keyword
MENU ▼
Read by QxMD icon Read
search

Microvascular disease of the brain

keyword
https://www.readbyqxmd.com/read/27883015/mr-vascular-fingerprinting-in-stroke-and-brain-tumors-models
#1
B Lemasson, N Pannetier, N Coquery, Ligia S B Boisserand, Nora Collomb, N Schuff, M Moseley, G Zaharchuk, E L Barbier, T Christen
In this study, we evaluated an MRI fingerprinting approach (MRvF) designed to provide high-resolution parametric maps of the microvascular architecture (i.e., blood volume fraction, vessel diameter) and function (blood oxygenation) simultaneously. The method was tested in rats (n = 115), divided in 3 models: brain tumors (9 L, C6, F98), permanent stroke, and a control group of healthy animals. We showed that fingerprinting can robustly distinguish between healthy and pathological brain tissues with different behaviors in tumor and stroke models...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27869115/cerebral-vascular-amyloid-seeds-drive-amyloid-%C3%AE-protein-fibril-assembly-with-a-distinct-anti-parallel-structure
#2
Feng Xu, Ziao Fu, Sharmila Dass, AnnMarie E Kotarba, Judianne Davis, Steven O Smith, William E Van Nostrand
Cerebrovascular accumulation of amyloid β-protein (Aβ), a condition known as cerebral amyloid angiopathy (CAA), is a common pathological feature of patients with Alzheimer's disease. Familial Aβ mutations, such as Dutch-E22Q and Iowa-D23N, can cause severe cerebrovascular accumulation of amyloid that serves as a potent driver of vascular cognitive impairment and dementia. The distinctive features of vascular amyloid that underlie its unique pathological properties remain unknown. Here, we use transgenic mouse models producing CAA mutants (Tg-SwDI) or overproducing human wild-type Aβ (Tg2576) to demonstrate that CAA-mutant vascular amyloid influences wild-type Aβ deposition in brain...
November 21, 2016: Nature Communications
https://www.readbyqxmd.com/read/27863376/cxcr4-increases-in-vivo-glioma-perivascular-invasion-and-reduces-radiation-induced-apoptosis-a-genetic-knockdown-study
#3
Viveka Nand Yadav, Daniel Zamler, Gregory J Baker, Padma Kadiyala, Anat Erdreich-Epstein, Ana C DeCarvalho, Tom Mikkelsen, Maria G Castro, Pedro R Lowenstein
Glioblastoma (GBM) is a highly invasive brain tumor. Perivascular invasion, autovascularization and vascular co-option occur throughout the disease and lead to tumor invasion and progression. The molecular basis for perivascular invasion, i.e., the interaction of glioma tumor cells with endothelial cells is not well characterized. Recent studies indicate that glioma cells have increased expression of CXCR4. We investigated the in-vivo role of CXCR4 in perivascular invasion of glioma cells using shRNA-mediated knock down of CXCR4...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27856004/microbleeds-and-cavernomas-after-radiotherapy-for-paediatric-primary-brain-tumours
#4
João Passos, Hipólito Nzwalo, Mariana Valente, Joana Marques, Ana Azevedo, Eduardo Netto, António Mota, Alexandra Borges, Sofia Nunes, Duarte Salgado
BACKGROUND: With the expected growth and aging of the population of primary central nervous system tumours (PCNST) survivors, attention to the radiation-induced late brain injury is fundamental. Late focal hemosiderin deposition (FHD) lesions, namely microbleeds and cavernomas, are among the presumable late cerebrovascular complications associated with radiotherapy for PCNST. OBJECTIVE: To explore association between PCNST radiotherapy and the occurrence FHD lesions and to address the correlation between the topographic location of these microvascular lesions with the focal radiotherapy location...
November 11, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27846787/cryopreservation-of-brain-endothelial-cells-derived-from-human-induced-pluripotent-stem-cells-is-enhanced-by-rock-inhibition
#5
Hannah Kathryn Wilson, Madeline G Faubion, Michael K Hjortness, Sean P Palecek, Eric V Shusta
The blood-brain barrier (BBB) maintains brain homeostasis but also presents a major obstacle to brain drug delivery. Brain microvascular endothelial cells (BMECs) form the principal barrier and therefore represent the major cellular component of in vitro BBB models. Such models are often used for mechanistic studies of the BBB in health and disease and for drug screening. Recently, human induced pluripotent stem cells (iPSCs) have emerged as a new source for generating BMEC-like cells for use in in vitro human BBB studies...
