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https://www.readbyqxmd.com/read/29161309/dronedarone-produces-early-regression-of-myocardial-remodelling-in-structural-heart-disease
#1
Begoña Quintana-Villamandos, Jose Juan Gomez de Diego, María Jesús Delgado-Martos, David Muñoz-Valverde, María Luisa Soto-Montenegro, Manuel Desco, Emilio Delgado-Baeza
BACKGROUND AND AIMS: Left ventricular hypertrophy (LVH) in hypertension is associated with a greater risk of sustained supraventricular/atrial arrhythmias. Dronedarone is an antiarrhythmic agent that was recently approved for the treatment of atrial fibrillation. However, its effect on early regression of LVH has not been reported. We tested the hypothesis that short-term administration of dronedarone induces early regression of LVH in spontaneously hypertensive rats (SHRs). METHODS: Ten-month-old male SHRs were randomly assigned to an intervention group (SHR-D), where animals received dronedarone treatment (100 mg/kg) for a period of 14 days, or to a control group (SHR) where rats were given vehicle...
2017: PloS One
https://www.readbyqxmd.com/read/29156597/different-ways-to-apply-a-measurement-instrument-of-e-nose-type-to-evaluate-ambient-air-quality-with-respect-to-odour-nuisance-in-a-vicinity-of-municipal-processing-plants
#2
REVIEW
Bartosz Szulczyński, Tomasz Wasilewski, Wojciech Wojnowski, Tomasz Majchrzak, Tomasz Dymerski, Jacek Namieśnik, Jacek Gębicki
This review paper presents different ways to apply a measurement instrument of e-nose type to evaluate ambient air with respect to detection of the odorants characterized by unpleasant odour in a vicinity of municipal processing plants. An emphasis was put on the following applications of the electronic nose instruments: monitoring networks, remote controlled robots and drones as well as portable devices. Moreover, this paper presents commercially available sensors utilized in the electronic noses and characterized by the limit of quantification below 1 ppm v/v, which is close to the odour threshold of some odorants...
November 19, 2017: Sensors
https://www.readbyqxmd.com/read/29152904/creating-time-social-collaboration-in-music-improvisation
#3
Ashley E Walton, Auriel Washburn, Peter Langland-Hassan, Anthony Chemero, Heidi Kloos, Michael J Richardson
Musical collaboration emerges from the complex interaction of environmental and informational constraints, including those of the instruments and the performance context. Music improvisation in particular is more like everyday interaction in that dynamics emerge spontaneously without a rehearsed score or script. We examined how the structure of the musical context affords and shapes interactions between improvising musicians. Six pairs of professional piano players improvised with two different backing tracks while we recorded both the music produced and the movements of their heads, left arms, and right arms...
November 20, 2017: Topics in Cognitive Science
https://www.readbyqxmd.com/read/29152432/acute-changes-in-mentation-in-a-patient-with-hepatic-cirrhosis-treated-with-high-doses-of-dexamethasone
#4
Luis Dabul, Andrew Droney, Juan Oms, Marcos A Sanchez-Gonzalez
Despite the anti-inflammatory benefits of steroids in the management of multiple medical conditions, they are associated with undesired metabolic and psychiatric side effects. We present a case of a 57-year-old Hispanic man with hepatic cirrhosis due to hepatitis C and no past medical history of psychiatric illnesses who became delirious after treatment with high doses of intravenous Dexamethasone. The patient presented to Larkin Community Hospital, USA with complaints of lower back pain requiring treatment with steroids for severe lumbar central canal stenosis...
