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https://www.readbyqxmd.com/read/29760207/association-of-mycobacterium-proteins-to-lipid-droplets
#1
Richard M Armstrong, Dominique C Carter, Samantha N Atkinson, Scott S Terhune, Thomas C Zahrt
Mycobacterium tuberculosis is a global pathogen of significant medical importance. A key aspect of its lifecycle is the ability to enter into an altered physiological state of non-replicating persistence during latency and resist elimination by the host immune system. One mechanism by which M. tuberculosis facilitates its survival during latency is by producing and metabolizing intracytoplasmic lipid droplets (LDs). LDs are semi-quasi organelles consisting of a neutral lipid core such as triacylglycerol surrounded by a phospholipid monolayer and proteins...
May 14, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29576591/role-of-phage-shock-protein-in-recovery-of-heat-injured-salmonella
#2
Xiaowen Cui, Hsu-Ming Sherman Wen, Yoshimasa Kinoshita, Shota Koishi, Chika Isowaki, Liushu Ou, Yoshimitsu Masuda, Ken-Ichi Honjoh, Takahisa Miyamoto
 Sublethally heat-injured cells of Salmonella in food can recover under favorable conditions, leading to foodborne illness. To elucidate the molecular mechanism of recovery from heat injury, the global changes in gene transcription of Salmonella Typhimurium were investigated in previous study. In this study, the functions of genes involved in phage shock response (viz., phage shock protein (psp) genes), the transcription levels of which were found in previous study to be increased during recovery from heat injury, were investigated in recovering cells...
2018: Biocontrol Science
https://www.readbyqxmd.com/read/29488183/variations-on-a-theme-evolution-of-the-phage-shock-protein-system-in-actinobacteria
#3
Janani Ravi, Vivek Anantharaman, L Aravind, Maria Laura Gennaro
The phage shock protein (Psp) stress-response system protects bacteria from envelope stress through a cascade of interactions with other proteins and membrane lipids to stabilize the cell membrane. A key component of this multi-gene system is PspA, an effector protein that is found in diverse bacterial phyla, archaea, cyanobacteria, and chloroplasts. Other members of the Psp system include the cognate partners of PspA that are part of known operons: pspF||pspABC in Proteobacteria, liaIHGFSR in Firmicutes, and clgRpspAMN in Actinobacteria...
May 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29018419/gene-expression-response-of-salmonella-enterica-serotype-enteritidis-phage-type-8-to-subinhibitory-concentrations-of-the-plant-derived-compounds-trans-cinnamaldehyde-and-eugenol
#4
Anup Kollanoor Johny, Jonathan G Frye, Annie Donoghue, Dan J Donoghue, Steffen Porwollik, Michael McClelland, Kumar Venkitanarayanan
Background: Salmonella Enteritidis phage type 8 (PT8) is a major poultry-associated Salmonella strain implicated in foodborne outbreaks in the United States. We previously reported that two plant-derived compounds generally recognized as safe (GRAS), trans -cinnamaldehyde (TC), and eugenol (EG), significantly reduced S . Enteritidis colonization in broiler and layer chickens. To elucidate potential PT8 genes affected by TC and EG during colonization, a whole-genome microarray analysis of the bacterium treated with TC and EG was conducted...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28979244/lactobacillus-casei-bl23-produces-microvesicles-carrying-proteins-that-have-been-associated-with-its-probiotic-effect
#5
A Paula Domínguez Rubio, Jimena H Martínez, Diana C Martínez Casillas, Federico Coluccio Leskow, Mariana Piuri, Oscar E Pérez
Archaea, bacteria, and eukarya secrete membrane microvesicles (MVs) as a mechanism for intercellular communication. We report the isolation and characterization of MVs from the probiotic strain Lactobacillus casei BL23. MVs were characterized using analytical high performance techniques, DLS, AFM and TEM. Similar to what has been described for other Gram-positive bacteria, MVs were on the nanometric size range (30-50 nm). MVs carried cytoplasmic components such as DNA, RNA and proteins. Using a proteomic approach (LC-MS), we identified a total of 103 proteins; 13 exclusively present in the MVs...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28922502/the-three-component-system-esrisr-regulates-a-cell-envelope-stress-response-in-corynebacterium-glutamicum
#6
Britta Kleine, Ava Chattopadhyay, Tino Polen, Daniela Pinto, Thorsten Mascher, Michael Bott, Melanie Brocker, Roland Freudl
When the cell envelope integrity is compromised, bacteria trigger signaling cascades resulting in the production of proteins that counteract these extracytoplasmic stresses. Here, we show that the two-component system EsrSR regulates a cell envelope stress response in the Actinobacterium Corynebacterium glutamicum. The sensor kinase EsrS possesses an amino-terminal phage shock protein C (PspC) domain, a property that sets EsrSR apart from all other two-component systems characterized so far. An integral membrane protein, EsrI, whose gene is divergently transcribed to the esrSR gene locus and which interestingly also possesses a PspC domain, acts as an inhibitor of EsrSR under non-stress conditions...
