola Oyetunde, Forrest Sheng Bao, Jiung-Wen Chen, Hector Garcia Martin, Yinjie J Tang
Genome scale modeling (GSM) predicts the performance of microbial workhorses and helps identify beneficial gene targets. GSM integrated with intracellular flux dynamics, omics, and thermodynamics have shown remarkable progress in both elucidating complex cellular phenomena and computational strain design (CSD). Nonetheless, these models still show high uncertainty due to a poor understanding of innate pathway regulations, metabolic burdens, and other factors (such as stress tolerance and metabolite channeling)...
May 2, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29728557/flutter-to-tumble-transition-of-buoyant-spheres-triggered-by-rotational-inertia-changes
#8
Varghese Mathai, Xiaojue Zhu, Chao Sun, Detlef Lohse
Heavy particles sink straight in water, while buoyant bubbles and spheres may zigzag or spiral as they rise. The precise conditions that trigger such path-instabilities are still not completely understood. For a buoyant rising sphere, two parameters are believed to govern the development of unsteady dynamics: the particle's density relative to the fluid, and its Galileo number. Consequently, with these parameters specified, the opportunities for variation in particle dynamics appear limited. In contrast to this picture, here we demonstrate that vigorous path-oscillations can be triggered by modulating a spherical particle's moment of inertia (MoI)...
May 4, 2018: Nature Communications
https://www.readbyqxmd.com/read/29723313/a-five-year-retrospective-assay-of-implant-treatments-and-complications-in-private-practice-restorative-treatment-profiles-of-long-span-implant-supported-fixed-and-removable-dental-prostheses
#9
Vahed Parzham, Roy B Judge, Denise Bailey
PURPOSE: To describe the restorative treatment profiles of long-span (> three units), implant-supported dental prostheses (LIDPs) prescribed in 27 private practices in the state of Victoria, Australia, during the period from January 1, 2005, to December 31, 2009. The restorative treatment profiles of these prostheses refer to the framework/veneering materials, number of prosthetic units/supporting implants, location in the oral cavity, retention methods, and cantilever designs. LIDPs refer to implant-supported prostheses of fixed or removable design; namely, fixed partial dentures (IFPDs), fixed complete dentures (IFCDs), removable partial dentures (IRPDs), and complete overdentures (IODs)...
May 2018: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29718244/burden-of-ulcerative-colitis-on-functioning-and-well-being-a-systematic-literature-review-of-the-sf-36%C3%A2-health-survey
#10
Aaron Yarlas, David T Rubin, Julian Panés, James O Lindsay, Séverine Vermeire, Martha Bayliss, Joseph C Cappelleri, Stephen Maher, Andrew G Bushmakin, Lea Ann Chen, Marco DiBonaventura
Background and Aims: This review is the first to evaluate the burden of ulcerative colitis [UC] on patients' quality of life by synthesizing data from studies comparing scores from the SF-36® Health Survey, a generic measure assessing eight quality-of-life domains, between UC patients and matched reference samples. Methods: A systematic review of the published literature identified articles reporting SF-36 domains or physical and mental component summary scores [PCS, MCS] from UC and reference samples...
April 27, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29698914/error-quantification-of-osteometric-data-in-forensic-anthropology
#11
Natalie R Langley, Lee Meadows Jantz, Shauna McNulty, Heli Maijanen, Stephen D Ousley, Richard L Jantz
This study evaluates the reliability of osteometric data commonly used in forensic case analyses, with specific reference to the measurements in Data Collection Procedures 2.0 (DCP 2.0). Four observers took a set of 99 measurements four times on a sample of 50 skeletons (each measurement was taken 200 times by each observer). Two-way mixed ANOVAs and repeated measures ANOVAs with pairwise comparisons were used to examine interobserver (between-subjects) and intraobserver (within-subjects) variability. Relative technical error of measurement (TEM) was calculated for measurements with significant ANOVA results to examine the error among a single observer repeating a measurement multiple times (e...
April 10, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29696932/-origin-and-evolution-of-the-thunder-fire-moxibustion-therapy
#12
Hao Xue, Jianbin Zhang, Renshou Chen
Through analyzing the origin and evolution of the thunder-fire moxibustion therapy, the mysteries and misunderstandings of it were revealed. As a result, a more objective and comprehensive recognition of this ancient therapy was displayed to the people nowadays. The thunder-fire moxibustion therapy maybe originate from the Taoism magic arts before the Yuan Dynasty and became matured in the middle of the Ming Dynasty. Two categories were divided during the long-term evolution in the history. In one category, the peach twig was taken as the moxa material rather than moxa stick and the incantation of Taoism remained...
April 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29683722/recursive-partitioning-with-nonlinear-models-of-change
#13
Gabriela Stegmann, Ross Jacobucci, Sarfaraz Serang, Kevin J Grimm
In this article, we introduce nonlinear longitudinal recursive partitioning (nLRP) and the R package longRpart2 to carry out the analysis. This method implements recursive partitioning (also known as decision trees) in order to split data based on individual- (i.e., cluster) level covariates with the goal of predicting differences in nonlinear longitudinal trajectories. At each node, a user-specified linear or nonlinear mixed-effects model is estimated. This method is an extension of Abdolell et al.'s (2002) longitudinal recursive partitioning while permitting a nonlinear mixed-effects model in addition to a linear mixed-effects model in each node...
