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https://www.readbyqxmd.com/read/28207296/gambit-a-parameterless-model-based-evolutionary-algorithm-for-mixed-integer-problems
#1
Krzysztof L Sadowski, Dirk Thierens, Peter A N Bosman
Learning and exploiting problem structure is one of the key challenges in optimization. This is especially important for black-box optimization (BBO) where prior structural knowledge of a problem is not available. Existing model-based Evolutionary Algorithms (EAs) are very efficient at learning structure in both the discrete, and in the continuous domain. In this paper, discrete and continuous model-building mechanisms are integrated for the Mixed-Integer (MI) domain, comprising discrete and continuous variables...
February 16, 2017: Evolutionary Computation
https://www.readbyqxmd.com/read/28193242/process-evaluation-of-a-cluster-randomised-trial-testing-a-pressure-ulcer-prevention-care-bundle-a-mixed-methods-study
#2
Shelley Roberts, Elizabeth McInnes, Tracey Bucknall, Marianne Wallis, Merrilyn Banks, Wendy Chaboyer
BACKGROUND: As pressure ulcers contribute to significant patient burden and increased health care costs, their prevention is a clinical priority. Our team developed and tested a complex intervention, a pressure ulcer prevention care bundle promoting patient participation in care, in a cluster-randomised trial. The UK Medical Research Council recommends process evaluation of complex interventions to provide insight into why they work or fail and how they might be improved. This study aimed to evaluate processes underpinning implementation of the intervention and explore end-users' perceptions of it, in order to give a deeper understanding of its effects...
February 13, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28184334/mixed-states-in-bipolar-disorder-etiology-pathogenesis-and-treatment
#3
REVIEW
Ather Muneer
Many bipolar disorder patients exhibit mixed affective states, which portend a generally more severe illness course and treatment resistance. In the previous renditions of Diagnostic and Statistical Manual mixed states were narrowly defined in the context of bipolar I disorder, but with the advent of DSM-5 the term "mixed episode" was dropped and replaced by "mixed features" specifier which could be broadly applied to manic, hypomanic and depressive episodes in both the bipolar spectrum and major depressive disorders...
January 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/28179417/green-shoots-of-recovery-a-realist-evaluation-of-a-team-to-support-change-in-general-practice
#4
Maggie Bartlett, Ruth Basten, Robert K McKinley
OBJECTIVE: A multidisciplinary support team for general practice was established in April 2014 by a local National Health Service (NHS) England management team. This work evaluates the team's effectiveness in supporting and promoting change in its first 2 years, using realist methodology. SETTING: Primary care in one area of England. PARTICIPANTS: Semistructured interviews were conducted with staff from 14 practices, 3 key senior NHS England personnel and 5 members of the support team...
February 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28177326/supracricoid-laryngectomy-for-recurrent-laryngeal-cancer-after-chemoradiotherapy-a-systematic-review-and-meta-analysis
#5
C A Leone, P Capasso, D Topazio, G Russo
Residual or recurrent laryngeal cancer after irradiation is a difficult clinical problem with a rate that ranges from 13% to 36% of cases. Supracricoid laryngectomy (SCL) with cricohyoidopexy (CHP) or cricohyoidoepiglottopexy (CHEP) provide reliable oncological and functional results for selected primary and recurrent patients with glottic and supraglottic carcinomas. We conducted a systematic review and meta-analysis to assess the oncological and functional outcomes of patients treated with open partial horizontal laryngectomy types IIa and IIb (CHEP, CHP) in terms of the recurrence of squamocellular cancer of the larynx after radiotherapy failure...
December 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28166237/no-benefits-of-statins-for-sudden-cardiac-death-prevention-in-patients-with-heart-failure-and-reduced-ejection-fraction-a-meta-analysis-of-randomized-controlled-trials
#6
Muaamar Al-Gobari, Hai-Ha Le, Mor Fall, François Gueyffier, Bernard Burnand
BACKGROUND AND OBJECTIVES: Statins showed mixed results in heart failure (HF) patients. The benefits in major HF outcomes, including all-cause mortality and sudden cardiac death (SCD), have always been discordant across systematic reviews and meta-analyses. We intended to systematically identify and appraise the available evidence that evaluated the effectiveness of statins in clinical outcomes for HF patients. DESIGN: Systematic review and meta-analysis. DATA SOURCES: We searched, until April 28, 2016: Medline, Embase, ISI Web of Science and EBM reviews (Cochrane DSR, ACP journal club, DARE, CCTR, CMR, HTA, and NHSEED), checked clinicaltrials...
2017: PloS One
https://www.readbyqxmd.com/read/28162812/intensity-of-exposure-to-a-patient-activation-intervention-and-patient-engagement-in-medical-visit-communication
#7
Chidinma Ibe, Janice Bowie, Debra Roter, Kathryn A Carson, Bone Lee, Dwyan Monroe, Lisa A Cooper
OBJECTIVE: We examined associations between intensity of exposure to a community health worker (CHW) delivered communication activation intervention targeting low-income patients with hypertension. METHODS: We analyzed question-asking behaviors of patients assigned to the intervention arms (n=140) in a randomized controlled trial. Intensity of exposure to the intervention was operationalized as the duration of face-to-face coaching and number of protocol-specified topics discussed...
