keyword
https://read.qxmd.com/read/31889044/involvement-of-epithelial-mesenchymal-transition-inducing-transcription-factors-in-the-mechanism-of-helicobacter-pylori-induced-fibroblasts-activation
#21
JOURNAL ARTICLE
G Krzysiek-Maczka, A Targosz, U Szczyrk, M Strzalka, T Brzozowski, A Ptak-Belowska
Gastric cancer (GC) originating from the lining of the stomach is one of the most frequent malignancies in humans. The most efficient method giving hope of full recovery from GC is gastric resection combined with adjuvant chemotherapy and radiotherapy. However, over 50% of patients after treatment suffer from recurrence and peritoneal metastasis. The bacteria Helicobacter pylori (Hp) is nowadays considered as the major pathogen capable of colonizing gastric mucosa. This bug causes deregulation of multiple signaling pathways including the activation of nuclear factor kappaB (NFκB) and Janus kinase/signal transducers and activators of transcription (JAK/STAT) responsible for inflammation and development of carcinogenic cascade...
October 2019: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/30979739/noncanonical-tgf%C3%AE-pathway-relieves-the-blockade-of-il1%C3%AE-tgf%C3%AE-mediated-crosstalk-between-tumor-and-stroma-tgfbr1-and-tak1-inhibition-in-colorectal-cancer
#22
JOURNAL ARTICLE
Natalia Guillén Díaz-Maroto, Rebeca Sanz-Pamplona, Mireia Berdiel-Acer, Francisco J Cimas, Elena García, Samuel Gonçalves-Ribeiro, Nerea Albert, Gemma Garcia-Vicién, Gabriel Capella, Victor Moreno, Ramon Salazar, Alberto Villanueva, David G Molleví
PURPOSE: The aim of the study is blocking the recruitment of a protective stroma by altering the crosstalk between normal stromal cells and tumor cells for stripping tumors of the protection conferred by the microenvironment. EXPERIMENTAL DESIGN: A transcriptomic analysis of cocultured normal colonic fibroblasts and colorectal tumor cells was performed. We focused on the study of molecules that mediate the communication between both compartments and that entail fibroblasts' activation and the alteration of the sensitivity to chemotherapy...
July 15, 2019: Clinical Cancer Research
https://read.qxmd.com/read/30706361/combination-of-mek-inhibitor-and-the-jak2-stat3-pathway-inhibition-for-the-therapy-of-colon-cancer
#23
JOURNAL ARTICLE
Jianying Jin, Qunyi Guo, Jingjing Xie, Dan Jin, Yanan Zhu
The study aimed to investigate the reason of HCT116 cell resistance to MEK inhibitor, and the combination treatment effects of MEK inhibitor AZD6244 and JAK2/STAT3 inhibitor AG490 on colon cancer in vitro and in vivo, including cell viability, apoptosis, and explore the partial mechanisms focused on AZD6244 promoted the activation of JAK2-STAT3 pathways. In vitro, we examined the HCT116 cell viability by CCK8, cell apoptosis by flow cytometry; Western blot measured p-ERK, p-JAK2, p-STAT3 and STAT3 expression...
April 2019: Pathology Oncology Research: POR
https://read.qxmd.com/read/30670049/jak-stat5-mediated-subtype-specific-lymphocyte-antigen-6-complex-locus-g6d-ly6g6d-expression-drives-mismatch-repair-proficient-colorectal-cancer
#24
JOURNAL ARTICLE
Guido Giordano, Pietro Parcesepe, Mario Rosario D'Andrea, Luigi Coppola, Tania Di Raimo, Andrea Remo, Erminia Manfrin, Claudia Fiorini, Aldo Scarpa, Carla Azzurra Amoreo, Fabiana Conciatori, Michele Milella, Francesca Pia Caruso, Luigi Cerulo, Almudena Porras, Massimo Pancione
BACKGROUND: Human microsatellite-stable (MSS) colorectal cancers (CRCs) are immunologically "cold" tumour subtypes characterized by reduced immune cytotoxicity. The molecular linkages between immune-resistance and human MSS CRC is not clear. METHODS: We used transcriptome profiling, in silico analysis, immunohistochemistry, western blot, RT-qPCR and immunofluorescence staining to characterize novel CRC immune biomarkers. The effects of selective antagonists were tested by in vitro assays of long term viability and analysis of kinase active forms using anti-phospho antibodies...
