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hypertriglyceridemia, pancreatitis

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https://www.readbyqxmd.com/read/29207918/intake-of-green-plant-membrane-with-dietary-oil-suppresses-postprandial-hypertriglyceridemia-in-rats-via-promoting-excretion-of-bile-acids
#1
Hiroko Matsuda, Shinpei Ooi, Ryo Otokozawa, Kodai Kumazaki, Eri Udagawa, Masaya Asakura, Daisuke Suzuki, Takaaki Shirai
Green-plant membrane is a phytonutrient present in green leafy vegetables at high concentration. Postprandial increases in blood triglyceride levels result in insulin resistance and type 2 diabetes. Additionally, dietary life and eating order also affect postprandial hypertriglyceridemia. In this study, the effects of once-daily intake of green-plant membrane with dietary oil on postprandial hypertriglyceridemia were investigated in vitro and in vivo. In vitro, green-plant membrane bound hydrophobic bile acids but did not inhibit pancreatic lipase activity...
December 6, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29200694/pancreatitis-in-acute-promyelocytic-leukemia-drug-induced-or-differentiation-syndrome
#2
Dibyendu De, Uttam Kumar Nath, Prantar Chakrabarti
Acute promyelocytic leukemia (APL) constitutes about 15% of all acute myeloid leukemia patients and can now be treated even without any chemotherapy, with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO). Acute pancreatitis (AP) is a rare adverse event in APL, which is primarily reported to be secondary to hypertriglyceridemia. Here, we have reported AP developed in a patient of APL, during induction with ATRA and ATO, but it was not associated with hypertriglyceridemia. Rather, it was associated with respiratory distress and weight gain, coincidental leukocytosis, bilateral pleural effusion, and edematous pancreatitis without any necrosis...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29195809/reduced-psychological-distress-in-familial-chylomicronemia-syndrome-after-patient-support-group-intervention
#3
Leah M Wilson, Russell R Cross, P Barton Duell
Familial chylomicronemia syndrome (FCS) is a rare genetic disorder that is associated with severe hypertriglyceridemia and complications that often include recurrent pancreatitis beginning in childhood. Patients with FCS frequently struggle to maintain normality in their lives as a consequence of the necessity to severely restrict their intake of dietary fat coupled with the constant threat of recurrent pancreatitis. Patients typically face a high level of psychological stress and anxiety in association with reduced measures of quality of life...
November 13, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29174078/acute-pancreatitis-admission-trends-a-national-estimate-through-the-kids-inpatient-database
#4
Maisam Abu-El-Haija, Samer El-Dika, Alice Hinton, Darwin L Conwell
OBJECTIVES: To evaluate national health care use and costs for pediatric acute pancreatitis. STUDY DESIGN: The Kids' Inpatient Database for 2006, 2009, and 2012 was queried for patients with a principal diagnosis of acute pancreatitis. Cases were grouped by age: preschool (<5 years of age), school age (5-14 years of age), and adolescents (>14 years of age). RESULTS: A total of 27 983 discharges for acute pancreatitis were found. The number of admissions increased with age: young n = 1279, middle n = 8012, and older n = 18 692...
November 21, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29174071/exchange-transfusions-for-extreme-hypertriglyceridemia-in-a-7-week-old-infant-with-multi-organ-failure
#5
Samira Ghoor, Peter Berlyn, Naeem Brey
Severe hypertriglyceridemia is the third most common cause of acute pancreatitis and is strongly associated with an increased risk of cardiovascular disease. In infants, the most common cause of severe hypertriglyceridemia is lipoprotein lipase deficiency. We describe a 7-week-old infant with severe hypertriglyceridemia, who presented with frequent gastrointestinal bleeding, respiratory distress, a decreased level of consciousness and lipemia retinalis. Triglycerides were reduced from 734 to 2 mmol/L (64,956-177 mg/dL), by exchange transfusions...