January 9, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28161512/a-preference-for-some-types-of-complexity-comment-on-perceived-beauty-of-random-texture-patterns-a-preference-for-complexity
#8
Nicolas Gauvrit, Fernando Soler-Toscano, Alessandro Guida
In two experiments, Friedenberg and Liby (2016) studied how a diversity of complexity estimates such as density, number of blocks, GIF compression rate and edge length impact the perception of beauty of semi-random two-dimensional patterns. They concluded that aesthetics ratings are positively linked with GIF compression metrics and edge length, but not with the number of blocks. They also found an inverse U-shaped link between aesthetic judgments and density. These mixed results originate in the variety of metrics used to estimate what is loosely called "complexity" in psychology and indeed refers to conflicting notions...
February 2, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28149362/a-systematic-review-of-psychological-studies-applied-to-futsal
#9
Wichai Yeemin, Cláudia Salomé Dias, António Manuel Fonseca
This study presents a systematic review of psychological studies applied to futsal. A total of 23 studies were analyzed within five sections: a year overview and the name of journals, research designs, data collection, sample characteristics, and a focus category. This study found that the first psychological articles that were applied to futsal were published in 2008, and the number of publications gradually increased since then. The majority of examined studies were cross-sectional designs and conducted at the elite level in European and Asian countries...
April 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28130934/response-style-analysis-with-threshold-and-multi-process-irt-models-a-review-and-tutorial
#10
Ulf Böckenholt, Thorsten Meiser
Two different item response theory model frameworks have been proposed for the assessment and control of response styles in rating data. According to one framework, response styles can be assessed by analysing threshold parameters in Rasch models for ordinal data and in mixture-distribution extensions of such models. A different framework is provided by multi-process item response tree models, which can be used to disentangle response processes that are related to the substantive traits and response tendencies elicited by the response scale...
February 2017: British Journal of Mathematical and Statistical Psychology
https://www.readbyqxmd.com/read/28129357/enrichment-and-molecular-analysis-of-breast-cancer-disseminated-tumor-cells-from-bone-marrow-using-microfiltration
#11
Sreeraj G Pillai, Peixuan Zhu, Chidananda M Siddappa, Daniel L Adams, Shuhong Li, Olga V Makarova, Pete Amstutz, Ryan Nunley, Cha-Mei Tang, Mark A Watson, Rebecca L Aft
PURPOSE: Molecular characterization of disseminated tumor cells (DTCs) in the bone marrow (BM) of breast cancer (BC) patients has been hindered by their rarity. To enrich for these cells using an antigen-independent methodology, we have evaluated a size-based microfiltration device in combination with several downstream biomarker assays. METHODS: BM aspirates were collected from healthy volunteers or BC patients. Healthy BM was mixed with a specified number of BC cells to calculate recovery and fold enrichment by microfiltration...
2017: PloS One
https://www.readbyqxmd.com/read/28097044/study-on-the-single-dose-toxicity-of-shineumhur-pharmacopuncture-injected-into-the-muscles-of-rats
#12
Hohyun Jeong, Eunhye Cha, Jongcheol Lee, Seongjin Lee, Manyong Park, Dongwoung Kim, Bongkeun Song, Jongdeok Lee, Sungchul Kim
OBJECTIVES: This study was carried out to analyze the single dose toxicity of ShinEumHur (SEH) pharmacopuncture injected into the muscles of Sprague-Dawley rats. METHODS: The SEH pharmacopuncture was made in a clean room at the Korean Pharmacopuncture Institute (K-GMP). After the mixing process with sterile distilled water had been completed, the pH was controlled to between 7.0 and 7.5. All experiments were conducted at Biotoxtech, an institution authorized to perform non-clinical studies under the Good Laboratory Practice (GLP) regulations...
December 2016: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/28086857/evaluating-a-multicomponent-social-behaviour-change-communication-strategy-to-reduce-intimate-partner-violence-among-married-couples-study-protocol-for-a-cluster-randomized-trial-in-nepal
#13
Cari Jo Clark, Rachael A Spencer, Binita Shrestha, Gemma Ferguson, J Michael Oakes, Jhumka Gupta
BACKGROUND: Intimate partner violence (IPV) is a significant public health issue that affects 1 in 3 women globally and a similarly large number of women in Nepal. Over the past decade, important policy and programmatic steps have been taken to address violence against women in Nepal. There remains a dearth of evidence on the effectiveness of primary violence prevention strategies. The Change Starts at Home study begins to fill this gap by utilizing a multi-component social behaviour change communication (SBCC) strategy involving a radio drama and community mobilization to shift attitudes, norms and behaviours that underpin IPV perpetration in Nepal...
