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https://www.readbyqxmd.com/read/27433836/identification-of-telomerase-activating-blends-from-naturally-occurring-compounds
#1
Ghania Ait-Ghezala, Samira Hassan, Miles Tweed, Daniel Paris, Gogce Crynen, Zuchra Zakirova, Stefan Crynen, Fiona Crawford
Context • Telomeres are repeated deoxyribonucleic acid (DNA) sequences (TTAGGG) that are located on the 5' ends of chromosomes, and they control the life span of eukaryotic cells. Compelling evidence has shown that the length of a person's life is dictated by the limited number of times that a human cell can divide. The enzyme telomerase has been shown to bind to and extend the length of telomeres. Thus, strategies for activating telomerase may help maintain telomere length and, thus, may lead to improved health during aging...
June 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/26561078/chlorella-vulgaris-a-multifunctional-dietary-supplement-with-diverse-medicinal-properties
#2
REVIEW
Yunes Panahi, Behrad Darvishi, Narges Jowzi, Fatemeh Beiraghdar, Amirhossein Sahebkar
Chlorella vulgaris is a green unicellular microalgae with biological and pharmacological properties important for human health. C. vulgaris has a long history of use as a food source and contains a unique and diverse composition of functional macro- and micro-nutrients including proteinsChlorella vulgaris is a green unicellular microalgae with biological and pharmacological properties important for human health. C. vulgaris has a long history of use as a food source and contains a unique and diverse composition of functional macro- and micro-nutrients including proteins, omega-3 polyunsaturated fatty acids, polysaccharides, vitamins and minerals...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/25770318/antineoplastic-effects-of-chlorella-pyrenoidosa-in-the-breast-cancer-model
#3
Peter Kubatka, Andrea Kapinová, Peter Kružliak, Martin Kello, Desanka Výbohová, Karol Kajo, Miroslav Novák, Martina Chripková, Marián Adamkov, Martin Péč, Ján Mojžiš, Bianka Bojková, Monika Kassayová, Nadežda Stollárová, Dušan Dobrota
OBJECTIVES: There has been considerable interest in both clinical and preclinical research about the role of phytochemicals in the reduction of risk for cancer in humans. The aim of this study was to determine the antineoplastic effects of Chlorella pyrenoidosa in experimental breast cancer in vivo and in vitro. METHODS: In this experiment, the antineoplastic effects of C. pyrenoidosa in the chemoprevention of N-methyl-N-nitrosourea-induced mammary carcinogenesis in female rats were evaluated...
April 2015: Nutrition
https://www.readbyqxmd.com/read/25666175/tamoxifen-ecotoxicity-and-resulting-risks-for-aquatic-ecosystems
#4
Frédéric Orias, Sylvie Bony, Alain Devaux, Claude Durrieu, Marion Aubrat, Thibault Hombert, Adriana Wigh, Yves Perrodin
Tamoxifen, a drug used to treat cancer, is regularly found in hydrosystems at concentrations of several hundred ng L(-1). To characterize its ecotoxicity, we implemented a battery of bioassays on organisms belonging to 3 different trophic levels: Pseudokirchneriella subcapitata, Chlorella vulgaris and Chlamydomonas reinhardtii, for primary producers, Daphnia magna (immobilization, grazing and reproduction) for primary consumers, and Danio rerio for secondary consumers (embryotoxicity test). In view of the results obtained and the ecotoxicity values of tamoxifen available in the literature, we established a PNEC (Predictive No Effect Concentration) equal to 81 ng L(-1) for continental water...
June 2015: Chemosphere
https://www.readbyqxmd.com/read/25169524/application-of-biosynthesized-silver-nanoparticles-against-a-cancer-promoter-cyanobacterium-microcystis-aeruginosa
#5
Mostafa Mohamed El-Sheekh, Hala Yassin El-Kassas
BACKGROUND: Nanotechnology opens new applications in many fields including medicine. Among all metallic nanoparticles, silver nanoparticles (silver NPS) have proved to be the most effective against a large variety of organisms including toxic cyanobacteria. MATERIALS AND METHODS: Silver NPs were biosynthesized in vivo with different alga species namely, Spirulina platensis, Chlorella vulgaris and Scenedesmus obliquus following two scenarios. First: by suspending a thoroughly washed algae biomass in 1 mM aqueous AgNO3 solution...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25130499/rapid-one-step-purification-of-single-cells-encapsulated-in-alginate-microcapsules-from-oil-to-aqueous-phase-using-a-hydrophobic-filter-paper-implications-for-single-cell-experiments
#6
Do-Hyun Lee, Miran Jang, Je-Kyun Park
By virtue of the biocompatibility and physical properties of hydrogel, picoliter-sized hydrogel microcapsules have been considered to be a biometric signature containing several features similar to that of encapsulated single cells, including phenotype, viability, and intracellular content. To maximize the experimental potential of encapsulating cells in hydrogel microcapsules, a method that enables efficient hydrogel microcapsule purification from oil is necessary. Current methods based on centrifugation for the conventional stepwise rinsing of oil, are slow and laborious and decrease the monodispersity and yield of the recovered hydrogel microcapsules...