November 2, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29164335/clinical-characteristics-of-acute-pancreatitis-in-pregnancy-experience-based-on-121-cases
#6
Lingyu Luo, Hao Zen, Hongrong Xu, Yin Zhu, Pi Liu, Liang Xia, Wenhua He, Nonghua Lv
PURPOSE: Acute pancreatitis in pregnancy (APIP) is a rare condition; however, it markedly affects maternal and fetal health. This study aimed to describe the types, clinical characteristics, mortality, and the safety and necessity of gestation termination of acute pancreatitis in pregnancy (APIP). METHODS: We retrospectively reviewed 121 APIP cases in the Gastroenterology Department of The First Affiliated Hospital of Nanchang University. APIP diagnosis were based on 2012 Atlanta Criteria...
November 21, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29164010/chewing-the-fat-a-case-report-of-therapeutic-plasma-exchange-in-hypertriglyceridemia-induced-pancreatitis
#7
Cory Madigan, Troy Denunzio, Jessica Bunin
Hypertriglyceridemia is the third most common etiology of acute pancreatitis, but lacks a clear, evidence-based treatment approach. We present the case of a 25-year-old man who was admitted eleven times over seven years for hypertriglyceridemia-induced pancreatitis. In his first ten admissions, he received conservative therapy. During his eleventh admission, he underwent therapeutic plasma exchange with lowering of serum triglycerides from 5080 to 332 mg/dL. He was discharged on hospital day five and was noted to have persistently lowered triglyceride levels upon follow up...
November 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/29153744/molecular-and-functional-characterization-of-familial-chylomicronemia-syndrome
#8
Ryota Teramoto, Hayato Tada, Masa-Aki Kawashiri, Atsushi Nohara, Takuya Nakahashi, Tetsuo Konno, Akihiro Inazu, Hiroshi Mabuchi, Masakazu Yamagishi, Kenshi Hayashi
BACKGROUND AND AIMS: Familial chylomicronemia syndrome is a rare autosomal recessive disorder leading to severe hypertriglyceridemia (HTG) due to mutations in lipoprotein lipase (LPL)-associated genes. Few data exist on the clinical features of the disorder or on comprehensive genetic approaches to uncover the causative genes and mutations. METHODS: Eight patients diagnosed with familial hyperchylomicronemia with recessive inheritance were included in this study (two males and six females; median age of onset 23...
November 14, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29142480/case-of-familial-hyperlipoproteinemia-type-iii-hypertriglyceridemia-induced-acute-pancreatitis-role-for-outpatient-apheresis-maintenance-therapy
#9
Mohannad Abou Saleh, Emad Mansoor, Gregory S Cooper
Hypertriglyceridemic pancreatitis (HTGP) accounts for up to 10% of acute pancreatitis presentations in non-pregnant individuals and is the third most common cause of acute pancreatitis after alcohol and gallstones. There are a number of retrospective studies and case reports that have suggested a role for apheresis and insulin infusion in the acute inpatient setting. We report a case of HTGP in a male with hyperlipoproteinemia type III who was treated successfully with insulin and apheresis on the initial inpatient presentation followed by bi-monthly outpatient maintenance apheresis sessions for the prevention of recurrent HTGP...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29096837/the-role-of-antisense-oligonucleotide-therapy-against-apolipoprotein-ciii-in-hypertriglyceridemia
#10
Ioanna Gouni-Berthold
Increased triglyceride levels (higher than ∼1000 mg/dL) are associated with an increased risk for pancreatitis. Apolipoprotein-CIII (apo-CIII) plays a key role in the metabolism of triglycerides and triglyceride-rich lipoproteins. While loss of function mutations in the gene encoding apo-CIII (APOC3) are associated with low triglyceride levels and a decreased risk for cardiovascular disease (CVD), overexpression of APOC3 is associated with hypertriglyceridemia. Although many drugs such as fibrates, statins and omega-3 fatty acids modestly decrease triglyceride levels (and apo-CIII concentrations), there are many patients who still have severe hypertriglyceridemia and are at risk for pancreatitis and potentially CVD...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29088999/antioxidant-antihyperglycemic-and-antidyslipidemic-effects-of-brazilian-native-fruit-extracts-in-an-animal-model-of-insulin-resistance
#11
Juliane de Souza Cardoso, Pathise Souto Oliveira, Natália Pontes Bona, Flávia Aleixo Vasconcellos, Jucimara Baldissarelli, Marcia Vizzotto, Mayara Sandrielly Pereira Soares, Vanessa Plasse Ramos, Roselia Maria Spanevello, Claiton Leoneti Lencina, Rejane Giacomelli Tavares, Francieli Moro Stefanello
OBJECTIVE: Insulin resistance (IR) plays an important role in the development of many diseases, such as diabetes mellitus. Therefore, the aim of the present study was to evaluate the effects of the extracts from fruits native to Brazil on metabolic parameters and hepatic oxidative markers in an animal model of insulin resistance induced by dexamethasone (DEX). METHODS: Wistar rats received water or extracts of Eugenia uniflora or Psidium cattleianum, once a day for 21 days...
