keyword
https://read.qxmd.com/read/38527593/hippocampal-hdac6-promotes-pocd-by-regulating-nlrp3-induced-microglia-pyroptosis-via-hsp90-hsp70-in-aged-mice
#21
JOURNAL ARTICLE
Qi-Cheng Lin, Jiao Wang, Xin-Lin Wang, Chi Pan, Shao-Wu Jin, Steven Char, Yuan-Xiang Tao, Hong Cao, Jun Li
BACKGROUND: Postoperative Cognitive Dysfunction (POCD) has attracted increased attention, but its precise mechanism remains to be explored. This study aimed to figure out whether HDAC6 could regulate NLRP3-induced pyroptosis by modulating the functions of HSP70 and HSP90 in microglia to participate in postoperative cognitive dysfunction in aged mice. METHODS: Animal models of postoperative cognitive dysfunction in aged mice were established by splenectomy under sevoflurane anesthesia...
March 23, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38527325/patient-with-sitosterolemia-with-slow-healing-sternal-wound-from-coronary-artery-bypass-surgery
#22
JOURNAL ARTICLE
Catherine R Ratliff
BACKGROUND: Sitosterolemia, also known as phytosterolemia, is a rare recessive genetic disorder characterized by accumulation of sitosterol from vegetable oils, nuts, and other plant-based foods in the body. In those with sitosterolemia, there is an increase of fatty deposits in the arteries (atherosclerosis), which may occur in early childhood, impeding blood flow and increasing the risk of a heart attack, stroke, or sudden death at a very early age. Visual signs of sitosterolemia may include small yellowish xanthomas beginning in early childhood...
March 2024: Journal of Wound, Ostomy, and Continence Nursing
https://read.qxmd.com/read/38527023/retinoic-acid-attenuates-ischemic-injury-induced-activation-of-glial-cells-and-inflammatory-factors-in-a-rat-stroke-model
#23
JOURNAL ARTICLE
Ju-Bin Kang, Hyun-Kyoung Son, Murad-Ali Shah, Phil-Ok Koh
Stroke is a leading cause of death and long-term disability which can cause oxidative damage and inflammation of the neuronal cells. Retinoic acid is an active metabolite of vitamin A that has various beneficial effects including antioxidant and anti-inflammatory effects. In this study, we investigated whether retinoic acid modulates oxidative stress and inflammatory factors in a stroke animal model. A middle cerebral artery occlusion (MCAO) was performed on adult male rats to induce focal cerebral ischemia...
2024: PloS One
https://read.qxmd.com/read/38526448/linking-renal-hypoxia-and-oxidative-stress-in-chronic-kidney-disease-based-on-clinical-subjects-and-animal-models
#24
JOURNAL ARTICLE
Yizeng Xu, Fang Lu, Meng Wang, Lingchen Wang, Chaoyang Ye, Shuohui Yang, Chen Wang
This study aims to explore the relationships between renal function, hypoxia, and oxidative stress in chronic kidney disease (CKD). Seventy-six non-dialysis patients with CKD stages 1-5 and eight healthy subjects were included in the clinical research. They were divided into three groups: healthy subjects, CKD stages 1-3, and CKD stages 4-5. In the animal study, 16 rat models of CKD were established through 5/6 renal ablation/infarction (A/I) surgery, and 8 normal rats were split into 3 groups: Sham, CKD, and losartan groups...
March 24, 2024: Biomol Biomed
https://read.qxmd.com/read/38526116/heterotopic-auxiliary-whole-liver-rat-transplant-model-utilizing-a-hepaticoureterostomy-for-allograft-rejection-studies
#25
JOURNAL ARTICLE
Bret Verhoven, Weifeng Zeng, Peter Chlebeck, Kristina Matkowskyj, Heather Jennings, Samuel Poore, David Al-Adra
Small animal transplant models are indispensable for organ tolerance studies investigating feasible therapeutic interventions in preclinical studies. Rat liver transplantation (LTx) protocols typically use an orthotopic model where the recipients' native liver is removed and replaced with a donor liver. This technically demanding surgical procedure requires advanced micro-surgical skills and is further complicated by lengthy anhepatic and lower body ischemia times. This prompted the development of a less complicated heterotopic method that can be performed faster with no anhepatic or lower body ischemia time, reducing post-surgery stress for the recipient animal...