October 2014: Biotechnology Journal
https://www.readbyqxmd.com/read/25073513/effect-of-lycopene-isolated-from-chlorella-marina-on-proliferation-and-apoptosis-in-human-prostate-cancer-cell-line-pc-3
#7
G L Renju, G Muraleedhara Kurup, Venkata Reddy Bandugula
Even though the role of lycopene from tomato (trans form) in controlling prostate cancer was reported, lycopene (cis and trans 60:40) isolated from green algae Chlorella marina was not reported so far. The present study aimed to assess the anti-proliferative and apoptotic effect of lycopene from a new source and to compare the activity with available trans lycopene by using androgen-independent human prostate cancer cell lines. Exposure of PC-3 and DU-145 cell lines to algal lycopene (AL) at a dose of 20 and 50 μM significantly inhibited the growth and colony formation, and the percentage of inhibition was higher than tomatal lycopene (TL)-treated groups...
November 2014: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/25020149/potential-of-fluorescence-imaging-techniques-to-monitor-mutagenic-pah-uptake-by-microalga
#8
Suresh Ramraj Subashchandrabose, Kannan Krishnan, Enrico Gratton, Mallavarapu Megharaj, Ravi Naidu
Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is one of the major environmental pollutants that causes mutagenesis and cancer. BaP has been shown to accumulate in phytoplankton and zooplankton. We have studied the localization and aggregation of BaP in Chlorella sp., a microalga that is one of the primary producers in the food chain, using fluorescence confocal microscopy and fluorescence lifetime imaging microscopy with the phasor approach to characterize the location and the aggregation of BaP in the cell...
August 19, 2014: Environmental Science & Technology
https://www.readbyqxmd.com/read/24799942/the-influence-of-chlorella-and-its-hot-water-extract-supplementation-on-quality-of-life-in-patients-with-breast-cancer
#9
Naoto Noguchi, Isao Maruyama, Akira Yamada
A self-control, randomized, and open-label clinical trial was performed to test the effects of the unicellular green algae Chlorella and hot water extract supplementation on quality of life (QOL) in patients with breast cancer. Forty-five female patients with breast cancer who were living at home and not hospitalized were randomly assigned to 3 groups receiving vitamin mix tablet (control), Chlorella granules (test food-1), or Chlorella extract drink (test food-2) daily for one month. The Functional Assessment of Cancer Therapy-Breast (FACT-B), the Izumo scale for abdominal symptom-specific QOL, and a narrative-form questionnaire were used to determine outcomes...
2014: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/24660471/phomopsolides-and-related-compounds-from-the-alga-associated-fungus-penicillium-clavigerum
#10
Andrea A Stierle, Donald B Stierle, Grant G Mitman, Shea Snyder, Christophe Antczak, Hakim Djaballah
For the past fifteen years we have studied the secondary metabolites of extremophilic fungi from the Berkeley Pit, an abandoned acid mine waste lake. Fungi associated with an acid-tolerant alga have also been harvested from the Pit. Penicillium clavigerum Demelius was isolated from the green alga Chlorella vulgaris Beyerinck [Beijerinck]. In culture it produced the known compounds phomfuranone (1), patulin (2), dimethylphthalides (3) and (4), phomopsolide A (5), phomopsolide C (6), phomopsolide B (7), phomopsolide E (8), phomopsolide F (9), and phompyrone (10) and the new compound berkbenzofuran thioester (11)...
