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https://www.readbyqxmd.com/read/28422805/a-randomized-pilot-study-comparing-ketamine-and-methohexital-anesthesia-for-electroconvulsive-therapy-in-patients-with-depression
#1
Shona L Ray-Griffith, Lou Ann Eads, Xiaotong Han, Kimberly Golden, Zachary N Stowe
OBJECTIVE: This randomized controlled pilot study examines the differences in response to electroconvulsive therapy (ECT) as defined by an improvement of depressive symptoms between ketamine and methohexital as the primary anesthetic agent. Adverse effects and cognitive tolerability were also examined. METHODS: Subjects undergoing ECT for unipolar or bipolar depression were randomized to receive ketamine or methohexital as the anesthetic agent. Primary outcome measure includes the Hamilton rating scale for depression (17-item)...
April 18, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28421980/guidelines-for-the-recognition-and-management-of-mixed-depression
#2
Stephen M Stahl, Debbi A Morrissette, Gianni Faedda, Maurizio Fava, Joseph F Goldberg, Paul E Keck, Yena Lee, Gin Malhi, Ciro Marangoni, Susan L McElroy, Michael Ostacher, Joshua D Rosenblat, Eva Solé, Trisha Suppes, Minoru Takeshima, Michael E Thase, Eduard Vieta, Allan Young, Mark Zimmerman, Roger S McIntyre
A significant minority of people presenting with a major depressive episode (MDE) experience co-occurring subsyndromal hypo/manic symptoms. As this presentation may have important prognostic and treatment implications, the DSM-5 codified a new nosological entity, the "mixed features specifier," referring to individuals meeting threshold criteria for an MDE and subthreshold symptoms of (hypo)mania or to individuals with syndromal mania and subthreshold depressive symptoms. The mixed features specifier adds to a growing list of monikers that have been put forward to describe phenotypes characterized by the admixture of depressive and hypomanic symptoms (e...
February 28, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28421011/practical-consequences-of-item-response-theory-model-misfit-in-the-context-of-test-equating-with-mixed-format-test-data
#3
Yue Zhao, Ronald K Hambleton
In item response theory (IRT) models, assessing model-data fit is an essential step in IRT calibration. While no general agreement has ever been reached on the best methods or approaches to use for detecting misfit, perhaps the more important comment based upon the research findings is that rarely does the research evaluate IRT misfit by focusing on the practical consequences of misfit. The study investigated the practical consequences of IRT model misfit in examining the equating performance and the classification of examinees into performance categories in a simulation study that mimics a typical large-scale statewide assessment program with mixed-format test data...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28420342/impact-of-correlation-of-predictors-on-discrimination-of-risk-models-in-development-and-external-populations
#4
Suman Kundu, Madhu Mazumdar, Bart Ferket
BACKGROUND: The area under the ROC curve (AUC) of risk models is known to be influenced by differences in case-mix and effect size of predictors. The impact of heterogeneity in correlation among predictors has however been under investigated. We sought to evaluate how correlation among predictors affects the AUC in development and external populations. METHODS: We simulated hypothetical populations using two different methods based on means, standard deviations, and correlation of two continuous predictors...
April 19, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28401382/first-application-of-newly-developed-ft-nir-spectroscopic-methodology-to-predict-authenticity-of-extra-virgin-olive-oil-retail-products-in-the-usa
#5
Magdi M Mossoba, Hormoz Azizian, Ali Reza Fardin-Kia, Sanjeewa R Karunathilaka, John K G Kramer
Economically motivated adulteration (EMA) of extra virgin olive oils (EVOO) has been a worldwide problem and a concern for government regulators for a long time. The US Food and Drug Administration (FDA) is mandated to protect the US public against intentional adulteration of foods and has jurisdiction over deceptive label declarations. To detect EMA of olive oil and address food safety vulnerabilities, we used a previously developed rapid screening methodology to authenticate EVOO. For the first time, a recently developed FT-NIR spectroscopic methodology in conjunction with partial least squares analysis was applied to commercial products labeled EVOO purchased in College Park, MD, USA to rapidly predict whether they are authentic, potentially mixed with refined olive oil (RO) or other vegetable oil(s), or are of lower quality...
April 11, 2017: Lipids
https://www.readbyqxmd.com/read/28393500/enhanced-direct-ethanol-production-by-cofactor-optimization-of-cell-surface-displayed-xylose-isomerase-in-yeast
#6
Yusuke Sasaki, Toshiyuki Takagi, Keisuke Motone, Kouichi Kuroda, Mitsuyoshi Ueda
Xylose isomerase (XylC) from Clostridium cellulovorans can simultaneously perform isomerization and fermentation of d-xylose, the main component of lignocellulosic biomass, and is an attractive candidate enzyme. In this study, we optimized a specified metal cation in a previously established Saccharomyces cerevisiae strain displaying XylC. We investigated the effect of each metal cation on the catalytic function of the XylC-displaying S. cerevisiae. Results showed that the divalent cobalt cations (Co(2+) ), especially enhanced the activity by 46-fold...
