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Metastatic prostatic cancer clinical treatment

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https://www.readbyqxmd.com/read/29901632/alloreactive-cytotoxic-t-lymphocyte-immunotherapy-treatment-of-a-patient-with-metastatic-prostate-cancer-a-case-report
#1
Junfeng Shi, Yi Chen, Yuetong Chen, Yunzhu Shen, Huanyu Zhao, Hui Sun, Jinfei Chen
RATIONALE: Cytotoxic T lymphocyte (CTL) immunotherapy is an autologous cellular immune therapy that has been approved for treating patients with malignant tumors. However, there is still limited information regarding the impact of CTL on metastatic prostate cancer (PC) patients with bone metastatic lesions. PATIENT CONCERNS: An 82-year-old male patient complained of interrupted urination, urination pain, and significant dysuria on November 24, 2014. Transurethral resection of the prostate (TURP) and postoperative pathological examination showed prostatic adenocarcinoma, and a SPECT/CT scan demonstrated multiple bone metastases...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29900882/impact-of-taxanes-on-androgen-receptor-signaling
#2
REVIEW
Shanshan Bai, Bryan Y Zhang, Yan Dong
The development and progression of metastatic castration-resistant prostate cancer is the major challenge in the treatment of advanced prostate cancer. The androgen receptor signaling pathway remains active in metastatic castration-resistant prostate cancer. Docetaxel and cabazitaxel are the first- and second-line chemotherapy, respectively, for patients with metastatic castration-resistant prostate cancer. These two taxanes, in general, function by (i) inhibiting mitosis and inducing apoptosis and (ii) preventing microtubule-dependent cargo trafficking...
June 12, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29899810/gene-therapy-with-rala-inos-composite-nanoparticles-significantly-enhances-survival-in-a-model-of-metastatic-prostate-cancer
#3
Cian M McCrudden, John W McBride, Joanne McCaffrey, Emma M McErlean, Nicholas J Dunne, Vicky L Kett, Jonathan A Coulter, Tracy Robson, Helen O McCarthy
Background: Recent approvals of gene therapies by the FDA and the EMA for treatment of inherited disorders have further opened the door for assessment of nucleic acid pharmaceuticals for clinical usage. Arising from the presence of damaged or inappropriate DNA, cancer is a condition particularly suitable for genetic intervention. The RALA peptide has been shown to be a potent non-viral delivery platform for nucleic acids. This study examines the use of RALA to deliver a plasmid encoding inducible nitric oxide synthase (iNOS) as an anti-cancer treatment...
2018: Cancer Nanotechnology
https://www.readbyqxmd.com/read/29890702/cellular-and-molecular-mediators-of-bone-metastatic-lesions
#4
REVIEW
Giulia Battafarano, Michela Rossi, Francesco Marampon, Andrea Del Fattore
Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling activity, and displaying some features of bone cells. This interplay between tumor and bone cells alters the physiological bone remodeling, leading to the generation of a vicious cycle that promotes bone metastasis growth. To prevent the skeletal-related events (SRE) associated with bone metastasis, approaches to inhibit osteoclast bone resorption are reported...
June 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29887240/intratumor-heterogeneity-in-prostate-cancer
#5
REVIEW
Shalini S Yadav, Jennifer A Stockert, Victoria Hackert, Kamlesh K Yadav, Ashutosh K Tewari
Prostate cancer (PCa) has long been thought of as a disease with a heterogeneous phenotype. It can manifest in men as benign growths that can be safely watched or as more aggressive malignancies that can prove fatal. Recent investigations at the genomic, histopathological and molecular levels have identified tumor heterogeneity, the phenomenon of individual tumor cells presenting distinct genomic and phenotypic characteristics, as one of the most confounding and complex factors underlying PCa diagnosis, prognosis, and treatment...
June 7, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29882332/treatment-selection-for-men-with-metastatic-prostate-cancer-who-progress-on-upfront-chemo-hormonal-therapy
#6
Pedro Barata, Hamid Emamekhoo, Prateek Mendiratta, Vadim Koshkin, Allison Tyler, Moshe Ornstein, Brian I Rini, Timothy Gilligan, Christos Kyriakopoulos, Jorge A Gracia
BACKGROUND: Androgen deprivation therapy plus docetaxel (D-ADT) increases overall survival (OS) in men with high-volume, metastatic hormone-sensitive prostate cancer (mHSPC). Although the vast majority of men initially respond to D-ADT, most will progress and develop castration-resistant prostate cancer (CRPC). Little is known about the optimal treatment sequence for men with progressive disease on D-ADT. PATIENT AND METHODS: Retrospective analysis of consecutive mHSPC patients treated with ≥3 cycles of D-ADT at Cleveland Clinic and University of Wisconsin-Madison was undertaken...
