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Elvira Boere, Astrid M Kamperman, Arianne E van 't Hoog, Walter W van den Broek, Tom K Birkenhäger
Electroconvulsive therapy (ECT) is considered an effective treatment for major depression with melancholic features. However, neurocognitive side-effects such as anterograde amnesia still regularly occur. The present study aims to evaluate the severity and course of anterograde amnesia in severely depressed patients undergoing ECT. In a prospective naturalistic study, anterograde memory function was assessed among inpatients who underwent ECT (n = 11). Subjects met DSM-IV criteria for major depressive disorder...
2016: PloS One
Michitaka Funayama, Motoichiro Kato, Masaru Mimura
BACKGROUND: Although post-stroke depression is a well-characterized disorder, there is less understanding of how pre-existence of depression is affected by a stroke. CASE PRESENTATION: We describe a patient with treatment-resistant major depression, which had been ongoing for 14 years but disappeared shortly after onset of a subarachnoid hemorrhage. Her cognitive function and functional status were mostly unaffected by the stroke. However, she no longer excessively regretted past events...
October 19, 2016: BMC Neurology
A M Lasserre, M-P F Strippoli, J Glaus, M Gholam-Rezaee, C L Vandeleur, E Castelao, P Marques-Vidal, G Waeber, P Vollenweider, M Preisig
The mechanisms and temporal sequence underlying the association between major depressive disorder (MDD) and cardio-metabolic diseases are still poorly understood. Recent research suggests subtyping depression to study the mechanisms underlying its association with biological correlates. Accordingly, our aims were to (1) assess the prospective associations of the atypical, melancholic and unspecified subtypes of MDD with changes of fasting glucose, high-density lipoprotein-cholesterol, triglycerides, systolic blood pressure and the incidence of the metabolic syndrome, (2) determine the potential mediating role of inflammatory marker or adipokine concentrations, eating behaviors and changes in waist circumference during follow-up...
October 11, 2016: Molecular Psychiatry
Gordon Parker, Stacey McCraw
BACKGROUND: The CORE measure was designed to assess a central feature of melancholia - signs of psychomotor disturbance (PMD) - and so provide an alternate non-symptom based measure of melancholia or of its probability. This review evaluates development and application studies undertaken over the last 25 years to consider how well it has met its original objectives. METHODS: All studies published using the CORE measure as either the only or an adjunctive measure of melancholia were obtained and are considered in this review...
September 25, 2016: Journal of Affective Disorders
Marcin Siwek, Magdalena Sowa-Kućma, Krzysztof Styczeń, Paulina Misztak, Rafał J Nowak, Bernadeta Szewczyk, Dominika Dudek, Janusz K Rybakowski, Gabriel Nowak, Michael Maes
To examine cytokine receptor biomarkers in bipolar disorder (BD), we recruited 133 well-phenotyped BD patients and 50 normal controls and measured serum levels of soluble interleukin 1 receptor antagonist (sIL-1RA), soluble interleukin-2 receptor (sIL-2R), sIL-6R, and tumor necrosis factor receptor 60 and 80 kDa (sTNFR60/80). sIL-1RA and sTNFR80 are significantly higher in BD than in controls and sTNFR80 and higher in melancholic than in non-melancholic patients and controls. Kapczinski's stages 3 + 4 are characterized by lowered sIL-2R and increased sTNFR80 levels...
September 23, 2016: Molecular Neurobiology
J Vandevoorde, N Estano, G Painset
OBJECTIVES: Suicide-homicide could be defined as a "suicidal" behaviour, which also includes the death of at least one other individual and sometimes up to hundreds. This literature review intends to highlight some characteristic features that might be found amongst the various types of suicide-homicide. It is a complex phenomenon which can occur in different situations, from a familial and somehow intimate setting (filicide, uxoricide, marital homicide…) to a public one (workplace shooting, school shooting), including a wide range of victims, from a single victim in marital cases of suicide-homicide to hundreds of victims in certain types, such as suicide by aircraft or warrior-like multi-homicids in terrorist acts...
