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https://www.readbyqxmd.com/read/28109666/diminished-auditory-sensory-gating-during-active-auditory-verbal-hallucinations
#1
Robert J Thoma, Andrew Meier, Jon Houck, Vincent P Clark, Jeffrey D Lewine, Jessica Turner, Vince Calhoun, Julia Stephen
Auditory sensory gating, assessed in a paired-click paradigm, indicates the extent to which incoming stimuli are filtered, or "gated", in auditory cortex. Gating is typically computed as the ratio of the peak amplitude of the event related potential (ERP) to a second click (S2) divided by the peak amplitude of the ERP to a first click (S1). Higher gating ratios are purportedly indicative of incomplete suppression of S2 and considered to represent sensory processing dysfunction. In schizophrenia, hallucination severity is positively correlated with gating ratios, and it was hypothesized that a failure of sensory control processes early in auditory sensation (gating) may represent a larger system failure within the auditory data stream; resulting in auditory verbal hallucinations (AVH)...
January 18, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28109602/strategies-to-gain-body-condition-score-in-pasture-based-dairy-cows-during-late-lactation-and-the-far-off-nonlactating-period-and-their-interaction-with-close-up-dry-matter-intake
#2
J R Roche, A Heiser, M D Mitchell, M A Crookenden, C G Walker, J K Kay, M Vailati Riboni, J J Loor, S Meier
In pasture-based systems, cows are generally thinner at the end of lactation than cows fed total mixed rations and, as a result, over-feeding of metabolizable energy (ME) during the far-off nonlactating period is a standard management policy to achieve optimum calving body condition score (BCS). An alternative would be to manage cows to gain BCS through late lactation, such that cows ended lactation close to optimum calving BCS and maintenance of BCS through to calving. We sought to quantify the effect of moderate or excessive ME intakes during the far-off nonlactating period in cows that had been managed to gain or maintain BCS through late lactation and whether the far-off management strategy interacted with close-up level of feeding...
January 18, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28109212/two-structure-thermodynamics-for-the-tip4p-2005-model-of-water-covering-supercooled-and-deeply-stretched-regions
#3
John W Biddle, Rakesh S Singh, Evan M Sparano, Francesco Ricci, Miguel A González, Chantal Valeriani, José L F Abascal, Pablo G Debenedetti, Mikhail A Anisimov, Frédéric Caupin
One of the most promising frameworks for understanding the anomalies of cold and supercooled water postulates the existence of two competing, interconvertible local structures. If the non-ideality in the Gibbs energy of mixing overcomes the ideal entropy of mixing of these two structures, a liquid-liquid phase transition, terminated at a liquid-liquid critical point, is predicted. Various versions of the "two-structure equation of state" (TSEOS) based on this concept have shown remarkable agreement with both experimental data for metastable, deeply supercooled water and simulations of molecular water models...
January 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28108875/against-the-odds-syringe-exchange-policy-implementation-in-indiana
#4
Beth E Meyerson, Carrie A Lawrence, Laura Miller, Anthony Gillespie, Daniel Raymond, Kristen Kelley, D J Shannon
Indiana recently passed legislation allowing local governments to establish syringe exchanges. While the effectiveness of syringe exchange programming is established, there is a dearth of studies about associated policy adoption and implementation. This study documents the experiences of 24 Indiana counties engaged in the process of establishing syringe exchange programming under new state law. A mixed method, qualitative, exploratory case study was conducted from May 2015 to April 2016. We observed rapid and widespread policy adoption interest, and yet counties reported significant policy ambiguity, epidemiologic and resource capacity issues...
January 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28108823/which-clinical-and-patient-factors-influence-the-national-economic-burden-of-hospital-readmissions-after-total-joint-arthroplasty
#5
Steven M Kurtz, Edmund C Lau, Kevin L Ong, Edward M Adler, Frank R Kolisek, Michael T Manley
BACKGROUND: The Affordable Care Act of 2010 advanced the economic model of bundled payments for total joint arthroplasty (TJA), in which hospitals will be financially responsible for readmissions, typically at 90 days after surgery. However, little is known about the financial burden of readmissions and what patient, clinical, and hospital factors drive readmission costs. QUESTIONS/PURPOSES: (1) What is the incidence, payer mix, and demographics of THA and TKA readmissions in the United States? (2) What patient, clinical, and hospital factors are associated with the cost of 30- and 90-day readmissions after primary THA and TKA? (3) Are there any differences in the economic burden of THA and TKA readmissions between payers? (4) What types of THA and TKA readmissions are most costly to the US hospital system? METHODS: The recently developed Nationwide Readmissions Database from the Healthcare Cost and Utilization Project (2006 hospitals from 21 states) was used to identify 719,394 primary TJAs and 62,493 90-day readmissions in the first 9 months of 2013 based on International Classification of Diseases, 9th Revision, Clinical Modification codes...
