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https://www.readbyqxmd.com/read/29334637/contamination-characteristics-and-source-apportionment-of-heavy-metals-in-topsoil-from-an-area-in-xi-an-city-china
#1
Xiuduan Chen, Xinwei Lu
As soil-extractable elements potentially pose ecological and health risks, identifying their contamination characteristics and sources is crucial. Therefore, to understand topsoil trace elements in the urban ring zone from the Second Ring Road to the Third Ring of Xi'an city in China, we determined the concentrations of Zn, Co, V, As, Cu, Mn, Ba, Ni and Pb, and analyzed the sources of the contamination. The results showed that the individual pollution indices of Pb, Co, Cu, Zn, Ba, Ni, Mn, As, and V were 1...
January 11, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29330761/correction-to-scientific-white-paper-on-concentration-qtc-modeling
#2
Christine Garnett, Peter L Bonate, Qianyu Dang, Georg Ferber, Dalong Huang, Jiang Liu, Devan Mehrotra, Steve Riley, Philip Sager, Christoffer Tornoe, Yaning Wang
The original version of this article unfortunately contained an error in Equation 1 under the section "Pre-specified linear mixed effects model". The correct equation has given below.
January 12, 2018: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/29325355/-comparison-of-prognosis-between-invasive-micropapillary-carcinoma-and-invasive-ductal-carcinoma-of-breast-a-single-center-retrospective-case-control-study
#3
B Hua, X Lu, W Z Xiao, X Yang, S R He, Z Wang
Objective: To elucidate the clinicopathological characters and prognostic factors of invasive micropapillary carcinoma of the breast (IMPC) by compared with invasive ductal carcinoma, not otherwise specified of the breast (IDC). Methods: The retrospective study was performed with female patients who had undergone curative resection for breast cancer without neoadjuvant chemotherapy from June 2008 to April 2016 in Breast Center of Beijing Hospital. Forty-seven mixed or pure IMPC patients and 93 pure IDC patients(admitted in the same center from October 2008 to January 2016 ) were matched for tumor stage, nodal status and age...
January 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29315733/a-comparison-of-7-random-effects-models-for-meta-analyses-that-estimate-the-summary-odds-ratio
#4
Dan Jackson, Martin Law, Theo Stijnen, Wolfgang Viechtbauer, Ian R White
Comparative trials that report binary outcome data are commonly pooled in systematic reviews and meta-analyses. This type of data can be presented as a series of 2-by-2 tables. The pooled odds ratio is often presented as the outcome of primary interest in the resulting meta-analysis. We examine the use of 7 models for random-effects meta-analyses that have been proposed for this purpose. The first of these models is the conventional one that uses normal within-study approximations and a 2-stage approach. The other models are generalised linear mixed models that perform the analysis in 1 stage and have the potential to provide more accurate inference...
January 8, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29312846/role-of-fast-setting-cements-in-arthroplasty-a-comparative-analysis-of-characteristics
#5
Neil Ayron Caraan, Reinhard Windhager, Jason Webb, Nadine Zentgraf, Klaus-Dieter Kuehn
AIM: To evaluate the behaviour of two fast-setting polymethylmethacrylate (PMMA) cements CMW® 2G and Palacos® fast R + G, as reference: Standard-setting Palacos® R + G. METHODS: The fast-setting cements CMW® 2G and Palacos® fast R + G were studied, using standard-setting high viscosity Palacos® R + G as a reference. Eleven units (of two batch numbers) of each cement were tested. All cements were mixed as specified by the manufacturer and analysed on the following parameters: Handling properties (mixing, waiting, working and hardening phase) according to Kuehn, Mechanical properties according to ISO 5833 and DIN 53435, Fatigue strength according to ISO 16402, Benzoyl Peroxide (BPO) - Content by titration, powder/liquid-ratio by weighing, antibiotic elution profile by High Performance Liquid Chromatography...
