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hypertriglyceridemia, pancreatitis

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https://www.readbyqxmd.com/read/29556780/taurine-supplementation-induces-long-term-beneficial-effects-on-glucose-homeostasis-in-ob-ob-mice
#1
Patricia Cristine Borck, Jean Franciesco Vettorazzi, Renato Chaves Souto Branco, Thiago Martins Batista, Junia Carolina Santos-Silva, Vanessa Yumi Nakanishi, Antonio Carlos Boschero, Rosane Aparecida Ribeiro, Everardo Magalhães Carneiro
The sulfur-containing amino acid, taurine (Tau), regulates glucose and lipid homeostasis under normal, pre- and diabetic conditions. Here, we aimed to verify whether Tau supplementation exerts its beneficial effects against obesity, hyperglycemia and alterations in islet functions, in leptin-deficient obese (ob/ob), over a long period of treatment. From weaning until 12 months of age, female ob/ob mice received, or not, 5% Tau in drinking water (obTau group). After this period, a reduction in hypertriglyceridemia and an improvement in glucose tolerance and insulin sensitivity were observed in obTau mice...
March 19, 2018: Amino Acids
https://www.readbyqxmd.com/read/29530731/hypertriglyceridemia-induced-acute-pancreatitis-with-normal-pancreatic-enzymes
#2
Sho Kitagawa, Koya Sawai
We declare that this manuscript is original, has not been published before and is not currently being considered for publication elsewhere. There are no conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. We obtained informed consent from the patient. The manuscript has been read and approved by all named authors. S. Kitagawa diagnosed the case and wrote the manuscript, and is the article guarantor. K...
March 9, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29498913/acute-pancreatitis-in-patients-with-severe-hypertriglyceridemia-in-a-multiethnic-minority-population
#3
Ambika Amblee, Divyanshu Mohananey, Micheal Morkos, Sanjib Basu, Ayokunle Abegunde, Malini Ganesh, Neil Bhalerao, Amrutha Mary George, Milli Jain, Leon Fogelfeld
OBJECTIVE: To investigate the prevalence and predictors of hypertriglycerdemic acute pancreatitis (HTG-AP) in a multiethnic minority population. METHODS: A retrospective cross-sectional study from 2003 to 2013 of 1157 adults with serum triglyceride (TG) level ≥ 1000 mg/dL comparing baseline characteristics and risk factors between those with and without HTG-AP. RESULTS: Mean study population age was 49.2±11.5 years; 75.6% males; 31.6% African Americans, 38...
March 2, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29491271/effects-of-pediococcus-acidilactici-r037-on-serum-triglyceride-levels-in-mice-and-rats-after-oral-administration
#4
Takahiro Ueda, Airo Tategaki, Kazuya Hamada, Hideyuki Kishida, Kazunori Hosoe, Hideyuki Morikawa, Kaku Nakagawa
The biological effects of heat-killed Pediococcus acidilactici R037 (R037) were evaluated when orally administered in mice and rats. Oral R037 administration at a daily dose of 10 and 100 mg/kg for 3 wk dose-dependently reduced fasting and non-fasting serum triglyceride concentrations in KK-Ay /TaJcl mice, a model of type II diabetes, obesity, hypercholesterolemia, and hypertriglyceridemia. Serum levels of free fatty acids in the 100 mg/kg group tended to decrease (not statistically significant), and total cholesterol levels remained unchanged...