January 2014: Natural Product Communications
https://www.readbyqxmd.com/read/24347763/evaluation-of-antiangiogenic-and-antiproliferative-potential-of-the-organic-extract-of-green-algae-chlorella-pyrenoidosa
#11
Mahender Kyadari, Tasneem Fatma, Rajvardhan Azad, Thirumurthy Velpandian
OBJECTIVE: algae isolates obtained from fresh and marine resources could be one of the richest sources of novel bioactive secondary metabolites expected to have pharmaceutical significance for new drug development. This study was conducted to evaluate the antiangiogenic and antiproliferative activity of Chlorella pyrenoidosa in experimental models of angiogenesis and by MTT assay. MATERIALS AND METHODS: lyophilized extract of C. pyrenoidosa was extracted using dichloromethane/methanol (2:1), concentrated and vacuum evaporated to obtain the dried extract...
November 2013: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/24012530/proteomic-approach-for-identifying-gonad-differential-proteins-in-the-oyster-crassostrea-angulata-following-food-chain-contamination-with-hgcl2
#12
Qing-Hong Zhang, Lin Huang, Yong Zhang, Cai-Huan Ke, He-Qing Huang
UNLABELLED: Hg discharged into the environmental waters can generally be bioaccumulated, transformed and transmited by living organisms, thus resulting in the formation of Hg-toxicity food chains. The pathway and toxicology of food chain contaminated with environmental Hg are rarely revealed by proteomics. Here, we showed that differential proteomics had the potential to understand reproduction toxicity mechanism in marine molluscs through the Hg-contaminated food chain. Hg bioaccumulation was found in every link of the HgCl2-Chlorella vulgaris-oyster-mice food chain...
December 6, 2013: Journal of Proteomics
https://www.readbyqxmd.com/read/23865357/investigation-of-the-effects-of-chlorella-vulgaris-supplementation-on-the-modulation-of-oxidative-stress-in-apparently-healthy-smokers
#13
Yunes Panahi, Babak Mostafazadeh, Alireza Abrishami, Alireza Saadat, Fatemeh Beiraghdar, Sasan Tavana, Bahram Pishgoo, Shahram Parvin, Amirhossein Sahebkar
BACKGROUND: Smoking is among the established yet modifiable risk factors for cancers, cardiovascular diseases, and pulmonary disorders. Oxidative stress has been proposed as a key mechanism mediating the deleterious consequences of smoking. The present study evaluated the effect of supplementation with Chlorella vulgaris, a nutrient and bioactive green microalgae with proven antioxidant capacity, on the burden of oxidative stress in Iranian smokers. METHODS: Thirty-eight smokers (mean age: 37...
2013: Clinical Laboratory
https://www.readbyqxmd.com/read/23606619/separation-antitumor-activities-and-encapsulation-of-polypeptide-from-chlorella-pyrenoidosa
#14
Xiaoqin Wang, Xuewu Zhang
Chlorella pyrenoidosa is a unicellular green algae and has been a popular foodstuff worldwide. However, no reports on the antitumor peptides from such a microalgae are available in the literature. In this study, using low-temperature high-pressure extraction, enzymatic hydrolysis, ion exchange, and gel filtration chromatography, we separated a polypeptide that exhibited inhibitory activity on human liver cancer HepG2 cells, and named the polypeptide CPAP (C. pyrenoidosa antitumor polypeptide). Furthermore, the micro- and nanoencapsulation of CPAP were investigated by using two methods: complex coacervation and ionotropic gelation...
May 2013: Biotechnology Progress
https://www.readbyqxmd.com/read/23495251/separation-antitumor-activities-and-encapsulation-of-polypeptide-from-chlorella-pyrenoidosa
#15
Xiaoqin Wang, Xuewu Zhang
Chlorella pyrenoidosa is an unicellular green algae and has been a popular foodstuff worldwide. However, no reports on the antitumor peptides from such a microalgae are available in the literature. In this study, using low-temperature high-pressure extraction, enzymatic hydrolysis, ion exchange and gel filtration chromatography, we separated a polypeptide that exhibited inhibitory activity on human liver cancer HepG2 cells, and named the polypeptide CPAP (Chlorella pyrenoidosa antitumor polypeptide). Furthermore, the micro- and nanoencapsulation of CPAP were investigated by using two methods: complex coacervation and ionotropic gelation...
