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membrano proliferative

Prasenjit Das, Ramakant Rawat, Anil K Verma, Geetika Singh, Archana G Vallonthaiel, Rajni Yadav, Gaurav P S Gahlot, Amit K Dinda, Vineet Ahuja, Siddhartha Datta Gupta, Sanjay K Agarwal, Govind K Makharia
Tissue transglutaminase 2 enzyme plays a diverse role in intracellular and extracellular functioning. Aberrant expression of anti-TG2 antibody has recently been proposed for extraintestinal identification of celiac disease (CeD), but its utility is questionable. To examine whether anti-TG2 immunohistochemical (IHC) staining can be of diagnostic value in identifying extraintestinal involvement in CeD, tissue blocks of patients with IgA nephropathies (IgAN), minimal change disease, membranous glomerulonephritis, membrano-proliferative glomerulonephritis, normal kidney, intestinal biopsies from CeD, tropical sprue, nonspecific duodenitis, and inflammatory bowel disease; liver biopsies from patients with chronic hepatitis B and C, acute liver failure (ALF), and CeD-associated liver diseases were retrieved and subjected to IHC staining for anti-tissue transglutaminase 2 enzyme...
October 7, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
Corinne Isnard Bagnis, Patrice Cacoub
Renal patients are overexposed to hepatitis C virus (HCV) infection. Hepatitis C virus infection may induce renal disease, i.e., cryoglobulinemic membrano-proliferative glomerulopathy and non-cryoglobulinemic nephropathy. Hepatitis C virus impacts general outcomes in chronic kidney disease, dialysis or transplanted patients. Hepatitis C virus infection is now about to be only part of their medical history thanks to new direct acting antiviral drugs exhibiting as much as over 95% of sustained virological response...
September 2016: Infectious Diseases and Therapy
L Cañas, D López, J F Pérez, I Bancu, J Juega, A Ariza, J Bonet, R Lauzurica
BACKGROUND: Post-transplant recurrent glomerulonephritis (RGN) is the third cause of graft failure in the first year after renal transplantation (RT). The purpose of this study was to analyze the incidence of RGN, clinical presentation, and clinical evolution of transplanted renal graft in patients who underwent RT at our center. METHODS: We studied patients with glomerulonephritis (GN) who underwent RT (2007 to 2013).We analyzed sex, age, time in dialysis, type of GN, type of RT, time to post-transplant RGN, kidney function at the time of diagnosis of RGN, and renal graft evolution...
October 2015: Transplantation Proceedings
Cesare Mazzaro, Giacomo Panarello, Endri Mauro, Valter Gattei, Gabriele Pozzato
BACKGROUND: The most frequent form of renal involvement in patients with hepatitis C infection is cryoglobulinemic membrano-proliferative glomerulonephritis. Nonetheless, some reports indicate that the eradication of the hepatitis C virus may also lead to the remission of this renal disease. METHODS: The virological, immunological and nephrological response to pegylated interferon α plus ribavirin (48 weeks in patients infected with genotype 1, and 24 weeks for patients infected with genotypes 2 and 3) was evaluated retrospectively in 10 patients with cryoglobulinemic glomerulonephritis...
July 2015: Digestive and Liver Disease
Rapur Ram, Peddi Sandeep, Annapindi Venkatasatya Surya Naga Sridhar, Nandyala Rukumangadha, Vishnubotla Sivakumar
The reports of glomerular lesions of kidney due to tuberculosis are sparse. A 48-year-old gentleman, presented with swelling of feet of 3 months duration. As he had renal impairment, proteinuria and normal-sized kidneys, he was subjected to renal biopsy. The light microscopy and immunofluorescence revealed the diagnosis was membrano-proliferative glomerulonephritis. During hospital stay, the patient complained fever and stiffness at thoracic spine. The MRI of thoraco-lumbo-sacral spine revealed paravertebral abscess at D11-D12...
August 2014: Clinical Kidney Journal
C Yuste, M Rapalai, B A Pritchard, T J Jones, B Tucker, S B Ramakrishna
We present a case report of a 37-year-old woman with multiple sclerosis (MS) who developed nephrotic-range proteinuria secondary to membrano proliferative glomerulonephritis (MPGN)-like disease with mesangial C3 deposition without evidence of immune-complex deposition in the context of long-term interferon-β (IFN-β) therapy. The complete remission of proteinuria following cessation of IFN-β, strongly suggests causality. To our knowledge, this is the second case report of MPGN associated with IFN-β use. This being the case, the negative immune screen, normal inflammatory markers and the absence of immune complex deposits would imply a different pathway to that previously suggested...
