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https://www.readbyqxmd.com/read/28073175/post-reperfusion-microcirculatory-derangements-after-liver-transplantation-relationship-to-hemodynamics-serum-mediators-and-outcome
#1
Carlo Pulitano, David Joseph, Charbel Sandroussi, Deborah Verran, Phong Ho, Ashe Debiasio, Adriano Luongo, Geoffrey W McCaughan, Nicholas Shackel, Michael Crawford
INTRODUCTION: Despite the growing data supporting the role of microcirculation in regulating liver function, little of this knowledge has been translated into clinical practice. The aim of this study is to quantify hepatic microcirculation in-vivo using sidestream dark-field (SDF) imaging and correlate these finding with hepatic blood flow, hemodynamic parameters, and soluble mediators. METHODS: Post-reperfusion hepatic microcirculation was assessed using SDF imaging...
January 10, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28070551/data-on-circulating-leukocyte-subpopulations-and-inflammatory-proteins-in-children-with-familial-hypercholesterolemia-and-healthy-children
#2
Jacob J Christensen, Liv Osnes, Bente Halvorsen, Kjetil Retterstøl, Martin P Bogsrud, Cecilie Wium, Arne Svilaas, Ingunn Narverud, Stine M Ulven, Pål Aukrust, Kirsten B Holven
The data in this relies on a previous publication: "Altered leukocyte distribution under hypercholesterolemia: a cross-sectional study in children with familial hypercholesterolemia" (Christensen et al. 2016) [1]. In the present paper, whole blood leukocyte distribution and plasma inflammatory proteins were measured for association with cholesterol concentration and CRP in children with familial hypercholesterolemia (FH) and healthy children.
February 2017: Data in Brief
https://www.readbyqxmd.com/read/28065523/a-web-based-registry-for-familial-hypercholesterolaemia
#3
Kathryn R Napier, Jing Pang, Leanne Lamont, Caroline E Walker, Hugh Js Dawkins, Adam A Hunter, Frank M van Bockxmeer, Gerald F Watts, Matthew I Bellgard
Familial hypercholesterolaemia (FH) is the most common and serious monogenic disorder of lipoprotein metabolism that leads to premature coronary heart disease. Patients with FH are often under-treated, and many remain undiagnosed. The deployment of the FH Australasia Network Registry is a crucial component of the comprehensive model of care for FH, which aims to provide a standardised, high-quality and cost-effective system of care that is likely to have the highest impact on patient outcomes. The FH Australasia Network Registry was customised using a registry framework that is an open source, interoperable system that enables the efficient customisation and deployment of national and international web-based disease registries that can be modified dynamically as registry requirements evolve...
November 30, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28058510/homozygous-mutation-p-pro304his-in-idh3a-encoding-isocitrate-dehydrogenase-subunit-is-associated-with-severe-encephalopathy-in-infancy
#4
Aviva Fattal-Valevski, Hila Eliyahu, NItai D Fraenkel, Ganit Elmaliach, Moran Hausman-Kedem, Avraham Shaag, Dror Mandel, Ophry Pines, Orly Elpeleg
Mitochondrial encephalopathies are a heterogeneous group of disorders which generally carries a grave prognosis. Using exome sequencing, we identified a homozygous mutation, Pro-304-His in the IDH3A gene, in a patient suffering from infantile encephalopathy with peripheral and autonomic nervous system involvement. Mammalian isocitrate dehydrogenase (IDH) 3 is a heterotetramer of 2alfa, 1beta, and 1gamma subunits, and IDH3A encodes the alfa subunit of the mitochondrial NAD(+)-dependent IDH. Here we show that in contrast to wild-type human IDH3A, the human IDH3A which harbor the p...
January 5, 2017: Neurogenetics
https://www.readbyqxmd.com/read/28057640/murine-systemic-thrombophilia-and-hemolytic-uremic-syndrome-from-a-factor-h-point-mutation
#5
Yoshiyasu Ueda, Imran Mohammed, Delu Song, Damodar Gullipalli, Lin Zhou, Sayaka Sato, Yuan Wang, Shuchi Gupta, Zhongjian Cheng, Hong Wang, Jialing Bao, Yingying Mao, Lawrence Brass, X Long Zheng, Takashi Miwa, Matthew Palmer, Joshua Dunaief, Wen-Chao Song
Complement plays a key role in host defense but its dysregulation can cause autologous tissue injury. Complement activation is normally controlled by regulatory proteins including factor H (FH) in plasma and membrane cofactor protein (MCP) on the cell surface. Mutations in FH and MCP are linked to atypical hemolytic uremic syndrome, a type of thrombotic microangiopathy (TMA) that causes renal failure in patients. We describe here that disruption of FH function on the cell surface can also lead to disseminated complement-dependent macrovascular thrombosis...
