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https://www.readbyqxmd.com/read/28239610/preparing-and-analyzing-expressed-sequence-tags-ests-library-for-the-mammary-tissue-of-local-turkish-kivircik-sheep
#1
Nehir Ozdemir Ozgenturk, Zehra Omeroglu Ulu, Salih Ulu, Cemal Un, Kemal Ozdem Oztabak, Kemal Altunatmaz
Kivircik sheep is an important local Turkish sheep according to its meat quality and milk productivity. The aim of this study was to analyze gene expression profiles of both prenatal and postnatal stages for the Kivircik sheep. Therefore, two different cDNA libraries, which were taken from the same Kivircik sheep mammary gland tissue at prenatal and postnatal stages, were constructed. Total 3072 colonies which were randomly selected from the two libraries were sequenced for developing a sheep ESTs collection...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/28239330/a-statistical-method-for-synthesizing-mediation-analyses-using-the-product-of-coefficient-approach-across-multiple-trials
#2
Shi Huang, David P MacKinnon, Tatiana Perrino, Carlos Gallo, Gracelyn Cruden, C Hendricks Brown
Mediation analysis often requires larger sample sizes than main effect analysis to achieve the same statistical power. Combining results across similar trials may be the only practical option for increasing statistical power for mediation analysis in some situations. In this paper, we propose a method to estimate: 1) marginal means for mediation path a, the relation of the independent variable to the mediator; 2) marginal means for path b, the relation of the mediator to the outcome, across multiple trials; and 3) the between-trial level variance-covariance matrix based on a bivariate normal distribution...
November 2016: Statistical Methods & Applications
https://www.readbyqxmd.com/read/28237520/smoking-as-a-risk-factor-for-breast-reduction-an-analysis-of-13-503-cases
#3
Jeffery S Hillam, Emily A Borsting, Jimmy H Chim, Seth R Thaller
BACKGROUND: Reduction mammaplasty is one of the most common reconstructive procedures performed by plastic surgeons. Over 100,000 procedures are performed annually. Although important for relieving the painful symptoms associated with macromastia, complication rates of this procedure are not insignificant. They are reported in up to half the cases. Reported risk factors for adverse outcomes include obesity, preoperative wound infection, and advanced American Society of Anesthesiologists status...
January 16, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28236983/pilot-study-on-use-of-home-telephoning-to-identify-and-recruit-high-risk-individuals-for-lung-cancer-screening
#4
Giulia Veronesi, Paolo Colombo, Pierluigi Novellis, Alessandro Crepaldi, Romano Fabio Lutman, Elisa Dieci, Manuel Profili, Licia Siracusano, Marco Alloisio
Widespread lung cancer screening with low-dose computed tomography is urgently needed in Europe to identify lung cancers early and reduce lung cancer deaths. The most effective method of identifying high-risk individuals and recruiting them for screening has not been determined. In the present pilot study we investigated direct telephoning to families as a way of identifying high risk individuals and recruiting them to a screening/smoking cessation program, that avoided the selection bias of voluntary screening...
March 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28236800/impact-of-the-new-handling-recommendations-for-hazardous-drugs-in-a-hospital-pharmacy-service
#5
Beatriz G García-Alcántara, Catalina Perelló Alomar, Elena Moreno Centeno, Pilar Modamio, Eduardo L Mariño, Olga Delgado Sánchez
OBJECTIVE: To describe the actions taken by the Pharmacy Unit in a tertiary hospital in order to adapt to the recommendations established by NIOSH 2014 for handling Hazardous Drugs. Method: A retrospective observational study. A list was prepared including all hazardous drugs according to NIOSH 2014 that were available at the hospital as marketed or foreign drugs, or used in clinical trials, and there was a review of the processes of acquisition, repackaging, preparation, circuits, organizational, dispensing and identification...
March 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28236744/identification-of-potential-inhibitors-against-the-zika-virus-using-consensus-scoring
#6
Abdulmujeeb T Onawole, Kazeem O Sulaiman, Rukayat O Adegoke, Temitope U Kolapo
The Zika virus (ZIKV) is a life threatening pathogen of zoonotic importance with prevalence in some parts of Africa and America. Unfortunately, there is yet to be a single approved vaccine or antiviral drug to treat the diseases and deformations being caused by the Zika virus infection. In this study, about 36 million compounds from MCULE database were virtually screened against a real matured ZIKV protein using a consensus scoring method to get improved hit rates. The consensus scoring method combined the result from the 25 top ranked molecules from both MCULE and Drug Score eXtended (DSX) docking programs which led to the selection of two hit compounds...
February 9, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28236603/computational-modelling-of-bone-fracture-healing-under-partial-weight-bearing-exercise
#7
Lihai Zhang, Saeed Miramini, Martin Richardson, Peter Ebeling, David Little, Yi Yang, Zhiyong Huang
A great deal of evidence suggests that partial weight-bearing exercise plays an important role in bone fracture healing. However, current physiotherapy program tends to follow the "Let's try it and see" strategy due to the lack of a fundamental understanding of in vivo mechanical environment required for the better healing outcomes. The purpose of present study is to develop an innovative framework to predict the healing outcomes as a result of post-surgical physical therapy. The raw acceleration data corresponding to a series of walking tests is firstly captured by ActiGraph accelerometers, and then used as input to theoretically estimate the peak ground reaction force (PGRF) and peak loading rate (PLR)...