January 20, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28106984/pore-space-partition-in-metal-organic-frameworks
#6
Quan-Guo Zhai, Xianhui Bu, Xiang Zhao, Dong-Sheng Li, Pingyun Feng
Metal-organic framework (MOF) materials have emerged as one of the favorite crystalline porous materials (CPM) because of their compositional and geometric tunability and many possible applications. In efforts to develop better MOFs for gas storage and separation, a number of strategies including creation of open metal sites and implantation of Lewis base sites have been used to tune host-guest interactions. In addition to these chemical factors, the geometric features such as pore size and shape, surface area, and pore volume also play important roles in sorption energetics and uptake capacity...
January 20, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28106846/competition-between-methanogens-and-acetogens-in-biocathodes-a-comparison-between-potentiostatic-and-galvanostatic-control
#7
Sam D Molenaar, Pradip Saha, Annemerel R Mol, Tom H J A Sleutels, Annemiek Ter Heijne, Cees J N Buisman
Microbial electrosynthesis is a useful form of technology for the renewable production of organic commodities from biologically catalyzed reduction of CO₂. However, for the technology to become applicable, process selectivity, stability and efficiency need strong improvement. Here we report on the effect of different electrochemical control modes (potentiostatic/galvanostatic) on both the start-up characteristics and steady-state performance of biocathodes using a non-enriched mixed-culture inoculum. Based on our results, it seems that kinetic differences exist between the two dominant functional microbial groups (i...
January 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28106408/giant-spin-orbit-splitting-in-inverted-inas-gasb-double-quantum-wells
#8
Fabrizio Nichele, Morten Kjaergaard, Henri J Suominen, Rafal Skolasinski, Michael Wimmer, Binh-Minh Nguyen, Andrey A Kiselev, Wei Yi, Marko Sokolich, Michael J Manfra, Fanming Qu, Arjan J A Beukman, Leo P Kouwenhoven, Charles M Marcus
Transport measurements in inverted InAs/GaSb quantum wells reveal a giant spin-orbit splitting of the energy bands close to the hybridization gap. The splitting results from the interplay of electron-hole mixing and spin-orbit coupling, and can exceed the hybridization gap. We experimentally investigate the band splitting as a function of top gate voltage for both electronlike and holelike states. Unlike conventional, noninverted two-dimensional electron gases, the Fermi energy in InAs/GaSb can cross a single spin-resolved band, resulting in full spin-orbit polarization...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28103891/a-mixed-methods-assessment-of-barriers-to-maternal-newborn-and-child-health-in-gogrial-west-south-sudan
#9
Lynn Lawry, Covadonga Canteli, Tahina Rabenzanahary, Wartini Pramana
BACKGROUND: Health conditions for mothers, newborns, and children in South Sudan are among the worst worldwide. South Sudan has the highest rate of maternal mortality in the world and despite alarming statistics, few women and children in South Sudan have access to needed healthcare, especially in rural areas. The purpose of this study was to understand the barriers to maternal, newborn and child health in Gogrial West, Warrap State, South Sudan, one of the most underdeveloped states...
January 19, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28103803/variational-inference-for-rare-variant-detection-in-deep-heterogeneous-next-generation-sequencing-data
#10
Fan Zhang, Patrick Flaherty
BACKGROUND: The detection of rare single nucleotide variants (SNVs) is important for understanding genetic heterogeneity using next-generation sequencing (NGS) data. Various computational algorithms have been proposed to detect variants at the single nucleotide level in mixed samples. Yet, the noise inherent in the biological processes involved in NGS technology necessitates the development of statistically accurate methods to identify true rare variants. RESULTS: We propose a Bayesian statistical model and a variational expectation maximization (EM) algorithm to estimate non-reference allele frequency (NRAF) and identify SNVs in heterogeneous cell populations...