September 19, 2016: L'Encéphale
Brian Watermeyer
Social scientific analyses of inequality inform interventions ranging from the material and political to the personal and psychological. At the extremes of this continuum, Marxian militants view the exploration of the inner lives of oppressed people as irrelevant to liberation, while psychoanalysts bemoan the naïveté of "depsychologized" conceptions of the social subject. While both approaches have been applied to disability inequality, an historical materialist view has dominated the discipline of disability studies, where attention has only recently turned to psychological aspects of oppression...
September 8, 2016: Culture, Medicine and Psychiatry
Shinji Sakamoto, Itsuki Yamakawa, Masaki Muranaka
BACKGROUND: In Japan, psychiatrists have noted two different types of depression, traditional/melancholic depression and 'modern-type' depression (MTD). Although both the modern and the traditional types of depression overlap in regard to symptoms, these are two distinct syndromes, which can lead to confusion for Japanese people. AIMS: This study aims to examine impressions of two types of depression using vignettes and clarify the differences in perceptions of the two types...
August 29, 2016: International Journal of Social Psychiatry
Marianna Karamanou, Elias Tzavellas, Konstantinos Laios, Michalis Koutsilieris, George Androutsos
In antiquity, physicians related depression or melancholic humour to cancer's pathogenesis. Galen (130-201 AD), sustained that melancholy could give rise to a tumour and his theory was repeated by the Byzantine and Arab physicians. In the 19th century, malignancy and depression became synonymous and people attributed their cancer to sadness. In 1893, the London surgeon Hebert Snow (1847-1930), performed an epidemiological study in order to clarify that link. The results revealed a probable connection. His work was followed by several large scale prospective studies some of which identified depression as a risk factor for cancer where others found no association...
May 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Katariina Korniloff, Satu Kotiaho, Mauno Vanhala, Hannu Kautiainen, Hannu Koponen, Pekka Mäntyselkä
OBJECTIVE:  Pain and depressive disorders often present together, but little is known about the prevalence of pain in depression subgroups. The objective of this study was to examine the possible differences in the prevalence of musculoskeletal pain between participants in melancholic and atypical depression subgroups. DESIGN:  Cross-sectional study. SETTING:  Depression nurse case managers where depression patients receive treatment in primary health care...
August 22, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Yashu Liu, Lynn Yieh, Tao Yang, Wilhelmus Drinkenburg, Pieter Peeters, Thomas Steckler, Vaibhav A Narayan, Gayle Wittenberg, Jieping Ye
BACKGROUND: Major depressive disorder (MDD) is a heterogeneous disease at the level of clinical symptoms, and this heterogeneity is likely reflected at the level of biology. Two clinical subtypes within MDD that have garnered interest are "melancholic depression" and "anxious depression". Metabolomics enables us to characterize hundreds of small molecules that comprise the metabolome, and recent work suggests the blood metabolome may be able to inform treatment decisions for MDD, however work is at an early stage...
2016: BMC Genomics
Krzysztof Styczeń, Magdalena Sowa-Kućma, Marcin Siwek, Dominika Dudek, Witold Reczyński, Bernadeta Szewczyk, Paulina Misztak, Roman Topór-Mądry, Włodzimierz Opoka, Gabriel Nowak
Despite many clinical trials assessing the role of zinc in major depressive disorder (MDD), the conclusions still remain ambiguous. The aim of the present clinical study was to determine and comparison the zinc concentration in the blood of MDD patients (active stage or remission) and healthy volunteers (controls), as well as to discuss its potential clinical usefulness as a biomarker of the disease. In this study 69 patients with current depressive episode, 45 patients in remission and 50 controls were enrolled...
August 8, 2016: Metabolic Brain Disease
Femke Lamers, Lihong Cui, Ian B Hickie, Catherine Roca, Rodrigo Machado-Vieira, Carlos A Zarate, Kathleen R Merikangas
BACKGROUND: The heterogeneity of mood disorders has been a challenge to our understanding of their underlying biologic and genetic pathways. This report examines the specificity of the familial aggregation of atypical and melancholic subtypes of depression and their clinical correlates in a large community based family study of affective spectrum disorders. METHODS: The sample includes 457 probands and their directly interviewed adult first degree relatives from the National Institute of Mental Health (NIMH) Family Study of Affective Spectrum Disorder...
