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Thromboprophylaxis

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https://www.readbyqxmd.com/read/29353416/physicians-decision-about-long-term-thromboprophylaxis-in-cancer-outpatients-cat-axis-a-case-vignette-study-on-clinical-practice-in-france
#1
Florian Scotté, I Elalamy, D Mayeur, G Meyer
PURPOSE: Data on long-term venous thromboembolism prophylaxis in cancer outpatients remain scarce. In the absence of clear and consistent treatment guidelines, our objectives were to describe and better understand clinical practice and to identify factors influencing the use of thromboprophylaxis. METHODS: CAT AXIS was a multicentred cross-sectional study based on the completion of physician-profile questionnaires and the assessment of 10 e-mailed credible clinical scenarios of lung, colon and breast cancers by each of participants using the case vignette-validated method...
January 20, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29351927/bet-2-is-early-chemical-thromboprophylaxis-safe-in-patients-with-blunt-trauma-solid-organ-injury-soi-undergoing-non-operative-management-nom
#2
Craig Ferguson, Jonathan Lewin
A short cut review was carried out to establish whether chemical thromboprophylaxis was a safe early intervention in patients with solid organ injury that is being managed non-operatively. Eight papers presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated. It is concluded that there is inadequate evidence assessing safety of low molecular weight heparin (LMWH) within 24 hours of trauma...
February 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29343245/an-unusual-case-of-symptomatic-deep-vein-thrombosis-and-pulmonary-embolism-after-arthroscopic-meniscus-surgery
#3
Chao-Hua Fang, Hua Liu, Jun-Hui Zhang, Shi-Gui Yan
BACKGROUND: Although thrombosis complication is rare after arthroscopic meniscus surgery, deep vein thrombosis and pulmonary embolism can be fatal. The associated risk factors and whether anticoagulant prevention after arthroscopic knee surgery is necessary have not reach consensus. Here we present a case of deep vein thrombosis and pulmonary embolism after a common arthroscopic meniscectomy. CASE PRESENTATION: The patient had no risk factors except ipsilateral leg varicose veins...
January 17, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29338332/venous-thromboembolism-in-podiatric-foot-and-ankle-surgery
#4
Jemma H Matthews, Alexander J Terrill, Alex L Barwick, Paul A Butterworth
BACKGROUND: The extent to which podiatric surgeons follow venous thromboembolism guidelines is unknown. The aim of this study therefore, was 2-fold: (a) to determine the rate of venous thromboembolism following podiatric surgery and (b) to investigate the factors that influence the use of thromboprophylaxis. METHODS: Data from 4238 patients who underwent foot and ankle surgery over 2 years were analyzed. Venous thromboembolism within the first 30 days following surgery was recorded using the Australasian College of Podiatric Surgeons surgical audit tool...
January 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29338293/betrixaban-a-new-oral-factor-xa-inhibitor-for-extended-venous-thromboembolism-prophylaxis-in-high-risk-hospitalized-patients
#5
Scott G Garland, Christina E DeRemer, Steven M Smith, John G Gums
OBJECTIVE: To review the pharmacology, pharmacokinetics, efficacy, and safety of the factor Xa (FXa) inhibitor betrixaban for extended-duration prophylaxis of acute medically ill patients with venous thromboembolism (VTE) risk factors. DATA SOURCES: A MEDLINE/PubMed (January 1990 to October 2017) search was conducted using the following keywords: betrixaban, PRT054021, FXa inhibitor, novel oral anticoagulant, NOAC, direct oral anticoagulant, DOAC, and target specific oral anticoagulant, TSOAC...