March 8, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38525608/targeted-gene-deletion-or-antagonism-of-the-prostaglandin-e2-ep3-receptor-protects-against-cardiac-injury-postmyocardial-infarction
#26
JOURNAL ARTICLE
Timothy D Bryson, Shaheen Y Bhat, Carlin Moore, David Taube, Jiang Xu, Edward Peterson, Pamela Harding
BACKGROUND: Prostaglandin E2 acts through 4 G-protein-coupled receptors (EP1-EP4). We previously reported that activation of the EP3 receptor reduces cardiac contractility, and its expression increases after a myocardial infarction (MI), mediating the reduction in cardiac function. In contrast, cardiac overexpression of the EP4 receptor in MI substantially improves cardiac function. Moreover, we recently reported that mice overexpressing EP3 have heart failure under basal conditions and worsened cardiac function after MI...
March 25, 2024: Circulation. Heart Failure
https://read.qxmd.com/read/38521902/surgical-management-of-urethral-obstruction-secondary-to-perineal-liposarcoma-in-a-dog-a-case-report
#27
JOURNAL ARTICLE
Natália Korytárová, Beate Bosch, Luise Grace Klass, Pavel Slunsky
BACKGROUND: Swelling of the perineal region in male dogs is most commonly caused by a perineal hernia. Clinical signs associated with perineal hernia are constipation, tenesmus or stranguria. This case report documents a rare cause of perineal swelling created by the growth of a malignant tumour leading to urethral obstruction and subsequent stranguria. CASE PRESENTATION: An 11-year-old neutered male German Shepherd was presented for swelling in the perineal region and stranguria for three days...
March 23, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38521695/development-of-an-mr-guided-focused-ultrasound-mrgfus-lesioning-approach-for-the-fornix-in-the-rat-brain
#28
JOURNAL ARTICLE
Carena Cornelssen, Allison Payne, Dennis L Parker, Matthew Alexander, Robb Merrill, Sharayu Senthilkumar, Jacob Christensen, Karen S Wilcox, Henrik Odéen, John D Rolston
OBJECTIVE: High-intensity magnetic resonance-guided focused ultrasound (MRgFUS) is a non-invasive therapy to lesion brain tissue, used clinically in patients and pre-clinically in several animal models. Challenges with focused ablation in rodent brains can include skull and near-field heating and accurately targeting small and deep brain structures. We overcame these challenges by creating a novel method consisting of a craniectomy skull preparation, a high-frequency transducer (3 MHz) with a small ultrasound focal spot, a transducer positioning system with an added manual adjustment of ∼0...
March 22, 2024: Ultrasound in Medicine & Biology
https://read.qxmd.com/read/38521317/swelling-behavior-of-calcium-ion-crosslinked-sodium-alginate-in-an-in-vitro-hemostatic-tamponade-model
#29
JOURNAL ARTICLE
Kousuke Yamauchi, Takahiro Yoshihara, Sayaka Suzuki, Hideto Sugawara, Shinya Maehara, Masahiro Sato, Ryuichi Nishida, Tsutomu Azuma, Junji Yamamoto, Kiyokazu Nakajima
Various types of hemostatic agents are used to manage bleeding in surgery. Many such agents are animal products, which carry the risk of secondary infection. The aim of this study is to develop a novel hemostatic agent from a non-animal source that quickly stops bleeding, is easy to use, and has no risk of infection. In this study, we synthesized calcium ion-crosslinked sodium alginate (Alg-Na/Ca) by partial substitution of Ca ions for Na ions in sodium alginate. We prepared 12 kinds of Alg-Na/Ca powders with different Ca mass ratios, molecular weights, M/G ratios and particle size distributions and measured their swelling ratio and the burst pressure generated...
March 21, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38519573/evaluation-of-different-fixation-methods-combinations-after-l-shaped-osteotomy-reduction-malarplasty-an-in-vitro-biomechanical-study
#30
JOURNAL ARTICLE
Mohammed Qasem Al-Watary, Jiansuo Hao, Yingyou He, Libin Song, Heyou Gao, Khaled Alkebsi, Saddam Ahmed Elayah, Bin Ye, Jihua Li
BACKGROUND: This in vitro study compared the stability of different fixation method combinations for the zygomatic complex after simulated L-shaped osteotomy reduction malarplasty, a common facial contouring surgery in East Asia with high postoperative complications due to poor fixation methods. MATERIALS AND METHODS: The study used 108 zygoma replicas with various fixation methods combinations in the zygomatic body (L-shaped plate with short wing on zygoma and on the maxilla, two bicortical screws, one bicortical screw with L-shaped plate, square plate, and rectangular plate) and zygomatic arch (Mortise-Tenon structure, 3-hole plate, and Mortise-Tenon structure plus short screw)...