April 2014: Clinical Kidney Journal
(no author information available yet)
OBJECTIVE: To investigate the treatment of multi-center hospitalized children with steroid resistant nephrotic syndrome (SRNS) retrospectively. METHOD: The Subspecialty Group of Nephrology, The Society of Pediatrics, Chinese Medical Association organized 35 hospitals to investigate children with primary SRNS from 2008 to 2011. By filling in the questionnaire, data including age, gender, clinical type, related examination, pathology and treatment in local hospitals were collected, and then statistical analysis was performed...
July 2014: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
F Fabrizi, F Donato, P Messa
The association between hepatitis C virus (HCV) infection and chronic kidney disease (CKD) is well established and remains an area of intense research. HCV infection is associated with a large spectrum of histo-pathological lesions in both native and transplanted kidneys. The frequency of kidney damage in HCV-infected patients appears low even if is not fully detailed. The most frequent HCV-associated renal lesion is type I membrano-proliferative glomerulonephritis, usually in the context of type II mixed cryoglobulinemia...
June 2014: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Cristiana Rollino
C3 glomerulopathy includes C3 glomerulonephritis, Dense Deposit Disease, Factor H-Related Protein 5 (CFHR5) nephropathy and most atypical acute postinfectious glomerulonephritis. The characteristic of this nephropathy is C3 deposits without immunoglobulins. Light microscopy pattern can be mesangial proliferative or membrano-proliferative. A dysregulation of complement is at the base of the disease: acquired changes (autoantibodies anti-C3 convertase -C3 Nephritic Factor-, anti-factor H, I or B) or genetic changes (mutations of factors B, H, I, or 1-5 Factor H-related proteins) are found...
January 2014: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Fabrizio Fabrizi, Alessio Aghemo, Gabriella Moroni, Patrizia Passerini, Roberta D'Ambrosio, Paul Martin, Piergiorgio Messa
No abstract text is available yet for this article.
March 2014: Digestive Diseases and Sciences
Z Nawaz, F Mushtaq, D Mousa, E Rehman, M Sulaiman, N Aslam, N Khawaja
Glomerular diseases continue to be the leading cause of end-stage renal disease (ESRD) globally. Hence, it is important to recognize the pattern of glomerular diseases in different geographical areas in order to understand the patho-biology, incidence and progression of the disorder. Published studies from different centers in Saudi Arabia have reported contradicting results. In this retrospective study, we report our experience at the Armed Forces Hospital, Riyadh, Saudi Arabia. A total of 348 native renal biopsies performed at our center on patients with proteinuria >1 g, hematuria and/or renal impairment during a period of 5 years (between January 2005 and December 2009) were studied by a histopathologist using light microscopy, immunofluorescence and electron microscopy, and were categorized...
November 2013: Saudi Journal of Kidney Diseases and Transplantation
W K Nadium, H H Abdelwahab, M A Ibrahim, M M Shigidi
In Sudan, like most developing countries, the incidence and histologic patterns of primary glomerulonephritis (GN) remains undetermined. A cross-sectional hospital-based prospective study was performed to determine the pattern of primary GN among adult Sudanese patients. The study was conducted at Khartoum Teaching Hospital from September 2010 to August 2011. It included all adult patients with suspected primary glomerular disease and who underwent native kidney biopsy. A total of 83 adult patients were biopsied with 71 patients (85...
May 2013: Indian Journal of Nephrology
R Rodrigo, N Atapattu, K S H de Silva
No abstract text is available yet for this article.
March 2013: Ceylon Medical Journal
Krishan L Gupta, K G Rajaram, Kusum Joshi, Vinay Sakhuja
Invasive aspergillosis is a serious complication in renal transplant recipients. Hepatic involvement, although seen in liver transplant recipients, has not been reported following renal transplantation. We describe here an interesting occurrence of hepatic Aspergillus infection in a renal transplant recipient. The infection responded to anti-fungal therapy, but there was re-activation following a second renal transplant. In addition, the patient had recurrence of the underlying membrano-proliferative glomerulonephritis following both transplants...