January 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29335910/duration-and-magnitude-of-postoperative-risk-of-venous-thromboembolism-after-planned-inguinal-hernia-repair-in-men-a-population-based-cohort-study
#6
D J Humes, A Abdul-Sultan, A J Walker, J F Ludvigsson, J West
PURPOSE: Little is known regarding the magnitude and timing of the risk of VTE following inguinal hernia surgery. We aimed to determine the absolute and relative rates of venous thromboembolism (VTE) following planned inguinal hernia repair. METHODS: We analysed male adults with a first inguinal hernia repair with no prior record of VTE from the Clinical Practice Research Datalink, linked to the Hospital Episode Statistics (2001-2011). Crude rates and adjusted hazard ratios (HR) of the first VTE were calculated using Cox regression analysis to compare specific time periods following the surgery compared to the general population...
January 15, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29325495/management-of-cancer-associated-venous-thromboembolism-a-case-based-practical-approach
#7
Minna Voigtlaender, Florian Langer
In patients with solid tumours or haematological malignancies, venous thromboembolism (VTE) is a leading cause of death and significantly contributes to morbidity and healthcare resource utilization. Current practice guidelines recommend long-term anticoagulation with low-molecular-weight heparin (LMWH) as the treatment of choice for cancer-associated VTE, based on clinical trial data showing an overall improved safety and efficacy profile of LMWH compared to vitamin K antagonists. However, several open questions remain, e...
January 12, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29325349/-introduction-and-interpretation-of-guidelines-on-thromboprophylaxis-in-the-perioperative-period-of-urological-surgery
#8
X Wang, Z Y Liu
Venous thromboembolism had drawn great attention of global experts, as it is the third leading cause of cardiovascular-associated death, ranking after coronary heart disease and stroke. Numerous health care organizations had introduced guidelines for thromboprophylaxis during the perioperative period in their own fields. The paper reviewed the available guidelines pertaining to urological surgery from America Urological Association, American College of Chest Physicians and European Association of Urology. Compared with the first two guidelines, the European Association of Urology guideline is a milestone which recommended the most detailed prophylactic measures for the procedure-specific and patient-specific according to the evidence-based medicine...
January 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29316202/anticoagulant-prophylaxis-and-therapy-in-children-current-challenges-and-emerging-issues
#9
Fiona Newall, Brian Branchford, Christoph Male
This review aims to describe the unique challenges of anticoagulant prophylaxis and treatment in children, and to highlight areas for research for improving clinical outcomes of children with thromboembolic disease. The evidence presented demonstrates the challenges of advancing the evidence-base informing optimal management of thromboembolic disease in children. Recent observational studies have identified risk factors of venous thromboembolism in children, but there are few interventional studies assessing the benefit-risk of using thromboprophylaxis in risk-stratified clinical subgroups...
January 6, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29309713/routine-preoperative-venous-doppler-screening-is-not-effective-in-preventing-thromboembolic-events-after-total-joint-arthroplasty
#10
Morteza Meftah, Peter B White, Ahmed Siddiqi, Vinayak S Perake, Ira H Kirschenbaum
Despite advances in thromboprophylaxis, the relationship between preexisting deep venous thromboses (DVTs) and postoperative thromboembolic complications is not fully established. The aim of this study was to assess the utility of selective and nonselective preoperative lower extremity venous Doppler screening protocols as tools in reducing the incidence of thromboembolic events (DVT/pulmonary embolism [PE]) after total joint arthroplasty. In the 2-year period from August 2013 to August 2015, a total of 455 consecutive elective primary total joint arthroplasties were identified from the authors' database...