February 21, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28236243/identifying-loop-mediated-protein-protein-interactions-using-loopfinder
#8
Timothy R Siegert, Michael Bird, Joshua A Kritzer
Peptides are an increasingly useful class of molecules, finding unique applications as chemical probes and potential drugs. They are particularly adept at inhibiting protein-protein interactions, which are often difficult to target using small molecules. The identification and rational design of protein-binding epitopes remains a bottleneck in the development of bioactive peptides. One fruitful strategy has been using structured scaffolds to present essential hot spot residues involved in protein-protein recognition, and this process has been greatly advanced by computational tools that can identify hot spot residues...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28236014/the-smartor-a-distributed-sensor-network-to-improve-operating-room-efficiency
#9
Albert Y Huang, Guillaume Joerger, Vid Fikfak, Remi Salmon, Brian J Dunkin, Barbara L Bass, Marc Garbey
BACKGROUND: Despite the significant expense of OR time, best practice achieves only 70% efficiency. Compounding this problem is a lack of real-time data. Most current OR utilization programs require manual data entry. Automated systems require installation and maintenance of expensive tracking hardware throughout the institution. This study developed an inexpensive, automated OR utilization system and analyzed data from multiple operating rooms. STUDY DESIGN: OR activity was deconstructed into four room states...
February 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28235960/successful-reperfusion-with-mechanical-thrombectomy-is-associated-with-reduced-disability-and-mortality-in-patients-with-pretreatment-diffusion-weighted-imaging-alberta-stroke-program-early-computed-tomography-score-%C3%A2-6
#10
Jean-Philippe Desilles, Arthuro Consoli, Hocine Redjem, Oguzhan Coskun, Gabriele Ciccio, Stanislas Smajda, Julien Labreuche, Cristian Preda, Clara Ruiz Guerrero, Jean-Pierre Decroix, Georges Rodesch, Mikael Mazighi, Raphaël Blanc, Michel Piotin, Bertrand Lapergue
BACKGROUND AND PURPOSE: In acute ischemic stroke patients, diffusion-weighted imaging (DWI)-Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is correlated with infarct volume and is an independent factor of functional outcome. Patients with pretreatment DWI-ASPECTS ≤6 were excluded or under-represented in the recent randomized mechanical thrombectomy trials. Our aim was to assess the impact of reperfusion in pretreatment DWI-ASPECTS ≤6 patients treated with mechanical thrombectomy...
February 24, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28235751/online-dissemination-strategies-of-a-canada-research-chair-overview-and-lessons-learned
#11
Jessica Hébert, Hubert Robitaille, Stéphane Turcotte, France Légaré
BACKGROUND: Little is known about the use of online dissemination strategies, such as websites and social media, to increase the visibility and uptake of research. OBJECTIVE: To describe two online dissemination strategies of the Canada Research Chair in Implementation of Shared Decision Making in Primary Care over an eight-year period. METHODS: Our two sources of online dissemination data were the website of the Canada Research Chair in Implementation of Shared Decision Making in Primary Care and the Chair's Twitter account...
February 24, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28231405/three-dimensional-printing-of-x-ray-computed-tomography-datasets-with-multiple-materials-using-open-source-data-processing
#12
Ian M Sander, Matthew T McGoldrick, My N Helms, Aislinn Betts, Anthony van Avermaete, Elizabeth Owers, Evan Doney, Taimi Liepert, Glen Niebur, Douglas Liepert, W Matthew Leevy
Advances in three-dimensional (3D) printing allow for digital files to be turned into a "printed" physical product. For example, complex anatomical models derived from clinical or pre-clinical X-ray computed tomography (CT) data of patients or research specimens can be constructed using various printable materials. Although 3D printing has the potential to advance learning, many academic programs have been slow to adopt its use in the classroom despite increased availability of the equipment and digital databases already established for educational use...
February 23, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28229962/overexpression-of-hsa-mir-939-follows-by-ngfr-down-regulation-and-apoptosis-reduction
#13
Fahimeh Hosseini Aghdaei, Bahram M Soltani, Sadat Dokanehiifard, Seyed Javad Mowla, Masoud Soleimani
Neurotrophin receptors play a crucial role in neuronal survival, differentiation and regeneration. Nerve growth factor receptor (NGFR) or P75(NTR) is a neurotrophin receptor that is involved in many pathological conditions including cancers. Genetic factors that are involved in regulation of neurotrophin receptors are under intense investigation. MiRNAs are novel regulators of signalling pathways that are candidates for regulation of neurotrophin receptors. Computational programs predicted that NGFR gene is a bona fide target for hsa-miR- 939...
