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https://www.readbyqxmd.com/read/29927721/exploring-patients-consultation-behaviors-in-the-online-health-community-the-role-of-disease-risk
#1
Fei Liu, Yingying Li, Xiaofeng Ju
INTRODUCTION: An online health community (OHC) is a unique social network that provides a platform for sharing healthcare information, communicating about health and offering health services. While many researchers have examined OHCs, the impact of patient reviews on patient consultation behavior in the OHCs has rarely been discussed in the existing literature. METHODS: A computer program was developed to download the required information. This process was conducted monthly to capture the variation in the dependent variable...
June 21, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29927712/case-series-rheumatological-manifestations-attributed-to-exposure-to-libby-asbestiform-amphiboles
#2
Roger Diegel, Brad Black, Jean C Pfau, Tracy McNew, Curtis Noonan, Raja Flores
An increased risk for Systemic Autoimmune Diseases (SAID) has been reported in Libby, Montana, where extensive exposures to fibrous amphiboles occurred due to mining and use of asbestos-laden vermiculite. In addition, positive antinuclear autoantibody tests are associated with exposure to Libby Asbestiform Amphiboles (LAA) in both humans and mice. Among 6603 subjects who underwent health screening at the Center for Asbestos Related Diseases (CARD, Libby MT), 13.8% were diagnosed with an autoimmune disease, with prevalence values for the most common SAID being significantly higher than expected in the United States...
June 21, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29927083/blind-spots-spatial-analytics-can-identify-nonrandom-geographic-variation-in-first-episode-psychosis-program-enrollments
#3
Walter S Mathis, Scott Woods, Vinod Srihari
AIM: To apply spatial analytics to an underway first episode psychosis program to identify areas of significant variation in the geographical distribution of program enrollees from an underlying at-risk population. METHODS: Adaptive bandwidth kernel smoothing was used to estimate spatial density functions from program enrollee home addresses and a control population computed from US Census data. A relative risk surface derived from the ratio of these functions was used to discover under-represented areas, or areas from which fewer enrollees where produced than suggested by the underlying population density at the P < ...
June 21, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29926441/comparing-computer-adaptive-testing-stopping-rules-under-the-generalized-partial-credit-model
#4
Rose E Stafford, Christopher R Runyon, Jodi M Casabianca, Barbara G Dodd
An important consideration of any computer adaptive testing (CAT) program is the criterion used for ending item administration-the stopping rule, which ensures that all examinees are assessed to the same standard. Although various stopping rules exist, none of them have been compared under the generalized partial-credit model (Muraki in Applied Psychological Measurement, 16, 159-176, 1992). In this simulation study we compared the performance of three variable-length stopping rules-standard error (SE), minimum information (MI), and change in theta (CT)-both in isolation and in combination with requirements of minimum and maximum numbers of items, as well as a fixed-length stopping rule...
June 20, 2018: Behavior Research Methods
https://www.readbyqxmd.com/read/29926260/prospective-predictors-of-multiple-sexual-partners-among-african-american-men-who-have-sex-with-men
#5
Deepti Chittamuru, Larry D Icard, John B Jemmott, Ann O'Leary
Studies show that having sex with multiple partners increases the risk of acquiring and transmitting sexually transmitted diseases, including HIV. The present article reports prospective predictors of having multiple sexual partners among 505 African American men in Philadelphia who have sex with men (MSM) who participated in an intervention trial and attended a 6-month follow-up. Participants completed audio computer-assisted surveys of demographics, sexual behavior, and Reasoned Action Approach and Social Cognitive Theory mediators concerning multiple partners...
June 20, 2018: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29925783/construction-of-red-fox-chromosomal-fragments-from-the-short-read-genome-assembly
#6
Halie M Rando, Marta Farré, Michael P Robson, Naomi B Won, Jennifer L Johnson, Ronak Buch, Estelle R Bastounes, Xueyan Xiang, Shaohong Feng, Shiping Liu, Zijun Xiong, Jaebum Kim, Guojie Zhang, Lyudmila N Trut, Denis M Larkin, Anna V Kukekova
The genome of a red fox ( Vulpes vulpes ) was recently sequenced and assembled using next-generation sequencing (NGS). The assembly is of high quality, with 94X coverage and a scaffold N50 of 11.8 Mbp, but is split into 676,878 scaffolds, some of which are likely to contain assembly errors. Fragmentation and misassembly hinder accurate gene prediction and downstream analysis such as the identification of loci under selection. Therefore, assembly of the genome into chromosome-scale fragments was an important step towards developing this genomic model...