January 8, 2018: Orthopedics
https://www.readbyqxmd.com/read/29304528/comparative-performance-of-clinical-risk-assessment-models-for-hospital-acquired-venous-thromboembolism-in-medical-patients
#11
Marc Blondon, David Spirk, Nils Kucher, Drahomir Aujesky, Daniel Hayoz, Jürg H Beer, Marc Husmann, Beat Frauchiger, Wolfgang Korte, Walter A Wuillemin, Henri Bounameaux, Marc Righini, Mathieu Nendaz
BACKGROUND:  Improved thromboprophylaxis for acutely ill medical patients relies on valid predictions of thrombotic risks. Our aim was to compare the performance of the Improve and Geneva clinical risk assessment models (RAMs), and to simplify the current Geneva RAM. METHODS:  Medical inpatients from eight Swiss hospitals were prospectively followed during 90 days, for symptomatic venous thromboembolism (VTE) or VTE-related death. We compared discriminative performance and calibration of the RAMs, using time-to-event methods with competing risk modelling of non-VTE death...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29302726/which-patients-require-extended-thromboprophylaxis-after-colectomy-modeling-risk-and-assessing-indications-for-post-discharge-pharmacoprophylaxis
#12
Eliza W Beal, Dmitry Tumin, Jeffery Chakedis, Erica Porter, Dimitrios Moris, Xu-Feng Zhang, Mark Arnold, Alan Harzman, Syed Husain, Carl R Schmidt, Timothy M Pawlik
BACKGROUND: Given the conflicting nature of reported risk factors for post-discharge venous thromboembolism (VTE) and unclear guidelines for post-discharge pharmacoprophylaxis, we sought to determine risk factors for 30-day post-discharge VTE after colectomy to predict which patients will benefit from post-discharge pharmacoprophylaxis. METHODS: Patients who underwent colectomy in the American College of Surgeons National Surgical Quality Improvement Project Participant Use Files from 2011 to 2015 were identified...
January 4, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29302621/a-systematic-review-on-the-use-of-aspirin-in-the-prevention-of-deep-vein-thrombosis-in-major-elective-lower-limb-orthopedic-surgery-an-update-from-the-past-3-years
#13
REVIEW
Dylan A Mistry, Amit Chandratreya, Paul Y F Lee
Introduction  Currently there are no consensuses in the national guidance on thromboprophylaxis following major elective lower limb surgery. Emerging clinical evidence suggests that aspirin could be just as effective as anticoagulants with a lower cost. The aim of this study was to provide an update based on literature of the past 3 years for the use of aspirin as thromboprophylaxis after knee and hip arthroplasty. Materials and Methods  MEDLINE/EMBASE search was performed with appropriate terms for original articles from 2014 to 2017...
October 2017: The surgery journal
https://www.readbyqxmd.com/read/29291451/effects-of-forced-deep-breathing-on-blood-flow-velocity-in-the-femoral-vein-developing-a-new-physical-prophylaxis-for-deep-vein-thrombosis-in-patients-with-plaster-cast-immobilization-of-the-lower-limb
#14
Keisuke Nakanishi, Naonobu Takahira, Miki Sakamoto, Minako Yamaoka-Tojo, Masato Katagiri, Jun Kitagawa
INTRODUCTION: Patients with plaster cast immobilization of the lower limb have an estimated symptomatic venous thromboembolism rate of 5.5%. However, there is currently no practical physical prophylaxis for deep-vein thrombosis (DVT). The objective of this study was to examine the effects of forced deep breathing on peak blood velocity in the superficial femoral vein (PBVFV), which is a surrogate measure of the efficacy of thromboprophylaxis against DVT, in patients with plaster cast immobilization of the lower limb...
December 23, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29288608/thromboprophylaxis-in-elderly-surgical-patients-current-state-and-future-considerations
#15
Christina Delimpalta, Luca Ponchietti
Venous thromboembolism is the number one cause of preventable death for hospital inpatients. Aging general surgical patients are especially susceptible to DVT/PE and this risk increases in the presence of other comorbidities prevalent in the elderly. However, it is often unrecognised and undertreated. Various risk scores classify patients in low, moderate and high risk categories. Current guidelines for thromboprophylaxis advocate combination of mechanical methods in the form of elastic stockings or intermittent pneumatic leg compression and pharmacological agents such as low molecular weight heparins and oral anticoagulants...