November 15, 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/27845201/impaired-neurovascular-coupling-in-aging-and-alzheimer-s-disease-contribution-of-astrocyte-dysfunction-and-endothelial-impairment-to-cognitive-decline
#6
REVIEW
Stefano Tarantini, Cam Ha T Tran, Grant R Gordon, Zoltan Ungvari, Anna Csiszar
The importance of (micro)vascular contributions to cognitive impairment and dementia (VCID) in aging cannot be overemphasized, and the pathogenesis and prevention of age-related cerebromicrovascular pathologies are a subject of intensive research. In particular, aging impairs the increase in cerebral blood flow triggered by neural activation (termed neurovascular coupling or functional hyperemia), a critical mechanism that matches oxygen and nutrient delivery with the increased demands in active brain regions...
November 11, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27806704/vascular-depression-consensus-report-a-critical-update
#7
EDITORIAL
Howard J Aizenstein, Andrius Baskys, Maura Boldrini, Meryl A Butters, Breno S Diniz, Manoj Kumar Jaiswal, Kurt A Jellinger, Lev S Kruglov, Ivan A Meshandin, Milija D Mijajlovic, Guenter Niklewski, Sarah Pospos, Keerthy Raju, Kneginja Richter, David C Steffens, Warren D Taylor, Oren Tene
BACKGROUND: Vascular depression is regarded as a subtype of late-life depression characterized by a distinct clinical presentation and an association with cerebrovascular damage. Although the term is commonly used in research settings, widely accepted diagnostic criteria are lacking and vascular depression is absent from formal psychiatric manuals such as the Diagnostic and Statistical Manual of Mental Disorders, 5(th) edition - a fact that limits its use in clinical settings. Magnetic resonance imaging (MRI) techniques, showing a variety of cerebrovascular lesions, including extensive white matter hyperintensities, subcortical microvascular lesions, lacunes, and microinfarcts, in patients with late life depression, led to the introduction of the term "MRI-defined vascular depression"...
November 3, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27793855/functional-vascular-contributions-to-cognitive-impairment-and-dementia-vcid-mechanisms-and-consequences-of-cerebral-microvascular-dysfunction-in-aging
#8
Peter Toth, Stefano Tarantini, Anna Csiszar, Zoltan I Ungvari
Increasing evidence from epidemiological, clinical and experimental studies indicate that age-related cerebromicrovascular dysfunction and microcirculatory damage play critical roles in the pathogenesis of many types of dementia in the elderly, including Alzheimer's disease. Understanding and targeting the age-related pathophysiological mechanisms that underlie vascular contributions to cognitive impairment and dementia (VCID) is expected to have a major role in preserving brain health in older individuals...
October 28, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27753846/ed-02-3-clinical-implications-of-central-hemodynamics-on-aortic-and-end-organ-diseases
#9
Junichiro Hashimoto
The central aorta constitutes the main trunk of the systemic arterial tree. It dilates passively with cardiac ejection during systole and then constricts with its recoil function during diastole, thereby regulating blood pressure and blood flow. The central pulsatile hemodynamics affects local hemodynamics within as well as downstream of the aorta (e.g., end organs).The aorta progressively stiffens and dilates with advancing age, and such age-dependent change is accelerated by hypertension. According to the law of Laplace, wall stress depends on the diameter and pressure of the blood vessel...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27752478/aortic-stiffness-cerebrovascular-dysfunction-and-memory
#10
Leroy L Cooper, Gary F Mitchell
BACKGROUND: Aortic stiffness is associated with cardiovascular and cerebrovascular events and cognitive decline. This mini-review focuses on relations of aortic stiffness with microvascular dysfunction and discusses the contribution of abnormal pulsatile hemodynamics to cerebrovascular damage and cognitive decline. We also provide a rationale for considering aortic stiffness as a putative and important contributor to memory impairment in older individuals. SUMMARY: Aging is associated with stiffening of the aorta but not the muscular arteries, which reduces wave reflection and increases the transmission of pulsatility into the periphery...