June 7, 2018: Prostate
https://www.readbyqxmd.com/read/29880291/olaparib-combined-with-abiraterone-in-patients-with-metastatic-castration-resistant-prostate-cancer-a-randomised-double-blind-placebo-controlled-phase-2-trial
#7
Noel Clarke, Pawel Wiechno, Boris Alekseev, Nuria Sala, Robert Jones, Ivo Kocak, Vincenzo Emanuele Chiuri, Jacek Jassem, Aude Fléchon, Charles Redfern, Carsten Goessl, Joseph Burgents, Robert Kozarski, Darren Hodgson, Maria Learoyd, Fred Saad
BACKGROUND: Patients with metastatic castration-resistant prostate cancer and homologous recombination repair (HRR) mutations have a better response to treatment with the poly(ADP-ribose) polymerase inhibitor olaparib than patients without HRR mutations. Preclinical data suggest synergy between olaparib and androgen pathway inhibitors. We aimed to assess the efficacy of olaparib plus the androgen pathway inhibitor abiraterone in patients with metastatic castration-resistant prostate cancer regardless of HRR mutation status...
June 4, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29876010/concurrent-but-not-sequential-pd-1-blockade-with-a-dna-vaccine-elicits-anti-tumor-responses-in-patients-with-metastatic-castration-resistant-prostate-cancer
#8
Douglas G McNeel, Jens C Eickhoff, Ellen Wargowski, Christopher Zahm, Mary Jane Staab, Jane Straus, Glenn Liu
T-cell checkpoint inhibitors have demonstrated dramatic clinical activity against multiple cancer types, however little activity in patients with prostate cancer. Conversely, an anti-tumor vaccine was approved for the treatment of prostate cancer, having demonstrated an improvement in overall survival, despite few objective disease responses. In murine studies, we found that PD-1 expression on CD8+ T cells increased following anti-tumor vaccination, and that PD-1/PD-L1 blockade at the time of immunization elicited greater anti-tumor responses...
May 22, 2018: Oncotarget
https://www.readbyqxmd.com/read/29872559/rankl-blockade-improves-efficacy-of-pd1-pd-l1-blockade-or-dual-pd1-pd-l1-and-ctla4-blockade-in-mouse-models-of-cancer
#9
Elizabeth Ahern, Heidi Harjunpää, Jake S O'Donnell, Stacey Allen, William C Dougall, Michele W L Teng, Mark J Smyth
Receptor activator of NF-κB ligand (RANKL) and its receptor RANK, are members of the tumor necrosis factor and receptor superfamilies, respectively. Antibodies targeting RANKL have recently been evaluated in combination with anti-CTLA4 in case reports of human melanoma and mouse models of cancer. However, the efficacy of anti-RANKL in combination with antibodies targeting other immune checkpoint receptors such as PD1 has not been reported. In this study, we demonstrated that blockade of RANKL improves anti-metastatic activity of antibodies targeting PD1/PD-L1 and improves subcutaneous growth suppression in mouse models of melanoma, prostate and colon cancer...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29869454/treatment-of-oligometastatic-hormone-sensitive-prostate-cancer-a-comprehensive-review
#10
REVIEW
Kyo Chul Koo, Prokar Dasgupta
With advancements in diagnostic techniques, including molecular and clinical imaging, that directly target cancer cells, oligometastatic prostate cancer (PCa) is being diagnosed in patients who were, in the past, considered to have localized disease. With accumulating evidence, there has been a paradigm shift in considering aggressive treatments targeted at both the primary tumor and metastatic lesions in an aim to avoid and delay the need for palliative treatments and, ultimately, to achieve survival benefits...