October 31, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/29082890/acute-pancreatitis-after-coronary-artery-bypass-surgery-treated-by-plasmapheresis
#12
Emine Şeyma Denli Yalvaç, Mustafa Aldağ, Cemal Kocaaslan, Ebubekir Şenateş, Ebuzer Aydın
Acute pancreatitis (AP) is a common disorder and an important cause of morbidity and mortality. There are different causes of AP, including gallstones and excessive alcohol consumption. AP after coronary artery bypass grafting (CABG) surgery is seen less frequently but it is associated with a high mortality rate due to its atypical and misleading symptoms. Supportive treatment, pain management, and treatment of complications are used in the treatment of AP. The treatment of hypertriglyceridemia-induced pancreatitis is plasmapheresis, which is an extracorporeal separation of blood components to assist in the removal of inflammatory mediators...
October 30, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29080985/comparing-the-impact-of-prescription-omega-3-fatty-acid-products-on-low-density-lipoprotein-cholesterol
#13
REVIEW
Randall P Sharp, Barry J Gales, Riaz Sirajuddin
Elevated levels of triglycerides are associated with pancreatitis and an increased risk of coronary heart disease. Numerous pharmacologic therapies are available to treat hypertriglyceridemia, including prescription omega-3 fatty acids, which reduce triglyceride levels by 20-50%. Available data indicate the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may be beneficial for secondary prevention of coronary heart disease. Products containing DHA may increase low-density lipoprotein cholesterol (LDL-C) and, subsequently, coronary heart disease risk...
October 28, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29062184/a-case-of-massive-hypertriglyceridemia-in-6-year-old-boy
#14
Purvi Purohit, Daisy Khera, Praveen Sharma, Kuldeep Singh
Type V hypertriglyceridemia in children is a rare condition since it has often been associated with obesity, type II diabetes, metabolic syndrome and hormone therapy. We encountered a case of massive hypertriglyceridemia (1900 mg/dl) in a 6 years old boy with complains of acute pancreatitis but no physical manifestations. There was no family history of sudden cardiac death, father and younger male sibling were found to be normal. The mother however had hypertriglyceridemia. The child was managed by dietary changes, omega 3 capsules and low dose fenofibrate...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29030078/evaluation-of-the-prognostic-value-of-neutrophil-to-lymphocyte-ratio-in-patients-with-hypertriglyceridemia-induced-acute-pancreatitis
#15
Yuchen Wang, Harry E Fuentes, Bashar M Attar, Palash Jaiswal, Melchor Demetria
INTRODUCTION: Recent studies attribute promising prognostic values to various inflammatory biomarkers in acute pancreatitis, including the following: the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red cell distribution width (RDW). We aimed to determine the performance of these biomarkers for detecting disease severity in patients with hypertriglyceridemia-induced acute pancreatitis (HTG-AP). METHODS: We retrospectively reviewed 110 patients with HTG-AP and compared the NLR, PLR, and RDW in different severity groups...