June 20, 2018: Genes
https://www.readbyqxmd.com/read/29925468/hospital-type-predicts-computed-tomography-use-for-pediatric-appendicitis
#7
Kathryn Tinsley Anderson, Marisa A Bartz-Kurycki, Mary T Austin, Akemi L Kawaguchi, Lillian S Kao, Kevin P Lally, Kuojen Tsao
BACKGROUND: Evidence-based guidelines recommend ultrasound (US) over computed tomography (CT) as the primary imaging modality for suspected pediatric appendicitis. Continued high rates of CT use may result in significant unnecessary radiation exposure in children. The purpose of this study was to evaluate variables associated with preoperative CT use in pediatric appendectomy patients. METHODS: A retrospective cohort study of pediatric patients who underwent appendectomy for acute appendicitis in 2015-2016 at National Surgical Quality Improvement Program for Pediatrics (NSQIP-P) hospitals was conducted...
May 29, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29924768/autologous-dental-pulp-mesenchymal-stem-cells-for-inferior-third-molar-post-extraction-socket-healing-a-split-mouth-randomised-clinical-trial
#8
L Barbier, E Ramos, J Mendiola, O Rodriguez, G Santamaria, J Santamaria, I Arteagoitia
BACKGROUND: Since the discovery of adult mesenchymal stem cells extensive research has been conducted to determine their mechanisms of differentiation and effectiveness in cell therapy and regenerative medicine. MATERIAL AND METHODS: To assess the efficacy of autologous dental pulp mesenchymal stem cells delivered in a collagen matrix for post-extraction socket healing, a single-centre, double-blind, randomised, split-mouth, controlled clinical trial was performed...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29924695/exposing-school-employee-sexual-abuse-and-misconduct-shedding-light-on-a-sensitive-issue
#9
Molly M Henschel, Billie-Jo Grant
While the media continue to report incidents of school employee sexual misconduct, few empirical studies focus on this issue. To address this gap in the literature, expand knowledge and awareness around the problem, and inform future research and programs, this research intends to document and analyze the characteristics of school employee sexual misconduct cases reported in the media. The authors conducted a landscape analysis of 361 published school employee sexual misconduct cases in the United States from 2014, documenting factors such as offender and victim characteristics, type of incident, technology use, location of offense, and resulting disciplinary actions by schools and law enforcement...
June 20, 2018: Journal of Child Sexual Abuse
https://www.readbyqxmd.com/read/29922146/self-perceived-benefits-of-cognitive-training-in-healthy-older-adults
#10
Vina M Goghari, Linette Lawlor-Savage
The idea that individualized, computer-based cognitive training improves cognitive functioning in non-trained domains is highly contested. An understudied area is whether cognitive training improves one's own perception of cognitive and day-to-day functioning. Furthermore, no studies have compared working memory training to programs that train higher-level processes themselves, namely logic and planning, in improving perception of cognitive abilities. We investigated self-reported changes in: (a) cognitive errors relevant to daily life; (b) expectations regarding training; and (c) impact of training on daily life, in healthy older adults who completed working memory training or logic and planning training...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29921955/leukemic-stem-cell-signatures-identify-novel-therapeutics-targeting-acute-myeloid-leukemia
#11
Isabelle Laverdière, Meaghan Boileau, Andrea L Neumann, Héloïse Frison, Amanda Mitchell, Stanley W K Ng, Jean C Y Wang, Mark D Minden, Kolja Eppert
Therapy for acute myeloid leukemia (AML) involves intense cytotoxic treatment and yet approximately 70% of AML are refractory to initial therapy or eventually relapse. This is at least partially driven by the chemo-resistant nature of the leukemic stem cells (LSCs) that sustain the disease, and therefore novel anti-LSC therapies could decrease relapses and improve survival. We performed in silico analysis of highly prognostic human AML LSC gene expression signatures using existing datasets of drug-gene interactions to identify compounds predicted to target LSC gene programs...
June 6, 2018: Blood Cancer Journal
https://www.readbyqxmd.com/read/29921803/computer-assisted-learning-assessment-of-the-veterinary-virtual-anatomy-education-software-ivala%C3%A2
#12
William Brady Little, Elpida Artemiou, Anne Conan, Cathryn Sparks
Although cadaveric dissection has historically been the cornerstone of anatomical education, it comes at the cost of some emotional, moral, safety, and environmental concerns. Computer assisted learning (CAL) programs are an increasingly common solution to these issues; however, research regarding the efficacy of high fidelity simulation is limited. The traditional first semester veterinary gross anatomy course curriculum at Ross University School of Veterinary Medicine (RUSVM) was supplemented with a web based virtual anatomy program, IVALA&trade; (www...
June 19, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29920424/loop-modelling-1-0
#13
Niloofar Shirvanizadeh, Gert Vriend, Seyed Shahriar Arab
Engineering surface loops is a sub-topic of protein engineering that is used routinely in many research fields in academia and industry alike. We provide some tools that search in the PDB for loops satisfying a wide variety of constraints. We illustrate the usefulness of these tools by applying them to a series of recently published studies that included loop engineering or loop modelling. LoopFinder finds loops that fit between two anchor stretches of typically 2, 3, or 4 amino acids each. ProDA find loops of a given length with predefined secondary structure, residue types, hydrophobicity, etc...
