keyword
https://read.qxmd.com/read/38499279/affective-disorders-and-the-loudness-dependence-of-the-auditory-evoked-potential-serotonin-and-beyond
#1
REVIEW
Paul J Fitzgerald
Identifying additional noninvasive biomarkers for affective disorders, such as unipolar major depressive disorder (MDD) and bipolar disorder (BD), could aid in the diagnosis and treatment of these prevalent and debilitating neuropsychiatric conditions. One such candidate biomarker is the loudness dependence of the auditory evoked potential (LDAEP), an event-related potential that measures responsiveness of the auditory cortex to different intensities of sound. The LDAEP has been associated with MDD and BD, including therapeutic response to particular classes of antidepressant drugs, while also correlating with several other neuropsychiatric disorders...
March 16, 2024: Neuroscience Letters
https://read.qxmd.com/read/38495842/thiamine-deficiency-neuropathy-in-a-patient-with-malnutrition-due-to-melancholic-depression
#2
Rihene Melki, Rim Ben Soussia, Houcem Elomma Mrabet, Walid Bouali, Lazhar Zarrouk
INTRODUCTION: Melancholic depression is a daily clinical reality in psychiatry. It is a therapeutic emergency that can jeopardize life if not promptly and adequately treated. Apart from its high suicidal risk, complications related to the under-nourishment state are to be feared. Case Presentation . A 36-year-old woman was admitted with depressive symptoms, significant weight loss, and total functional impotence. Laboratory investigations revealed severe thiamine (vitamin B1) deficiency...
2024: Case Reports in Psychiatry
https://read.qxmd.com/read/38443878/reduced-gray-matter-volume-of-the-hippocampal-tail-in-melancholic-depression-evidence-from-an-mri-study
#3
JOURNAL ARTICLE
Zhaosong Chu, Lijin Yuan, Kun Lian, Mengxin He, Yi Lu, Yuqi Cheng, Xiufeng Xu, Zonglin Shen
BACKGROUND: Melancholic depression (MD) is one of the most prevalent and severe subtypes of major depressive disorder (MDD). Previous studies have revealed inconsistent results regarding alterations in grey matter volume (GMV) of the hippocampus and amygdala of MD patients, possibly due to overlooking the complexity of their internal structure. The hippocampus and amygdala consist of multiple and functionally distinct subregions, and these subregions may play different roles in MD. This study aims to investigate the volumetric alterations of each subregion of the hippocampus and amygdala in patients with MD and non-melancholic depression (NMD)...
March 5, 2024: BMC Psychiatry
https://read.qxmd.com/read/38405847/acylcarnitines-metabolism-in-depression-association-with-diagnostic-status-depression-severity-and-symptom-profile-in-the-nesda-cohort
#4
Silvia Montanari, Rick Jansen, Daniela Schranner, Gabi Kastenmüller, Matthias Arnold, Delfina Janiri, Gabriele Sani, Sudeepa Bhattacharyya, Siamak Mahmoudian Dehkordi, Boadie W Dunlop, A John Rush, Brenda W H J Penninx, Rima Kaddurah-Daouk, Yuri Milaneschi
BACKGROUND: Acylcarnitines (ACs) are involved in bioenergetics processes that may play a role in the pathophysiology of depression. Studies linking AC levels to depression are few and provide mixed findings. We examined the association of circulating ACs levels with Major Depressive Disorder (MDD) diagnosis, overall depression severity and specific symptom profiles. METHODS: The sample from the Netherlands Study of Depression and Anxiety included participants with current (n=1035) or remitted (n=739) MDD and healthy controls (n=800)...
February 15, 2024: medRxiv
https://read.qxmd.com/read/38272362/does-theta-burst-stimulation-have-differential-benefit-for-those-with-melancholic-or-non-melancholic-depression
#5
JOURNAL ARTICLE
Gordon Parker, Gabriela Tavella, Michael J Spoelma, Vladimir Sazhin
BACKGROUND: To determine if theta burst stimulation (TBS) is of preferential benefit to those with melancholic or non-melancholic depression as an adjunctive treatment for treatment resistant depression (TRD). METHODS: Fifty-two patients receiving TBS at a private psychiatric hospital participated in a naturalistic study. Four diagnostic strategies were used to assign melancholic versus non-melancholic depression subtype status. Depression symptoms were assessed at baseline, mid-treatment, and end of treatment using the Montgomery-Ǻsberg Depression Rating Scale - Self-Assessment (MADRS-S)...
