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https://www.readbyqxmd.com/read/28927193/timing-of-percutaneous-coronary-intervention-in-patients-with-non-st-elevation-myocardial-infarction-a-swedeheart-study
#1
Daniel Lindholm, Joakim Alfredsson, Oskar Angerås, Felix Böhm, Fredrik Calais, Sasha Koul, Bo Lagerqvist, Henrik Renlund, Giovanna Sarno, Christoph Varenhorst
Aims: Although routine invasive management is recommended in NSTEMI patients, the optimal timing of the procedure is not defined. The aim of this study was to assess outcomes in relation to timing of PCI in NSTEMI patients. Methods and results: This was an observational, prospective, multicentre cohort study from the SWEDEHEART registry including all Swedish PCI centres. We included 40 494 consecutive PCI-treated patients who were admitted to any coronary care unit from 2006 to 2013...
January 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28925352/bmps-direct-sensory-interneuron-identity-in-the-developing-spinal-cord-using-signal-specific-not-morphogenic-activities
#2
Madeline G Andrews, Lorenzo M Del Castillo, Eliana Ochoa-Bolton, Ken Yamauchi, Jan Smogorzewski, Samantha J Butler
The Bone Morphogenetic Protein (BMP) family reiteratively signals to direct disparate cellular fates throughout embryogenesis. In the developing dorsal spinal cord, multiple BMPs are required to specify sensory interneurons (INs). Previous studies suggested that the BMPs act as concentration-dependent morphogens to direct IN identity, analogous to the manner in which sonic hedgehog patterns the ventral spinal cord. However, it remains unresolved how multiple BMPs would cooperate to establish a unified morphogen gradient...
September 19, 2017: ELife
https://www.readbyqxmd.com/read/28922738/mixed-symptoms-in-major-depressive-and-bipolar-disorders-a-systematic-review
#3
REVIEW
Gustavo H Vázquez, María Lolich, Casimiro Cabrera, Ruzica Jokic, Dusan Kolar, Leonardo Tondo, Ross J Baldessarini
BACKGROUND: The DSM-5 mixed features specifier for mood disorders encourages renewed interest in mixed states and led us to pool research findings regarding prevalence of mixed features in episodes of major depressive (MDD) and bipolar disorders (BD). METHODS: We systematically searched to July 2017 for reports on mixed symptoms in depressive episodes of MDD and in depression and mania or hypomania in types I and II BD. For primary mood-states and diagnostic groups we compared rates of the presence of mixed symptoms: as defined by DSM-5 (≥3 features opposite to the dominant mood-polarity but not overlapping those of the primary disorder) or as having any ≥3 features of opposite polarity...
September 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28901663/antifungal-and-mechanical-properties-of-tissue-conditioner-containing-plant-derived-component-an-in-vitro-study
#4
Yoshihito Naito, Hiromichi Yumoto, Kiran Kumar Hs, Takashi Matsuo, Katsuhiko Hirota, Yoichiro Miyake, Kan Nagao, Yoritoki Tomotake, Ryo Jimbo, Tetsuo Ichikawa
PURPOSE: To evaluate the antifungal activity and mechanical properties of a novel antifungal tissue conditioner containing Juncus powder. MATERIALS AND METHODS: Juncus powder was mixed with GC tissue conditioner at concentrations of 2.5%, 5.0%, and 10.0% by mass. The cylindrical specimens of Juncus-mixed tissue conditioner (dimensions: 10 mm in diameter and 2 and 6 mm in height for antimicrobial and mechanical tests, respectively) were prepared. The specimens placed on the bottom of the 24-well tissue culture plate were cultured with Candida albicans CAD1 for 2 and 4 days...
September 13, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28895428/decreased-migration-with-locally-administered-bisphosphonate-in-cemented-cup-revisions-using-impaction-bone-grafting-technique
#5
Vasileios Zampelis, Ola Belfrage, Magnus Tägil, Martin Sundberg, Gunnar Flivik
Background and purpose - Impaction bone grafting (IBG) in revision hip surgery is an established method in restoring bone stock deficiencies. We hypothesized that local treatment of the morsellized allograft with a bisphosphonate in cemented revision would, in addition to increased bone density, also reduce the early migration of the cup as measured by radiostereometry (RSA). Patients and methods - 20 patients with aseptic cup loosening underwent revision using the IBG technique. The patients were randomized to either clodronate (10 patients) or saline (10 patients, control group) as local adjunct to the morsellized bone...