March 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/28226947/lower-limb-pose-estimation-for-monitoring-the-kicking-patterns-of-infants
#14
Miguel M Serrano, Yu-Ping Chen, Ayanna Howard, Patricio A Vela, Miguel M Serrano, Yu-Ping Chen, Ayanna Howard, Patricio A Vela, Miguel M Serrano, Ayanna Howard, Patricio A Vela, Yu-Ping Chen
Monitoring the spontaneous kicking patterns of infants can give insight into their development. A computer vision based method for estimating the pose of an infant's leg from range images is presented in this paper. After some manual inputs for initialization, the range data associated with the infant is extracted. The method uses Robust Point Set Registration (RPSR) to fit an articulated model to the subject in every frame in the sequence, thus it provides the joint trajectories over time of the kicking kinematics...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226262/an-urban-runoff-model-designed-to-inform-stormwater-management-decisions
#15
Nicole G Beck, Gary Conley, Lisa Kanner, Margaret Mathias
We present an urban runoff model designed for stormwater managers to quantify runoff reduction benefits of mitigation actions that has lower input data and user expertise requirements than most commonly used models. The stormwater tool to estimate load reductions (TELR) employs a semi-distributed approach, where landscape characteristics and process representation are spatially-lumped within urban catchments on the order of 100 acres (40 ha). Hydrologic computations use a set of metrics that describe a 30-year rainfall distribution, combined with well-tested algorithms for rainfall-runoff transformation and routing to generate average annual runoff estimates for each catchment...
February 19, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28223806/efficacy-of-a-short-cognitive-training-program-in-patients-with-multiple-sclerosis
#16
María Yaiza Pérez-Martín, Montserrat González-Platas, Pablo Eguía-Del Río, Cristina Croissier-Elías, Alejandro Jiménez Sosa
BACKGROUND: Cognitive impairment is a common feature in multiple sclerosis (MS) and may have a substantial impact on quality of life. Evidence about the effectiveness of neuropsychological rehabilitation is still limited, but current data suggest that computer-assisted cognitive training improves cognitive performance. OBJECTIVE: The objective of this study was to evaluate the efficacy of combined computer-assisted training supported by home-based neuropsychological training to improve attention, processing speed, memory and executive functions during 3 consecutive months...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28222075/a-pilot-study-of-a-cognitive-behavioral-intervention-for-breast-cancer-survivors
#17
Heather Becker, Ashley M Henneghan, Deborah L Volker, Sabrina Q Mikan
PURPOSE/OBJECTIVES: To test combining a group intervention to build self-efficacy for using compensatory strategies and lifestyle adjustments with brain-training practice to improve cognition.
. DESIGN: A quasiexperimental design.
. SETTING: Texas Oncology, a community oncology practice in Austin.
. SAMPLE: 20 women aged 35-65 years, who had finished chemotherapy at least three months before the study, were within five years of completing all treatment, and had self-reported cognitive concerns...
March 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28221714/photonic-devices-out-of-equilibrium-transient-memory-signal-propagation-and-sensing
#18
Thomas Heuser, Rémi Merindol, Sebastian Loescher, Aileen Klaus, Andreas Walther
Soft photonic materials are important for sensors, displays, or energy management and have become switchable under static equilibrium conditions by integration of responsive polymer features. The next step is to equip such materials with the ability for autonomously dynamic and self-regulating behavior, which would advance their functionality and application possibilities to new levels. Here, this study shows the system integration of a nonlinear, biocatalytic pH-feedback system with a pH-responsive block copolymer photonic gel, and demonstrates autonomous transient memories, remotely controlled signal propagation, and sensing...
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28221002/computational-biology-and-chemistry-in-mti-emphasis-on-the-prediction-of-some-admet-properties
#19
REVIEW
Maria A Miteva, Bruno O Villoutreix
Our research and teaching group called MTi (Molécules Thérapeutiques in silico) has developed numerous applications available online, thanks to the RPBS platform (Ressource Parisienne en Bioinformatique Structurale), in the field of chemoinformatics, structural bioinformatics and drug design. Since its opening in 2009, over 200 articles/reviews have been reported and involve virtual screening studies, prediction of druggability, analysis of protein-protein interaction inhibitors, development of databases, data mining and knowledge discovery, as well as combined in silico-in vitro work to search for new hits and chemical probes acting on original targets in several therapeutic areas...
February 21, 2017: Molecular Informatics
https://www.readbyqxmd.com/read/28220440/quantum-probability-ranking-principle-for-ligand-based-virtual-screening
#20
Mohammed Mumtaz Al-Dabbagh, Naomie Salim, Mubarak Himmat, Ali Ahmed, Faisal Saeed
Chemical libraries contain thousands of compounds that need screening, which increases the need for computational methods that can rank or prioritize compounds. The tools of virtual screening are widely exploited to enhance the cost effectiveness of lead drug discovery programs by ranking chemical compounds databases in decreasing probability of biological activity based upon probability ranking principle (PRP). In this paper, we developed a novel ranking approach for molecular compounds inspired by quantum mechanics, called quantum probability ranking principle (QPRP)...
February 20, 2017: Journal of Computer-aided Molecular Design
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