January 23, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38253135/joseph-guislain-s-writings-on-melancholia-from-1835-and-1852
#6
REVIEW
Kenneth S Kendler, Virginia Justis
Over the course of the 19th century, the concept of melancholia morphed from a partial insanity defined by disorders of judgment to a disorder characterized primarily by mood disturbances. The francophone Belgian psychiatrist Joseph Guislain, whose work has not been previously translated into English, played an important role in this transition. We translate and comment upon two of his key descriptions of melancholia from 1835 and 1852, emphasizing the following 5 features. First, his concept of melancholia is quite "modern" meeting all DSM-5 criteria for major depression...
January 20, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38216355/the-effects-of-light-therapy-on-sleep-depression-neuropsychiatric-behaviors-and-cognition-among-people-living-with-dementia-a-meta-analysis-of-randomized-controlled-trials
#7
JOURNAL ARTICLE
Nur Aini, Ruey Chen, Hsin Chu, Ching-Yi Chang, Hui-Chen Lin, Hsiu-Ju Jen, Doresses Liu, Tso-Ying Lee, Kuei-Ru Chou
OBJECTIVE: Alterations in the suprachiasmatic nucleus due to underlying pathologies disrupt the circadian rhythms in people living with dementia (PLWD). Circadian rhythms significantly impact sleep, emotional, and cognitive functions, with its synchronization depending on light exposure. We performed a meta-analysis to evaluate the effects of light therapy on sleep, depression, neuropsychiatric behaviors, and cognition among PLWD. METHODS: A systematic search was conducted in Cochrane, ClinicalTrials...
December 23, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/38159005/-adherence-to-treatment-of-hematological-malignancies-patients-with-anxiety-and-depression
#8
JOURNAL ARTICLE
D E Vybornykh, T N Moiseeva, E G Gemdzhian, T V Gaponova, L V Esina, E I Kolgaeva, D V Novikova
AIM: To establish the features of the influence of anxiety and depressive disorders on treatment adherence, as well as to clarify the factors associated with it in hematologic malignancies patients. MATERIALS AND METHODS: The study included 117 patients: 51 men and 66 women, aged 19 to 67 years, with Hodgkin's lymphoma - 88, acute lymphoblastic leukemia - 16 and aplastic anemia - 13 patients. Patients were examined by psychiatrist using the Brief Psychiatric Rating Scale, as well as some psychometric methods...
September 29, 2023: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/38127698/-psychosocial-pathomorphosis-of-depressions
#9
JOURNAL ARTICLE
V N Krasnov, V V Kryukov, S A Trushchelev
OBJECTIVE: The aim is to determine the changes in phenomenology of depressions (mostly of melancholic type with pronounced affect of sadness, chronobiological shift, neurovegetative changes and typical affect-congruent depressive ideas) over the past decades. MATERIAL AND METHODS: We've compared the archival data of one of the authors (V.N.K.) obtained in the study of depression within 1980-1086 years (1st group, 103 patients, 47 with recurrent depression and 56 with bipolar depression) and the data of the study of depression during 2015-2021 years with registration of symptoms with the same psychopathological scale at the same clinic for affective disorders (2nd group, 109 patients, 52 with recurrent depression and 57 with bipolar depression)...
2023: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38127474/mourning-in-hamlet-turning-ancestral-ghosts-into-ancestors
#10
JOURNAL ARTICLE
John Steiner
Extracts from Shakespeare's Hamlet are used to show how obstacles to mourning may arise from the persistent demands of melancholic internal objects demanding repair and revenge. It is only with the development of symbolic function as a result of separateness between self and object that reparation becomes possible and ghosts are turned into ancestors.
December 2023: International Journal of Psycho-analysis
https://read.qxmd.com/read/38070447/subtypes-of-major-depressive-disorders-and-objectively-measured-physical-activity-and-sedentary-behaviors-in-the-community
#11
JOURNAL ARTICLE
Maulde Rovero, Martin Preisig, Pedro Marques-Vidal, Marie-Pierre F Strippoli, Peter Vollenweider, Julien Vaucher, Alexandre Berney, Kathleen R Merikangas, Caroline L Vandeleur, Jennifer Glaus
BACKGROUND: Lack of physical activity (PA) and high sedentary behavior (SB) may enhance mental health problems, including depression, and are associated with increased mortality. Aside from a large body of research on major depressive disorder (MDD) assessed as an entity and either PA or SB, few studies have examined associations among subtypes of MDD and both PA and SB simultaneously derived from wrist-worn accelerometers. Accordingly, our aim was to explore the associations among MDD subtypes (atypical, melancholic, combined atypical-melancholic and unspecified) and four actigraphy-derived behaviors combining the levels of PA and SB...
