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https://www.readbyqxmd.com/read/28088225/using-low-cost-drones-to-map-malaria-vector-habitats
#1
Andy Hardy, Makame Makame, Dónall Cross, Silas Majambere, Mwinyi Msellem
BACKGROUND: There is a growing awareness that if we are to achieve the ambitious goal of malaria elimination, we must compliment indoor-based vector control interventions (such as bednets and indoor spraying) with outdoor-based interventions such as larval source management (LSM). The effectiveness of LSM is limited by our capacity to identify and map mosquito aquatic habitats. This study provides a proof of concept for the use of a low-cost (< $1000) drone (DJI Phantom) for mapping water bodies in seven sites across Zanzibar including natural water bodies, irrigated and non-irrigated rice paddies, peri-urban and urban locations...
January 14, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28066616/techniques-of-endoscopic-airway-tumor-treatment
#2
REVIEW
Nicolas Guibert, Laurent Mhanna, Sylvain Droneau, Gavin Plat, Alain Didier, Julien Mazieres, Christophe Hermant
Interventional bronchoscopy has a predominant role in the management of both early and advanced-stage airway tumors. Given the very poor prognosis of lung cancer, there is a need for new tools to improve early detection and bronchoscopic treatment of endo-bronchial precancerous lesions. In more advanced stages, interventional bronchoscopy plays an important role, as nearly a third of lung cancers lead to proximal airway obstruction. This will cause great discomfort or even life-threatening symptoms related to local extension, such as dyspnea, post-obstructive pneumonia, and hemoptysis...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28053220/application-of-static-modeling-in-the-prediction-of-in-vivo-drug-drug-interactions-between-rivaroxaban-and-anti-arrhythmic-agents-based-on-in-vitro-inhibition-studies
#3
Eleanor Jing Yi Cheong, Janice Jia Ni Goh, Yanjun Hong, Gopalakrishnan Venkatesan, Yuanjie Liu, Gigi Ngar Chee Chiu, Pipin Kojodjojo, Eric Chun Yong Chan
Rivaroxaban, a direct Factor Xa inhibitor, is indicated for stroke prevention in non-valvular atrial fibrillation (AF). Studies have revealed that the clearance of rivaroxaban is largely attributed to CYP3A4, CYP2J2 metabolism and P-gp efflux pathways. Amiodarone and dronedarone are anti-arrhythmic agents employed in AF management. Amiodarone, dronedarone and their major metabolites, N-desethylamiodarone (NDEA) and N-desbutyldronedarone (NDBD) demonstrate inhibitory effects on CYP3A4 and CYP2J2 with FDA recommended probe substrates...
January 4, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28044249/evaluation-of-facebook-and-twitter-monitoring-to-detect-safety-signals-for-medical-products-an-analysis-of-recent-fda-safety-alerts
#4
Carrie E Pierce, Khaled Bouri, Carol Pamer, Scott Proestel, Harold W Rodriguez, Hoa Van Le, Clark C Freifeld, John S Brownstein, Mark Walderhaug, I Ralph Edwards, Nabarun Dasgupta
INTRODUCTION: The rapid expansion of the Internet and computing power in recent years has opened up the possibility of using social media for pharmacovigilance. While this general concept has been proposed by many, central questions remain as to whether social media can provide earlier warnings for rare and serious events than traditional signal detection from spontaneous report data. OBJECTIVE: Our objective was to examine whether specific product-adverse event pairs were reported via social media before being reported to the US FDA Adverse Event Reporting System (FAERS)...
January 2, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27993369/marine-litter-abundance-and-distribution-on-beaches-on-the-isle-of-r%C3%A3-gen-considering-the-influence-of-exposition-morphology-and-recreational-activities
#5
Elena Hengstmann, Dennis Gräwe, Matthias Tamminga, Elke Kerstin Fischer
The abundance, weight and composition of marine debris were determined at the northwest coast of the Isle of Rügen in 2015. A total number of 1115 macrolitter items were registered, resulting in an abundance of 304±88.96 items per 100m of beach length and therefore being greater than the abundances found for other beaches at the Baltic Sea. Macrolitter items were predominantly composed of plastic, on average 83%. The four beaches under investigation have different exposition as well as touristic levels. The differing influence of wind and water currents as well as recreational activities on the macrolitter at these beaches was detectable...
December 16, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27992867/dronedarone-modulates-m1-and-m3-muscarinic-receptors-with-subtype-selectivity-functional-selectivity-and-probe-dependence
#6
Gihan M Jayasuriya, Gwendolynne Elmslie, Ethan S Burstein, John Ellis
We have previously reported that amiodarone interacts with a novel allosteric site on muscarinic receptors. Amiodarone's most striking effect is to enhance the maximal response elicited by muscarinic agonists at the M1, M3, and M5 receptors. Furthermore, the quaternary analog N-ethylamiodarone (NEA) is inhibitory at these receptors and appears to compete with amiodarone at that allosteric site. In the present studies, we show that dronedarone also modulates Gq-mediated responses at M1 and M3, although in a more discriminating manner...