January 22, 2019: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/30243096/pma-treated-thp-1-derived-il-6-promotes-emt-of-sw48-through-stat3-erk-dependent-activation-of-wnt-%C3%AE-catenin-signaling-pathway
#25
JOURNAL ARTICLE
Sikang Gao, Junwu Hu, Xiongwen Wu, Zhihui Liang
Colon cancer is one of the most common digestive malignant tumors that leads to high mortality worldwide, and metastasis is the primary cause of cancer-related death. It is well accepted that the epithelial-mesenchymal transition (EMT) plays a key role in the process of metastasis. As a cytokine that macrophage secretes, IL-6 is involved in the progression of tumors, including the invasion and metastasis via kinds of signaling pathways. However, the mechanism of interactions between IL-6, macrophage, EMT and colon cancer is not fully understood...
December 2018: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/30123970/randomized-double-blind-phase-two-study-of-ruxolitinib-plus-regorafenib-in-patients-with-relapsed-refractory-metastatic-colorectal-cancer
#26
JOURNAL ARTICLE
David Fogelman, Antonio Cubillo, Pilar García-Alfonso, María Luisa Limón Mirón, John Nemunaitis, Daniel Flora, Christophe Borg, Laurent Mineur, Jose M Vieitez, Allen Cohn, Gene Saylors, Albert Assad, Julie Switzky, Li Zhou, Johanna Bendell
BACKGROUND: The Janus kinase/signal transducer and activator of transcription (JAK-STAT) signaling pathway plays a key role in the systemic inflammatory response in many cancers, including colorectal cancer (CRC). This study evaluated the addition of ruxolitinib, a potent JAK1/2 inhibitor, to regorafenib in patients with relapsed/refractory metastatic CRC. METHODS: In this two-part, multicenter, phase 2 study, eligible adult patients had metastatic adenocarcinoma of the colon or rectum; an Eastern Cooperative Oncology Group performance status of 0-2; received fluoropyrimidine, oxaliplatin, and irinotecan-based chemotherapy, an anti-vascular endothelial growth factor therapy (if no contraindication); and if KRAS wild-type (and no contraindication), an anti-epidermal growth factor receptor therapy; and progressed following the last administration of approved therapy...
November 2018: Cancer Medicine
https://read.qxmd.com/read/29777330/down-regulating-il-6-gp130-targets-improved-the-anti-tumor-effects-of-5-fluorouracil-in-colon-cancer
#27
JOURNAL ARTICLE
Sanhong Li, Jilai Tian, Hongming Zhang, Shoubing Zhou, Xiyong Wang, Lei Zhang, Jiapeng Yang, Zhigang Zhang, Zhenling Ji
Recent studies have confirmed that IL-6/GP130 targets are closely associated with tumor growth, metastasis and drug resistance. 5-Fluorouracil (5-FU) is the most common chemotherapeutic agent for colon cancer but is limited due to chemoresistance and high cytotoxicity. Bazedoxifene (BZA), a third-generation selective estrogen receptor modulator, was discovered by multiple ligand simultaneous docking and drug repositioning approaches to have a novel function as an IL-6/GP130 target inhibitor. Thus, we speculated that in colon cancer, the anti-tumor efficacy of 5-FU might be increased in combination with IL-6/GP130 inhibitors...