January 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28077190/measures-of-the-dsm-5-mixed-features-specifier-of-major-depressive-disorder
#14
Mark Zimmerman
During the past two decades, a number of studies have found that depressed patients frequently have manic symptoms intermixed with depressive symptoms. While the frequency of mixed syndromes are more common in bipolar than in unipolar depressives, mixed states are also common in patients with major depressive disorder. The admixture of symptoms may be evident when depressed patients present for treatment, or they may emerge during ongoing treatment. In some patients, treatment with antidepressant medication might precipitate the emergence of mixed states...
January 12, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28075023/classifying-gestational-weight-gain-trajectories-using-the-sitar-growth-model
#15
Corinne A Riddell, Robert W Platt, Lisa M Bodnar, Jennifer A Hutcheon
BACKGROUND: Gestational weight gain is often characterized by the total amount of weight gained during pregnancy, however, the pattern of gain may be an important determinant of health outcomes. The SITAR (Super Imposition by Translation And Rotation) model has been used to describe childhood growth trajectories and has appeal because of the biological interpretability of its parameters. The objective of this study was to determine the feasibility of applying this model to gestational weight gain trajectories...
January 11, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28068361/the-use-of-mixed-effects-models-for-obtaining-low-cost-ecosystem-carbon-stock-estimates-in-mangroves-of-the-asia-pacific
#16
Jacob J Bukoski, Jeremy S Broadhead, Daniel C Donato, Daniel Murdiyarso, Timothy G Gregoire
Mangroves provide extensive ecosystem services that support local livelihoods and international environmental goals, including coastal protection, biodiversity conservation and the sequestration of carbon (C). While voluntary C market projects seeking to preserve and enhance forest C stocks offer a potential means of generating finance for mangrove conservation, their implementation faces barriers due to the high costs of quantifying C stocks through field inventories. To streamline C quantification in mangrove conservation projects, we develop predictive models for (i) biomass-based C stocks, and (ii) soil-based C stocks for the mangroves of the Asia-Pacific...
2017: PloS One
https://www.readbyqxmd.com/read/28060414/standardizing-ct-lung-density-measure-across-scanner-manufacturers
#17
Huaiyu Heather Chen-Mayer, Matthew K Fuld, Bernice Hoppel, Philip F Judy, Jered P Sieren, Junfeng Guo, David A Lynch, Antonio Possolo, Sean B Fain
PURPOSE: Computed Tomography (CT) imaging of the lung, reported in Hounsfield Units (HU), can be parameterized as a quantitative image biomarker for the diagnosis and monitoring of lung density changes due to emphysema, a type of chronic obstructive pulmonary disease (COPD). CT lung density metrics are global measurements based on lung CT number histograms, and are typically a quantity specifying either the percentage of voxels with CT numbers below a threshold, or a single CT number below which a fixed relative lung volume, nth percentile, falls...
January 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28060411/scarless-cas9-assisted-recombineering-no-scar-in-escherichia-coli-an-easy-to-use-system-for-genome-editing
#18
Christopher R Reisch, Kristala L J Prather
The discovery and development of genome editing systems that leverage the site-specific DNA endonuclease system CRISPR/Cas9 has fundamentally changed the ease and speed of genome editing in many organisms. In eukaryotes, the CRISPR/Cas9 system utilizes a "guide" RNA to enable the Cas9 nuclease to make a double-strand break at a particular genome locus, which is repaired by non-homologous end joining (NHEJ) repair enzymes, often generating random mutations in the process. A specific alteration of the target genome can also be generated by supplying a DNA template in vivo with a desired mutation, which is incorporated by homology-directed repair...
January 5, 2017: Current Protocols in Molecular Biology
https://www.readbyqxmd.com/read/28049424/a-mixed-integer-linear-programming-approach-to-the-reduction-of-genome-scale-metabolic-networks
#19
Annika Röhl, Alexander Bockmayr
BACKGROUND: Constraint-based analysis has become a widely used method to study metabolic networks. While some of the associated algorithms can be applied to genome-scale network reconstructions with several thousands of reactions, others are limited to small or medium-sized models. In 2015, Erdrich et al. introduced a method called NetworkReducer, which reduces large metabolic networks to smaller subnetworks, while preserving a set of biological requirements that can be specified by the user...
January 3, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28047992/su-f-t-94-plan2pdf-a-software-tool-for-automatic-plan-report-for-philips-pinnacle-tps
#20
C Wu
PURPOSE: To implement an automatic electronic PDF plan reporting tool for Philips Pinnacle treatment planning system (TPS) METHODS: An electronic treatment plan reporting software is developed by us to enable fully automatic PDF report from Pinnacle TPS to external EMR programs such as MOSAIQ. The tool is named "plan2pdf". plan2pdf is implemented using Pinnacle scripts, Java and UNIX shell scripts, without any external program needed. plan2pdf supports full auto-mode and manual mode reporting...
June 2016: Medical Physics
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