July 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29861844/transcriptome-analysis-reveals-a-long-non-coding-rna-signature-to-improve-biochemical-recurrence-prediction-in-prostate-cancer
#11
Jinyuan Xu, Yujia Lan, Fulong Yu, Shiwei Zhu, Jianrong Ran, Jiali Zhu, Hongyi Zhang, Lili Li, Shujun Cheng, Yun Xiao, Xia Li
Despite highly successful treatments for localized prostate cancer (PCa), prognostic biomarkers are needed to improve patient management and prognosis. Accumulating evidence suggests that long noncoding RNAs (lncRNAs) are key regulators with biological and clinical significance. By transcriptome analysis, we identified a set of consistently dysregulated lncRNAs in PCa across different datasets and revealed an eight-lncRNA signature that significantly associated with the biochemical recurrence (BCR)-free survival...
May 18, 2018: Oncotarget
https://www.readbyqxmd.com/read/29861199/pretreatment-multiparametric-magnetic-resonance-imaging-findings-are-more-accurate-independent-predictors-of-outcome-than-clinical-variables-in-localized-prostate-cancer
#12
Alfonso Gomez-Iturriaga, Francisco Casquero, Jose Ignacio Pijoan, Juanita Crook, Arantza Urresola, Ana Ezquerro, Geert M Villeirs, Alberto Bossi, Jon Cacicedo, David Buchser, Pedro Bilbao
PURPOSE: To prospectively determine whether multiparametric magnetic resonance imaging (mpMRI)-based staging is a more accurate independent predictor of outcome than traditional clinical variables for patients undergoing brachytherapy and external beam radiation therapy. METHODS AND MATERIALS: The primary endpoints were biochemical (nadir plus 2 ng/mL) and metastatic failure. Descriptive, univariate, and multivariate competing risks analyses were performed. The cumulative incidence rates were estimated to describe the cumulative risk of the events of interest...
April 22, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29860890/bicalutamide-enhances-fodrin-mediated-apoptosis-through-calpain-in-lncap
#13
Jiyeong Lee, Sora Mun, Arum Park, Doojin Kim, Byung Heun Cha, Hee-Gyoo Kang
Prostate cancer is the most common cancer in men, and before it progresses and metastasizes, the anticancer drug bicalutamide is often administered to patients. Many cases of androgen-dependent prostate cancer develop resistance during treatment with bicalutamide. Therefore, the effect of bicalutamide on androgen-dependent LNCaP prostate cancer cells is of clinical interest. The aim of this study was to demonstrate the effects of the anticancer drug bicalutamide on LNCaP prostate cancer cells by using a proteomics approach...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29850791/ar-signaling-in-prostate-cancer-regulates-a-feed-forward-mechanism-of-androgen-synthesis-by-way-of-hsd3b1-upregulation
#14
Daniel Hettel, Ao Zhang, Mohammad Alyamani, Michael Berk, Nima Sharifi
3βHSD1 enzymatic activity is essential for synthesis of potent androgens from adrenal precursor steroids in prostate cancer. A germline variant in HSD3B1, the gene that encodes 3βHSD1, encodes for a stable enzyme, regulates adrenal androgen dependence, and is a predictive biomarker of poor clinical outcomes after gonadal testosterone deprivation therapy. However, little is known about HSD3B1 transcriptional regulation. Generally, it is thought that intratumoral androgen synthesis is up-regulated after gonadal testosterone deprivation, enabling development of castration-resistant prostate cancer (CRPC)...
May 29, 2018: Endocrinology
https://www.readbyqxmd.com/read/29845595/primary-cryotherapy-for-localised-or-locally-advanced-prostate-cancer
#15
REVIEW
Jae Hung Jung, Michael C Risk, Robert Goldfarb, Balaji Reddy, Bernadette Coles, Philipp Dahm
BACKGROUND: Traditionally, radical prostatectomy and radiotherapy with or without androgen deprivation therapy have been the main treatment options to attempt to cure men with localised or locally advanced prostate cancer. Cryotherapy is an alternative option for treatment of prostate cancer that involves freezing of the whole prostate (whole gland therapy) or only the cancer (focal therapy), but it is unclear how effective this is in comparison to other treatments. OBJECTIVES: To assess the effects of cryotherapy (whole gland or focal) compared with other interventions for primary treatment of clinically localised (cT1-T2) or locally-advanced (cT3) non-metastatic prostate cancer...