June 7, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29916604/-probability-of-causation-pc-historical-motivations-and-legal-transposition
#14
Giorgio Trenta
OBJECTIVES: The Probability of Causation (PC) was introduced to compensate objectively and more possible legally the U.S. diseased subjects involved in the nuclear armament activities. METHODS: The methodology is related to the attributable risk concept, but it is widely different from it, since it doesn't evaluate the "attributablity" from a collective point of view, but from a "personalistic" point, that is from the particular exposure condition, from the specific physical parameters and from the biological individual features of the single exposed subject...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29915814/scaling-computation-and-memory-in-living-cells
#15
Kevin Yehl, Timothy Lu
The semiconductor revolution that began in the 20th century has transformed society. Key to this revolution has been the integrated circuit, which enabled exponential scaling of computing devices using silicon-based transistors over many decades. Analogously, decreasing costs in DNA sequencing and synthesis, along with the development of robust genetic circuits, are enabling a "biocomputing revolution". First-generation gene circuits largely relied on assembling various transcriptional regulatory elements to execute digital and analog computing functions in living cells...
December 2017: Current Opinion in Biomedical Engineering
https://www.readbyqxmd.com/read/29915783/computational-chemical-synthesis-analysis-and-pathway-design
#16
REVIEW
Fan Feng, Luhua Lai, Jianfeng Pei
With the idea of retrosynthetic analysis, which was raised in the 1960s, chemical synthesis analysis and pathway design have been transformed from a complex problem to a regular process of structural simplification. This review aims to summarize the developments of computer-assisted synthetic analysis and design in recent years, and how machine-learning algorithms contributed to them. LHASA system started the pioneering work of designing semi-empirical reaction modes in computers, with its following rule-based and network-searching work not only expanding the databases, but also building new approaches to indicating reaction rules...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29915077/origami-mechanologic
#17
Benjamin Treml, Andrew Gillman, Philip Buskohl, Richard Vaia
Robots autonomously interact with their environment through a continual sense-decide-respond control loop. Most commonly, the decide step occurs in a central processing unit; however, the stiffness mismatch between rigid electronics and the compliant bodies of soft robots can impede integration of these systems. We develop a framework for programmable mechanical computation embedded into the structure of soft robots that can augment conventional digital electronic control schemes. Using an origami waterbomb as an experimental platform, we demonstrate a 1-bit mechanical storage device that writes, erases, and rewrites itself in response to a time-varying environmental signal...
June 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29914572/prescription-opioid-dispensing-in-new-south-wales-australia-spatial-and-temporal-variation
#18
M Mofizul Islam, Ian S McRae, Soumya Mazumdar, Paul Simpson, Dennis Wollersheim, Kaniz Fatema, Tony Butler
BACKGROUND: Patterns of opioid dispensing often exhibit substantial temporal and geographical variability, which has implications for public health policy decisions and interventions. The study examined recent trends in prescription opioid dispensing and identified high dispensing areas and factors associated with the doses dispensed. METHODS: Three years (1 January 2013-31 December 2015) of dispensing data of prescription opioids in local government areas (LGAs) for New South Wales (NSW), Australia's most populous state, were analyzed...
June 18, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29914471/how-accurate-is-automated-gap-filling-of-metabolic-models
#19
Peter D Karp, Daniel Weaver, Mario Latendresse
BACKGROUND: Reaction gap filling is a computational technique for proposing the addition of reactions to genome-scale metabolic models to permit those models to run correctly. Gap filling completes what are otherwise incomplete models that lack fully connected metabolic networks. The models are incomplete because they are derived from annotated genomes in which not all enzymes have been identified. Here we compare the results of applying an automated likelihood-based gap filler within the Pathway Tools software with the results of manually gap filling the same metabolic model...
June 19, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29913228/effects-of-prenatal-exposure-to-cigarettes-on-anthropometrics-energy-intake-energy-expenditure-and-screen-time-in-children
#20
Jameason D Cameron, Éric Doucet, Kristi B Adamo, Mark Walker, Alessandro Tirelli, Joel D Barnes, Kaamel Hafizi, Marisa Murray, Gary S Goldfield
BACKGROUND: Maternal prenatal smoking is associated with downstream childhood obesity. Although animal research suggests reduced resting energy expenditure (REE), decreased physical activity (PA), and increased energy intake as mechanisms, these relationships are unclear in humans. The objectives were to examine the association of prenatal maternal smoking with non-volitional energy expenditure (REE and the thermic effect of feeding [TEF]), child adiposity, energy intake, free-living PA (daily light PA (LPA), daily moderate-to-vigorous PA (MVPA), daily sedentary behavior (SB)), and screen time (television and computer/video game) in children...
June 15, 2018: Physiology & Behavior
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