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Obesity tnf alpha

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https://www.readbyqxmd.com/read/27917214/treadmill-walking-exercise-modulates-bone-mineral-status-and-inflammatory-cytokines-in-obese-asthmatic-patients-with-long-term-intake-of-corticosteroids
#1
Shehab M Abd El-Kader, Osama H Al-Jiffri, Eman M Ashmawy, Riziq Allah M Gaowgzeh
BACKGROUND: Obesity and asthma are an important public health problem in Saudi Arabia. An increasing body of data supports the hypothesis that obesity is a risk factor for asthma. Asthma appears to be associated with low bone mineral density (BMD) due to long-term use of corticosteroids. Studies recently showed that weight bearing exercise training can increase mineral bone density, reduce weight and improve metabolic control. OBJECTIVE: The present study aimed to measure the effects of treadmill walking exercises on bone mineral status and inflammatory cytokines in obese asthmatic patients treated with long term intake of corticosteroids...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27917205/impact-of-weight-loss-on-oxidative-stress-and-inflammatory-cytokines-in-obese-type-2-diabetic-patients
#2
Shehab M Abd El-Kader, Mohammed H Saiem Al-Dahr
BACKGROUND: Type 2 diabetes mellitus is associated with abnormal markers of inflammatory cytokines and oxidative stress markers. Although, these abnormalities could be modulated with weight reduction; there is limitation in clinical studies that have addressed the beneficial effects of weight reduction in modulating biomarkers of inflammatory cytokines and oxidative stress for obesity associated with type 2 diabetes mellitus. OBJECTIVE: This study was designed to detect the effects of weight loss on the inflammatory cytokines, oxidative stress markers in obese type 2 diabetic patients...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27904616/effect-of-folic-acid-and-metformin-on-insulin-resistance-and-inflammatory-factors-of-obese-children-and-adolescents
#3
Elham Hashemi Dehkordi, Farnaz Sattari, Abolfazl Khoshdel, Karamali Kasiri
BACKGROUND: Considering the increasing trend of obesity, especially in developing countries such as Iran, and the role of inflammatory factors and insulin resistance (IR) in the occurrence of obesity-related complications as well as the safety of some agents such as folic acid and metformin, this clinical trial was designed to investigate the effect of metformin and folic acid on inflammatory factors and IR among obese children. MATERIALS AND METHODS: In this randomized, double-blind, controlled clinical trial study, sixty obese children aged 6-12 years were enrolled...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27864335/effects-of-maternal-obesity-on-placental-function-and-fetal-development
#4
Kristy R Howell, Theresa Powell
Obesity has reached epidemic proportions and pregnancies in obese mothers have increased risk for complications including gestational diabetes, hypertensive disorders, preterm birth and caesarian section. Children born to obese mothers are at increased risk of obesity and metabolic disease and are susceptible to develop neuropsychiatric and cognitive disorders. Changes in placental function not only play a critical role in the development of pregnancy complications but may also be involved in linking maternal obesity to long-term health risks in the infant...
November 18, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27843953/considerations-for-defining-cytokine-dose-duration-and-milieu-that-are-appropriate-for-modeling-chronic-low-grade-inflammation-in-type-2-diabetes
#5
REVIEW
Craig S Nunemaker
Proinflammatory cytokines have been implicated in the pathophysiology of both type 1 diabetes (T1D) and type 2 diabetes (T2D). T1D is an autoimmune disease involving the adaptive immune system responding to pancreatic beta-cells as antigen-presenting cells. This attracts immune cells that surround pancreatic islets (insulitis) and secrete cytokines, such as IL-1beta, IFN-gamma, and TNF-alpha, in close proximity to pancreatic beta-cells. In contrast, there is little evidence for such a focused autoimmune response in T2D...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27795608/cytokine-profile-in-chronic-periodontitis-patients-with-and-without-obesity-a-systematic-review-and-meta-analysis
#6
REVIEW
Zohaib Akram, Tariq Abduljabbar, Mohamed Ibrahim Abu Hassan, Fawad Javed, Fahim Vohra
To investigate the cytokine profile as biomarkers in the gingival crevicular fluid (GCF) of chronic periodontitis (CP) patients with and without obesity, MEDLINE/PubMed, EMBASE, ScienceDirect, and SCOPUS databases were combined with handsearching of articles published from 1977 up to May 2016 using relevant MeSH terms. Meta-analyses were conducted separately for each of the cytokines: resistin, adiponectin, TNF-α, leptin, IL-6, IL-8, and IL-1β. Forest plots were produced reporting standardized mean difference of outcomes and 95% confidence intervals...