September 2016: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/27747196/shiga-toxin-mediated-neurologic-changes-in-murine-model-of-disease
#11
Suman Pradhan, Christine Pellino, Kayleigh MacMaster, Dennis Coyle, Alison A Weiss
Seizures and neurologic involvement have been reported in patients infected with Shiga toxin (Stx) producing E. coli, and hemolytic uremic syndrome (HUS) with neurologic involvement is associated with more severe outcome. We investigated the extent of renal and neurologic damage in mice following injection of the highly potent form of Stx, Stx2a, and less potent Stx1. As observed in previous studies, Stx2a brought about moderate to acute tubular necrosis of proximal and distal tubules in the kidneys. Brain sections stained with hematoxylin and eosin (H&E) appeared normal, although some red blood cell congestion was observed...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27734405/analysis-of-ccn-protein-expression-and-activities-in-vasoproliferative-retinopathies
#12
Sangmi Lee, Menna Elaskandrany, Afruja Ahad, Brahim Chaqour
The retina is a complex neurovascular structure that conveys light/visual image through the optic nerve to the visual cortex of the brain. Neuronal and vascular activities in the retina are physically and functionally intertwined, and vascular alterations are consequential to the proper function of the entire visual system. In particular, alteration of the structure and barrier function of the retinal vasculature is commonly associated with the development of vasoproliferative ischemic retinopathy, a set of clinically well-defined chronic ocular microvascular complications causing blindness in all age groups...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27725773/analysis-of-the-brain-mural-cell-transcriptome
#13
Liqun He, Michael Vanlandewijck, Elisabeth Raschperger, Maarja Andaloussi Mäe, Bongnam Jung, Thibaud Lebouvier, Koji Ando, Jennifer Hofmann, Annika Keller, Christer Betsholtz
Pericytes, the mural cells of blood microvessels, regulate microvascular development and function and have been implicated in many brain diseases. However, due to a paucity of defining markers, pericyte identification and functional characterization remain ambiguous and data interpretation problematic. In mice carrying two transgenic reporters, Pdgfrb-eGFP and NG2-DsRed, we found that double-positive cells were vascular mural cells, while the single reporters marked additional, but non-overlapping, neuroglial cells...
October 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27718541/trafficking-of-aav-vectors-across-a-model-of-the-blood-brain-barrier-a-comparative-study-of-transcytosis-and-transduction-using-primary-human-brain-endothelial-cells
#14
Steven F Merkel, Allison M Andrews, Evan M Lutton, Dakai Mu, Eloise Hudry, Bradley T Hyman, Casey A Maguire, Servio H Ramirez
Developing therapies for central nervous system (CNS) diseases is exceedingly difficult due to the blood-brain barrier (BBB). Notably, emerging technologies may provide promising new options for the treatment of CNS disorders. Adeno-associated virus serotype 9 (AAV9) has been shown to transduce cells in the CNS following intravascular administration in rodents, cats, pigs, and non-human primates. These results suggest that AAV9 is capable of crossing the BBB. However, mechanisms that govern AAV9 transendothelial trafficking at the BBB remain unknown...
October 8, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27709330/microvascular-function-in-aging-among-women-living-with-hiv
#15
REVIEW
Jean-Jacques Monsuez, Catherine Belin, Olivier Bouchaud
Combined antiretroviral therapy (CART) has turned HIV-infection to a treatable chronic disease during which many patients survive to middle and older age. However, they prematurely develop non-AIDS comorbidities such as cardiovascular disease, metabolic syndrome, diabetes, and HIV-associated neurocognitive disorders (HAND). Microcirculatory changes and endothelial dysfunction occur early both in HIV-infected and in aging patients, in whom they usually precede cardiovascular and neurocognitive impairments. Also, mild cognitive involvement has been reported in women during the menopausal transition...