November 1, 2016: Journal of Affective Disorders
Pina Antinucci
In this paper, I propose a psychoanalytic reading of some of the writings of Amelia Rosselli, a trilingual poet who, at the age of seven, lost her father Carlo, who was persecuted and murdered by Mussolini's regime. History and her history conflate into personal and collective trauma which defies human possibilities to work through and mourn. Rosselli's work testifies to such predicament of the human subject of the 20th century, his/her dislocation, alienation and internal irreconcilable divisions. In particular I examine Diary in three tongues, which is the most autobiographical of her works and a self-analytic piece, written after the conclusion of her second analysis...
July 20, 2016: International Journal of Psycho-analysis
Gordon Parker
OBJECTIVES: The objective of this study was to offer some personal observations as to how melancholia can be diagnosed and differentiated from the non-melancholic depressive conditions. METHODS: Personal clinical and research-based observations are presented following a critique of common current strategies. RESULTS: The paper offers views on the most differentiating clinical features, argues for adding illness course variables to symptoms and provides details of the Sydney Melancholic Prototypic Index, a measure with a high overall classification rate in differentiating melancholic and non-melancholic depression...
July 15, 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Gavin Rush, Aoife O'Donovan, Laura Nagle, Catherine Conway, AnnMaria McCrohan, Cliona O'Farrelly, James V Lucey, Kevin M Malone
BACKGROUND: Immune system dysfunction is implicated in the pathophysiology of major depression, and is hypothesized to normalize with successful treatment. We aimed to investigate immune dysfunction in melancholic depression and its response to ECT. METHODS: 55 melancholic depressed patients and 26 controls participated. 33 patients (60%) were referred for ECT. Blood samples were taken at baseline, one hour after the first ECT session, and 48h after ECT series completion...
June 17, 2016: Journal of Affective Disorders
Gordon Parker
OBJECTIVES: The objective of this article is to offer a personal perspective on managing melancholia by interpreting both the limited salient evidence base and offering clinical observations. CONCLUSIONS: It is suggested that medication needs to be prioritised, that not all antidepressants are equally potent for those with melancholia and that as response to a single antidepressant alone (especially a narrow-spectrum one) is low, management commonly requires broader-spectrum antidepressant drugs and augmentation strategies...
July 12, 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
F Lamers, M Bot, R Jansen, M K Chan, J D Cooper, S Bahn, B W J H Penninx
Depression is a highly heterogeneous disorder. Accumulating evidence suggests biological and genetic differences between subtypes of depression that are homogeneous in symptom presentation. We aimed to evaluate differences in serum protein profiles between persons with atypical and melancholic depressive subtypes, and compare these profiles with serum protein levels of healthy controls. We used the baseline data from the Netherlands Study of Depression and Anxiety on 414 controls, 231 persons with a melancholic depressive subtype and 128 persons with an atypical depressive subtype for whom the proteomic data were available...
2016: Translational Psychiatry
Alexandre Surget, Petra S Van Nieuwenhuijzen, Jan-Michael Heinzmann, Alana Knapman, Silja McIlwrick, Willy-Paul Westphal, Chadi Touma, Catherine Belzung
Modelling key endophenotypes can be a powerful approach to gain insight into mechanisms underlying the aetiology and pathophysiology of neuropsychiatric disorders. Based on evidence of stress hormone system dysregulations in depression, the Stress Reactivity (SR) mouse model has been generated by a selective breeding approach for extremes in HPA axis reactivity, resulting in high (HR), intermediate (IR) and low (LR) reactive mice. The characterisation of their phenotypic alterations has highlighted many similarities of HR and LR mice with the melancholic and atypical depression, respectively...
November 2016: Neuropharmacology
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2016: BMJ: British Medical Journal
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