March 22, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38519389/antenatal-administration-of-extracellular-vesicles-derived-from-amniotic-fluid-stem-cells-improves-lung-function-in-neonatal-rats-with-congenital-diaphragmatic-hernia
#31
JOURNAL ARTICLE
Rebeca L Figueira, Naghmeh Khoshgoo, Fabian Doktor, Kasra Khalaj, Tasneem Islam, Nazgol Moheimani, Matisse Blundell, Lina Antounians, Martin Post, Augusto Zani
BACKGROUND: The severity of pulmonary hypoplasia is a main determinant of outcome for babies with congenital diaphragmatic hernia (CDH). Antenatal administration of extracellular vesicles derived from amniotic fluid stem cells (AFSC-EVs) has been shown to rescue morphological features of lung development in the rat nitrofen model of CDH. Herein, we evaluated whether AFSC-EV administration to fetal rats with CDH is associated with neonatal improvement in lung function. METHODS: AFSC-EVs were isolated by ultracentrifugation and characterized by size, morphology, and canonical marker expression...
February 28, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38519369/augmenting-veterinary-minimally-invasive-surgery-evidence-based-review-of-foundational-and-novel-devices-and-technology
#32
REVIEW
Erin A Gibson
Veterinary minimally invasive surgery continues to grow as a specialty. With increasing experience in this field, comes improved accessibility as well as progressive complexity of procedures performed. Advancement in technology has been both a response to the growth and a necessary driver of continued refinement of this field. Innovative research leading to advancements in surgical equipment has led to the development of novel image acquisition platforms, cannulas, smoke evacuation systems, antifog devices, instrumentation, and ligating/hemostatic devices...
March 21, 2024: Veterinary Clinics of North America. Small Animal Practice
https://read.qxmd.com/read/38518623/construct-validation-of-a-novel-synthetic-tendon-model-used-for-assessing-surgeon-performance-in-a-simulated-core-suture-tendon-repair-technique
#33
JOURNAL ARTICLE
Luke F Western, Patrick G Roberts, Jonathan Rees, Daniel Howgate
BACKGROUND: The strength of tendon repair is dependent on the quality of the core suture. Organic and synthetic materials have been used to simulate tendon repair for training; however, no model has undergone construct validation. OBJECTIVES: To determine the construct validity of a novel synthetic tendon repair model. METHODS: Synthetic silicone tendon models were used to simulate adult Achilles tendon (AT) and digital flexor tendon (FT)...
February 28, 2024: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://read.qxmd.com/read/38517246/chronic-critical-illness-induced-muscle-atrophy-insights-from-a-trauma-mouse-model-and-potential-mechanism-mediated-via-serum-amyloid-a
#34
JOURNAL ARTICLE
Mingxing Lei, Taojin Feng, Mingming Zhang, Feifan Chang, Jiang Liu, Baisheng Sun, Ming Chen, Yi Li, Licheng Zhang, Peifu Tang, Pengbin Yin
BACKGROUND: Chronic critical illness (CCI), which was characterized by persistent inflammation, immunosuppression, and catabolism syndrome (PICS), often leads to muscle atrophy. Serum amyloid A (SAA), a protein upregulated in critical illness myopathy, may play a crucial role in these processes. However, the effects of SAA on muscle atrophy in PICS require further investigation. This study aims to develop a mouse model of PICS combined with bone trauma to investigate the mechanisms underlying muscle weakness, with a focus on SAA...
February 27, 2024: Shock
https://read.qxmd.com/read/38517016/implant-retention-in-a-rabbit-model-of-fracture-related-infection
#35
JOURNAL ARTICLE
Jan Puetzler, Alejandro Vallejo Diaz, Georg Gosheger, Martin Schulze, Daniel Arens, Stephan Zeiter, Claudia Siverino, Robert G Richards, Thomas F Moriarty
AIMS: Fracture-related infection (FRI) is commonly classified based on the time of onset of symptoms. Early infections (< two weeks) are treated with debridement, antibiotics, and implant retention (DAIR). For late infections (> ten weeks), guidelines recommend implant removal due to tolerant biofilms. For delayed infections (two to ten weeks), recommendations are unclear. In this study we compared infection clearance and bone healing in early and delayed FRI treated with DAIR in a rabbit model...
March 22, 2024: Bone & Joint Research
https://read.qxmd.com/read/38516557/unscheduled-changes-in-pre-clinical-stroke-model-housing-contributes-to-variance-in-physiological-and-behavioural-data-outcomes-a-post-hoc-analysis
#36
JOURNAL ARTICLE
Aisling McFall, Delyth Graham, Stuart A Nicklin, Lorraine M Work
Ischaemic stroke presents a significant problem worldwide with no neuroprotective drugs available. Many of the failures in the search for neuroprotectants are attributed to failure to translate from pre-clinical models to humans, which has been combatted with rigorous pre-clinical stroke research guidelines. Here, we present post hoc analysis of a pre-clinical stroke trial, conducted using intraluminal filament transient middle cerebral artery occlusion in the stroke-prone spontaneously hypertensive rat, whereby unscheduled changes were implemented in the animal housing facility...