December 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28900025/psp-stress-response-proteins-form-a-complex-with-mislocalized-secretins-in-the-yersinia-enterocolitica-cytoplasmic-membrane
#7
Disha Srivastava, Amal Moumene, Josué Flores-Kim, Andrew J Darwin
The bacterial phage shock protein system (Psp) is a conserved extracytoplasmic stress response that is essential for the virulence of some pathogens, including Yersinia enterocolitica It is induced by events that can compromise inner membrane (IM) integrity, including the mislocalization of outer membrane pore-forming proteins called secretins. In the absence of the Psp system, secretin mislocalization permeabilizes the IM and causes rapid cell death. The Psp proteins PspB and PspC form an integral IM complex with two independent roles...
September 12, 2017: MBio
https://www.readbyqxmd.com/read/28588134/the-rcs-regulated-colanic-acid-capsule-maintains-membrane-potential-in-salmonella-enterica-serovar-typhimurium
#8
Jasmine M Pando, Joyce E Karlinsey, Jimmie C Lara, Stephen J Libby, Ferric C Fang
The Rcs phosphorelay and Psp (phage shock protein) systems are envelope stress responses that are highly conserved in gammaproteobacteria. The Rcs regulon was found to be strongly induced during metal deprivation of Salmonella enterica serovar Typhimurium lacking the Psp response. Nineteen genes activated by the RcsA-RcsB response regulator make up an operon responsible for the production of colanic acid capsular polysaccharide, which promotes biofilm development. Despite more than half a century of research, the physiological function of colanic acid has remained elusive...
June 6, 2017: MBio
https://www.readbyqxmd.com/read/28551403/chaperone-like-activity-of-synthetic-polyanions-can-be-higher-than-the-activity-of-natural-chaperones-at-elevated-temperature
#9
Pavel I Semenyuk, Lidia P Kurochkina, Nikolai B Gusev, Vladimir A Izumrudov, Vladimir I Muronetz
Polyelectrolytes are a prospective tool for protection of proteins against aggregation. We compared synthetic polyanion, poly(styrene sulfonate), and natural chaperones of different types, namely, GroEL-like chaperonin from Pseudomonas aeruginosa phage EL and human small heat shock protein HspB5 (αB-crystallin), in their ability to prevent aggregation of client proteins. At 45 °C, all three agents efficiently suppressed thermal aggregation of phage endolysin. At higher temperatures, HspB5 and poly(styrene sulfonate) also inhibited endolysin aggregation, though polyanion became less efficient than HspB5 at 55 °C and 60 °C...
July 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28505134/a-novel-roseosiphophage-isolated-from-the-oligotrophic-south-china-sea
#10
Yunlan Yang, Lanlan Cai, Ruijie Ma, Yongle Xu, Yigang Tong, Yong Huang, Nianzhi Jiao, Rui Zhang
The Roseobacter clade is abundant and widespread in marine environments and plays an important role in oceanic biogeochemical cycling. In this present study, a lytic siphophage (labeled vB_DshS-R5C) infecting the strain type of Dinoroseobacter shibae named DFL12T , which is part of the Roseobacter clade, was isolated from the oligotrophic South China Sea. Phage R5C showed a narrow host range, short latent period and low burst size. The genome length of phage R5C was 77, 874 bp with a G+C content of 61.5%. Genomic comparisons detected no genome matches in the GenBank database and phylogenetic analysis based on DNA polymerase I revealed phylogenetic features that were distinct to other phages, suggesting the novelty of R5C...