2018: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29486665/mirtazapine-induced-pancreatitis-a-case-report
#5
Riley D Bowers, Sara M Valanejad, Ashley A Holombo
Acute pancreatitis has numerous etiologies, with the most common including gallstones, alcohol abuse, and medications such as angiotensin-converting enzyme (ACE) inhibitors, statins, and diuretics. Mirtazapine has been associated with increased serum cholesterol and serum triglyceride levels. However, few studies have reported dangerously elevated triglyceride levels resulting in acute pancreatitis. This report discusses a case of mirtazapine-induced pancreatitis in a 46-year-old African American female. The patient presented to the emergency department with pancreatitis, presumably alcohol-induced as with a prior admission, but she denied any recent alcohol use...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29454679/the-prevalence-and-etiology-of-extreme-hypertriglyceridemia-in-children-data-from-a-tertiary-children-s-hospital
#6
Nivedita Patni, Xilong Li, Beverley Adams-Huet, Abhimanyu Garg
BACKGROUND: Extreme hypertriglyceridemia (eHTG; serum triglycerides ≥ 2000 mg/dL) poses a significant risk for acute pancreatitis. There is paucity of data regarding the prevalence and etiology of eHTG in children. OBJECTIVE: To determine the prevalence, clinical features and etiologies of patients with eHTG at a tertiary children's hospital in the United States and in the United States National Health and Nutrition Examination Survey (NHANES). METHODS: A retrospective analysis was conducted of the electronic medical records of the Children's Medical Center, Dallas, from 2000-2015, and the NHANES data from 2005-2014 for eHTG...
January 12, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29439301/safe-and-effective-triglyceride-lowering-therapy-for-hypertriglyceridemia-associated-pancreatitis-insulin-mono-therapy-in-a-non-diabetic-patient
#7
Chencheng Xie, Dennis C Stevens, Tamera Sturm
This report was prepared to describe a case in which insulin monotherapy was efficacious for the management of hypertriglyceridemia-associated pancreatitis (HGTP) in a patient who was not diabetic. Currently, there are no definite clinical guidelines or standards of practice for nondiabetic HGTP. Apart from insulin infusion, other regimens include plasmapheresis and heparin administration, both of which carry significant risks. We reported a case of a non-diabetic male with HTGP (triglyceride greater than 3,000 mg/dL) who was successfully managed with an insulin infusion...
January 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/29390422/type-v-hypertriglyceridemia-in-children-a-therapeutic-challenge-in-pediatrics-a-case-report-and-a-review-of-the-literature
#8
Cristina Oana Mărginean, Lorena Elena Meliţ, Minodora Dobreanu, Maria Oana Mărginean
RATIONALE: Hypertriglyceridemia is defined as a level of triglycerides above 150 mg/dL. The complex causes and classification of hypertriglyceridemia lead to difficulties in the diagnosis and management of this condition. PATIENT CONCERNS: We present the case of a 15 years and 6 months old female teenager, admitted in our clinic for the following complaints: severe abdominal pain predominantly in the lateral left quadrant, nausea, vomiting, and the lack of stools for 2 days...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29381696/association-between-triglyceride-levels-and-cardiovascular-disease-in-patients-with-acute-pancreatitis
#9
Laurel A Copeland, C Scott Swendsen, Dawn M Sears, Andrea A MacCarthy, Catherine J McNeal
Conventional wisdom supports prescribing "fibrates before statins", that is, prioritizing treatment of hypertriglyceridemia (hTG) to prevent pancreatitis ahead of low-density lipoprotein cholesterol to prevent coronary heart disease. The relationship between hTG and acute pancreatitis, however, may not support this approach to clinical management. This study analyzed administrative data from the Veterans Health Administration for evidence of (1) temporal association between assessed triglycerides level and days to acute pancreatitis admission; (2) association between hTG and outcomes in the year after hospitalization for acute pancreatitis; (3) relative rates of prescription of fibrates vs statins in patients with acute pancreatitis; (4) association of prescription of fibrates alone versus fibrates with statins or statins alone with rates of adverse outcomes after hospitalization for acute pancreatitis...
