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aneurysm, carotid, PAD

Niki Katsiki, Dimitri P Mikhailidis, Maciej Banach
Leptin, an adipokine that is implicated in the control of food intake via appetite suppression, may also stimulate oxidative stress, inflammation, thrombosis, arterial stiffness, angiogenesis and atherogenesis. These leptin-induced effects may predispose to the development of cardiovascular diseases. In the present review we discuss the evidence linking leptin levels with the presence, severity and/or prognosis of both coronary artery disease and non-cardiac vascular diseases such as stroke, carotid artery disease, peripheral artery disease (PAD) and abdominal aortic aneurysms (AAA) as well as with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM)...
June 7, 2018: Acta Pharmacologica Sinica
Marie Dahl, Rikke Søgaard, Lars Frost, Annette Høgh, Jes Lindholt
OBJECTIVES: To investigate the effectiveness of systematic screening for multifaceted cardiovascular disease (CVD) in postmenopausal women on all cause mortality and, secondarily, on CVD morbidity. Effectiveness was also evaluated across age strata. METHODS: This was a population based, prospective, parallel cohort study. In total, 107,491 women born in 1936-1951 living in the Central Denmark region were identified in the Danish Civil Registration System. From this population, all women born in 1936, 1941, 1946, and 1951 (n = 1984) living in the Viborg municipality were invited to attend screening...
May 2018: European Journal of Vascular and Endovascular Surgery
Marie Dahl, Lars Frost, Rikke Søgaard, Ib Christian Klausen, Vibeke Lorentzen, Jes Lindholt
BACKGROUND: Reducing women's cardiovascular risk and the economic costs associated with cardiovascular diseases (CVD) and diabetes (DM) continues to be a challenge. Whether a multifaceted CVD screening programme is beneficial as a preventive strategy in women remains uncertain. The aim of this study was to investigate the prevalence of CVD and DM as well as the acceptability toward screening and preventive actions. METHODS: An observational study was performed among all women born in 1936, 1941, 1946 and 1951 living in Viborg Municipality, Denmark, from October 2011...
February 5, 2018: BMC Cardiovascular Disorders
Thomas E Reeve, Rebecca Ur, Timothy E Craven, James H Kaan, Matthew P Goldman, Matthew S Edwards, Justin B Hurie, Gabriela Velazquez-Ramirez, Matthew A Corriere
OBJECTIVE: Frailty is associated with adverse events, length of stay, and nonhome discharge after vascular surgery. Frailty measures based on walking-based tests may be impractical or invalid for patients with walking impairment from symptoms or sequelae of vascular disease. We hypothesized that grip strength is associated with frailty, comorbidity, and cardiac risk among patients with vascular disease. METHODS: Dominant hand grip strength was measured during ambulatory clinic visits among patients with vascular disease (abdominal aortic aneurysm [AAA], carotid stenosis, and peripheral artery disease [PAD])...
May 2018: Journal of Vascular Surgery
Peter A Soden, Sara L Zettervall, Sarah E Deery, Kakra Hughes, Michael C Stoner, Philip P Goodney, Ageliki G Vouyouka, Marc L Schermerhorn
BACKGROUND: Although many studies have demonstrated racial disparities after major vascular surgery, few have identified the reasons for these disparities, and those that did often lacked clinical granularity. Therefore, our aim was to evaluate differences in initial vascular intervention between black and white patients. METHODS: We identified black and white patients' initial carotid, abdominal aortic aneurysm (AAA), and infrainguinal peripheral artery disease (PAD) interventions in the Vascular Quality Initiative (VQI) registry from 2009 to 2014...
February 2018: Journal of Vascular Surgery
Niki Katsiki, Pablo Perez-Martinez, Dimitri P Mikhailidis
Elevated homocysteine (Hcy) levels are predictors of cardiovascular disease (CVD). Hyperhomocysteinemia has also been associated with total and CVD mortality. However, whether Hcy is just a marker or plays a causal role in CVD remains to be elucidated. In this narrative review, we discuss the associations between Hcy and non-cardiac vascular diseases, namely stroke, peripheral artery disease (PAD), carotid artery disease, chronic kidney disease (CKD), atherosclerotic renal artery stenosis (ARAS), abdominal aortic aneurysm (AAA) and erectile dysfunction (ED)...