January 5, 2017: Blood
https://www.readbyqxmd.com/read/28056451/disruption-of-the-hatching-dynamics-of-zooplankton-egg-banks-due-to-glyphosate-application
#6
María Florencia Gutierrez, Yamila Battauz, Belén Caisso
Hatching rhythms of eggs banks are important processes because they favor species co-existence and promote resilience of ecosystems after natural disturbances. Anthropogenic stressors can disrupt such natural hatching dynamics. This work examines the effects of concentrations ranging from 1 to 8 mg l(-1) of a commercial glyphosate-based formulation (Sulfosato Touchdown(®)) on the hatching dynamics of zooplankton dormant stages, present in the sediment of a natural lake. Sediment samples were collected from the surface sediment (<10 cm deep) of an isolated shallow lake free from pesticide pollution...
December 26, 2016: Chemosphere
https://www.readbyqxmd.com/read/28054268/optimizing-the-phosphorus-use-in-cotton-by-using-csm-cropgro-cotton-model-for-semi-arid-climate-of-vehari-punjab-pakistan
#7
Asad Amin, Wajid Nasim, Muhammad Mubeen, Muhammad Nadeem, Liaqat Ali, Hafiz Mohkum Hammad, Syeda Refat Sultana, Khawar Jabran, M Habib Ur Rehman, Shakeel Ahmad, Muhammad Awais, Atta Rasool, Shah Fahad, Shah Saud, Adnan Noor Shah, Zahid Ihsan, Shahzad Ali, Ali Ahsan Bajwa, Khalid Rehman Hakeem, Asif Ameen, Amanullah, Hafeez Ur Rehman, Fahad Alghabar, Ghulam Hussain Jatoi, Muhammad Akram, Aziz Khan, Faisal Islam, Syed Tahir Ata-Ul-Karim, Muhammad Ishaq Asif Rehmani, Sajid Hussain, Muhammad Razaq, Amin Fathi
Crop nutrient management is an essential component of any cropping system. With increasing concerns over environmental protection, improvement in fertilizer use efficiencies has become a prime goal in global agriculture system. Phosphorus (P) is one of the most important nutrients, and strategies are required to optimize its use in important arable crops like cotton (Gossypium hirsutum L.) that has great significance. Sustainable P use in crop production could significantly avoid environmental hazards resulting from over-P fertilization...
January 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28052761/increased-activity-of-the-complement-system-in-cerebrospinal-fluid-of-the-patients-with-non-hiv-cryptococcal-meningitis
#8
Lei Shen, Jianming Zheng, Yan Wang, Mengqi Zhu, Haoxiang Zhu, Qi Cheng, Qian Li
BACKGROUNDS: Cryptococcal meningitis (CM) has been known to lead to significant morbidity and mortality. The relative contribution of the complement system in protection and pathogenesis during CM remains largely unknown. The purpose of this study was to evaluate the baseline complement component profiles in human cerebrospinal fluid (CSF) and plasma from non-HIV patients with CM, and therefore to provide insights of possible roles of the complement system in CM. METHODS: CSF and blood samples from forty two CM patients not infected with HIV and thirteen non-CM control patients (Ctrl) were retrospectively selected and evaluated from the patients admitted to the hospital with a suspected diagnosis of CM...
January 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28052405/myocardial-layer-specific-analysis-in-patients-with-heterozygous-familial-hypercholesterolemia-using-speckle-tracking-echocardiography
#9
Zhaoting Leng, Rongjuan Li, Yijia Li, Lvya Wang, Yueli Wang, Ya Yang
OBJECTIVE: Familial hypercholesterolemia (FH) is the most common and serious monogenic disorder of lipid metabolism, causing premature coronary heart disease (CHD) due to accelerated atherosclerosis from birth, and the study of left ventricular (LV) function of this disease is seldom. The purpose of this study was to explore the value of layer-specific strain on assessing the early damage of LV function in asymptomatic and left ventricular ejection fraction (LVEF) well-preserved patients with heterozygous FH (HeFH)...