December 5, 2023: Comprehensive Psychiatry
https://read.qxmd.com/read/38052767/effects-of-melancholic-features-on-positive-and-negative-suicidal-ideation-in-patients-with-treatment-resistant-depression-and-strong-suicidal-ideation-receiving-low-dose-ketamine-infusion
#12
JOURNAL ARTICLE
Mu-Hong Chen, Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Hui-Ju Wu, Shih-Jen Tsai, Ya-Mei Bai, Wei-Chung Mao, Pei-Chi Tu
The role of melancholic features on the antisuicidal effect of 0.5 mg/kg ketamine infusion has remained unclear in patients with treatment-resistant depression (TRD) and strong suicidal ideation (SI). Whether ketamine diminishes suicidal ideation in patients with TRD-SI was also unknown. We enrolled 84 patients with TRD-SI, including 27 with melancholic features and 57 without, and then randomly administered a single infusion of 0.5 mg/kg ketamine or 0.045 mg/kg midazolam. The clinician-rated Montgomery-Åsberg Depression Rating Scale (MADRS) item 10, Columbia Suicide Severity Rating Scale-Ideation Severity Subscale (CSSRS-ISS), and self-reported Positive and Negative Suicide Ideation Inventory (PANSI) were used to assess suicidal symptoms from baseline to day 7...
December 5, 2023: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38037069/methods-for-quantifying-the-heterogeneity-of-psychopathology
#13
JOURNAL ARTICLE
John F Buss, Ashley L Watts, Lorenzo Lorenzo-Luaces
OBJECTIVES: Specifiers for a major depressive disorder (MDE) are supposed to reduce diagnostic heterogeneity. However, recent literature challenges the idea that the atypical and melancholic specifiers identify more homogenous or coherent subgroups. We introduce the usage of distance metrics to characterize symptom heterogeneity. We attempt to replicate prior findings and explore whether symptom heterogeneity is reduced using specifier subgroups. METHODS: We used data derived from the National Epidemiological Survey on Alcohol and Related Conditions (NESARC Wave I; N = 5,749) and the Sequenced Treatment Alternatives to Relieve Depression study (STAR*D; N = 2,498)...
November 30, 2023: BMC Psychiatry
https://read.qxmd.com/read/38002532/affective-prosody-and-its-impact-on-the-neurology-of-language-depression-memory-and-emotions
#14
REVIEW
Elliott D Ross
Based on the seminal publications of Paul Broca and Carl Wernicke who established that aphasic syndromes (disorders of the verbal-linguistic aspects of communication) were predominantly the result of focal left-hemisphere lesions, "language" is traditionally viewed as a lateralized function of the left hemisphere. This, in turn, has diminished and delayed the acceptance that the right hemisphere also has a vital role in language, specifically in modulating affective prosody, which is essential for communication competency and psychosocial well-being...
November 9, 2023: Brain Sciences
https://read.qxmd.com/read/37995807/increased-brain-nucleus-accumbens-functional-connectivity-in-melancholic-depression
#15
JOURNAL ARTICLE
Zhaobin Chen, Yangpan Ou, Feng Liu, Huabing Li, Ping Li, Guangrong Xie, Xilong Cui, Wenbin Guo
BACKGROUND: Melancholic depression, marked by typical symptoms of anhedonia, is regarded as a homogeneous subtype of major depressive disorder (MDD). However, little attention was paid to underlying mechanisms of melancholic depression. This study aims to examine functional connectivity of the reward circuit associated with anhedonia symptoms in melancholic depression. METHODS: Fifty-nine patients with first-episode drug- naive MDD, including 31 melancholic patients and 28 non-melancholic patients, were recruited and underwent resting-state functional magnetic resonance imaging (rs-fMRI)...