2017: Current Pharmaceutical Design
Bryan A Ehlert, Alireza Najafian, Kristine C Orion, Mahmoud B Malas, James H Black, Christopher J Abularrage
BACKGROUND: Patient frailty has been implicated as a predictor of poor patient outcomes; however, there is no consensus on how to define or quantify frailty to assess perioperative risk. A previously described modified Frailty Index (mFI) has been shown to predict adverse outcomes after selected vascular surgical procedures, but no studies to date have compared its utility against other recognized risk indices in specific populations of vascular surgery patients. METHODS: National Surgical Quality Improvement Program data were reviewed for all patients undergoing carotid revascularization, abdominal aortic aneurysm (AAA) repair, and lower extremity revascularization for peripheral arterial disease (PAD) from 2006 to 2012...
June 2016: Journal of Vascular Surgery
K H J Ultee, F Bastos Gonçalves, S E Hoeks, E V Rouwet, E Boersma, R J Stolker, H J M Verhagen
OBJECTIVE/BACKGROUND: The association between socioeconomic status (SES), presentation, and outcome after vascular surgery is largely unknown. This study aimed to determine the influence of SES on post-operative survival and severity of disease at presentation among vascular surgery patients in the Dutch setting of equal access to and provision of care. METHODS: Patients undergoing surgical treatment for peripheral artery disease (PAD), abdominal aortic aneurysm (AAA), or carotid artery stenosis between January 2003 and December 2011 were retrospectively included...
November 2015: European Journal of Vascular and Endovascular Surgery
Matthew A Corriere, Jennifer A Avise, Laura A Peterson, Jeanette M Stafford, Douglas Easterling, Derrick S Boone, Edward Ip, Adam S Hyde, Gregory L Burke
BACKGROUND: Developing patient-centered approaches to health care requires increased engagement of patients in their own care, including treatment decisions. Current levels of patient involvement in treatment choices have not been quantified, however, and whether patients desire greater decision-making responsibility is unknown. We conducted a prospective study to explore patients' desired vs experienced roles in treatment decisions, characterize perceptions of treatment outcomes, and identify important sources of information...
October 2015: Journal of Vascular Surgery
Cleona Gray, Patrick Goodman, Paul Cullen, Stephen A Badger, Kevin O'Malley, Martin K O'Donohoe, Ciaran O McDonnell
Screening for concomitant atherosclerotic disease is important in cardiovascular risk reduction. This study assessed the prevalence of carotid artery disease (CAD) and peripheral arterial disease (PAD) in patients with known abdominal aortic aneurysms (AAAs). All patients with AAA attending the vascular laboratory between the January 1, 2007, and December 31, 2009, were eligible for a carotid ultrasound and measurement of ankle brachial indices. A total of 389 (305 males) patients were identified on the AAA surveillance program with a mean (±standard deviation) age of 76 (±8) years...
April 2016: Angiology
Steven M Weisman, Elizabeth A Brooks
PURPOSE: Perform an initial formal assessment of the costs and benefits of bundled cardiovascular screening. Primarily, determine the relative importance of data uncertainties to the integrity ofmodeled outcomes associated with bundled screening for carotid artery stenosis (CAS), peripheral artery disease (PAD), and abdominal aortic aneurysm (AAA); secondarily, establish parameters around potential costs and outcomes benefits of this screening bundle. DESIGN: A decision-analysis framework composed of four decision tree submodels with transition probabilities specific to four age- and gender-specific subgroups...
January 2015: Managed Care
Mohammad H Eslami, Denis Rybin, Gheorghe Doros, Alik Farber
OBJECTIVE: This study compared in-hospital mortality and resource utilization among vascular surgical patients at safety net public hospitals (SNPHs) with those at nonsafety net public hospitals (nSNPHs). METHODS: The National Inpatient Sample (2003-2011) was queried to identify surgical patients with peripheral arterial disease (PAD), carotid stenosis, or nonruptured abdominal aorta aneurysm based on International Classification of Diseases, Ninth Revision, Clinical Modification diagnostic and procedure codes...
December 2014: Journal of Vascular Surgery
Won Pyo Cho, In Soo Park, Yong Sun Jeon, Jang Yong Kim, Taehyeon Kong, Ji-eun Jung, Soon Gu Cho, Kee Chun Hong, Seok-Hwan Shin
BACKGROUND: Vascular diseases, such as carotid artery stenosis (CAS), abdominal aortic aneurysm (AAA), and peripheral arterial occlusive disease (PAD) of the lower limb, are common in elderly men. These diseases have not been thoroughly reported in Eastern countries as well as in Western countries. We compare the prevalence rates in Korea with previous reports, and evaluate correlations between known risk factors and these conditions in this population. MATERIALS AND METHODS: From November 2008 to December 2012, elderly men (≥65 years) were randomly referred from the Incheon Federation of the Korean Senior Citizens' Association, which is one of the major organizations representing retired individuals in Korea...