January 3, 2017: Echocardiography
https://www.readbyqxmd.com/read/28044312/optimization-of-contrast-enhanced-breast-imaging-analysis-using-a-cascaded-linear-system-model
#10
Yue-Houng Hu, David A Scaduto, Wei Zhao
PURPOSE: Contrast-enhanced (CE) breast imaging involves the injection contrast agents (i.e., iodine) to increase conspicuity of malignant lesions. CE imaging may be used in conjunction with digital mammography (DM) or digital breast tomosynthesis (DBT) and has shown promise in improving diagnostic specificity. Both CE-DM and CE-DBT techniques require optimization as clinical diagnostic tools. Physical factors including x-ray spectra, subtraction technique, and the signal from iodine contrast, must be considered to provide the greatest object detectability and image quality...
November 21, 2016: Medical Physics
https://www.readbyqxmd.com/read/28043133/long-term-physical-stability-of-pvp-and-pvpva-amorphous-solid-dispersions
#11
Kristin Lehmkemper, Samuel O Kyeremateng, Oliver Heinzerling, Matthias Degenhardt, Gabriele Sadowski
The preparation of amorphous solid dispersion (ASD) formulations is a promising strategy to improve the bioavailability of an active pharmaceutical ingredient (API). By dissolving the API in a polymer it is stabilized in its amorphous form, which usually shows higher water solubility than its crystalline counterpart. To prevent recrystallization, the long-term physical stability of ASD formulations is of big interest. In this work, the solubility of the APIs acetaminophen and naproxen in the excipient polymers poly(vinylpyrrolidone) (PVP K25) and poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64) was calculated with three models: the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT), the Flory-Huggins model (FH), and an empirical model (Kyeremateng et al...
January 3, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28042093/expression-and-antigenicity-of-recombinant-human-respiratory-syncytial-virus-glycoproteins-having-different-affinity-tags
#12
Han Saem Lee, A-Reum Kim, Kisoon Kim, Wan-Ji Lee, Sung Soon Kim, You-Jin Kim
Human respiratory syncytial virus (HRSV) is a main cause of lower respiratory tract infections in infants and the elderly. Glycoprotein (G) is major antigen on the viral surface, and plays a key role for virus entry. Therefore, purification of the glycoprotein of HRSV is critical for the development of HRSV vaccine and serological diagnosis. In this study, we report the design and characterization of glycoprotein engineered rationally to enhance the protein solubility and to facilitate efficient purification...
December 29, 2016: Protein Expression and Purification
https://www.readbyqxmd.com/read/28039657/self-reported-questionnaire-detects-family-history-of-cancer-in-a-pancreatic-cancer-screening-program
#13
Aimee L Lucas, Adam Tarlecki, Kellie Van Beck, Casey Lipton, Arindam RoyChoudhury, Elana Levinson, Sheila Kumar, Wendy K Chung, Harold Frucht, Jeanine M Genkinger
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer death; approximately 5-10% of PDAC is hereditary. Self-administered health history questionnaires (HHQs) may provide a low-cost method to detail family history (FH) of malignancy. Pancreas Center patients were asked to enroll in a registry; 149 with PDAC completed a HHQ which included FH data. Patients with FH of PDAC, or concern for inherited PDAC syndrome, were separately evaluated in a Prevention Program and additionally met with a genetic counselor (GC) to assess PDAC risk (n = 61)...
December 30, 2016: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28030379/genotype-guided-diagnosis-in-familial-hypercholesterolemia-population-burden-and-cascade-screening
#14
Paul N Hopkins
PURPOSE OF REVIEW: In this review, how genetic testing has provided major new insights regarding the population burden of familial hypercholesterolemia (FH) are reviewed. In addition, the role of genetic testing in cascade screening for FH and an updated Make Early Diagnoses to Prevent Early Death in MEDical PEDigrees algorithm for the clinical diagnosis of FH are presented. RECENT FINDINGS: For the first time, recent application of genetic testing for FH in large populations has provided firm estimates of the prevalence of FH (at least one in 220) in the USA...
December 24, 2016: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28028493/mutation-detection-in-chinese-patients-with-familial-hypercholesterolemia
#15
Ran Du, Liang-Liang Fan, Min-Jie Lin, Zhi-Jian He, Hao Huang, Ya-Qin Chen, Jing-Jing Li, Kun Xia, Shui-Ping Zhao, Rong Xiang
BACKGROUND: Familial hypercholesterolemia (FH) is the first molecularly and clinically characterized genetic disease of lipid metabolism. It is an autosomal dominant disorder with significantly elevated levels of total cholesterol and low density of lipoprotein cholesterol in serum, which would lead to extensive xanthomas and premature coronary heart disease. Mutations in low density lipoprotein receptor (LDLR), proprotein convertase subtilisin/kexin type 9 and Apo lipoprotein B-100 (APOB) have been identified to be the underlying cause of this disease...
