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Song-Hee Ham, Kyoung Ah Min, Meong Cheol Shin
Therapeutically potent macromolecular drugs have shown great promise for overcoming the limitations of small-molecule anti-cancer drugs. But tumor cell-selective intracellular delivery of the macromolecules remains a major hurdle for their successful clinical application. To overcome this challenge, we engineered a novel genetic fusion protein (F3-Gel) that composed of F3 peptide, a tumor-homing peptide, and gelonin, a plant-derived ribosome-inactivating protein (RIP), and then evaluated its anti-cancer activity in vitro and in vivo...
April 17, 2017: Acta Pharmacologica Sinica
Seo Ah Hong, Noppawan Piaseu
BACKGROUND/OBJECTIVES: Low consumption of fruit and vegetable is frequently viewed as an important contributor to obesity risk. With increasing childhood obesity and relatively low fruit and vegetable consumption among Thai children, there is a need to identify the determinants of the intake to promote fruit and vegetable consumption effectively. SUBJECTS/METHODS: This cross-sectional study was conducted at two conveniently selected primary schools in Nakhon Pathom...
April 2017: Nutrition Research and Practice
Meong Cheol Shin, Kyoung Ah Min, Heesun Cheong, Cheol Moon, Yongzhuo Huang, Huining He, Victor C Yang
Despite significant progress in prostate cancer treatment, yet, it remains the leading diagnosed cancer and is responsible for high incidence of cancer related deaths in the U.S. Because of the insufficient efficacy of small molecule anti-cancer drugs, significant interest has been drawn to more potent macromolecular agents such as gelonin, a plant-derived ribosome inactivating protein (RIP) that efficiently inhibits protein translation. However, in spite of the great potency to kill tumor cells, gelonin lacks ability to internalize tumor cells and furthermore, cannot distinguish between tumor and normal cells...
March 27, 2017: International Journal of Pharmaceutics
Riccardo Gobbi, Simone Baiardi, Susanna Mondini, Luca Cerritelli, Ottavio Piccin, Giuseppe Scaramuzzino, Francesca Milano, Maria Rita Melotti, Francesco Mordini, Antonio Pirodda, Fabio Cirignotta, Giovanni Sorrenti
Importance: Drug-induced sleep endoscopy is a diagnostic technique that allows dynamic evaluation of the upper airway during artificial sleep. The lack of a standardized procedure and the difficulties associated with direct visual detection of obstructive events result in poor intraobserver and interobserver reliability, especially when otolaryngology surgeons not experienced in the technique are involved. Objectives: To describe a drug-induced sleep endoscopy technique implemented with simultaneous polygraphic monitoring of cardiorespiratory parameters (DISE-PG) in patients with a diagnosis of obstructive sleep apnea syndrome and discuss the technique's possible advantages compared with the standard procedure...
March 2, 2017: JAMA Otolaryngology—Head & Neck Surgery
Dawoon Jung, Jung-Ah Kim, Myung-Sook Park, Un Hyuk Yim, Kyungho Choi
Hebei Spirit oil spill (HSOS) of December 2007 is one of the worst oil spill accidents that occurred in Yellow Sea. The affected coastline along the west coast of Korean Peninsula hosts one of the largest tidal flats worldwide, and is home to tens of thousands of human residents. Based on nation-wide concerns on ecosystem damages and adverse human health effects, two separate surveillance programs on ecosystem and human health were initiated: a 10-year follow-up program by Ministry of Oceans and Fisheries to assess ecological impacts of the oil spill, and an exposure and health effect assessment program by Ministry of Environment for the residents of Taean and its vicinity...
April 2017: Chemosphere
Tomasz Maślanka, Natalia Ziółkowska, Hubert Ziółkowski, Joanna Małaczewska
The aim of this study has been to determine whether eye chambers constitute part of the normal migratory pathway of naive CD4+ and CD8+ T cells in mouse and if natural CD4+CD25+Foxp3+ and CD8+CD25+Foxp3+ regulatory T cells are present within these eye compartments. To this aim, the cells obtained from aqueous humor (AH) of normal mice were phenotyped in terms of the expression CD4, CD8, CD25, CD127 and transcription factor Foxp3. The mean percentage of CD8+ T cells in the total AH lymphocyte population was as high as 28...
2017: PloS One
Leila Freidoony, Chhabi Lal Ranabhat, Chun-Bae Kim, Chang-Soo Kim, Dong-Won Ahn, Young Ah Doh
Use of institutional delivery services can be effective in reducing maternal and infant mortality. In Nepal, however, the majority of women deliver at home. Using Andersen's behavioral model of use of health care services, this cross-sectional study aimed to identify factors associated with use of institutional delivery services in four villages and one municipality in Kailali district, Nepal. Mothers (N = 500) who had given birth in the 5 years preceding the survey (conducted between January and February 2015) were randomly selected by cluster sampling and interviewed using a semi-structured questionnaire...