May 15, 2017: Viruses
https://www.readbyqxmd.com/read/27923541/protecting-from-envelope-stress-variations-on-the-phage-shock-protein-theme-trends-in-microbiology-25-first-page-en-dash-last-page-2017
#11
Riccardo Manganelli, Maria Laura Gennaro
No abstract text is available yet for this article.
December 3, 2016: Trends in Microbiology
https://www.readbyqxmd.com/read/27879679/hydrostatin-tl1-an-anti-inflammatory-active-peptide-from-the-venom-gland-of-hydrophis-cyanocinctus-in-the-south-china-sea
#12
Ningyuan Wang, Yan Huang, An Li, Hailong Jiang, Jie Wang, Jianzhong Li, Lei Qiu, Ka Li, Yiming Lu
Tumor necrosis factor (TNF)-α is a pleiotropic cytokine with intense pro-inflammatory and immunomodulatory properties, and anti-TNF-α biologics are effective therapies for various inflammatory diseases such as inflammatory bowel disease (IBD) and sepsis. Snake venom, as a traditional Chinese medicine, has been used in the treatment of inflammatory diseases in China for centuries. In this research, we constructed a venom gland T7 phage display library of the sea snake Hydrophis cyanocinctus to screen bioactive compounds that antagonize TNF-α and identified a novel nine-amino-acid peptide, termed hydrostatin-TL1 (H-TL1)...
November 22, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27865622/protecting-from-envelope-stress-variations-on-the-phage-shock-protein-theme
#13
REVIEW
Riccardo Manganelli, Maria Laura Gennaro
During envelope stress, critical inner-membrane functions are preserved by the phage-shock-protein (Psp) system, a stress response that emerged from work with Escherichia coli and other Gram-negative bacteria. Reciprocal regulatory interactions and multiple effector functions are well documented in these organisms. Searches for the Psp system across phyla reveal conservation of only one protein, PspA. However, examination of Firmicutes and Actinobacteria reveals that PspA orthologs associate with non-orthologous regulatory and effector proteins retaining functions similar to those in Gram-negative counterparts...
March 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/27806910/structure-and-function-of-pspa-and-vipp1-n-terminal-peptides-insights-into-the-membrane-stress-sensing-and-mitigation
#14
Christopher McDonald, Goran Jovanovic, B A Wallace, Oscar Ces, Martin Buck
The phage shock protein (Psp) response maintains integrity of the inner membrane (IM) in response to extracytoplasmic stress conditions and is widely distributed amongst enterobacteria. Its central component PspA, a member of the IM30 peripheral membrane protein family, acts as a major effector of the system through its direct association with the IM. Under non-stress conditions PspA also negatively regulates its own expression via direct interaction with the AAA+ ATPase PspF. PspA has a counterpart in cyanobacteria called Vipp1, which is implicated in protection of the thylakoid membranes...
January 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27698088/interactions-between-the-cytoplasmic-domains-of-pspb-and-pspc-silence-the-yersinia-enterocolitica-phage-shock-protein-response
#15
Josué Flores-Kim, Andrew J Darwin
The phage shock protein (Psp) system is a widely conserved cell envelope stress response that is essential for the virulence of some bacteria, including Yersinia enterocolitica Recruitment of PspA by the inner membrane PspB-PspC complex characterizes the activated state of this response. The PspB-PspC complex has been proposed to be a stress-responsive switch, changing from an OFF to an ON state in response to an inducing stimulus. In the OFF state, PspA cannot access its binding site in the C-terminal cytoplasmic domain of PspC (PspCCT ), because this site is bound to PspB...