April 10, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28389945/dynamic-measures-of-flagellar-gene-expression
#7
Santosh Koirala, Christopher V Rao
Many genes are required to assemble flagella. These genes encode not only the structural elements of the flagellum but also a number of regulators that control how the flagellar genes are temporally expressed during the assembly process. These regulators also specify the likelihood that a given cell will express the flagellar genes. In particular, not all cells express the flagellar genes, resulting in mixed populations of motile and non-motile cells. Nutrients provide one signal that specifies the motile fraction...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28386439/parapatric-speciation-in-three-islands-dynamics-of-geographical-configuration-of-allele-sharing
#8
Ryo Yamaguchi, Yoh Iwasa
We studied the time to speciation by geographical isolation for a species living on three islands connected by rare migration. We assumed that incompatibility was controlled by a number of quantitative loci and that individuals differing in loci by more than a threshold did not mix genetically with each other. For each locus, we defined the geographical configuration (GC), which specifies islands with common alleles, and traced the stochastic transitions between different GCs. From these results, we calculated the changes in genetic distances...
February 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28384988/shade-guide-for-the-fabrication-of-acrylic-denture-based-on-mucosal-colour
#9
Godwin Clovis Da Costa, Meena Ajay Aras, Paul Chalakkal
This article highlights the use of a simple and convenient shade guide system which not only helps in choosing the shade tab that matches with the colour of the mucosa, but, also helps in the fabrication of the precise shade of acrylic resin for making the denture. The shade guide is fabricated by mixing specified quantities of various colours of acrylic polymer in order to obtain various shade tabs. The method for fabrication of the shade guide and the clinical procedure has been discussed.
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28382718/a-bivariate-contaminated-binormal-model-for-robust-fitting-of-proper-roc-curves-to-a-pair-of-correlated-possibly-degenerate-roc-datasets
#10
Xuetong Zhai, Dev P Chakraborty
PURPOSE: The objective was to design and implement a bivariate extension to the contaminated binormal model (CBM) to fit paired receiver operating characteristic (ROC) datasets -NDASH- possibly degenerate - with proper ROC curves. Paired datasets yield two correlated ratings per case. Degenerate datasets have no interior operating points and proper ROC curves do not inappropriately cross the chance diagonal. The existing method, developed more than 3 decades ago utilizes a bivariate extension to the binormal model, implemented in CORROC2 software, which yields improper ROC curves and cannot fit degenerate datasets...
April 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28379559/sperm-recovery-and-icsi-outcomes-in-klinefelter-syndrome-a-systematic-review-and-meta-analysis
#11
Giovanni Corona, Alessandro Pizzocaro, Fabio Lanfranco, Andrea Garolla, Fiore Pelliccione, Linda Vignozzi, Alberto Ferlin, Carlo Foresta, Emmanuele A Jannini, Mario Maggi, Andrea Lenzi, Daniela Pasquali, Sandro Francavilla
BACKGROUND: Specific factors underlying successful surgical sperm retrieval rates (SRR) or pregnancy rates (PR) after testicular sperm extraction (TESE) in adult patients with Klinefelter syndrome (KS) have not been completely clarified. OBJECTIVE AND RATIONALE: The aim of this review was to meta-analyse the currently available data from subjects with KS regarding SRRs as the primary outcome. In addition, when available, PRs and live birth rates (LBRs) after the ICSI technique were also investigated as secondary outcomes...
April 4, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28378504/mixed-models-linear-dependency-and-identification-in-age-period-cohort-models
#12
Robert M O'Brien
This paper examines the identification problem in age-period-cohort models that use either linear or categorically coded ages, periods, and cohorts or combinations of these parameterizations. These models are not identified using the traditional fixed effect regression model approach because of a linear dependency between the ages, periods, and cohorts. However, these models can be identified if the researcher introduces a single just identifying constraint on the model coefficients. The problem with such constraints is that the results can differ substantially depending on the constraint chosen...
April 4, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28367756/a-multi-objective-model-for-sustainable-recycling-of-municipal-solid-waste
#13
Ali Mirdar Harijani, Saeed Mansour, Behrooz Karimi
The efficient management of municipal solid waste is a major problem for large and populated cities. In many countries, the majority of municipal solid waste is landfilled or dumped owing to an inefficient waste management system. Therefore, an optimal and sustainable waste management strategy is needed. This study introduces a recycling and disposal network for sustainable utilisation of municipal solid waste. In order to optimise the network, we develop a multi-objective mixed integer linear programming model in which the economic, environmental and social dimensions of sustainability are concurrently balanced...