September 10, 2017: Curēus
https://www.readbyqxmd.com/read/29139031/in-vivo-analysis-of-the-anti-atrial-fibrillatory-proarrhythmic-and-cardiodepressive-profiles-of-dronedarone-as-a-guide-for-safety-pharmacological-evaluation-of-antiarrhythmic-drugs
#5
Yoshiyuki Motokawa, Yuji Nakamura, Mihoko Hagiwara-Nagasawa, Ai Goto, Koki Chiba, Nur Jaharat Lubna, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsuhiko T Naito, Hiroshi Yamazaki, Atsushi Sugiyama
Anti-atrial fibrillatory, proarrhythmic and cardiodepressive profiles of dronedarone were analyzed using the halothane-anesthetized beagle dogs (n = 4) to create a standard protocol for clarifying both efficacy and adverse effects of anti-atrial fibrillatory drugs. Intravenous administration of dronedarone hydrochloride in doses of 0.3 and 3 mg/kg over 30 s attained the peak plasma concentrations of 61 and 1248 ng/mL, respectively, reflecting sub- to supra-therapeutic ones. The low dose decreased the left ventricular contraction and mean blood pressure, which were enhanced at the high dose...
November 14, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29113104/super-resolution-of-plant-disease-images-for-the-acceleration-of-image-based-phenotyping-and-vigor-diagnosis-in-agriculture
#6
Kyosuke Yamamoto, Takashi Togami, Norio Yamaguchi
Unmanned aerial vehicles (UAVs or drones) are a very promising branch of technology, and they have been utilized in agriculture-in cooperation with image processing technologies-for phenotyping and vigor diagnosis. One of the problems in the utilization of UAVs for agricultural purposes is the limitation in flight time. It is necessary to fly at a high altitude to capture the maximum number of plants in the limited time available, but this reduces the spatial resolution of the captured images. In this study, we applied a super-resolution method to the low-resolution images of tomato diseases to recover detailed appearances, such as lesions on plant organs...
November 6, 2017: Sensors
https://www.readbyqxmd.com/read/29110379/a-comparison-of-honeybee-apis-mellifera-queen-worker-and-drone-larvae-by-rna-seq
#7
Xu-Jiang He, Wu-Jun Jiang, Mi Zhou, Andrew B Barron, Zhi-Jiang Zeng
Honeybees (Apis mellifera) have haplodiploid sex determination: males develop from unfertilized eggs and females develop from fertilized ones. The differences in larval food also determine the development of females. Here we compared the total somatic gene expression profiles of 2-day and 4-day-old drone, queen and worker larvae by RNA-Seq. The results from a co-expression network analysis on all expressed genes showed that 2-day-old drone and worker larvae were closer in gene expression profiles than 2-day-old queen larvae...
November 6, 2017: Insect Science
https://www.readbyqxmd.com/read/29101908/using-drone-mounted-cameras-for-on-site-body-documentation-3d-mapping-and-active-survey
#8
Petra Urbanová, Mikoláš Jurda, Tomáš Vojtíšek, Jan Krajsa
Recent advances in unmanned aerial technology have substantially lowered the cost associated with aerial imagery. As a result, forensic practitioners are today presented with easy low-cost access to aerial photographs at remote locations. The present paper aims to explore boundaries in which the low-end drone technology can operate as professional crime scene equipment, and to test the prospects of aerial 3D modeling in the forensic context. The study was based on recent forensic cases of falls from height admitted for postmortem examinations...
October 26, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29099087/multipass-target-search-in-natural-environments
#9
Michael J Kuhlman, Michael W Otte, Donald Sofge, Satyandra K Gupta
Consider a disaster scenario where search and rescue workers must search difficult to access buildings during an earthquake or flood. Often, finding survivors a few hours sooner results in a dramatic increase in saved lives, suggesting the use of drones for expedient rescue operations. Entropy can be used to quantify the generation and resolution of uncertainty. When searching for targets, maximizing mutual information of future sensor observations will minimize expected target location uncertainty by minimizing the entropy of the future estimate...