November 2017: Chirurgia
https://www.readbyqxmd.com/read/29279638/prophylaxis-and-incidence-of-symptomatic-deep-vein-thrombosis-in-indian-patients-with-sepsis-detect-deep-vein-thrombosis-registry
#16
Nagarajan Ramakrishnan, Detect-Dvt Investigators
Purpose: To assess thromboprophylaxis rate and incidence of symptomatic deep vein thrombosis (DVT) in Indian patients with acute sepsis. Materials and Methods: Adult patients with sepsis, within 48 h of sepsis onset/hospital admission were included. DVT was assessed using Doppler ultrasonography if clinical signs were present. Data were collected at inclusion, discharge, and 30 ± 7 days (if discharged before 30 days). Results: The study included 278 patients (men: 69...
November 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29277101/incidence-and-management-of-thrombotic-and-thromboembolic-complications-following-the-superior-cavopulmonary-anastomosis-procedure-a-literature-review
#17
Arnav Agarwal, Mohammed Firdouse, Nishaan Brar, Andy Yang, Panos Lambiris, Anthony K Chan, Tapas Kumar Mondal
The objective of this literature review was to estimate the incidence of thrombosis and thromboembolism associated with the superior cavopulmonary anastomosis (SCPA) procedure and its variants and to examine current thromboprophylaxis regimens utilized. MEDLINE and EMBASE were searched from inception to August 2017 for all prospective and retrospective cohort studies explicitly reporting incidence of thrombosis, thromboembolism, or shunt occlusion in neonates, infants, and children undergoing 1 or more variants of the SCPA procedure...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29259514/dabigatran-induced-spontaneous-hemopericardium-and-cardiac-tamponade
#18
Qurat-Ul-Ain Jelani, Ram Gordon, Adam Schussheim
Four novel oral anticoagulant agents are currently available for the prevention and treatment of thromboembolic events in patients with nonvalvular atrial fibrillation. We present an unusual case of spontaneous hemopericardium and tamponade in an 87-year-old man with atrial fibrillation who was taking one such agent, dabigatran, as thromboprophylaxis. Our case highlights both a rare bleeding complication of dabigatran use and the effectiveness of idarucizumab, its newly approved reversal agent. Especially in elderly patients, we recommend that clinicians evaluate risk factors, closely monitor patient status, and consider alternatives to the newer anticoagulants when the risk of bleeding is high...
October 2017: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/29251025/low-molecular-weight-heparin-use-during-pregnancy-and-risk-of-postpartum-hemorrhage-a-systematic-review-and-meta-analysis
#19
Angelo Sirico, Gabriele Saccone, Maria Maruotti M D Giuseppe, Elvira Grandone, Laura Sarno, Vincenzo Berghella, M D Fulvio Zullo, Pasquale Martinelli
INTRODUCTION: Postpartum hemorrhage (PPH) is the leading cause of maternal mortality worldwide with a prevalence rate of approximately 6%. Although most cases of PPH have no identifiable risk factors, the incidence of PPH has been associated to the thromboprophylaxis in pregnancy with low molecular weight heparin (LMWH). Thus, the aim of the study is to evaluate the risk of PPH in cases of pregnant women exposed to LMWH. MATERIALS AND METHODS: Electronic research was performed in Ovid, Scopus, ClinicalTrials...
December 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29247594/genes-associated-with-venous-thromboembolism-in-colorectal-cancer-patients
#20
Betül Ünlü, Nick van Es, Wibowo Arindrarto, Szymon M Kiełbasa, Hailiang Mei, Johan Westerga, Saskia Middeldorp, Peter J K Kuppen, Hans-Martin Otten, Suzanne Cannegieter, Henri H Versteeg
BACKGROUND: Venous thromboembolism (VTE) is a frequent complication in patients with cancer and is associated with significant morbidity and mortality. However, the mechanisms behind cancer-associated thrombosis are still incompletely understood. OBJECTIVES: The aim is to identify novel genes that associate with VTE in patients with colorectal cancer (CRC). METHODS: Twelve CRC patients with VTE were age- and sex-matched to twelve CRC patients without VTE...
December 16, 2017: Journal of Thrombosis and Haemostasis: JTH
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