October 2012: Indian Journal of Pathology & Microbiology
Maria Francesca Donato, Giovanni Banfi, Donata Cresseri, G Battista Fogazzi, Paul Martin, Piergiorgio Messa, Fabrizio Fabrizi
Hepatitis C virus (HCV) infection may be associated with extra-hepatic illness including mixed cryoglobulinemia (MC). Consistent evidence exists on HCV-MC in the non-transplantation setting but information on HCV-related cryoglobulinemia after solid organ transplantation is limited, particularly after liver transplantation (LT). We report on a 48-year-old man who developed HCV-associated cryoglobulinemic vasculitis with recurrent hepatitis after liver transplant. One year after transplant for HCV-positive 
cirrhosis, he presented severe cutaneous manifestations, and biopsy-proven cryoglobulinemic membrano-proliferative glomerulonephritis (MPGN)...
May 17, 2013: International Journal of Artificial Organs
Li Zhuo, Guming Zou, Wenge Li, Jianhua Lu, Wenwen Ren
BACKGROUND: The incidence of diabetes mellitus (DM) and diabetic nephropathy (DN) have risen rapidly in the past few decades and have become an economic burden to the healthcare system in China. DN is a major complication of DM and is a leading cause of end-stage renal disease (ESRD). The occurrence of non-diabetic renal disease (NDRD) in diabetic patients has been increasingly recognized in recent years. It is generally believed that it is difficult to reverse DN, whereas some cases of NDRD are readily treatable and remittable...
2013: European Journal of Medical Research
Maria Paola Canale, Valentina Rovella, Emiliano Staffolani, Natascia Miani, Maria Silvia Borzacchi, Konstantinos Giannakakis, Annalisa Noce, Nicola Di Daniele
We report the case of a 34-year-old black African hypertensive woman who presented with nephrotic proteinuria, mild renal failure and abdominal bruits on physical examination. The renal Doppler ultrasound revealed bilateral artery stenosis. Thoracoabdominal aortic nuclear magnetic resonance showed a restriction of proximal descending aorta with post-stenotic spindle dilation while abdominal aorta and iliac vessels appeared diffusely stenotic with atherosclerotic plaques and infrequent spindle dilations and right ostial renal artery stenosis...
December 2012: Archivio Italiano di Urologia, Andrologia
Margret E Bock, Richard A Cohn, Farah N Ali
AIM: Children with steroidresistant (SR) and steroid-dependent (SD) nephrotic syndrome (NS) pose a treatment challenge. Literature on the use of tacrolimus (TAC), a calcineurin inhibitor, for maintenance treatment of NS is sparse. We aimed to evaluate the efficacy and safety of low-dose, long-term TAC for inducing and sustaining remission in children with SD/SR NS. METHODS: Data from patients treated at our center from 1999 to 2009 were analyzed. RESULTS: 40 patients with NS were treated with TAC for 3 - 80-month periods (median 25...
June 2013: Clinical Nephrology
Maria Francesca Donato, Fabrizio Fabrizi, Giovanni Battista Fogazzi, Donata Cresseri, Patrizia Passerini, Paul Martin, Piergiorgio Messa
BACKGROUND: Hepatitis C virus infection is associated with a variety of extrahepatic disorders such as membrano-proliferative glomerulonephritis, which is generally due to cryoglobulinemia. 
 SETTING: We describe the case of one liver transplant recipient who received antiviral therapy (subcutaneous administration of peg-IFN-alpha-2a 180 mcg weekly and oral ribavirin 200 mg thrice a day) 
for HCV-related membrano-proliferative glomerulonephritis. He presented normal kidney function, non-nephrotic proteinuria (2 g/24 h) and mild hematuria...
January 2013: International Journal of Artificial Organs
N Mittal, R Bansal, R Nada, R Minz, M Minz, K Joshi
The morphological spectrum of light chain deposition disease (LCDD) may range from normal glomerular morphology to mesangio-proliferative to mesangio-capillary to nodular sclerosing patterns. Due to the inconsistencies regarding treatment and the universally poor graft outcome of post-transplant LCDD, it is imperative to maintain a high index of suspicion and perform relevant investigations for clinching this diagnosis. A 40-year-old lady was diagnosed as a case of membrano-proliferative glomerulonephritis 3 years back, for which she underwent a live unrelated renal allograft transplant...
May 2012: Indian Journal of Nephrology
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