2018: PloS One
https://www.readbyqxmd.com/read/29365789/hypertriglyceridemia-induced-acute-pancreatitis-in-third-trimester-of-pregnancy-a-case-report
#10
Ioanna Polypathelli, Christos Demosthenous, Maria Gavra, Eleni Matsaridou, Glykeria Tzatzagou
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29345595/hospital-management-of-severe-hypertriglyceridemia-in-children
#11
Ambika Ashraf, Badhma Valaiyapathi
Severe hypertriglyceridemia (HTG), i.e., triglyceride levels exceeding 1000 mg/dL, is one of the established causes of acute pancreatitis and severe abdominal pain. There are no established pediatric guidelines for treatment of children and adolescents with severe HTG. Management often includes hospital admission, fasting followed by fat free diet until the triglyceride (TG) levels are below 1000 mg/dL. Insulin infusion lowers TG levels in patients, especially in those with diabetes. Plasmapheresis is a limited option due to its restricted availability and scarcity of studies on its efficacy and safety in children...
January 16, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29334743/-adiponectin-in-patients-with-metabolic-syndrome-and-diseases-of-the-liver-bile-ducts-and-pancreas
#12
Adam Vašura, Martin Blaho, Petr Dítě, Tomáš Kupka, Pavel Svoboda, Arnošt Martínek
Epidemiological data show that the metabolic syndrome can be diagnosed in up to 30 % of the population. Regarding 5 components of the metabolic syndrome, three of them, in case of positivity (visceral obesity, arterial hypertension, hypertriglyceridemia, changes of HDL-cholesterol levels and type 2 diabetes mellitus), are pathogenic factors which are the most frequently related to cardiovascular diseases, but currently they are also the focus of interest for gastroenterologists. The relationship between non-alcoholic hepatic steatosis, including non-alcoholic steatohepatitis, has been described...
December 0: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29304082/striated-muscle-gene-therapy-for-the-treatment-of-lipoprotein-lipase-deficiency
#13
Katherine E Gadek, Hong Wang, Monica N Hall, Mitchell Sungello, Andrew Libby, Drew MacLaskey, Robert H Eckel, Bradley B Olwin
Excessive circulating triglycerides due to reduction or loss of lipoprotein lipase activity contribute to hypertriglyceridemia and increased risk for pancreatitis. The only gene therapy treatment for lipoprotein lipase deficiency decreases pancreatitis but minimally reduces hypertriglyceridemia. Synthesized in multiple tissues including striated muscle and adipose tissue, lipoprotein lipase is trafficked to blood vessel endothelial cells where it is anchored at the plasma membrane and hydrolyzes triglycerides into free fatty acids...
2018: PloS One
https://www.readbyqxmd.com/read/29289538/omega-3-carboxylic-acids-in-patients-with-severe-hypertriglyceridemia-evolve-ii-a-randomized-placebo-controlled-trial
#14
Erik S G Stroes, Andrey V Susekov, Tjerk W A de Bruin, Mats Kvarnström, Hong Yang, Michael H Davidson
BACKGROUND: Adult patients with severe hypertriglyceridemia (SHTG) are at increased risk of developing acute pancreatitis and cardiovascular disease. Omega-3 carboxylic acids (OM3-CA) are approved for treatment as an adjunct to diet to reduce triglyceride (TG) concentrations in patients with SHTG. OBJECTIVE: The aim of the study was to assess efficacy and safety of the intermediate dose of OM3-CA (2 g daily), compared with olive oil 2 g daily, in reducing serum TG and lipid concentrations in patients with SHTG...
March 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29288010/molecular-analysis-of-three-known-and-one-novel-lpl-variants-in-patients-with-type-i-hyperlipoproteinemia
#15
A Caddeo, R M Mancina, C Pirazzi, C Russo, K Sasidharan, J Sandstedt, S Maurotti, T Montalcini, A Pujia, T P Leren, S Romeo, P Pingitore
BACKGROUND AND AIMS: Type I hyperlipoproteinemia, also known as familial chylomicronemia syndrome (FCS), is a rare autosomal recessive disorder caused by variants in LPL, APOC2, APOA5, LMF1 or GPIHBP1 genes. The aim of this study was to identify novel variants in the LPL gene causing lipoprotein lipase deficiency and to understand the molecular mechanisms. METHODS AND RESULTS: A total of 3 individuals with severe hypertriglyceridemia and recurrent pancreatitis were selected from the Lipid Clinic at Sahlgrenska University Hospital and LPL was sequenced...