December 20, 2016: Pharmacology
https://www.readbyqxmd.com/read/27895050/social-signals-and-aversive-learning-in-honey-bee-drones-and-workers
#7
Arian Avalos, Eddie Pérez, Lianna Vallejo, María E Pérez, Charles I Abramson, Tugrul Giray
The dissemination of information is a basic element of group cohesion. In honey bees (Apis mellifera Linnaeus 1758), like in other social insects, the principal method for colony-wide information exchange is communication via pheromones. This medium of communication allows multiple individuals to conduct tasks critical to colony survival. Social signaling also establishes conflict at the level of the individual who must trade-off between attending to the immediate environment or the social demand. In this study we examined this conflict by challenging highly social worker honey bees, and less social male drone honey bees undergoing aversive training by presenting them with a social stress signal (isopentyl acetate, IPA)...
January 15, 2017: Biology Open
https://www.readbyqxmd.com/read/27894553/drones-rule
#8
John R Clark
No abstract text is available yet for this article.
November 2016: Air Medical Journal
https://www.readbyqxmd.com/read/27863364/interactions-of-digitalis-and-class-iii-antiarrhythmic-drugs-amiodarone-versus-dronedarone
#9
Gerrit Frommeyer, Dirk Puckhaber, Christian Ellermann, Dirk G Dechering, Simon Kochhäuser, Patrick Leitz, Florian Reinke, Lars Eckardt
BACKGROUND: A post hoc analysis of the PALLAS trial suggested possible interactions of dronedarone and digitalis glycosides. The aim of the present study was to compare the effects dronedarone or amiodarone in combination with digitalis glycosides. METHODS AND RESULTS: Eleven female rabbits underwent chronic oral treatment with amiodarone (50mg/kg/d for 6weeks). Ten rabbits were treated with dronedarone (50mg/kg/d for 6weeks). Ten rabbits were used as controls. Hearts were isolated and Langendorff-perfused...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27861967/drone-transportation-of-blood-products
#10
Timothy Amukele, Paul M Ness, Aaron A R Tobian, Joan Boyd, Jeff Street
BACKGROUND: Small civilian unmanned aerial vehicles (drones) are a novel way to transport small goods. To the best of our knowledge there are no studies examining the impact of drone transport on blood products, describing approaches to maintaining temperature control, or component physical characteristics during drone transport. STUDY DESIGN AND METHODS: Six leukoreduced red blood cell (RBC) and six apheresis platelet (PLT) units were split using sterile techniques...
November 11, 2016: Transfusion
https://www.readbyqxmd.com/read/27852762/transcriptomic-analysis-of-instinctive-and-learned-reward-related-behaviors-in-honey-bees
#11
Nicholas L Naeger, Gene E Robinson
We used transcriptomics to compare instinctive and learned, reward-based honey bee behaviors with similar spatio-temporal components: mating flights by males (drones) and time-trained foraging flights by females (workers), respectively. Genome-wide gene expression profiling via RNA sequencing was performed on the mushroom bodies, a region of the brain known for multi-modal sensory integration and responsive to various types of reward. Differentially expressed genes (DEGs) associated with the onset of mating (623 genes) were enriched for the gene ontology (GO) categories of Transcription, Unfolded Protein Binding, Post-embryonic Development, and Neuron Differentiation...
November 15, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27834367/wearable-energy-smart-ribbons-for-synchronous-energy-harvest-and-storage
#12
Chao Li, Md Monirul Islam, Julian Moore, Joseph Sleppy, Caleb Morrison, Konstantin Konstantinov, Shi Xue Dou, Chait Renduchintala, Jayan Thomas
A promising energy source for many current and future applications is a ribbon-like device that could simultaneously harvest and store energy. Due to the high flexibility and weavable property, a fabric/matrix made using these ribbons could be highly beneficial for powering wearable electronics. Unlike the approach of using two separate devices, here we report a ribbon that integrates a solar cell and a supercapacitor. The electrons generated by the solar cell are directly transferred and stored on the reverse side of its electrode which in turn also functions as an electrode for the supercapacitor...
November 11, 2016: Nature Communications
https://www.readbyqxmd.com/read/27807272/shunt-peaking-in-neural-membranes
#13
Francisco J H Heras, Simon B Laughlin, Jeremy E Niven
Capacitance limits the bandwidth of engineered and biological electrical circuits because it determines the gain-bandwidth product (GBWP). With a fixed GBWP, bandwidth can only be improved by decreasing gain. In engineered circuits, an inductance reduces this limitation through shunt peaking but no equivalent mechanism has been reported for biological circuits. We show that in blowfly photoreceptors a voltage-dependent K(+) conductance, the fast delayed rectifier (FDR), produces shunt peaking thereby increasing bandwidth without reducing gain...