October 6, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28986186/fatal-abdominal-compartment-syndrome-due-to-severe-triglyceride-induced-pancreatitis-in-early-pregnancy
#16
Tamanna Chibber, Paul S Gibson
Serum levels of maternal lipids rise physiologically in normal pregnancy, and women with underlying hypertriglyceridemia may experience dramatic elevations which place them at risk for pancreatitis. We describe the case of a woman with severe familial hypertriglyceridemia and prior pancreatitis who discontinued her lipid-lowering therapy early in pregnancy. She promptly developed severe abdominal pain and was hospitalized with acute pancreatitis during the late first trimester. Despite aggressive medical treatment and critical care monitoring, she developed abdominal compartment syndrome (ACS) with associated acute renal failure, which progressed to cardiorespiratory failure and was ultimately fatal...
October 3, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28984788/concurrent-diabetic-ketoacidosis-in-hypertriglyceridemia-induced-pancreatitis-how-does-it-affect-the-clinical-course-and-severity-scores
#17
Yuchen Wang, Bashar M Attar, Keiki Hinami, Palashkumar Jaiswal, John Erikson Yap, Radhika Jaiswal, Kalpit Devani, Carlos Roberto Simons-Linares, Melchor V Demetria
OBJECTIVES: Concurrent diabetic ketoacidosis (DKA) is highly prevalent in patients with hypertriglyceridemia-induced pancreatitis (HP). Diabetic ketoacidosis could potentially complicate the diagnosis, management, and prognosis of HP. This study aimed to directly compare the clinical course of HP with and without DKA and assess the outcomes of frequently used severity-prediction scores in such population. METHODS: We retrospectively analyzed 140 patients with HP; 37 patients (26...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28969260/tamoxifen-induced-pancreatitis-an-unusual-complication-of-commonly-used-drug
#18
Pritam Suresh Chandra Kataria, Pradip Piraji Kendre, Apurva Ashok Patel, Murtaza Zoher Bohra, Nahush Tahiliani
Tamoxifen is a selective oestrogen receptor modulator used for the treatment of oestrogen/progesterone receptor positive breast cancer. It possess antagonistic or agonistic activity depending on the tissue location i.e., antagonistic action on breast but agonist action on endometrium and bones. The side effects of tamoxifen include hot flushes, gynaecologic symptoms (vaginal dryness, vaginal discharge), depression, forgetfulness, sleep alterations, weight gain, alteration of lipoprotein metabolism, thromboembolic disorder...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28966501/hypertriglyceridemia-induced-acute-pancreatitis-with-diabetic-ketoacidosis-a-rare-presentation-of-type-1-diabetes-mellitus
#19
Prabhat Kumar, Abhishek Sakwariya, Amit Ranjan Sultania, Renu Dabas
Diabetic ketoacidosis (DKA) is a frequently encountered complication of diabetes mellitus. DKA is an insulin deficit state and results in moderate to severe hypertriglyceridemia (HTG). HTG is the third leading cause of acute pancreatitis (AP) and often goes unnoticed. The triad of DKA, HTG, and AP is rarely seen, and literature on the same is sparse. We report a case of AP which was due to DKA-induced secondary HTG in an adult with previously undiagnosed type 1 diabetes. His HbA1c was significantly raised, and C-peptide level was low, confirming chronic hyperglycemia...
October 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28958672/severe-hypertriglyceridemia-in-japan-differences-in-causes-and-therapeutic-responses
#20
Toshio Murase, Minoru Okubo, Tetsu Ebara, Yasumichi Mori
BACKGROUND: Severe hypertriglyceridemia (>1000 mg/dL) has a variety of causes and frequently leads to life-threating acute pancreatitis. However, the origins of this disorder are unclear for many patients. OBJECTIVE: We aimed to characterize the causes of and responses to therapy in rare cases of severe hypertriglyceridemia in a group of Japanese patients. METHODS: We enrolled 121 patients from a series of case studies that spanned 30 years...
August 24, 2017: Journal of Clinical Lipidology
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