February 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29276238/treatment-of-hypertriglyceridemia-induced-acute-pancreatitis-with-insulin-heparin-and-gemfibrozil-a-case-series
#16
Drayton A Hammond, Laura Finlay
Hypertriglyceridemia is the third most common worldwide cause of acute pancreatitis. Resolving the underlying etiology is imperative for optimal management. This is especially true with regard to hypertriglyceridemia, as this etiology may cause more severe acute pancreatitis and worse symptoms than other causes of the disease. Many pharmacological treatment options for hypertriglyceridemia-induced acute pancreatitis (HTGP) have been proposed; however, the safety and efficacy for specific treatment regimens remain nebulous...
November 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/29238515/role-of-therapeutic-plasma-exchange-in-the-treatment-of-severe-hypertriglyceridemia-an-experience
#17
Shaikh Ahmed Muntajib Wassay, Farhan Javed Dar, Asem K Saleh, Ibrahim Mansoor
Hypertriglyceridemia of obesity, the metabolic syndrome, and type II diabetes mellitus are highly prevalent in Saudi Arabia. Severe hypertriglyceridemia is a rare but well known cause of acute pancreatitis. In treatment pancreatic rest, lifestyle changes, and lipid-lowering medications are essential, but the response is slow. Recently the role of therapeutic plasma exchange (TPE) has been stressed for fast and effective management in addition to insulin and heparin infusion. TPE for hypertriglyceridemic pancreatitis resulted in drastic improvements in clinical and laboratory findings and patient outcomes as suggested in our cases...
December 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29207918/intake-of-green-plant-membrane-with-dietary-oil-suppresses-postprandial-hypertriglyceridemia-in-rats-via-promoting-excretion-of-bile-acids
#18
Hiroko Matsuda, Shinpei Ooi, Ryo Otokozawa, Kodai Kumazaki, Eri Udagawa, Masaya Asakura, Daisuke Suzuki, Takaaki Shirai
Green-plant membrane is a phytonutrient present in green leafy vegetables at high concentration. Postprandial increases in blood triglyceride levels result in insulin resistance and type 2 diabetes. Additionally, dietary life and eating order also affect postprandial hypertriglyceridemia. In this study, the effects of once-daily intake of green-plant membrane with dietary oil on postprandial hypertriglyceridemia were investigated in vitro and in vivo. In vitro, green-plant membrane bound hydrophobic bile acids but did not inhibit pancreatic lipase activity...
January 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29200694/pancreatitis-in-acute-promyelocytic-leukemia-drug-induced-or-differentiation-syndrome
#19
Dibyendu De, Uttam Kumar Nath, Prantar Chakrabarti
Acute promyelocytic leukemia (APL) constitutes about 15% of all acute myeloid leukemia patients and can now be treated even without any chemotherapy, with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO). Acute pancreatitis (AP) is a rare adverse event in APL, which is primarily reported to be secondary to hypertriglyceridemia. Here, we have reported AP developed in a patient of APL, during induction with ATRA and ATO, but it was not associated with hypertriglyceridemia. Rather, it was associated with respiratory distress and weight gain, coincidental leukocytosis, bilateral pleural effusion, and edematous pancreatitis without any necrosis...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29195809/reduced-psychological-distress-in-familial-chylomicronemia-syndrome-after-patient-support-group-intervention
#20
Leah M Wilson, Russell R Cross, P Barton Duell
Familial chylomicronemia syndrome (FCS) is a rare genetic disorder that is associated with severe hypertriglyceridemia and complications that often include recurrent pancreatitis beginning in childhood. Patients with FCS frequently struggle to maintain normality in their lives as a consequence of the necessity to severely restrict their intake of dietary fat coupled with the constant threat of recurrent pancreatitis. Patients typically face a high level of psychological stress and anxiety in association with reduced measures of quality of life...
January 2018: Journal of Clinical Lipidology
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