December 15, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27678123/comparative-genome-analysis-of-the-daptomycin-resistant-streptococcus-anginosus-strain-j4206-associated-with-breakthrough-bacteremia
#16
Maliha Rahman, Scott V Nguyen, Kimberly A McCullor, Catherine J King, James H Jorgensen, W Michael McShan
Streptococcus anginosus is a member of the normal oral flora that can become a pathogen causing pyogenic infections in humans. The genome of daptomycin-resistant strain J4206, originally isolated from a patient suffering from breakthrough bacteremia and septic shock at the University of Texas Health Science Center at San Antonio, was determined. The circular genome is 2,001,352 bp long with a GC content of 38.62% and contains multiple mobile genetic elements, including the phage-like chromosomal island SanCI that mediates a mutator phenotype, transposons, and integrative conjugative elements...
December 31, 2016: Genome Biology and Evolution
https://www.readbyqxmd.com/read/27659529/induction-of-anti-egfr-immune-response-with-mimotopes-identified-from-a-phage-display-peptide-library-by-panitumumab
#17
Aidong Wang, Ming Cui, Hong Qu, Jiabo Di, Zaozao Wang, Jiadi Xing, Fan Wu, Wei Wu, Xicheng Wang, Lin Shen, Beihai Jiang, Xiangqian Su
The epidermal growth factor receptor (EGFR) is overexpressed in several epithelial tumors. Anti-EGFR humanized monoclonal antibodies, cetuximab and panitumumab, in combination with chemotherapy have improved the prognosis for patients with wild-type RAS tumors. To identify mimotopes of EGFR and develop mimotope-based EGFR vaccines, we screened a phage display peptide library with panitumumab. Two EGFR mimotopes P19 and P26, which could be recognized by panitumumab specifically, were isolated. To enhance the immune responses, we generated recombinant proteins of P19 or P26 fused to a heat-shock cognate protein 70 (Hsc70), and evaluated the efficacy of Hsc70-P19 and Hsc70-P26 as vaccines in vivo...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27643500/in-vitro-structural-and-functional-characterization-of-the-small-heat-shock-proteins-shsp-of-the-cyanophage-s-shm2-and-its-host-synechococcus-sp-wh7803
#18
Maxime Bourrelle-Langlois, Geneviève Morrow, Stéphanie Finet, Robert M Tanguay
We previously reported the in silico characterization of Synechococcus sp. phage 18 kDa small heat shock protein (HspSP-ShM2). This small heat shock protein (sHSP) contains a highly conserved core alpha crystalline domain of 92 amino acids and relatively short N- and C-terminal arms, the later containing the classical C-terminal anchoring module motif (L-X-I/L/V). Here we establish the oligomeric profile of HspSP-ShM2 and its structural dynamics under in vitro experimental conditions using size exclusion chromatography (SEC/FPLC), gradient native gels electrophoresis and dynamic light scattering (DLS)...
2016: PloS One
https://www.readbyqxmd.com/read/27583250/modulating-salmonella-typhimurium-s-response-to-a-changing-environment-through-bacterial-enhancer-binding-proteins-and-the-rpon-regulon
#19
REVIEW
Christine E Hartman, David J Samuels, Anna C Karls
Transcription sigma factors direct the selective binding of RNA polymerase holoenzyme (Eσ) to specific promoters. Two families of sigma factors determine promoter specificity, the σ(70) (RpoD) family and the σ(54) (RpoN) family. In transcription controlled by σ(54), the Eσ(54)-promoter closed complex requires ATP hydrolysis by an associated bacterial enhancer-binding protein (bEBP) for the transition to open complex and transcription initiation. Given the wide host range of Salmonella enterica serovar Typhimurium, it is an excellent model system for investigating the roles of RpoN and its bEBPs in modulating the lifestyle of bacteria...
2016: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/27297125/the-phage-shock-protein-response
#20
REVIEW
Josué Flores-Kim, Andrew J Darwin
The phage shock protein (Psp) system was identified as a response to phage infection in Escherichia coli, but rather than being a specific response to a phage, it detects and mitigates various problems that could increase inner-membrane (IM) permeability. Interest in the Psp system has increased significantly in recent years due to appreciation that Psp-like proteins are found in all three domains of life and because the bacterial Psp response has been linked to virulence and other important phenotypes. In this article, we summarize our current understanding of what the Psp system detects and how it detects it, how four core Psp proteins form a signal transduction cascade between the IM and the cytoplasm, and current ideas that explain how the Psp response keeps bacterial cells alive...
September 8, 2016: Annual Review of Microbiology
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