December 2016: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/27702879/pulsatility-and-high-shear-stress-deteriorate-barrier-phenotype-in-brain-microvascular-endothelium
#16
Fernando Garcia-Polite, Jordi Martorell, Paula Del Rey-Puech, Pedro Melgar-Lesmes, Caroline C O'Brien, Jaume Roquer, Angel Ois, Alessandro Principe, Elazer R Edelman, Mercedes Balcells
Microvascular endothelial cells at the blood-brain barrier exhibit a protective phenotype, which is highly induced by biochemical and biomechanical stimuli. Amongst them, shear stress enhances junctional tightness and limits transport at capillary-like levels. Abnormal flow patterns can reduce functional features of macrovascular endothelium. We now examine if this is true in brain microvascular endothelial cells. We suggest in this paper a complex response of endothelial cells to aberrant forces under different flow domains...
October 4, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27684568/scanning-electron-microscopy-of-the-adhesion-of-treponema-pallidum-subspecies-pallidum-nichol-strain-to-human-brain-microvascular-endothelial-cells-in-vitro
#17
Fan Wu, Jing-Ping Zhang, Qian-Qiu Wang
Treponema pallidum subspecies pallidum (T. pallidum), the pathogen of syphilis, can invade the central nervous system (CNS) and causes a series of severe diseases collectively termed neurosyphilis (NS).(1) Recently, there are increasing reports of NS cases, especially in HIV-infected syphilis patients.(2,3) Meanwhile, the misdiagnosis rate of NS is high, that of neurosyphilitic ischemic stroke was up to 80.95%.(4) This article is protected by copyright. All rights reserved.
September 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27683553/dysregulation-of-angiopoietin-1-plays-a-mechanistic-role-in-the-pathogenesis-of-cerebral-malaria
#18
Sarah J Higgins, Lisa A Purcell, Karlee L Silver, Vanessa Tran, Valerie Crowley, Michael Hawkes, Andrea L Conroy, Robert O Opoka, John G Hay, Susan E Quaggin, Gavin Thurston, W Conrad Liles, Kevin C Kain
Cerebral malaria is a leading cause of global morbidity and mortality. Interventions targeting the underlying pathophysiology of cerebral malaria may improve outcomes compared to treatment with antimalarials alone. Microvascular leak plays an important role in the pathogenesis of cerebral malaria. The angiopoietin (Ang)-Tie-2 system is a critical regulator of vascular function. We show that Ang-1 expression and soluble Tie-2 expression were associated with disease severity and outcome in a prospective study of Ugandan children with severe malaria and in a preclinical murine model of experimental cerebral malaria...
September 28, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27643439/angiotensin-receptors-and-%C3%AE-catenin-regulate-brain-endothelial-integrity-in-malaria
#19
Julio Gallego-Delgado, Upal Basu-Roy, Maureen Ty, Matilde Alique, Cristina Fernandez-Arias, Alexandru Movila, Pollyanna Gomes, Ada Weinstock, Wenyue Xu, Innocent Edagha, Samuel C Wassmer, Thomas Walther, Marta Ruiz-Ortega, Ana Rodriguez
Cerebral malaria is characterized by cytoadhesion of Plasmodium falciparum-infected red blood cells (Pf-iRBCs) to endothelial cells in the brain, disruption of the blood-brain barrier, and cerebral microhemorrhages. No available antimalarial drugs specifically target the endothelial disruptions underlying this complication, which is responsible for the majority of malaria-associated deaths. Here, we have demonstrated that ruptured Pf-iRBCs induce activation of β-catenin, leading to disruption of inter-endothelial cell junctions in human brain microvascular endothelial cells (HBMECs)...
October 3, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27643006/ed-02-3-clinical-implications-of-central-hemodynamics-on-aortic-and-end-organ-diseases
#20
Junichiro Hashimoto
The central aorta constitutes the main trunk of the systemic arterial tree. It dilates passively with cardiac ejection during systole and then constricts with its recoil function during diastole, thereby regulating blood pressure and blood flow. The central pulsatile hemodynamics affects local hemodynamics within as well as downstream of the aorta (e.g., end organs).The aorta progressively stiffens and dilates with advancing age, and such age-dependent change is accelerated by hypertension. According to the law of Laplace, wall stress depends on the diameter and pressure of the blood vessel...
September 2016: Journal of Hypertension
keyword
keyword
104229
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"