March 13, 2013: Biotechnology Progress
https://www.readbyqxmd.com/read/23436171/total-and-inorganic-arsenic-in-dietary-supplements-based-on-herbs-other-botanicals-and-algae-a-possible-contributor-to-inorganic-arsenic-exposure
#16
Rikke V Hedegaard, Inge Rokkjær, Jens J Sloth
The content of total and inorganic arsenic was determined in 16 dietary supplements based on herbs, other botanicals and algae purchased on the Danish market. The dietary supplements originated from various regions, including Asia, Europe and USA. The contents of total and inorganic arsenic was determined by inductively coupled plasma mass spectrometry (ICP-MS) and anion exchange HPLC-ICP-MS, respectively, were in the range of 0.58 to 5.0 mgkg(-1) and 0.03 to 3.2 mg kg(-1), respectively, with a ratio between inorganic arsenic and total arsenic ranging between 5 and 100%...
May 2013: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/22983174/gene-transfer-of-chlorella-vulgaris-n-3-fatty-acid-desaturase-optimizes-the-fatty-acid-composition-of-human-breast-cancer-cells
#17
Meilan Xue, Yinlin Ge, Jinyu Zhang, Qing Wang, Lin Hou
Chlorella vulgaris has the gene of n-3 fatty acid desaturase (CvFad3), which can synthesize the precursor of n-3 polyunsaturated fatty acids (PUFAs) or convert n-6 to n-3 PUFAs. The objective of the present study was to examine whether the CvFad3 gene from C. vulgaris can be functionally and efficiently expressed in human breast cancer cells and whether its expression can exert a significant effect on cell fatty acid composition. We inserted the CvFad3 gene into the plasmid pEGFP-C3 to construct the eukaryotic expression vector pEGFP-C3-n-3 and to express the n-3 Fad gene in human breast cancer cells (MCF-7 cells)...
December 2012: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/21340229/hot-water-extract-of-chlorella-vulgaris-induced-dna-damage-and-apoptosis
#18
Yasmin Anum Mohd Yusof, Suhana Md Saad, Suzana Makpol, Nor Aripin Shamaan, Wan Zurinah Wan Ngah
OBJECTIVES: The aim of this study was to determine the antiproliferative and apoptotic effects of hot water extracts of Chlorella vulgaris on hepatoma cell line HepG2. INTRODUCTION: The search for food and spices that can induce apoptosis in cancer cells has been a major study interest in the last decade. Chlorella vulgaris, a unicellular green algae, has been reported to have antioxidant and anti-cancer properties. However, its chemopreventive effects in inhibiting the growth of cancer cells have not been studied in great detail...
2010: Clinics
https://www.readbyqxmd.com/read/21307952/prospects-for-skin-cancer-treatment-and-prevention-the-potential-contribution-of-an-engineered-virus
#19
COMMENT
Jennifer A Cafardi, Rubina Shafi, Mohammad Athar, Craig A Elmets
Nonmelanoma skin cancers are among the most common human malignancies. Although typically not lethal, they are responsible for tissue deformity and substantial morbidity, particularly in high-risk populations. Solar UVB radiation-a major etiologic factor for this kind of malignancy-produces DNA lesions such as cyclobutane pyrimidine dimers and 6-4 photoproducts in skin. These lesions are removed through nucleotide excision repair because humans lack a DNA glycosylase required to initiate base excision repair of pyrimidine-pyrimidine photoproducts but produce all the other proteins required for this process...
March 2011: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/21207519/potential-health-promoting-effects-of-astaxanthin-a-high-value-carotenoid-mostly-from-microalgae
#20
REVIEW
Jian-Ping Yuan, Juan Peng, Kai Yin, Jiang-Hai Wang
The ketocarotenoid astaxanthin can be found in the microalgae Haematococcus pluvialis, Chlorella zofingiensis, and Chlorococcum sp., and the red yeast Phaffia rhodozyma. The microalga H. pluvialis has the highest capacity to accumulate astaxanthin up to 4-5% of cell dry weight. Astaxanthin has been attributed with extraordinary potential for protecting the organism against a wide range of diseases, and has considerable potential and promising applications in human health. Numerous studies have shown that astaxanthin has potential health-promoting effects in the prevention and treatment of various diseases, such as cancers, chronic inflammatory diseases, metabolic syndrome, diabetes, diabetic nephropathy, cardiovascular diseases, gastrointestinal diseases, liver diseases, neurodegenerative diseases, eye diseases, skin diseases, exercise-induced fatigue, male infertility, and HgCl₂-induced acute renal failure...
January 2011: Molecular Nutrition & Food Research
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