September 12, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28886064/sexcmd-development-and-validation-of-sex-marker-sequences-for-whole-exome-genome-and-rna-sequencing
#6
Seongmun Jeong, Jiwoong Kim, Won Park, Hongmin Jeon, Namshin Kim
Over the last decade, a large number of nucleotide sequences have been generated by next-generation sequencing technologies and deposited to public databases. However, most of these datasets do not specify the sex of individuals sampled because researchers typically ignore or hide this information. Male and female genomes in many species have distinctive sex chromosomes, XX/XY and ZW/ZZ, and expression levels of many sex-related genes differ between the sexes. Herein, we describe how to develop sex marker sequences from syntenic regions of sex chromosomes and use them to quickly identify the sex of individuals being analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28878630/temporal-expression-of-wnt1-defines-the-competency-state-and-terminal-identity-of-progenitors-in-the-developing-cochlear-nucleus-and-inferior-colliculus
#7
Stephen Brown, Mark Zervas
The auditory system contains a diverse array of interconnected anatomical structures that mediate the perception of sound. The cochlear nucleus of the hindbrain serves as the initial site of convergence for auditory stimuli, while the inferior colliculus of the midbrain serves as an integration and relay station for all ascending auditory information. We used Genetic Inducible Fate Mapping (GIFM) to determine how the timing of Wnt1 expression is related to the competency states of auditory neuron progenitors...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28872693/modeling-continuous-response-variables-using-ordinal-regression
#8
Qi Liu, Bryan E Shepherd, Chun Li, Frank E Harrell
We study the application of a widely used ordinal regression model, the cumulative probability model (CPM), for continuous outcomes. Such models are attractive for the analysis of continuous response variables because they are invariant to any monotonic transformation of the outcome and because they directly model the cumulative distribution function from which summaries such as expectations and quantiles can easily be derived. Such models can also readily handle mixed type distributions. We describe the motivation, estimation, inference, model assumptions, and diagnostics...
September 5, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28859184/a-dual-approach-to-understanding-facial-perception-before-and-after-blepharoplasty
#9
Kristin L Bater, Masaru Ishii, Jason C Nellis, Andrew Joseph, Ira D Papel, Theda C Kontis, Patrick J Byrne, Kofi D O Boahene, Lisa E Ishii
Importance: Blepharoplasty consistently ranks among the most common facial plastic surgery procedure sought by both men and women. Despite the popularity of blepharoplasty, there has been little research focused on quantifying how eyelid surgery changes facial perceptions. Objectives: To quantify the effect of blepharoplasty on facial perceptions and measure patient-reported ratings of fatigue before and after surgery to compare observer and patient perceptions...
August 31, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28857305/the-relationship-of-bilingualism-to-cognitive-decline-the-australian-longitudinal-study-of-ageing
#10
Naaheed Mukadam, Fatima Jichi, David Green, Gill Livingston
OBJECTIVES: We wished to clarify the link between bilingualism and cognitive decline, and examine whether improved executive function due to bilingualism may be a factor in preventing cognitive decline. METHODS: We used the Australian Longitudinal Study of Ageing which collected data on 2087 participants aged over 65 over 20 years. We compared baseline demographics, health, and social characteristics between bilingual and non-bilingual participants. We used linear mixed models analysis to explore the effect of bilingualism on MMSE score over time and linear regression to explore the effect of bilingualism on baseline MMSE scores, controlling for pre-specified potential confounders...