January 19, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28103105/evolution-of-earth-like-extrasolar-planetary-atmospheres-assessing-the-atmospheres-and-biospheres-of-early-earth-analog-planets-with-a-coupled-atmosphere-biogeochemical-model
#11
S Gebauer, J L Grenfell, J W Stock, R Lehmann, M Godolt, P von Paris, H Rauer
Understanding the evolution of Earth and potentially habitable Earth-like worlds is essential to fathom our origin in the Universe. The search for Earth-like planets in the habitable zone and investigation of their atmospheres with climate and photochemical models is a central focus in exoplanetary science. Taking the evolution of Earth as a reference for Earth-like planets, a central scientific goal is to understand what the interactions were between atmosphere, geology, and biology on early Earth. The Great Oxidation Event in Earth's history was certainly caused by their interplay, but the origin and controlling processes of this occurrence are not well understood, the study of which will require interdisciplinary, coupled models...
January 2017: Astrobiology
https://www.readbyqxmd.com/read/28100295/physical-state-and-copy-numbers-of-hpv16-in-oral-asymptomatic-infections-that-persisted-or-cleared-during-the-six-year-follow-up
#12
Adriana Lorenzi, Jaana Rautava, Katja Kero, Kari Syrjänen, Adhemar Longatto-Filho, Seija Grenman, Stina Syrjänen
Persistent human papillomavirus (HPV) infection is a key event in HPV-induced carcinogenesis. As part of the prospective Finnish Family HPV Study, we analyzed the physical state and viral copy numbers of HPV16 in asymptomatic oral infections that either persisted or cleared during six-year follow-up. The persistor group comprised 14 women and seven men with 51 and 21 HPV16-positive brush samples. The clearance group included 41 women and 13 men, with 64 and 24 samples, respectively. Physical state and viral DNA load was assessed by using quantitative PCR for HPV16E2 and E6 genes...
January 18, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28100118/assessing-sexual-interest-in-children-using-the-go-no-go-association-test
#13
Ross M Bartels, Anthony R Beech, Leigh Harkins, David Thornton
The present study investigated whether a latency-based Go/No-Go Association Task (GNAT) could be used as an indirect measure of sexual interest in children. A sample of 29 individuals with a history of exclusive extrafamilial offenses against a child and 15 individuals with either a history of exclusive intrafamilial or mixed offenses (i.e., against both adults and children) were recruited from a treatment center in the United States. Also, a sample of 26 nonoffenders was recruited from a university in the United Kingdom...
January 1, 2017: Sexual Abuse: a Journal of Research and Treatment
https://www.readbyqxmd.com/read/28099024/surface-interactions-and-confinement-of-methane-a-high-pressure-magic-angle-spinning-nmr-and-computational-chemistry-study
#14
Salim Ok, David W Hoyt, Amity Andersen, Julie Sheets, Susan A Welch, David R Cole, Karl Todd Mueller, Nancy M Washton
Characterization and modeling of the molecular-level behavior of simple hydrocarbon gases, such as methane, in the presence of both nonporous and nano-porous mineral matrices allows for predictive understanding of important processes in engineered and natural systems. In this study, changes in local electromagnetic environments of the carbon atoms in methane under conditions of high pressure (up to 130 bar) and moderate temperature (up to 346 K) were observed with 13C magic-angle spinning (MAS) NMR spectroscopy while the methane gas was mixed with two model solid substrates: a fumed non-porous, 12 nm particle size silica and a mesoporous silica with 200 nm particle size and 4 nm average pore diameter...
January 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28098997/two-step-design-of-a-single-doped-white-phosphor-with-high-color-rendering
#15
Romain Gautier, Xueyan Li, Zhiguo Xia, Florian Massuyeau
A strategy to design step by step an inorganic single-doped white phosphor is demonstrated. The method consists in tuning different contributions of the emission by successively controlling the chemical compositions of the solid solution or nanosegregated host matrix and the oxidation states of the single dopant. We use this approach to design a white phosphor Na4CaMgSc4Si10O30:Eu with excellent color rendering (CRI > 90) which is similar to common mixed-phosphor light sources but for a single-phase. We show that this methodology can also be extended to other phosphors for use in diverse applications such as biomedicine or telecommunications...