November 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27782058/from-wsn-towards-wot-open-api-scheme-based-on-onem2m-platforms
#14
Jaeho Kim, Sung-Chan Choi, Il-Yeup Ahn, Nak-Myoung Sung, Jaeseok Yun
Conventional computing systems have been able to be integrated into daily objects and connected to each other due to advances in computing and network technologies, such as wireless sensor networks (WSNs), forming a global network infrastructure, called the Internet of Things (IoT). To support the interconnection and interoperability between heterogeneous IoT systems, the availability of standardized, open application programming interfaces (APIs) is one of the key features of common software platforms for IoT devices, gateways, and servers...
October 6, 2016: Sensors
https://www.readbyqxmd.com/read/27760589/bioanalytical-method-validation-for-dronedarone-and-duloxetine-in-blood-serum
#15
Alka Bali, Renu Chadha, Gulshan Bansal
The present work relates to the development and validation of reversed-phase HPLC-UV-photodiode array methods for the estimation of two drugs in blood serum: dronedarone hydrochloride (DDN), a class III antiarrhythmic drug, and duloxetine hydrochloride (DLX), an antidepressant. Chromatographic analysis of DLX was carried out on a Nucleodur C18 column (250 × 4.6 mm, 5 μm) using ammonium acetate buffer (32 mM, pH 5.5) and acetonitrile (40 + 60, v/v; flow rate of 1.0 mL/min; detection wavelength of 290 nm) as the mobile phase...
October 18, 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/27758968/the-novel-use-of-ranolazine-as-an-antiarrhythmic-agent-in-atrial-fibrillation
#16
REVIEW
C Michael White, Elaine Nguyen
OBJECTIVE: To review the limitations of current antiarrhythmic drugs in atrial fibrillation (AF) and discuss the rationale and clinical trials supporting the use of ranolazine in AF. DATA SOURCES: MEDLINE was searched from 1980 to September 2016 using the terms ranolazine, atrial fibrillation, coronary artery bypass grafting, and valve surgery STUDY SELECTION AND DATA EXTRACTION: English-language studies and reviews assessing antiarrhythmic drugs, including ranolazine, were incorporated...
October 6, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27743422/food-to-some-poison-to-others-honeybee-royal-jelly-and-its-growth-inhibiting-effect-on-european-foulbrood-bacteria
#17
Thomas V Vezeteu, Otilia Bobiş, Robin F A Moritz, Anja Buttstedt
Honeybee colonies (Apis mellifera) serve as attractive hosts for a variety of pathogens providing optimal temperatures, humidity, and an abundance of food. Thus, honeybees have to deal with pathogens throughout their lives and, even as larvae they are affected by severe brood diseases like the European Foulbrood caused by Melissococcus plutonius. Accordingly, it is highly adaptive that larval food jelly contains antibiotic compounds. However, although food jelly is primarily consumed by bee larvae, studies investigating the antibiotic effects of this jelly have largely concentrated on bacterial human diseases...
October 14, 2016: MicrobiologyOpen
https://www.readbyqxmd.com/read/27729058/unmanned-aerial-vehicles-drones-in-out-of-hospital-cardiac-arrest
#18
A Claesson, D Fredman, L Svensson, M Ringh, J Hollenberg, P Nordberg, M Rosenqvist, T Djarv, S Österberg, J Lennartsson, Y Ban
BACKGROUND: The use of an automated external defibrillator (AED) prior to EMS arrival can increase 30-day survival in out-of-hospital cardiac arrest (OHCA) significantly. Drones or unmanned aerial vehicles (UAV) can fly with high velocity and potentially transport devices such as AEDs to the site of OHCAs. The aim of this explorative study was to investigate the feasibility of a drone system in decreasing response time and delivering an AED. METHODS: Data of Global Positioning System (GPS) coordinates from historical OHCA in Stockholm County was used in a model using a Geographic Information System (GIS) to find suitable placements and visualize response times for the use of an AED equipped drone...
October 12, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27719634/outcomes-with-dronedarone-in-atrial-fibrillation-what-differences-between-real-world-practice-and-trials-a-meta-analysis-and-meta-regression-analysis
#19
Igor Diemberger, Giulia Massaro, Maria Letizia Bacchi Reggiani, Stefano Lorenzetti, Mauro Biffi, Matteo Ziacchi, Cristian Martignani, Giuseppe Boriani
Dronedarone was found to have divergent safety profiles in randomized controlled trials (RCT) in term of cardiac death and overall mortality. We decided to evaluate all available evidence on the cardiovascular safety of this drug. A systematic search was made of the MEDLINE and the Cochrane Central Register of Controlled Trials from January 2003 through April 2016 for RCT comparing dronedarone to placebo/active control, to provide the most accurate estimate of the effects of this agent and observational cohort studies (OBS) reporting clinical outcomes in patients treated with dronedarone, according to current guidelines, to obtain a real-life comparator for the findings summarized by RTC analysis...
October 6, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27693025/concomitant-rivaroxaban-and-dronedarone-administration-in-patients-with-nonvalvular-atrial-fibrillation
#20
Carlos Escobar, Martín Arceluz, Rosa Montes de Oca, Ricardo Mori, José Luis López-Sendón, José Luis Merino
No abstract text is available yet for this article.
September 28, 2016: Revista Española de Cardiología
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