November 2, 2017: Sensors
https://www.readbyqxmd.com/read/29090579/polyhwg-3d-printed-substrate-integrated-hollow-waveguides-for-mid-infrared-gas-sensing
#10
Robert Stach, Julian Haas, Erhan Tütüncü, Sven Daboss, Christine Kranz, Boris Mizaikoff
Gas analysis via mid-infrared (MIR) spectroscopic techniques has gained significance due to its inherent molecular selectivity and sensitivity probing pronounced vibrational, rotational, and roto-vibrational modes. In addition, MIR gas sensors are suitable for real-time monitoring in a wide variety of sensing scenarios. Our research team has recently introduced so-called substrate-integrated hollow waveguides (iHWGs) fabricated by precision milling, which have been demonstrated to be useful in online process monitoring, environmental sensing, and exhaled breath analysis especially if low sample volumes (i...
November 13, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29081605/robot-wars-us-empire-and-geopolitics-in-the-robotic-age
#11
Ian Gr Shaw
How will the robot age transform warfare? What geopolitical futures are being imagined by the US military? This article constructs a robotic futurology to examine these crucial questions. Its central concern is how robots - driven by leaps in artificial intelligence and swarming - are rewiring the spaces and logics of US empire, warfare, and geopolitics. The article begins by building a more-than-human geopolitics to de-center the role of humans in conflict and foreground a worldly understanding of robots. The article then analyzes the idea of US empire, before speculating upon how and why robots are materializing new forms of proxy war...
October 2017: Secur Dialogue
https://www.readbyqxmd.com/read/29078072/development-of-a-lane-change-risk-index-using-vehicle-trajectory-data
#12
Hyunjin Park, Cheol Oh, Jaepil Moon, Seongho Kim
Surrogate safety measures (SSMs) have been widely used to evaluate crash potential, which is fundamental for the development of effective safety countermeasures. Unlike existing SSMs, which are mainly focused on the evaluation of longitudinal vehicle maneuvering leading to rear-end crashes, this study proposes a new method for estimating crash risk while a subject vehicle changes lanes, referred to as the lane change risk index (LCRI). A novel feature of the proposed methodology is its incorporation of the amount of exposure time to potential crash and the expected crash severity level by applying a fault tree analysis (FTA) to the evaluation framework...
October 24, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29059234/neonicotinoid-pesticides-can-reduce-honeybee-colony-genetic-diversity
#13
Nadège Forfert, Aline Troxler, Gina Retschnig, Laurent Gauthier, Lars Straub, Robin F A Moritz, Peter Neumann, Geoffrey R Williams
Neonicotinoid insecticides can cause a variety of adverse sub-lethal effects in bees. In social species such as the honeybee, Apis mellifera, queens are essential for reproduction and colony functioning. Therefore, any negative effect of these agricultural chemicals on the mating success of queens may have serious consequences for the fitness of the entire colony. Queens were exposed to the common neonicotinoid pesticides thiamethoxam and clothianidin during their developmental stage. After mating, their spermathecae were dissected to count the number of stored spermatozoa...
2017: PloS One
https://www.readbyqxmd.com/read/29051969/-use-of-unmanned-drones-to-deliver-an-automated-external-defibrillator-for-out-of-hospital-cardiac-arrest
#14
K Fink, B Schmid, H-J Busch
No abstract text is available yet for this article.
October 19, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29051619/person-identification-from-aerial-footage-by-a-remote-controlled-drone
#15
Markus Bindemann, Matthew C Fysh, Sophie S K Sage, Kristina Douglas, Hannah M Tummon
Remote-controlled aerial drones (or unmanned aerial vehicles; UAVs) are employed for surveillance by the military and police, which suggests that drone-captured footage might provide sufficient information for person identification. This study demonstrates that person identification from drone-captured images is poor when targets are unfamiliar (Experiment 1), when targets are familiar and the number of possible identities is restricted by context (Experiment 2), and when moving footage is employed (Experiment 3)...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29035869/varroa-destructor-induces-changes-in-the-expression-of-immunity-related-genes-during-the-development-of-apis-mellifera-worker-and-drone-broods
#16
Ewa A Zaobidna, Krystyna Żółtowska, Elżbieta Łopieńska-Biernat
The ectoparasitic mite Varroa destructor has emerged as the major pest of honeybees. Despite extensive research efforts, the pathogenesis of varroosis has not been fully explained. Earlier studies suggested that V. destructor infestation leads to the suppression of the host's immune system. The aim of this study was to analyze the immune responses of 14 genes in the Toll signal transduction pathways, including effector genes of antimicrobial peptides (AMPs), in developing Apis mellifera workers and drones infested with V...