August 31, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28831618/a-pilot-randomized-controlled-trial-of-an-integrated-in-person-and-mobile-phone-delivered-counseling-and-text-messaging-intervention-to-reduce-hiv-transmission-risk-among-male-sex-workers-in-chennai-india
#11
Matthew J Mimiaga, Beena Thomas, Katie Biello, Blake E Johnson, Soumya Swaminathan, Pandiyaraja Navakodi, S Balaguru, A Dhanalakshmi, Elizabeth F Closson, Sunil Menon, Conall O'Cleirigh, Kenneth H Mayer, Steven A Safren
Men who have sex with men (MSM) are at increased risk for HIV infection in India, particularly those who engage in transactional sex with other men (i.e., male sex workers; MSW). Despite the need, HIV prevention efforts for Indian MSW are lacking. As in other settings, MSW in India increasingly rely on the use of mobile phones for sex work solicitation. Integrating mobile phone technology into an HIV prevention intervention for Indian MSW may mitigate some of the challenges associated with face-to face approaches, such as implementation, lack of anonymity, and time consumption, while at the same time proving to be both feasible and useful...
August 22, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28830929/discovery-of-a-widespread-prokaryotic-5-oxoprolinase-that-was-hiding-in-plain-sight
#12
Thomas D Niehaus, Mona Elbadawi-Sidhu, Valérie de Crécy-Lagard, Oliver Fiehn, Andrew D Hanson
5-Oxoproline (OP) is well known as an enzymatic intermediate in the eukaryotic γ-glutamyl cycle, but it is also an unavoidable damage product formed spontaneously from glutamine and other sources. Eukaryotes metabolize OP via an ATP-dependent 5-oxoprolinase; most prokaryotes lack homologs of this enzyme - and the γ-glutamyl cycle - but are predicted to have some way to dispose of OP if its spontaneous formation in vivo is significant. Comparative analysis of prokaryotic genomes showed that the gene encoding pyroglutamyl peptidase, which removes N-terminal OP residues, clusters in diverse genomes with genes specifying homologs of a fungal lactamase (renamed prokaryotic 5-oxoprolinase A, pxpA) and homologs of allophanate hydrolase subunits (renamed pxpB and pxpC)...
August 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28830408/the-ktx360%C3%A2-study-a-multicenter-multisectoral-multimodal-telemedicine-based-follow-up-care-model-to-improve-care-and-reduce-health-care-costs-after-kidney-transplantation-in-children-and-adults
#13
L Pape, M de Zwaan, U Tegtbur, F Feldhaus, J K Wolff, L Schiffer, C Lerch, N Hellrung, V Kliem, G Lonnemann, H D Nolting, M Schiffer
BACKGROUND: Follow-up care after kidney transplantation is performed in transplant centers as well as in local nephrologist's practices in Germany. However, organized integrated care of these different sectors of the German health care system is missing. This organizational deficit as well as non-adherence of kidney recipients and longterm cardiovascular complications are major reasons for an impaired patient and graft survival. METHODS: The KTx360° study is supported by a grant from the Federal Joint Committee of the Federal Republic of Germany...
August 23, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28829974/nurses-personal-and-ward-accountability-and-missed-nursing-care-a-cross-sectional-study
#14
Einav Srulovici, Anat Drach-Zahavy
BACKGROUND: Missed nursing care is considered an act of omission with potentially detrimental consequences for patients, nurses, and organizations. Although the theoretical conceptualization of missed nursing care specifies nurses' values, attitudes, and perceptions of their work environment as its core antecedents, empirical studies have mainly focused on nurses' socio-demographic and professional attributes. Furthermore, assessment of missed nursing care has been mainly based on same-source methods...
August 16, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28822017/validation-of-a-non-contact-screening-device-for-the-combination-of-sleep-disordered-breathing-and-periodic-limb-movements-in-sleep
#15
Gerhard Weinreich, Sarah Terjung, Yi Wang, Stefanie Werther, Alberto Zaffaroni, Helmut Teschler
PURPOSE: Recent studies found that the non-contact screening device SleepMinder (ResMed Sensor Technologies, Dublin, Ireland) detects sleep-disordered breathing (SDB) with high diagnostic accuracy in cohorts suspected of this disorder. However, it was reported that in patients with periodic limb movement in sleep (PLMS), this non-contact device overestimates the apnea-hypopnea index (AHI). We aimed to overcome this limitation by introducing the novel sleep disorder index (SDI) which is sum of the AHI and the period limb movement index (PLMI)...