2024: Brain and Neuroscience Advances
https://read.qxmd.com/read/38516541/effect-of-cochlear-implant-electrode-insertion-depth-on-speech-perception-outcomes-a-systematic-review
#37
JOURNAL ARTICLE
Tabita M Breitsprecher, Wolf-Dieter Baumgartner, Kevin Brown, Stefan Dazert, Una Doyle, Anandhan Dhanasingh, Wilma Großmann, Rudolf Hagen, Paul Van de Heyning, Robert Mlynski, Marcus Neudert, Gunesh Rajan, Kristen Rak, Vincent Van Rompaey, Joachim Schmutzhard, Stefan Volkenstein, Christiane Völter, Wilhelm Wimmer, Mario Zernotti, Nora M Weiss
OBJECTIVE: The suitable electrode array choice is broadly discussed in cochlear implantation surgery. Whether to use a shorter electrode length under the aim of structure preservation versus choosing a longer array to achieve a greater cochlear coverage is a matter of debate. The aim of this review is to identify the impact of the insertion depth of a cochlear implant (CI) electrode array on CI users' speech perception outcomes. DATABASES REVIEWED: PubMed was searched for English-language articles that were published in a peer-reviewed journal from 1997 to 2022...
December 2023: Otol Neurotol Open
https://read.qxmd.com/read/38515369/adjunctive-use-of-hyperbaric-oxygen-therapy-in-veterinary-dentistry-and-oral-surgery-a-case-series
#38
JOURNAL ARTICLE
Melanie Hunt, Danielle Mendelsohn, Katherine Queck, Carlos Rice
Hyperbaric oxygen therapy (HBOT) is utilized as an adjunctive treatment for human and veterinary patients with compromised tissues. Medical records from two veterinary hospitals with HBOT chambers were searched for small animal veterinary dentistry and oral surgery specialty patients. The HBOT records were combined with the medical records from the referring specialty veterinary dentistry and oral surgery services. Clinical indications for HBOT treatments associated with a positive outcome in this case series included resistant bacterial infections, electrical cord injury, bite wound injuries, osteomyelitis, crush/traumatic injuries including mandibular fractures, oral surgery performed at previously irradiated sites, and osteonecrosis, presumably radiation induced...
March 22, 2024: Journal of Veterinary Dentistry
https://read.qxmd.com/read/38515135/recent-research-advances-in-pain-mechanisms-in-mccune-albright-syndrome-thinking-about-the-pain-mechanism-of-fd-mas
#39
REVIEW
Yong Wang, Tao Jiang
BACKGROUND: The lack of effective understanding of the pain mechanism of McCune-Albright syndrome (MAS) has made the treatment of pain in this disease a difficult clinical challenge, and new therapeutic targets are urgently needed to address this dilemma. OBJECTIVE: This paper summarizes the novel mechanisms, targets, and treatments that may produce pain in MAS and fibrous dysplasia (polyfibrous dysplasia, or FD). METHODS: We conducted a systematic search in the PubMed database, Web of Science, China Knowledge Network (CNKI) with the following keywords: "McCune-Albright syndrome (MAS); polyfibrous dysplasia (FD); bone pain; bone remodeling; G protein coupled receptors; GDNF family receptors; purinergic receptors and glycogen synthase kinase", as well as other keywords were systematically searched...
March 21, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38512446/sleeve-gastrectomy-links-the-attenuation-of-diabetic-kidney-disease-to-the-inhibition-of-renal-tubular-ferroptosis-through-down-regulating-tgf-%C3%AE-1-smad3-signaling-pathway
#40
JOURNAL ARTICLE
C Liu, M Zhong, X Jin, J Zhu, Y Cheng, L Li, Q Xu, Q Liu, H Ding, G Zhang
PURPOSE: To investigate how sleeve gastrectomy (SG), a typical operation of bariatric surgery, attenuated symptom, and progression of diabetic kidney disease (DKD). METHODS: DKD model was induced by high-fat diet (HFD) combined with streptozocin in Wistar rats. SG was performed, and the group subjected to sham surgery served as control. The animals were euthanized 12 weeks after surgery, followed by sample collection for the subsequent experiment. The HK-2, a renal proximal tubular epithelial cell line derived from human, was utilized to investigate the potential mechanisms...
March 21, 2024: Journal of Endocrinological Investigation
keyword
keyword
104227
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.