2016: SpringerPlus
https://www.readbyqxmd.com/read/28026727/radiological-changes-after-interspinous-dynamic-stabilisation-for-lateral-stenosis-of-lumbar-spinal-canal-a-parallel-group-randomised-trial
#16
J Mohar, M Cimerman
PURPOSE OF THE STUDY Interspinous dynamic stabilisation devices (IDSDs) are used for stabilisation and indirect decompression of the spinal motion segment in minimally invasive treatment of degenerative conditions of lumbar spine. Good methodological quality studies on biomechanical effects of IDSDs are lacking in scientific literature. The purpose of this study was to evaluate the biomechanical effect of dynamic IDSD implantation on a spinal motion segment. MATERIAL AND METHODS We conducted a parallel group randomised trial (RT) on twelve patients, comparing radiological stabilisation and indirect decompression outcome measures between groups of patients with an isolated degenerative condition of L4-L5 motion segment and unilateral L5 nerve root radiculopathy...
2016: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28024183/altered-leukocyte-distribution-under-hypercholesterolemia-a-cross-sectional-study-in-children-with-familial-hypercholesterolemia
#17
Jacob J Christensen, Liv T Osnes, Bente Halvorsen, Kjetil Retterstøl, Martin P Bogsrud, Cecilie Wium, Arne Svilaas, Ingunn Narverud, Stine M Ulven, Pål Aukrust, Kirsten B Holven
BACKGROUND AND AIMS: Children with familial hypercholesterolemia (FH) have elevated LDL cholesterol from the first year of life, and represent a model of early-stage atherosclerosis. Data suggest that adults with FH have alterations in circulating monocyte subpopulations towards a more pro-inflammatory phenotype, but it is not known whether FH children have similar perturbations. In addition, there are no data on the distribution of lymphocyte subpopulations in FH children. The objective of the present study was to characterize the distributions of circulating monocyte and lymphocyte subpopulations in children with FH and healthy, normocholesterolemic children...
December 1, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28017173/femoral-nerve-block-versus-intravenous-fentanyl-in-adult-patients-with-hip-fractures-a-systematic-review
#18
Flávia Vieira Guimarães Hartmann, Maria Rita Carvalho Garbi Novaes, Marta Rodrigues de Carvalho
BACKGROUND: Hip fractures configure an important public health issue and are associated with high mortality taxes and lose of functionality. Hip fractures refer to a fracture occurring between the edge of the femoral head and 5cm below the lesser trochanter. They are common in orthopedic emergencies. The number of proximal femoral fractures is likely to increase as the population ages. The average cost of care during the initial hospitalization for hip fracture can be estimated about US$ 7,000 per patient...
January 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/28012444/carotid-artery-plaques-and-intima-medial-thickness-in-familial-hypercholesteraemic-patients-on-long-term-statin-therapy-a-case-control-study
#19
Sven Bos, Martijne H C Duvekot, Gert-Jan R Ten Kate, Adrie J M Verhoeven, Monique T Mulder, Arend F L Schinkel, Koen Nieman, Gerald F Watts, Eric J G Sijbrands, Jeanine E Roeters van Lennep
BACKGROUND AND AIMS: Statins reduce subclinical atherosclerosis and premature atherosclerotic cardiovascular disease (ASCVD) in patients with familial hypercholesterolemia (FH). However, some FH patients still develop ASCVD despite statin therapy. We compared subclinical atherosclerosis assessed by carotid plaque presence and intima media thickness (C-IMT), in long-term statin-treated FH patients and healthy controls. Furthermore, we analysed whether carotid ultrasonography findings associated with subclinical coronary atherosclerosis...
December 2, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28011410/rates-of-oxygen-uptake-increase-independently-of-changes-in-heart-rate-in-late-stages-of-development-and-at-hatching-in-the-green-iguana-iguana-iguana
#20
Marina R Sartori, Augusto S Abe, Dane A Crossley, Edwin W Taylor
Oxygen consumption (VO2), heart rate (fH), heart mass (Mh) and body mass (Mb) were measured during embryonic incubation and in hatchlings of green iguana (Iguana iguana). Mean fH and VO2 were unvarying in early stage embryos. VO2 increased exponentially during the later stages of embryonic development, doubling by the end of incubation, while fH was constant, resulting in a 2.7-fold increase in oxygen pulse. Compared to late stage embryos, the mean inactive level of VO2 in hatchlings was 1.7 fold higher, while fH was reduced by half resulting in a further 3...
December 21, 2016: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
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