February 2015: Annals of Vascular Surgery
Binita Shah, Caron B Rockman, Yu Guo, Jaclyn Chesner, Arthur Z Schwartzbard, Howard S Weintraub, Mark A Adelman, Thomas S Riles, Jeffrey S Berger
OBJECTIVE: The aim of this study was to investigate the relationship between diabetes and different phenotypes of peripheral vascular disease (lower extremity peripheral artery disease [PAD], carotid artery stenosis [CAS], and abdominal aortic aneurysm [AAA]). RESEARCH DESIGN AND METHODS: Prevalence of vascular disease was evaluated in 3,696,778 participants of the Life Line Screening survey between 2003 and 2008. PAD was defined as ankle-brachial pressure index <0...
June 2014: Diabetes Care
Matthew W Mell, Mary Pettinger, Lori Proulx-Burns, Susan R Heckbert, Matthew A Allison, Michael H Criqui, Mark A Hlatky, Dale R Burwen
OBJECTIVE: Capturing long-term outcomes from large clinical databases by use of claims data is a potential strategy for improving efficiency while reducing study costs. We sought to compare the use of Medicare data with data from the Women's Health Initiative (WHI) to determine peripheral vascular events, as defined by the WHI study design. METHODS: We studied participants from the WHI with both adjudicated outcomes and links to Medicare enrollment and utilization data through 2007...
July 2014: Journal of Vascular Surgery
D Martin, D Wallace, M Crowe, C Rush, P Tosenovsky, J Golledge
OBJECTIVES: Peripheral arterial disease (PAD) is principally caused by atherosclerosis, an established inflammatory disease. Total white cell count (TWCC) is a marker of inflammation and has been associated with outcomes for patients with inflammatory diseases. The aim of this systematic review was to assess the association of TWCC with mortality and major adverse events (MAEs) in PAD patients. METHODS: Studies investigating the association of TWCC with outcome in patients with PAD were identified by a literature search using the Medline and Cochrane databases...
April 2014: European Journal of Vascular and Endovascular Surgery
S Sultan, B Y C Chua, N Hamada, N Hynes
Background: The aim of this paper was to determine prevalence and incidence of intervention required for concomitant Asymptomatic Vascular Disease (AVD) on patients undergoing their first elective peripheral arterial intervention. Methods: This is a prospective observational study Data was obtained on patients undergoing peripheral revascularisation, abdominal aortic aneurysmal (AAA) repair or carotid procedure from 2006 to 2009. Of 542 complex arterial procedures, 328 patients had their first vascular intervention...
June 2013: International Angiology: a Journal of the International Union of Angiology
Jeffrey S Berger, Judith Hochman, Iryna Lobach, Mark A Adelman, Thomas S Riles, Caron B Rockman
BACKGROUND: The precise relationship between risk factor burden and prevalence of peripheral artery disease (PAD) in different vascular territories (PAD, carotid artery stenosis [CAS], and abdominal aortic aneurysms [AAAs]) is unclear. METHODS: We investigated the association of modifiable risk factors (hypertension, hypercholesterolemia, smoking, diabetes, and sedentary lifestyle) with any and type-specific peripheral vascular disease (PVD) among 3.3 million patients in the U...
September 2013: Journal of Vascular Surgery
Nazir Savji, Caron B Rockman, Adam H Skolnick, Yu Guo, Mark A Adelman, Thomas Riles, Jeffrey S Berger
OBJECTIVES: This study sought to determine the relationship between vascular disease in different arterial territories and advanced age. BACKGROUND: Vascular disease in the peripheral circulation is associated with significant morbidity and mortality. There is little data to assess the prevalence of different phenotypes of vascular disease in the very elderly. METHODS: Over 3.6 million self-referred participants from 2003 to 2008 who completed a medical and lifestyle questionnaire in the United States were evaluated by screening ankle brachial indices <0...
April 23, 2013: Journal of the American College of Cardiology
R T Grundmann, F Meyer
BACKGROUND: This overview comments on gender-specific differences in prevalence, treatment and outcome in patients with peripheral arterial disease (PAD), carotid stenosis, and abdominal aortic aneurysm (AAA). METHOD: For the literature review, the Medline database (PubMed) was searched under the key words "peripheral arterial disease AND gender", "carotid stenosis AND gender" and "abdominal aortic aneurysm AND gender". RESULTS: 1.) Women (preferably black women) with PAD experience rather than men bypass failure or amputation...
April 2013: Zentralblatt Für Chirurgie
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