December 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/29302612/an-application-of-extended-normalisation-process-theory-in-a-randomised-controlled-trial-of-a-complex-social-intervention-process-evaluation-of-the-strengthening-families-programme-10-14-in-wales-uk
#6
Jeremy Segrott, Simon Murphy, Heather Rothwell, Jonathan Scourfield, David Foxcroft, David Gillespie, Jo Holliday, Kerenza Hood, Claire Hurlow, Sarah Morgan-Trimmer, Ceri Phillips, Hayley Reed, Zoe Roberts, Laurence Moore
Purpose: Process evaluations generate important data on the extent to which interventions are delivered as intended. However, the tendency to focus only on assessment of pre-specified structural aspects of fidelity has been criticised for paying insufficient attention to implementation processes and how intervention-context interactions influence programme delivery. This paper reports findings from a process evaluation nested within a randomised controlled trial of the Strengthening Families Programme 10-14 (SFP 10-14) in Wales, UK...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29289831/quantification-of-spatial-and-seasonal-variations-in-the-proportional-contribution-of-nitrate-sources-using-a-multi-isotope-approach-and-bayesian-isotope-mixing-model
#7
Aminreza Meghdadi, Narmin Javar
Spatial and seasonal variations in nitrate contamination are a globally concern. While numerous studies have used δ15N-NO3 and δ18O-NO3 to elucidate the dominant sources of nitrate in groundwater, this approach has significant limitations due to the overlap of nitrate isotopic ranges and the occurrence of nitrate isotopic fractionation. This study quantitatively assessed the spatial and seasonal variations in the proportional contributions of nitrate sources from different land uses in the Tarom watershed in North-West Iran...
December 28, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29288683/what-is-difficult-for-you-can-be-easy-for-me-effects-of-increasing-individual-task-demand-on-prefrontal-lateralization-a-tdcs-study
#8
A Vergallito, Leonor J Romero Lauro, Rolando Bonandrini, Laura Zapparoli, Laura Danelli, Manuela Berlingeri
Neuroimaging studies suggest that increment of the cognitive load associated with a specific task may induce the recruitment of a more bilateral brain network. In most studies, however, task demand has been manipulated in a static and pre-specified way, regardless of individual cognitive resources. Here we implemented a new paradigm based on a pre-experimental assessment to set up subject-specific levels of task demand and applied tDCS (transcranial direct current stimulation) to assess each hemisphere involvement in task performance...
December 27, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29280252/sex-hormones-in-alcohol-consumption-a-systematic-review-of-evidence
#9
Almila Erol, Ada M-C Ho, Stacey J Winham, Victor M Karpyak
Sex hormones play an important role in establishing sex-distinctive brain structural and functional variations that could contribute to the sex differences in alcohol consumption behavior. Here, we systematically reviewed articles that studied sex hormone impacts on alcohol consumption and alcohol use disorder (AUD). An extensive literature search conducted in MEDLINE, PubMed, Scopus and CINAHL databases identified 776 articles, which were then evaluated for pre-specified criteria for relevance and quality assurance...
December 27, 2017: Addiction Biology
https://www.readbyqxmd.com/read/29275445/issues-on-the-diagnosis-and-etiopathogenesis-of-mood-disorders-reconsidering-dsm-5
#10
REVIEW
Kazuyoshi Ogasawara, Yukako Nakamura, Hiroyuki Kimura, Branko Aleksic, Norio Ozaki
The authors present a narrative review from the diagnostic and nosologic viewpoints of mood disorders (bipolar and depressive ones) by revisiting the revision from the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders, Text Revision to DSM-5, including the following: the separation of the bipolar and depressive sections; the addition of increased energy and continuation of symptoms to the hypo/manic criteria; the elimination of mixed episodes; the creation of new categories and specifiers ("other specified bipolar and related disorder", "disruptive mood dysregulation disorder", "with anxious distress", "with mixed features", "with peripartum onset"); the categorization of hypo/manic episodes during antidepressant treatment into bipolar disorder; the elimination of the "bereavement exclusion"; the ambiguous separation between bipolar I and II; the insufficient distinction between "other specified bipolar and related disorders" and major depressive disorder; the differentiation regarding borderline personality disorder; agitation; premenstrual dysphoric disorder; and society and psychiatry...