June 2018: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/29106440/identification-of-pmn-released-mutagenic-factors-in-a-co-culture-model-for-colitis-associated-cancer
#28
JOURNAL ARTICLE
Nicolas Granofszky, Michaela Lang, Vineeta Khare, Gerald Schmid, Theresa Scharl, Franziska Ferk, Kristine Jimenez, Siegfried Knasmüller, Christoph Campregher, Christoph Gasche
Microsatellite instability (MSI) is present in ulcerative colitis (UC) and colitis-associated colorectal cancers (CAC). Certain factors released by polymorphonuclear cells (PMNs) may drive mucosal frameshift mutations resulting in MSI and cancer. Here, we applied a co-culture system with PMNs and colon epithelial cells to identify such culprit factors. Subjecting HCT116 + chr3 and human colonic epithelial cells (HCEC)-1CT MSI-reporter cell lines harboring mono-, di- or tetranucleotide DNA repeats linked to enhanced green fluorescent protein (EGFP) to activated PMNs induced frameshift mutations within all repeats, as quantified by flow cytometry...
February 9, 2018: Carcinogenesis
https://read.qxmd.com/read/27613835/mechanism-of-suppressors-of-cytokine-signaling-1-inhibition-of-epithelial-mesenchymal-transition-signaling-through-ros-regulation-in-colon-cancer-cells-suppression-of-src-leading-to-thioredoxin-up-regulation
#29
JOURNAL ARTICLE
Sung-Hoon Jung, Su-Min Kim, Choong-Eun Lee
Reactive oxygen species (ROS) participate in malignant progression of cancers including epithelial-mesenchymal transition (EMT). We have investigated the role of suppressors of cytokine signaling (SOCS)1 as an inhibitor of ROS-induced EMT using colon cancer cell lines transduced with SOCS1 and shSOCS1. Hydrogen peroxide treatment induced EMT features such as elevation of vimentin and Snail with a corresponding reduction of E-cadherin. The EMT markers are significantly decreased upon SOCS1 over-expression while increased under SOCS1 knock-down...
September 20, 2016: Oncotarget
https://read.qxmd.com/read/27546461/iron-uptake-via-dmt1-integrates-cell-cycle-with-jak-stat3-signaling-to-promote-colorectal-tumorigenesis
#30
JOURNAL ARTICLE
Xiang Xue, Sadeesh K Ramakrishnan, Kevin Weisz, Daniel Triner, Liwei Xie, Durga Attili, Asha Pant, Balázs Győrffy, Mingkun Zhan, Christin Carter-Su, Karin M Hardiman, Thomas D Wang, Michael K Dame, James Varani, Dean Brenner, Eric R Fearon, Yatrik M Shah
Dietary iron intake and systemic iron balance are implicated in colorectal cancer (CRC) development, but the means by which iron contributes to CRC are unclear. Gene expression and functional studies demonstrated that the cellular iron importer, divalent metal transporter 1 (DMT1), is highly expressed in CRC through hypoxia-inducible factor 2α-dependent transcription. Colon-specific Dmt1 disruption resulted in a tumor-selective inhibitory effect of proliferation in mouse colon tumor models. Proteomic and genomic analyses identified an iron-regulated signaling axis mediated by cyclin-dependent kinase 1 (CDK1), JAK1, and STAT3 in CRC progression...
September 13, 2016: Cell Metabolism
https://read.qxmd.com/read/26078947/role-of-b7-h4-sirna-in-proliferation-migration-and-invasion-of-lovo-colorectal-carcinoma-cell-line
#31
JOURNAL ARTICLE
Hai-Xia Peng, Wei-Qi Wu, Da-Ming Yang, Rong Jing, Ji Li, Feng-Li Zhou, Yun-Fei Jin, Sai-Yu Wang, Yi-Min Chu
OBJECTIVES: Colorectal cancer is one of the most common malignancies. Recent studies investigated that B7-H4 is highly expressed in various cancers. We aimed at exploring the effect of B7-H4 siRNA on proliferation, invasion, and migration of LOVO cells which expressed B7-H4 notably. DESIGN AND METHODS: Colon adenocarcinoma dataset was downloaded from The Cancer Genome Atlas. 35 colorectal cancer patients admitted to Shanghai Tongren Hospital were enrolled in this study...