January 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28098456/ultrafast-electronic-relaxation-through-a-conical-intersection-nonadiabatic-dynamics-disentangled-through-an-oscillator-strength-based-diabatization-framework
#16
Gregory R Medders, Ethan C Alguire, Amber Jain, Joseph E Subotnik
We employ surface hopping trajectories to model the short-time dynamics of gas phase and partially solvated 4-(N,N-dimethylamino)benzonitrile (DMABN), a dual fluorescent molecule that is known to undergo a nonadiabatic transition through a conical intersection. To compare theory vs. time-resolved fluorescence measurements, we calculate the mixed quantum-classical density matrix and the ensemble averaged transition dipole moment. We introduce a diabatization scheme based on the oscillator strength to convert the TDDFT adiabatic states into diabatic states of La and Lb character...
January 18, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28098286/tridentate-lewis-acids-based-on-triphenylsilane
#17
Janek Tomaschautzky, Beate Neumann, Hans-Georg Stammler, Andreas Mix, Norbert W Mitzel
Several derivatives of the propeller-shaped ortho-substituted triphenylsilanes, carrying metal- or silicon-based acceptor groups, are reported. They were synthesized starting from tris(2-bromophenyl)fluorosilane, tris(2-vinylphenyl)fluorosilane and tris(2-ethynylphenyl)fluorosilane to generate a scope of Lewis-acidic molecules with different cavities. An improved synthetic protocol for donor-free tris(2-lithiophenyl)silanes is described. First attempts in host-guest chemistry to probe the binding between a threefold alane-functionalised ortho-substituted triphenylsilane and a tridentate Lewis-basic guest molecule are presented...
January 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28098198/climate-change-influences-on-crop-mix-shifts-in-the-united-states
#18
Sung Ju Cho, Bruce A McCarl
We examine the impact of current and future climate on crop mixes over space in the US. We find using historical data that temperature and precipitation are among the causal factors for shits in crop production location and mixes, with some crops being more sensitive than others. In particular, we find that when temperature rises, cotton, rice, sorghum and winter wheat are more likely to be chosen. We also find that barley, sorghum, winter wheat, spring wheat and hay are more likely to be chosen as regions become drier, and corn, cotton, rice and soybeans are more likely to be selected in wetter regions...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28098175/correlated-electronic-decay-in-expanding-clusters-triggered-by-intense-xuv-pulses-from-a-free-electron-laser
#19
Tim Oelze, Bernd Schütte, Maria Müller, Jan P Müller, Marek Wieland, Ulrike Frühling, Markus Drescher, Alaa Al-Shemmary, Torsten Golz, Nikola Stojanovic, Maria Krikunova
Irradiation of nanoscale clusters and large molecules with intense laser pulses transforms them into highly-excited non- equilibrium states. The dynamics of intense laser-cluster interaction is encoded in electron kinetic energy spectra, which contain signatures of direct photoelectron emission as well as emission of thermalized nanoplasma electrons. In this work we report on a so far not observed spectrally narrow bound state signature in the electron kinetic energy spectra from mixed Xe core - Ar shell clusters ionized by intense extreme-ultraviolet (XUV) pulses from a free-electron-laser...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097355/effect-of-etelcalcetide-vs-placebo-on-serum-parathyroid-hormone-in-patients-receiving-hemodialysis-with-secondary-hyperparathyroidism-two-randomized-clinical-trials
#20
Geoffrey A Block, David A Bushinsky, John Cunningham, Tilman B Drueke, Markus Ketteler, Reshma Kewalramani, Kevin J Martin, T Christian Mix, Sharon M Moe, Uptal D Patel, Justin Silver, David M Spiegel, Lulu Sterling, Liron Walsh, Glenn M Chertow
Importance: Secondary hyperparathyroidism contributes to extraskeletal complications in chronic kidney disease. Objective: To evaluate the effect of the intravenous calcimimetic etelcalcetide on serum parathyroid hormone (PTH) concentrations in patients receiving hemodialysis. Design, Setting, and Participants: Two parallel, phase 3, randomized, placebo-controlled treatment trials were conducted in 1023 patients receiving hemodialysis with moderate to severe secondary hyperparathyroidism...
January 10, 2017: JAMA: the Journal of the American Medical Association
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