December 23, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29233633/dynamic-ct-angiography-for-the-diagnosis-of-patients-with-thoracic-outlet-syndrome-correlation-with-patient-symptoms
#11
Romain Gillet, Pedro Teixeira, Jean-Baptiste Meyer, Aymeric Rauch, Ariane Raymond, François Dap, Alain Blum
INTRODUCTION: Vasculo-nervous structures serving the upper limbs may be compressed as they pass through three areas: the inter-scalene triangle (IST), the costo-clavicular space (CCS) and the retropectoralis minor space (RMS). The diagnosis of thoracic outlet syndrome (TOS) is essentially clinical, but requires imaging to specify the site of compression, its grade and the existence of predisposing anatomical factors, in order to guide the treatment and eliminate the main differential diagnoses...
December 2, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29223579/design-considerations-for-handling-dropouts-in-anti-depressant-drug-trials
#12
Jinglin Zhong, Ni A Khin, Peiling Yang
BACKGROUND: In clinical trials, statistical analysis often requires certain assumptions about missing data for a valid statistical inference. If the dropout rate is high, a wrong assumption about the missing data may compromise the validity of statistical inferences. PURPOSE: To mitigate the high dropout rates commonly observed in psychiatry clinical trials, we consider two design approaches for short-term controlled trials submitted in support of marketing applications for drug products for the major depressive disorder (MDD) indication: (1) shortening the trial duration and (2) treating time to treatment discontinuation as an alternative primary efficacy endpoint...
December 6, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29209907/scientific-white-paper-on-concentration-qtc-modeling
#13
REVIEW
Christine Garnett, Peter L Bonate, Qianyu Dang, Georg Ferber, Dalong Huang, Jiang Liu, Devan Mehrotra, Steve Riley, Philip Sager, Christoffer Tornoe, Yaning Wang
The International Council for Harmonisation revised the E14 guideline through the questions and answers process to allow concentration-QTc (C-QTc) modeling to be used as the primary analysis for assessing the QTc interval prolongation risk of new drugs. A well-designed and conducted QTc assessment based on C-QTc modeling in early phase 1 studies can be an alternative approach to a thorough QT study for some drugs to reliably exclude clinically relevant QTc effects. This white paper provides recommendations on how to plan and conduct a definitive QTc assessment of a drug using C-QTc modeling in early phase clinical pharmacology and thorough QT studies...
December 5, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/29194545/impact-of-integration-of-sexual-and-reproductive-health-services-on-consultation-duration-times-results-from-the-integra-initiative
#14
Mariana Siapka, Carol Dayo Obure, Susannah H Mayhew, Sedona Sweeney, Justin Fenty, Anna Vassall
The lack of human resources is a key challenge in scaling up of HIV services in Africa's health care system. Integrating HIV services could potentially increase their effectiveness and optimize the use of limited resources and clinical staff time. We examined the impact of integration of provider initiated HIV counselling and testing (PITC) and family planning (FP counselling and FP provision) services on duration of consultation to assess the impact of PITC and FP integration on staff workload. This study was conducted in 24 health facilities in Kenya under the Integra Initiative, a non-randomized, pre/post intervention trial to evaluate the impact of integrated HIV and sexual and reproductive health services on health and service outcomes...
November 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29185627/strategies-for-enhancing-the-implementation-of-school-based-policies-or-practices-targeting-risk-factors-for-chronic-disease
#15
REVIEW
Luke Wolfenden, Nicole K Nathan, Rachel Sutherland, Sze Lin Yoong, Rebecca K Hodder, Rebecca J Wyse, Tessa Delaney, Alice Grady, Alison Fielding, Flora Tzelepis, Tara Clinton-McHarg, Benjamin Parmenter, Peter Butler, John Wiggers, Adrian Bauman, Andrew Milat, Debbie Booth, Christopher M Williams
BACKGROUND: A number of school-based policies or practices have been found to be effective in improving child diet and physical activity, and preventing excessive weight gain, tobacco or harmful alcohol use. Schools, however, frequently fail to implement such evidence-based interventions. OBJECTIVES: The primary aims of the review are to examine the effectiveness of strategies aiming to improve the implementation of school-based policies, programs or practices to address child diet, physical activity, obesity, tobacco or alcohol use...