December 8, 2016: Women & Health
Maysa Magalhães Vaz, Lawrence Gonzaga Lopes, Paula Carvalho Cardoso, João Batista de Souza, Aline Carvalho Batista, Nádia Lago Costa, Érica Miranda Torres, Carlos Estrela
Objective: This study evaluated the inflammatory responses of human dental pulp after the use of two bleaching techniques. Material and Methods: Pulp samples were collected from human third molars extracted for orthodontic reasons and divided into three groups: control - no tooth bleaching (CG) (n=7); at-home bleaching with 15% carbamide peroxide (AH) (n = 10), and in-office bleaching with 38% hydrogen peroxide (IO) (n=12). Pulps were removed and stained with hematoxylin-eosin for microscopic analysis of inflammation intensity, collagen degradation, and pulp tissue organization...
September 2016: Journal of Applied Oral Science: Revista FOB
Pedro M Lourenço, José A Alves, Jeroen Reneerkens, Ah Jelle Loonstra, Peter M Potts, José P Granadeiro, Teresa Catry
Many migratory bird species show high levels of site fidelity to their wintering sites, which confers advantages due to prior knowledge, but may also limit the ability of the individual to move away from degrading sites or to detect alternative foraging opportunities. Winter site fidelity often varies among age groups, but sexual differences have seldom been recorded in birds. We studied a population of individually colour-marked sanderlings wintering in and around the Tejo estuary, a large estuarine wetland on the western coast of Portugal...
2016: PeerJ
Xudong Liu, Xiang Qian Lao, Claudie Chiu-Yi Wong, Lixing Tan, Zilong Zhang, Tze Wai Wong, Lap-Ah Tse, Arthur P S Lau, Ignatius T S Yu
BACKGROUND: Despite the popular use of household cleaning products worldwide, there is no published study investigating the health effects of these products on rhinitis in children. OBJECTIVE: We sought to investigate the household use of cleaning products and rhinitis patterns in Chinese children. METHODS: A total of 2299 children were recruited from 21 primary schools with wide geographic coverage in Hong Kong. Self-administered questionnaires were completed by parents/guardians to collect detailed information on respiratory symptoms and household use of 14 types of chemical cleaning products, as well as clean water...
September 2016: Journal of Allergy and Clinical Immunology
Seong-Woong Kang, Won Ah Choi, Han Eol Cho, Jang Woo Lee, Jung Hyun Park
Since 2001, financial support has been provided for all patients with neuromuscular disease (NMD) who require ventilatory support due to the paralysis of respiratory muscles in Korea. The purpose of this study was to identify ventilator usage status and appropriateness in these patients. We included 992 subjects with rare and incurable NMD registered for ventilator rental fee support. From 21 February 2011 to 17 January 2013, ventilator usage information, regular follow-up observation, and symptoms of chronic hypoventilation were surveyed by phone...
June 2016: Journal of Korean Medical Science
Jee Hyang Jeong, Hae Ri Na, Seong Hye Choi, Jungeun Kim, Duk L Na, Sang Won Seo, Juhee Chin, Sun Ah Park, Eun-Joo Kim, Hyun Jeong Han, Seol-Heui Han, Soo Jin Yoon, Jae-Hong Lee, Kyung Won Park, So Young Moon, Moon Ho Park, Mun Seong Choi, Il-Woo Han, Jun Hong Lee, Jung Seok Lee, Yong S Shim, Jeong Yeon Kim
BACKGROUND: We examined the efficacy of group-based cognitive intervention (GCI) and home-based cognitive intervention (HCI) in amnestic mild cognitive impairment (aMCI) and intervention effects on serum brain-derived neurotrophic factor (BDNF). METHODS: In this randomized and rater-blinded trial, 293 patients with aMCI from 18 nationwide hospitals were randomized: 96 to the GCI group, 98 to the HCI group and 99 to the control group. For 12 weeks, subjects receiving GCI participated twice per week in group sessions led by trained instructors, and those receiving HCI completed homework materials 5 days per week...
2016: Psychotherapy and Psychosomatics
Hyunok Choi, Norbert Schmidbauer, Carl-Gustaf Bornehag
BACKGROUND: The question regarding the true sources of the purported microbial volatile organic compounds (MVOCs) remains unanswered. OBJECTIVE: To identify microbial, as well as non-microbial sources of 28 compounds, which are commonly accepted as microbial VOCs (i.e. primary outcome of interest is Σ 28 VOCs). METHODS: In a cross-sectional investigation of 390 homes, six building inspectors assessed water/mold damage, took air and dust samples, and measured environmental conditions (i...