April 23, 2018: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/29682778/multivariate-generalized-hidden-markov-regression-models-with-random-covariates-physical-exercise-in-an-elderly-population
#14
Antonio Punzo, Salvatore Ingrassia, Antonello Maruotti
A time-varying latent variable model is proposed to jointly analyze multivariate mixed-support longitudinal data. The proposal can be viewed as an extension of hidden Markov regression models with fixed covariates (HMRMFCs), which is the state of the art for modelling longitudinal data, with a special focus on the underlying clustering structure. HMRMFCs are inadequate for applications in which a clustering structure can be identified in the distribution of the covariates, as the clustering is independent from the covariates distribution...
April 22, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29678137/supporting-teams-to-optimize-function-and-independence-in-veterans-a-multi-study-program-and-mixed-methods-protocol
#15
Virginia Wang, Kelli Allen, Courtney H Van Houtven, Cynthia Coffman, Nina Sperber, Elizabeth P Mahanna, Cathleen Colón-Emeric, Helen Hoenig, George L Jackson, Teresa M Damush, Erika Price, Susan N Hastings
BACKGROUND: Successful implementation of new clinical programs depends on effectively establishing, reorganizing, or enhancing team structures and processes to coordinate the work of individuals who are interdependent in their tasks, manage relationships, and share responsibility for outcomes. However, a one-size-fits-all approach is rarely effective. In partnership with VA national clinical leaders and local clinical champions, the Optimizing Function and Independence VA Quality Enhancement Research Initiative program (Function QUERI) will evaluate efforts to implement team-based clinical programs for Veterans at risk for functional decline and disability...
April 20, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29669709/implementing-an-open-source-electronic-health-record-system-in-kenyan-health-care-facilities-case-study
#16
Naomi Muinga, Steve Magare, Jonathan Monda, Onesmus Kamau, Stuart Houston, Hamish Fraser, John Powell, Mike English, Chris Paton
BACKGROUND: The Kenyan government, working with international partners and local organizations, has developed an eHealth strategy, specified standards, and guidelines for electronic health record adoption in public hospitals and implemented two major health information technology projects: District Health Information Software Version 2, for collating national health care indicators and a rollout of the KenyaEMR and International Quality Care Health Management Information Systems, for managing 600 HIV clinics across the country...
April 18, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29667709/the-outlet-patch-gastric-heterotopia-of-the-colo-rectum-and-anus
#17
Abul Ala Syed Rifat Mannan, Michael Vieth, Armen Khararjian, Binny Khandakar, Dora Lam-Himlin, David Heydt, Feriyl Bhaijee, Henry J Venbrux, Kathleen Byrnes, Lysandra Voltaggio, Norman Barker, Songyang Yuan, Elizabeth Montgomery
AIMS: Gastric heterotopia (GH) has been described throughout the gastrointestinal tract. However, the colorectal region is an extremely rare location for it. We describe the clinicopathologic features of GH of the colon, rectum, and anus. METHODS AND RESULTS: We identified 33 cases in 20 males and 13 females (median age 54 years; range, 4 months to 73 years). Sites included the rectum (N=26), anus (N=4), ileocecal junction (N=1), ascending colon (N=1) and descending colon (N=1)...
April 18, 2018: Histopathology
https://www.readbyqxmd.com/read/29665468/validation-of-haplotype-specific-extraction-for-separating-a-mitochondrial-dna-model-mixture-and-application-to-simulated-casework
#18
Judith Zander, Petra Otremba, Marion Nagy
Haplotype-specific extraction (HSE) is a new field of application for the separation of mitochondrial DNA (mtDNA) mixtures and is developed to identify the mtDNA haplotypes of the contributors subsequently by sequencing. Here we show the validation of HSE with an exemplary mitochondrial DNA mixture into its individual haplotypes according to our laboratory standards. These specify several critical areas of assay performance to be tested, such as sensitivity, robustness and mixture studies comprising varying proportions of their components,degraded samples and samples of different qualities and material...
April 11, 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29659058/polyethylene-glycol-solutions-rapidly-restore-and-maintain-axonal-continuity-neuromuscular-structures-and-behaviors-lost-after-sciatic-nerve-transections-in-female-rats
#19
Michelle Mikesh, Cameron L Ghergherehchi, Robert Louis Hastings, Amir Ali, Sina Rahesh, Karthik Jagannath, Dale R Sengelaub, Richard C Trevino, David M Jackson, George D Bittner
Complete severance of major peripheral mixed sensory-motor nerve proximally in a mammalian limb produces immediate loss of action potential conduction and voluntary behaviors mediated by the severed distal axonal segments. These severed distal segments undergo Wallerian degeneration within days. Denervated muscles atrophy within weeks. Slowly regenerating (∼1 mm/day) outgrowths from surviving proximal stumps that often nonspecifically reinnervate denervated targets produce poor, if any, restoration of lost voluntary behaviors...
April 16, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29603880/fmr1-premutation-frequency-in-a-large-ethnically-diverse-population-referred-for-carrier-testing
#20
Kailey M Owens, Lindsay Dohany, Carol Holland, Jeana DaRe, Tobias Mann, Christina Settler, Ryan E Longman
Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability and is caused by an expansion of cytosine-guanine-guanine (CGG) repeats in the FMR1 gene. Female premutation allele carriers (55-200 CGG repeats) are at risk to have an affected child. Currently, specific population-based carrier screening for FXS is not recommended. Previous studies exploring female premutation carrier frequency have been limited by size or ethnicity. This retrospective study provides a pan-ethnic estimate of the Fragile X premutation carrier frequency in a large, ethnically diverse population of women referred for routine carrier screening during a specified time period at Progenity, Inc...
March 31, 2018: American Journal of Medical Genetics. Part A
keyword
keyword
104251
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"