December 20, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/29034331/extensive-core-microbiome-in-drone-captured-whale-blow-supports-a-framework-for-health-monitoring
#17
Amy Apprill, Carolyn A Miller, Michael J Moore, John W Durban, Holly Fearnbach, Lance G Barrett-Lennard
The pulmonary system is a common site for bacterial infections in cetaceans, but very little is known about their respiratory microbiome. We used a small, unmanned hexacopter to collect exhaled breath condensate (blow) from two geographically distinct populations of apparently healthy humpback whales (Megaptera novaeangliae), sampled in the Massachusetts coastal waters off Cape Cod (n = 17) and coastal waters around Vancouver Island (n = 9). Bacterial and archaeal small-subunit rRNA genes were amplified and sequenced from blow samples, including many of sparse volume, as well as seawater and other controls, to characterize the associated microbial community...
September 2017: MSystems
https://www.readbyqxmd.com/read/29021803/uav-based-thermal-imaging-for-high-throughput-field-phenotyping-of-black-poplar-response-to-drought
#18
Riccardo Ludovisi, Flavia Tauro, Riccardo Salvati, Sacha Khoury, Giuseppe Mugnozza Scarascia, Antoine Harfouche
Poplars are fast-growing, high-yielding forest tree species, whose cultivation as second-generation biofuel crops is of increasing interest and can efficiently meet emission reduction goals. Yet, breeding elite poplar trees for drought resistance remains a major challenge. Worldwide breeding programs are largely focused on intra/interspecific hybridization, whereby Populus nigra L. is a fundamental parental pool. While high-throughput genotyping has resulted in unprecedented capabilities to rapidly decode complex genetic architecture of plant stress resistance, linking genomics to phenomics is hindered by technically challenging phenotyping...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29016811/drone-transport-of-chemistry-and-hematology-samples-over-long-distances
#19
Timothy K Amukele, James Hernandez, Christine L H Snozek, Ryan G Wyatt, Matthew Douglas, Richard Amini, Jeff Street
Objectives: We addressed the stability of biological samples in prolonged drone flights by obtaining paired chemistry and hematology samples from 21 adult volunteers in a single phlebotomy event-84 samples total. Methods: Half of the samples were held stationary, while the other samples were flown for 3 hours (258 km) in a custom active cooling box mounted on the drone. After the flight, 19 chemistry and hematology tests were performed. Results: Seventeen analytes had small or no bias, but glucose and potassium in flown samples showed an 8% and 6...
November 2, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28992468/dronedarone-exerts-anticoagulant-and-antiplatelet-effects-independently-of-its-antiarrhythmic-actions
#20
M Urooj Zafar, Carlos G Santos-Gallego, Donald A Smith, Jonathan L Halperin, Juan J Badimon
BACKGROUND AND AIMS: Dronedarone reduced the rate of stroke and transient ischemic attack in patients with paroxysmal atrial fibrillation (AF) in the ATHENA trial. This cannot be explained by its antiarrhythmic effect alone and may involve alternative mechanisms. This study aimed to investigate any direct effect of dronedarone on blood thrombogenicity, independent of its antiarrhythmic effects. METHODS: Blood samples from patients with cardiovascular disease (n = 30) taking no anticoagulant or antiplatelet medication except aspirin were incubated with dronedarone's active metabolite (SR35021A) at 66 ng/ml (am-L) and 119 ng/ml (am-H), i...
November 2017: Atherosclerosis
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