August 18, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28811075/regulatory-t-cell-deficient-scurfy-mice-exhibit-a-th2-m2-like-inflammatory-response-in-the-skin
#16
Stefanie Haeberle, Verena Raker, Jessica Haub, Yong O Kim, Shih-Yen Weng, Osman K Yilmaz, Alexander Enk, Kerstin Steinbrink, Detlef Schuppan, Eva N Hadaschik
BACKGROUND: Scurfy mice have a functional defect in regulatory T cells (Treg), which leads to lethal multi-organ inflammation. The missing Treg function results in uncontrolled autoimmune cellular and humoral inflammatory responses. We and others have previously shown that during the course of disease scurfy mice develop severe skin inflammation and autoantibodies including anti-nuclear autoantibodies (ANA). OBJECTIVE: Autoimmune skin inflammation and ANA are hallmarks for the diagnosis of autoimmune connective tissue diseases; therefore we analyzed scurfy mice for typical signs of these diseases...
September 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28807456/post-hospitalization-experiences-of-older-adults-diagnosed-with-diabetes-it-was-daunting
#17
Jacqueline B La Manna, Angeline Bushy, Denise Gammonley
Multimorbidity combined with geriatric syndromes in older adults with diabetes exacerbate their risks for poor post-discharge outcomes. The purpose of this study was to examine self-described hospital-to-home transition challenges encountered by older adults with a diagnosis of diabetes within the first 30 days following discharge. The qualitative responses for this paper emerged from a larger mixed methods study (n = 96) in which participants provided free responses specifying transition challenges during follow-up telephone interviews on the 7th day (n = 67) and 30th day (n = 55) post-discharge...
August 11, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/28804877/validation-of-a-geriatric-trauma-prognosis-calculator-a-p-a-l-li-a-t-e-consortium-study
#18
Allyson C Cook, Bellal Joseph, M Jane Mohler, Kenji Inaba, Brandon R Bruns, Paul A Nakonezny, Jeff D Kerby, Karen J Brasel, Steven E Wolf, Joseph Cuschieri, M Elizabeth Paulk, Ramona L Rhodes, Scott C Brakenridge, A Peter Ekeh, Herb A Phelan
BACKGROUND/OBJECTIVES: The P.A.L.Li.A.T.E. (prognostic assessment of life and limitations after trauma in the elderly) consortium has previously created a prognosis calculator for mortality after geriatric injury based on age, injury severity, and transfusion requirement called the geriatric trauma outcome score (GTOS). Here, we sought to create and validate a prognosis calculator called the geriatric trauma outcome score ii (GTOS II) estimating probability of unfavorable discharge. DESIGN: Retrospective cohort...
August 14, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28799389/dispersed-fluorescence-spectroscopy-of-the-sicn-a%C3%AC-2-%C3%AE-x%C3%AC-2-%C3%AE-system-observation-of-some-vibrational-levels-with-chaotic-characteristics
#19
Masaru Fukushima, Takashi Ishiwata
The laser induced fluorescence (LIF) spectrum of the à (2)Δ - X̃ (2)Π transition was obtained for SiCN generated by laser ablation under supersonic free jet expansion. The vibrational structures of the dispersed fluorescence (DF) spectra from single vibronic levels (SVL's) were analyzed with consideration of the Renner-Teller (R-T) interaction. Analysis of the pure bending (ν2) structure by a perturbation approach including R-T, anharmonicity, spin-orbit (SO), and Herzberg-Teller (H-T) interactions indicated considerably different spin splitting for the μ and κ levels of the X̃ (2)Π state of SiCN, in contrast to identical spin splitting for general species derived from the perturbation approach, where μ and κ specify the lower and upper levels, respectively, separated by R-T...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28797226/network-design-and-analysis-for-multi-enzyme-biocatalysis
#20
Lisa Katharina Blaß, Christian Weyler, Elmar Heinzle
BACKGROUND: As more and more biological reaction data become available, the full exploration of the enzymatic potential for the synthesis of valuable products opens up exciting new opportunities but is becoming increasingly complex. The manual design of multi-step biosynthesis routes involving enzymes from different organisms is very challenging. To harness the full enzymatic potential, we developed a computational tool for the directed design of biosynthetic production pathways for multi-step catalysis with in vitro enzyme cascades, cell hydrolysates and permeabilized cells...
August 10, 2017: BMC Bioinformatics
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