July 2016: Environmental Research
Valentina Pengo, Anna Zurlo, Alberto Voci, Elisabetta Valentini, Francesca De Zaiacomo, Massimo Catarini, Mario Iasevoli, Stefania Maggi, Renzo Pegoraro, Enzo Manzato, Valter Giantin
AIM: The aim of the present study was to investigate the proportion of physicians and nurses who agree with the administration of antibiotic therapy (AT), artificial hydration (AH), and artificial nutrition (AN) in patients with advanced dementia and different life expectancies. Furthermore, we aimed at analyzing the correlates of the opinion according to which medical treatments should no longer be given to advanced dementia patients once their life expectancy falls. METHODS: End-of-life decisions and opinions were measured with a questionnaire that was sent to geriatric units, hospices and nursing homes in three different regions of Italy...
March 23, 2016: Geriatrics & Gerontology International
Rachel van der Pols-Vijlbrief, Hanneke Ah Wijnhoven, Hilde Molenaar, Marjolein Visser
OBJECTIVE: It is generally thought that causes of undernutrition are multifactorial, but there are limited quantitative studies performed. We therefore examined a wide range of potential factors associated with undernutrition in community-dwelling older adults. DESIGN: Cross-sectional study. SETTING: Community-dwelling older adults (≥65 years) receiving home care in the Netherlands. SUBJECTS: Data on potential factors associated with (risk of) undernutrition were collected among 300 older adults...
August 2016: Public Health Nutrition
Yune-Jung Park, Seung-Ah Yoo, Daehee Hwang, Chul-Soo Cho, Wan-Uk Kim
To optimize treatment for rheumatoid arthritis (RA), it is ideal to monitor the disease activity on a daily basis because RA activity fluctuates over time. Urine can be collected routinely at home by patients. Recently, we identified four urinary biomarker candidates-gelsolin (GSN), orosomucoid (ORM)1, ORM2 and soluble CD14 (sCD14)-in RA patients through transcriptomic and proteomic studies. Here, we investigated the clinical significance of the aforementioned urinary biomarker candidates in a prospective manner...
February 26, 2016: Experimental & Molecular Medicine
Tim Aubry, Geoffrey Nelson, Sam Tsemberis
OBJECTIVE: To provide a review of the extant research literature on Housing First (HF) for people with severe mental illness (SMI) who are homeless and to describe the findings of the recently completed At Home (AH)-Chez soi (CS) demonstration project. HF represents a paradigm shift in the delivery of community mental health services, whereby people with SMI who are homeless are supported through assertive community treatment or intensive case management to move into regular housing. METHOD: The AH-CS demonstration project entailed a randomized controlled trial conducted in 5 Canadian cities between 2009 and 2013...
November 2015: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
Jinho Yu, Kangmo Ahn, Youn Ho Shin, Kyung Won Kim, Dong In Suh, Ho Sung Yu, Mi Jin Kang, Kyung Shin Lee, Seo Ah Hong, Kil Yong Choi, Eun Lee, Song I Yang, Ju Hee Seo, Byoung Ju Kim, Hyo Bin Kim, So Yeon Lee, Suk Joo Choi, Soo Young Oh, Ja Young Kwon, Kyung Ju Lee, Hee Jin Park, Pil Ryang Lee, Hye Sung Won, Soo Jong Hong
PURPOSE: Although home renovation exposure during childhood has been identified as a risk factor for the development of allergy, there is limited information on the association between prenatal exposure to home renovation and cord blood (CB) IgE response. The aims of this study were to identify the effect of prenatal exposure to home renovation on CB IgE levels, and to investigate whether this exposure interacts with neonatal genes and whether the effect can be modified by maternal atopy...
January 2016: Allergy, Asthma & Immunology Research
Yuqing Guo, Pamela Pimentel, Jared Lessard, Julie Rousseau, Jung-Ah Lee, Yvette Bojorquez, Michele Silva, Ellen Olshansky
BACKGROUND: MOMS Orange County is a coordinated home visitation program in which trained paraprofessional home visitors work under the close supervision of registered nurses. This model was developed to address health disparities in birth outcomes in a Hispanic community in Orange County, CA. PURPOSE: The primary objective was to test the impact of MOMS Orange County on birth outcomes. The second objective was to examine the breadth of prenatal health education topics as a mediator of the relationship between home visits and birth outcomes...
January 2016: MCN. the American Journal of Maternal Child Nursing
Jun-Ah Song, Younjae Oh
Behavioral and psychological symptoms of dementia (BPSD) are sources of psychological distress for caregivers who take care of people with dementia. The purpose of this study was to examine the association between BPSD and the burden on formal caregivers of nursing homes in South Korea. Results showed that the total severity score of BPSD had a statistically significant positive correlation with the total distress score. Agitation/Aggression was the most distressing symptom for registered nurses and care workers...
October 2015: Archives of Psychiatric Nursing
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