2016: Disease Markers
https://www.readbyqxmd.com/read/27785087/adiponectin-treatment-attenuates-inflammatory-response-during-early-sepsis-in-obese-mice
#7
XianFeng Wang, Nancy L Buechler, Barbara K Yoza, Charles E McCall, Vidula Vachharajani
BACKGROUND: Morbid obesity increases the cost of care in critically ill patients. Sepsis is the leading cause of death in noncoronary intensive care units. Circulating cell-endothelial cell interactions in microcirculation are the rate-determining factors in any inflammation; obesity increases these interactions further. Adiponectin deficiency is implicated in increased cardiovascular risk in obese patients. We have shown that adiponectin deficiency increases microvascular dysfunction in early sepsis...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27759977/association-of-the-rs9939609-gene-variant-in-fto-with-insulin-resistance-cardiovascular-risk-factor-and-serum-adipokine-levels-in-obese-patients
#8
Daniel A De Luis, Rocío Aller, Olatz Izaola, David Primo, E Romero
INTRODUCTION: The aim of our study was to analyze the relationship of the rs9939609 FTO gene polymorphism with insulin resistance and serum adipokine levels. MATERIAL AND METHODS: A population of 610 patients with obesity was analyzed in a cross sectional design. Weight, blood pressure, basal glucose, c-reactive protein (CRP), insulin, insulin resistance (HOMA), lipid profile and adipocytokines (leptin, adiponectin, resistin, TNF alpha, and interleukin 6) levels were measured...
September 20, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27751827/response-of-gut-microbiota-and-inflammatory-status-to-bitter-melon-momordica-charantia-l-in-high-fat-diet-induced-obese-rats
#9
Juan Bai, Ying Zhu, Ying Dong
ETHNOPHARMACOLOGICAL RELEVANCE: Bitter melon (Momordica charantia L.) is rich in a variety of biologically active ingredients, and has been widely used in traditional Chinese medicine (TCM) to treat various diseases, including type 2 diabetes and obesity. AIM OF THE STUDY: We aimed to investigate how bitter melon powder (BMP) could affect obesity-associated inflammatory responses to ameliorate high-fat diet (HFD)-induced insulin resistance, and investigated whether its anti-inflammatory properties were effected by modulating the gut microbiota...
October 14, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27746742/molecular-mechanisms-of-obesity-induced-osteoporosis-and-muscle-atrophy
#10
Bipradas Roy, Mary E Curtis, Letimicia S Fears, Samuel N Nahashon, Hugh M Fentress
Obesity and osteoporosis are two alarming health disorders prominent among middle and old age populations, and the numbers of those affected by these two disorders are increasing. It is estimated that more than 600 million adults are obese and over 200 million people have osteoporosis worldwide. Interestingly, both of these abnormalities share some common features including a genetic predisposition, and a common origin: bone marrow mesenchymal stromal cells. Obesity is characterized by the expression of leptin, adiponectin, interleukin 6 (IL-6), interleukin 10 (IL-10), monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), macrophage colony stimulating factor (M-CSF), growth hormone (GH), parathyroid hormone (PTH), angiotensin II (Ang II), 5-hydroxy-tryptamine (5-HT), Advance glycation end products (AGE), and myostatin, which exert their effects by modulating the signaling pathways within bone and muscle...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27741107/inflammatory-cytokines-in-pediatric-obstructive-sleep-apnea
#11
Yu-Shu Huang, Christian Guilleminault, Fang-Ming Hwang, Chuan Cheng, Cheng-Hui Lin, Hsueh-Yu Li, Li-Ang Lee
Pediatric obstructive sleep apnea (OSA) is associated with chronic systemic inflammation and with cognitive impairments. This study aimed to investigate the status of proinflammatory cytokines, particularly interleukin 17 (IL-17) and interleukin 23 (IL-23) and cognition in pediatric OSA.Controls and OSA children participated in the study. Exclusion criteria were adenotonsillectomy, heart, neurological and severe psychiatric diseases, craniofacial syndromes, and obesity. Polysomnogram was followed by serum testing for inflammatory markers and neurocognitive tests such as continuous performance task (CPT) and Wisconsin card sorting test, questionnaires, analyses of plasma high-sensitivity C-reactive protein (HS-CRP), tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-1), interleukin 6 (IL-6), IL-17, and IL-23...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27706555/expression-and-clinical-significance-of-the-obesity-related-gene-tnfaip9-in-obese-children
#12
L Y Gui, Y L Hu, Z L Hou, P Wang
To investigate the expression of tumor necrosis factor-alpha inducible protein 9 (TNFAIP9) gene in obese children and its clinical significance, 36 simple obese children and 17 non-obese children were recruited as research subjects. The adipose tissue was obtained by abdominal operation. The expression of TNFAIP9 was detected using real-time fluorescence quantitative polymerase chain reaction and western blot. The relationship between the expression of TNFAIP9 and blood lipid, blood glucose, and obesity indexes was analyzed...