May 30, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29808369/-metronomic-chemotherapy-with-oral-cyclophosphamide-an-individual-option-for-the-metastatic-castration-resistant-prostate-cancer-patient
#16
S Knipper, P Mandel, G V Amsberg, P Strölin, M Graefen, T Steuber
BACKGROUND: Multiple experimental approaches are meanwhile available for progressive metastatic castration resistant prostate cancer (mCRPC) patients after failure of guideline recommended therapy (i. e., chemotherapy and/or hormonal treatment). We evaluated the outcome of metronomic chemotherapy with cyclophosphamide (CY) in combination with low-dose prednisolone. MATERIALS AND METHODS: A total of 14 mCRPC-patients were treated with CY 50 mg/day (plus prednisolone 10 mg/day) between November 2012 and September 2017 after being resistant or unfit for chemotherapy and/or further hormonal treatment...
May 28, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29808368/-advanced-prostate-cancer-consensus-conference-2017-discussion-of-the-recommendations-for-diagnosis-and-treatment-of-metastatic-prostate-cancer-by-a-german-panel-of-experts
#17
M Schostak, F König, M Bögemann, P Goebell, P Hammerer, S Machtens, C Schwentner, C Thomas, G von Amsberg, F-C von Rundstedt, A Heidenreich
In March 2017 the 'Advanced Prostate Cancer Consensus Conference' (APCCC) took place in St. Gallen (Switzerland). The APCCC-panelists are internationally well known experts. With the actual data in mind they discussed treatment options for patients with advanced prostate cancer in order to update the international APCCC-recommendations from the previous meeting in 2015. Recently these consensus recommendations have been published in "European Urology".A group of German experts discussed this year APCCC-votes during the meeting and the recommendations that were concluded from the votes from the German perspective...
May 28, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29801018/prostate-specific-antigen-based-screening-for-prostate-cancer-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#18
REVIEW
Joshua J Fenton, Meghan S Weyrich, Shauna Durbin, Yu Liu, Heejung Bang, Joy Melnikow
Importance: Prostate cancer is the second leading cause of cancer death among US men. Objective: To systematically review evidence on prostate-specific antigen (PSA)-based prostate cancer screening, treatments for localized prostate cancer, and prebiopsy risk calculators to inform the US Preventive Services Task Force. Data Sources: Searches of PubMed, EMBASE, Web of Science, and Cochrane Registries and Databases from July 1, 2011, through July 15, 2017, with a surveillance search on February 1, 2018...
May 8, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29801017/screening-for-prostate-cancer-us-preventive-services-task-force-recommendation-statement
#19
David C Grossman, Susan J Curry, Douglas K Owens, Kirsten Bibbins-Domingo, Aaron B Caughey, Karina W Davidson, Chyke A Doubeni, Mark Ebell, John W Epling, Alex R Kemper, Alex H Krist, Martha Kubik, C Seth Landefeld, Carol M Mangione, Michael Silverstein, Melissa A Simon, Albert L Siu, Chien-Wen Tseng
Importance: In the United States, the lifetime risk of being diagnosed with prostate cancer is approximately 13%, and the lifetime risk of dying of prostate cancer is 2.5%. The median age of death from prostate cancer is 80 years. Many men with prostate cancer never experience symptoms and, without screening, would never know they have the disease. African American men and men with a family history of prostate cancer have an increased risk of prostate cancer compared with other men. Objective: To update the 2012 US Preventive Services Task Force (USPSTF) recommendation on prostate-specific antigen (PSA)-based screening for prostate cancer...
May 8, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29794540/closing-knowledge-gaps-to-optimize-patient-outcomes-and-advance-precision-medicine
#20
Kathy Giusti, Anne Quinn Young, Kerri Lehrhaupt
Realizing the promise of precision medicine requires patient engagement at the key decision points throughout the cancer journey. Previous research has shown that patients who make the "right" decisions, such as being treated at a high-volume academic medical center, for example, have better outcomes. An online survey was conducted to understand awareness of and barriers to these decision points among patients with multiple myeloma and pancreatic, lung, prostate, and metastatic breast cancers. Survey respondents were identified by 5 participating foundations (multiple myeloma: n = 86, pancreatic: n = 108, lung: n = 56, prostate: n = 50, metastatic breast: n = 86) and recruited by an e-mail or social media invitation...
May 2018: Cancer Journal
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