November 22, 2023: Neuropharmacology
https://read.qxmd.com/read/37981037/melancholic-features-and-treatment-response-to-selective-serotonin-reuptake-inhibitors-in-major-depressive-disorder-a-re-analysis-of-the-star-d-trial
#16
JOURNAL ARTICLE
Alejandro Szmulewicz, Marina P Valerio, Julieta Lomastro, Diego J Martino
BACKGROUND: Melancholia has been positioned as a qualitatively different form of Major Depressive Disorder (MDD). Some studies have suggested that melancholic MDD patients may show lower remission when receiving treatment with Selective Serotonin Reuptake Inhibitors, but this has not yet been explored in large, representative samples of MDD. METHODS: We used data from the STAR*D, a multisite randomized controlled trial (n = 4041). We defined melancholia status through the BA Melancholia Empirical Index, constructed using items from the Inventory of Depressive Symptomatology (IDSC)...
November 17, 2023: Journal of Affective Disorders
https://read.qxmd.com/read/37930968/impact-of-dysfunctional-parenting-affective-temperaments-and-stressful-life-events-on-the-development-of-melancholic-and-non-melancholic-depression-a-path-analysis-study
#17
JOURNAL ARTICLE
Yu Tamada, Takeshi Inoue, Atsushi Sekine, Hiroyuki Toda, Minoru Takeshima, Masaaki Sasaki, Yota Fujimura, Susumu Ohmae
BACKGROUND: The influence of psychosocial factors on differentiating between melancholic depression (MEL) and non-melancholic depression (NMEL) remains unclear. In this study, we aimed to investigate the interrelationship between dysfunctional parenting, personality traits, stressful life events, and the diagnosis of MEL and NMEL among patients with major depressive disorder (MDD). METHODS: Ninety-eight patients with MDD completed the following self-administered questionnaires: the Parental Bonding Instrument (PBI) for dysfunctional parenting, the short version of the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version (TEMPS-A) for affective temperaments, and the Life Experiences Survey (LES) for stressful life events...
2023: PloS One
https://read.qxmd.com/read/37856925/peripheral-inflammatory-markers-in-melancholic-versus-non-melancholic-depression
#18
JOURNAL ARTICLE
Adam Bayes, Thomas W Weickert, Gordon Parker, Michael J Spoelma, Hayley F North, John Lam-Po-Tang, Cyndi Shannon Weickert
BACKGROUND: Peripheral inflammation has been associated with major depression, however there is a paucity of studies examining whether inflammatory profiles differ across depressive subtypes. The current study sought to compare peripheral inflammatory markers in patients with melancholic versus non-melancholic depression and with healthy controls. METHOD: Eighty outpatients with a current major depressive episode (MDE) were assigned as having a melancholic or a non-melancholic depressive subtype based on clinician diagnosis and the Sydney Melancholic Prototypic Index (SMPI)...
October 13, 2023: Psychoneuroendocrinology
https://read.qxmd.com/read/37787546/personality-and-mental-disorders-sensitive-character-melancholic-type-and-addenda
#19
JOURNAL ARTICLE
Mauricio Viotti Daker
A traditional view in psychiatry is that personality disorders or traits are intimately related to primary mental disorders. Psychic functions with common roots might be constitutive of personality and psychosis or other disorders. Hoche held that paranoia, mania and melancholia lie in the normal psyche, and Kraepelin conceded such a view, explicitly implying personality. According to Carl Schneider, endogenous symptom complexes or associations and normal functional associations are fuzzy. Many other psychopathologists emphasize personality characteristics in connection with endogenous or functional psychoses, such as the sensitive and melancholic types...
December 2023: History of Psychiatry
https://read.qxmd.com/read/37655420/-steadfastly-increased-level-of-the-ciliary-neurotrophic-factor-in-the-blood-serum-within-the-positive-therapeutic-dynamics-of-depression-as-possible-prognostic-marker-of-depressive-relapse
#20
JOURNAL ARTICLE
M G Uzbekov, S N Shikhov, V V Kryukov, V N Krasnov
OBJECTIVE: To study a role of the ciliary neurotrophic factor (CNTF) in the pathogenesis of depression and its prognostic significance in dynamics of the antidepressant therapy. MATERIAL AND METHODS: CNTF level was investigated in the blood serum of patients with melancholic depression ( n =32) before the start of therapy and after 30 days, when improvement was achieved by at least 75% of baseline scores on the Hamilton Depression Rating Scale. RESULTS: Steadfastly increased level of CNTF in the blood serum of patients with melancholic depression compared with the control, remaining practically unchanged with an obvious improvement in the condition - 732...
2023: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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