April 2017: Waste Management & Research
https://www.readbyqxmd.com/read/28364607/passive-sampling-as-a-tool-for-identifying-micro-organic-compounds-in-groundwater
#14
N Mali, S Cerar, A Koroša, P Auersperger
The paper presents the use of a simple and cost efficient passive sampling device with integrated active carbon with which to test the possibility of determining the presence of micro-organic compounds (MOs) in groundwater and identifying the potential source of pollution as well as the seasonal variability of contamination. Advantage of the passive sampler is to cover a long sampling period by integrating the pollutant concentration over time, and the consequently analytical costs over the monitoring period can be reduced substantially...
March 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28339595/does-starting-to-smoke-cigars-trigger-onset-of-cannabis-blunt-smoking
#15
Brian J Fairman, James C Anthony
Introduction: Among United States teens during the 1990s, increasing cigar use coincided with increasing use of tobacco cigar shells filled with cannabis, called "blunts." Cigar smokers are more likely to use cannabis, and we hypothesized that starting to smoke cigars might be a probabilistic "trigger" of blunt smoking. We turned to the case-crossover approach to evaluate this hypothesis. Methods: Within US National Surveys on Drug Use and Health, 2009-2013, we identified a nationally representative sample of newly incident blunt smokers aged 12- to 21-years-old (n = 4868) and compared month-of-onsets for smoking of cigars and blunts...
January 25, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28333039/corrigendum-to-in-vivo-evaluation-of-copper-release-and-acute-local-tissue-reactions-after-implantation-of-copper-coated-titanium-implants-in-rats
#16
Andreas Hoene, Cornelia Prinz, Uwe Walschus, Silke Lucke, Maciej Patrzyk, Lutz Wilhelm, Hans-Georg Neumann, Michael Schlosser
In the "Materials and methods" chapter of the article given above, in section 2.1 titled "Implant samples and preparation" on page 2 (top paragraph of the right column), an incorrect value of 1 μg mm-2 for the average Cu load of the surface was inadvertently specified. This was due to an accidental mix-up of electronic data sets from examination of different implant series. The correct value is 0.2 μg mm-2. No other data given in the article are affected. The authors kindly apologize for this mistake.
March 23, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28330409/guidelines-on-constructing-funnel-plots-for-quality-indicators-a-case-study-on-mortality-in-intensive-care-unit-patients
#17
Ilona Wm Verburg, Rebecca Holman, Niels Peek, Ameen Abu-Hanna, Nicolette F de Keizer
Funnel plots are graphical tools to assess and compare clinical performance of a group of care professionals or care institutions on a quality indicator against a benchmark. Incorrect construction of funnel plots may lead to erroneous assessment and incorrect decisions potentially with severe consequences. We provide workflow-based guidance for data analysts on constructing funnel plots for the evaluation of binary quality indicators, expressed as proportions, risk-adjusted rates or standardised rates. Our guidelines assume the following steps: (1) defining policy level input; (2) checking the quality of models used for case-mix correction; (3) examining whether the number of observations per hospital is sufficient; (4) testing for overdispersion of the values of the quality indicator; (5) testing whether the values of quality indicators are associated with institutional characteristics; and (6) specifying how the funnel plot should be constructed...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28325442/a-two-stage-variable-selection-and-classification-approach-for-parkinson-s-disease-detection-by-using-voice-recording-replications
#18
Lizbeth Naranjo, Carlos J Pérez, Jacinto Martín, Yolanda Campos-Roca
BACKGROUND AND OBJECTIVE: In the scientific literature, there is a lack of variable selection and classification methods considering replicated data. The problem motivating this work consists in the discrimination of people suffering Parkinson's disease from healthy subjects based on acoustic features automatically extracted from replicated voice recordings. METHODS: A two-stage variable selection and classification approach has been developed to properly match the replication-based experimental design...
April 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28318480/supervision-in-motivational-interviewing-an-exploratory-study
#19
Maria Beckman, Benjamin Bohman, Lars Forsberg, Finn Rasmussen, Ata Ghaderi
BACKGROUND: Although supervision is believed to be an important strategy for training practitioners in evidence-based practice, little is known about how it should be organized and conducted to promote implementation fidelity. AIMS: To explore supervisor behaviours that might facilitate supervisees' proficiency in motivational interviewing. METHOD: In this exploratory study, ten supervisors from a primary prevention intervention of childhood obesity responded to semi-structured interviews about their supervision behaviours...
March 20, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28294388/interpretable-inference-on-the-mixed-effect-model-with-the-box-cox-transformation
#20
K Maruo, Y Yamaguchi, H Noma, M Gosho
We derived results for inference on parameters of the marginal model of the mixed effect model with the Box-Cox transformation based on the asymptotic theory approach. We also provided a robust variance estimator of the maximum likelihood estimator of the parameters of this model in consideration of the model misspecifications. Using these results, we developed an inference procedure for the difference of the model median between treatment groups at the specified occasion in the context of mixed effects models for repeated measures analysis for randomized clinical trials, which provided interpretable estimates of the treatment effect...
March 10, 2017: Statistics in Medicine
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