November 29, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29179230/endoscopic-subtypes-of-colorectal-laterally-spreading-tumors-lsts-and-the-risk-of-submucosal-invasion-a-meta-analysis
#16
Roel M M Bogie, Manon H J Veldman, Luc A R S Snijders, Bjorn Winkens, Tonya Kaltenbach, Ad A M Masclee, Takahisa Matsuda, Eveline J A Rondagh, Roy Soetikno, Shinji Tanaka, Han-Mo Chiu, Silvia Sanduleanu-Dascalescu
Background and study aims Many studies have reported on laterally spreading tumors (LSTs), but systematic reviews of the data to determine their risk of containing submucosal invasion (SMI) are lacking. We systematically screened and analyzed the available literature to provide a more solid basis for evidence-based treatment. Methods We conducted a systematic search in PubMed, Embase, the Cochrane Library, and Scopus for published articles until July 2017. We estimated pooled prevalence or odds ratios (ORs) with 95 % confidence intervals (CIs), using random-effects models...
November 27, 2017: Endoscopy
https://www.readbyqxmd.com/read/29174238/association-of-hospital-teaching-status-with-neurosurgical-outcomes-an-instrumental-variable-analysis
#17
Kimon Bekelis, Symeon Missios, Shannon Coy, Todd A MacKenzie
BACKGROUND: The interpretation of the results of prior studies on the association of hospital teaching status with surgical outcomes is limited by selection bias. We investigated whether undergoing surgical operations in teaching hospitals is associated with improved outcomes. METHODS: We performed a cohort study of all patients undergoing spine and cranial operations who were registered in the New York Statewide Planning and Research Cooperative System (SPARCS) database from 2009-2013...
November 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29164065/transcriptional-and-microenvironmental-regulation-of-lineage-ambiguity-in-leukemia
#18
REVIEW
Tianyuan Hu, Rebecca Murdaugh, Daisuke Nakada
Leukemia is characterized by the uncontrolled production of leukemic cells and impaired normal hematopoiesis. Although the combination of chemotherapies and hematopoietic stem cell transplantation has significantly improved the outcome of leukemia patients, a proportion of patients still suffer from relapse after treatment. Upon relapse, a phenomenon termed "lineage switch" is observed in a subset of leukemia patients, in which conversion of lymphoblastic leukemia to myeloid leukemia or vice versa is observed...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29159510/differences-in-sampling-techniques-on-total-post-mortem-tryptase
#19
R Tse, J Garland, K Kesha, H Elstub, A D Cala, Y Ahn, S Stables, C Palmiere
BACKGROUND: The measurement of mast cell tryptase is commonly used to support the diagnosis of anaphylaxis. In the post-mortem setting, the literature recommends sampling from peripheral blood sources (femoral blood) but does not specify the exact sampling technique. Sampling techniques vary between pathologists, and it is unclear whether different sampling techniques have any impact on post-mortem tryptase levels. AIM: The aim of this study is to compare the difference in femoral total post-mortem tryptase levels between two sampling techniques...
November 20, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29150713/efficacy-of-silexan-in-subthreshold-anxiety-meta-analysis-of-randomised-placebo-controlled-trials
#20
Hans-Jürgen Möller, Hans-Peter Volz, Angelika Dienel, Sandra Schläfke, Siegfried Kasper
Subthreshold psychiatric disorders do not fully meet the diagnostic criteria of syndromal disorders but may be associated with comparable disability. To investigate the anxiolytic effect of Silexan, an active substance from lavender oil for oral administration, in patients with subthreshold anxiety, a meta-analysis that included all published trials with Silexan in this indication was performed. Three randomised, placebo-controlled trials in subthreshold anxiety disorders (anxiety disorder not otherwise specified, restlessness and agitation, mixed anxiety and depressive disorder) were included...
November 17, 2017: European Archives of Psychiatry and Clinical Neuroscience
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