August 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27690087/a-trypsin-inhibitor-from-tamarind-reduces-food-intake-and-improves-inflammatory-status-in-rats-with-metabolic-syndrome-regardless-of-weight-loss
#13
Fabiana M C Carvalho, Vanessa C O Lima, Izael S Costa, Amanda F Medeiros, Alexandre C Serquiz, Maíra C J S Lima, Raphael P Serquiz, Bruna L L Maciel, Adriana F Uchôa, Elizeu A Santos, Ana H A Morais
Trypsin inhibitors are studied in a variety of models for their anti-obesity and anti-inflammatory bioactive properties. Our group has previously demonstrated the satietogenic effect of tamarind seed trypsin inhibitors (TTI) in eutrophic mouse models and anti-inflammatory effects of other trypsin inhibitors. In this study, we evaluated TTI effect upon satiety, biochemical and inflammatory parameters in an experimental model of metabolic syndrome (MetS). Three groups of n = 5 male Wistar rats with obesity-based MetS received for 10 days one of the following: (1) Cafeteria diet; (2) Cafeteria diet + TTI (25 mg/kg); and (3) Standard diet...
2016: Nutrients
https://www.readbyqxmd.com/read/27678438/nigella-sativa-oil-with-a-calorie-restricted-diet-can-improve-biomarkers-of-systemic-inflammation-in-obese-women-a-randomized-double-blind-placebo-controlled-clinical-trial
#14
Reza Mahdavi, Nazli Namazi, Mohammad Alizadeh, Safar Farajnia
BACKGROUND: Inflammation is one of the primary mechanisms in the development of metabolic complications. Although anti-inflammatory characteristics of Nigella sativa (NS) have been indicated in animal models, clinical trials related to the effects of NS on inflammatory parameters are relatively scarce. OBJECTIVE: The aim of the present study was to determine the effects of NS oil combined with a calorie-restricted diet on systemic inflammatory biomarkers in obese women...
September 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27669020/wild-blueberry-consumption-attenuates-local-inflammation-in-the-perivascular-adipose-tissue-of-obese-zucker-rats
#15
Stefano Vendrame, Panagiotis Tsakiroglou, Aleksandra S Kristo, Dale A Schuschke, Dorothy Klimis-Zacas
Perivascular adipose tissue (PVAT) has been shown to play important roles in regulating vascular tone and linking local and systemic vascular inflammation. We examined the impact of PVAT on phenylephrine-mediated vasoconstriction in the aorta of obese Zucker rats (OZR) and their lean littermates (LZR) by comparing aortic rings with or without PVAT. Subsequently we placed OZR and LZR on a control (C) or an 8% wild blueberry (WB) diet and evaluated the effect of WB consumption on such response. PVAT-released adipokine concentrations were also measured as a function of WB diet...
October 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27651112/inflammation-mediates-the-association-between-visceral-adiposity-and-obstructive-sleep-apnea-in-adolescents
#16
Jordan Gaines, Alexandros N Vgontzas, Julio Fernandez-Mendoza, Susan L Calhoun, Fan He, Duanping Liao, Marjorie D Sawyer, Edward O Bixler
Only a handful of studies, primarily in clinical samples, have reported an association between obesity, inflammation, and obstructive sleep apnea (OSA) in children and adolescents. No studies, however, have examined the pathogenetic link between visceral adiposity, systemic inflammation, and incident OSA in a large general population sample using objective measures of sleep and body fat. Adolescents (n = 392; mean age 17.0 ± 2.2 yr, 54.0% male) from the Penn State Child Cohort (PSCC) underwent 9-h overnight polysomnography; a DXA scan to assess body fat distribution; and a single fasting blood draw for the assessment of plasma interleukin-6 (IL-6), IL-6 soluble receptor (IL-6 sR), tumor necrosis factor alpha (TNFα), tumor necrosis factor receptor 1A (TNFR1), C-reactive protein (CRP), leptin, and adiponectin levels via ELISA...
November 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27640440/diet-induced-obesity-reduces-the-production-of-influenza-vaccine-induced-antibodies-via-impaired-macrophage-function
#17
W-J Cho, D-K Lee, S-Y Lee, S-H Sohn, H-L Park, Y-W Park, H Kim, J-H Nam
Obesity is a metabolic disease characterized by low-level chronic inflammation. Obese individuals are susceptible to infection by viruses, and vaccination against these pathogens is less effective than in nonobese individuals. Here, we sought to explore the immunological environment in a mouse model of obesity induced by a high-fat diet (HFD). HFD treatment increased the body weight and epididymal fat mass. The proportion of activated B cells, T cells, and macrophages was similar between mice in the HFD group and the regular-fat diet (RFD) group...
2016: Acta Virologica
https://www.readbyqxmd.com/read/27620999/revascularization-and-muscle-adaptation-to-limb-demand-ischemia-in-diet-induced-obese-mice
#18
Hassan Albadawi, A Aria Tzika, Christian Rask-Madsen, Lindsey M Crowley, Michael W Koulopoulos, Hyung-Jin Yoo, Michael T Watkins
BACKGROUND: Obesity and type 2 diabetes are major risk factors for peripheral arterial disease in humans, which can result in lower limb demand ischemia and exercise intolerance. Exercise triggers skeletal muscle adaptation including increased vasculogenesis. The goal of this study was to determine whether demand ischemia modulates revascularization, fiber size, and signaling pathways in the ischemic hind limb muscles of mice with diet-induced obesity (DIO). MATERIALS AND METHODS: DIO mice (n = 7) underwent unilateral femoral artery ligation and recovered for 2 wks followed by 4 wks with daily treadmill exercise to induce demand ischemia...
September 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27616737/chronic-leucine-supplementation-improves-lipid-metabolism-in-c57bl-6j-mice-fed-with-a-high-fat-cholesterol-diet
#19
Jun Jiao, Shu-Fen Han, Wei Zhang, Jia-Ying Xu, Xing Tong, Xue-Bin Yin, Lin-Xi Yuan, Li-Qiang Qin
BACKGROUND: Leucine supplementation has been reported to improve lipid metabolism. However, lipid metabolism in adipose tissues and liver has not been extensively studied for leucine supplementation in mice fed with a high-fat/cholesterol diet (HFCD). DESIGN: C57BL/6J mice were fed a chow diet, HFCD, HFCD supplemented with 1.5% leucine (HFCD+1.5% Leu group) or 3% leucine (HFCD+3% Leu group) for 24 weeks. The body weight, peritoneal adipose weight, total cholesterol (TC), triglyceride in serum and liver, and serum adipokines were analyzed...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27616162/resistance-training-improves-inflammatory-level-lipid-and-glycemic-profiles-in-obese-older-women-a-randomized-controlled-trial
#20
Crisieli M Tomeleri, Alex S Ribeiro, Mariana F Souza, Durcelina Schiavoni, Brad J Schoenfeld, Danielle Venturini, Décio S Barbosa, Kamila Landucci, Luís B Sardinha, Edilson S Cyrino
The main purpose of the present study was to investigate the effect of resistance training on inflammatory levels, lipid and glycemic profile in obese older women. Thirty-eight obese older women (68.2±4.2years, and 41.0±6.2% of body fat) were randomly assigned to one of two groups: A training group (TG, n=19) that performed 8weeks of RT; or a control group (CG, n=19) that did not perform any type of exercise. The RT program consisted of 8 whole-body exercises for 3 sets of 10-15 repetition maximum (RM) carried out 3 times a week...
November 2016: Experimental Gerontology
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