2015: BioMed Research International
https://read.qxmd.com/read/25982279/targeting-jak-kinase-in-solid-tumors-emerging-opportunities-and-challenges
#32
REVIEW
M Buchert, C J Burns, M Ernst
Various human malignancies are characterized by excessive activation of the Janus family of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and STAT5. In the majority of solid tumors, this occurs in response to increased abundance of inflammatory cytokines in the tumor microenvironment prominently produced by infiltrating innate immune cells. Many of these cytokines share common receptor subunits and belong to the interleukin (IL)-6/IL-11, IL-10/IL-22 and IL-12/IL-23 families...
February 25, 2016: Oncogene
https://read.qxmd.com/read/25787076/inhibition-of-stat3-activation-suppresses-caspase-3-and-the-ubiquitin-proteasome-system-leading-to-preservation-of-muscle-mass-in-cancer-cachexia
#33
JOURNAL ARTICLE
Kleiton Augusto Santos Silva, Jiangling Dong, Yanjun Dong, Yanlan Dong, Nestor Schor, David J Tweardy, Liping Zhang, William E Mitch
Cachexia occurs in patients with advanced cancers. Despite the adverse clinical impact of cancer-induced muscle wasting, pathways causing cachexia are controversial, and clinically reliable therapies are not available. A trigger of muscle protein loss is the Jak/Stat pathway, and indeed, we found that conditioned medium from C26 colon carcinoma (C26) or Lewis lung carcinoma cells activates Stat3 (p-Stat3) in C2C12 myotubes. We identified two proteolytic pathways that are activated in muscle by p-Stat3; one is activation of caspase-3, and the other is p-Stat3 to myostatin, MAFbx/Atrogin-1, and MuRF-1 via CAAT/enhancer-binding protein δ (C/EBPδ)...
April 24, 2015: Journal of Biological Chemistry
https://read.qxmd.com/read/25500581/comprehensive-suppression-of-all-apoptosis-induced-proliferation-pathways-as-a-proposed-approach-to-colorectal-cancer-prevention-and-therapy
#34
JOURNAL ARTICLE
Michael Bordonaro, Eric Drago, Wafa Atamna, Darina L Lazarova
Mutations in the WNT/beta-catenin pathway are present in the majority of all sporadic colorectal cancers (CRCs), and histone deacetylase inhibitors induce apoptosis in CRC cells with such mutations. This apoptosis is counteracted by (1) the signaling heterogeneity of CRC cell populations, and (2) the survival pathways induced by mitogens secreted from apoptotic cells. The phenomena of signaling heterogeneity and apoptosis-induced survival constitute the immediate mechanisms of resistance to histone deacetylase inhibitors, and probably other chemotherapeutic agents...
2014: PloS One
https://read.qxmd.com/read/25270258/partial-inhibition-of-gp130-jak-stat3-signaling-prevents-wnt-%C3%AE-catenin-mediated-intestinal-tumor-growth-and-regeneration
#35
JOURNAL ARTICLE
Toby J Phesse, Michael Buchert, Emma Stuart, Dustin J Flanagan, Maree Faux, Shoukat Afshar-Sterle, Francesca Walker, Hui-Hua Zhang, Cameron J Nowell, Robert Jorissen, Chin Wee Tan, Yumiko Hirokawa, Moritz F Eissmann, Ashleigh R Poh, Jordane Malaterre, Helen B Pearson, David G Kirsch, Paolo Provero, Valeria Poli, Robert G Ramsay, Oliver Sieber, Antony W Burgess, Dennis Huszar, Elizabeth Vincan, Matthias Ernst
Most colon cancers arise from somatic mutations in the tumor suppressor gene APC (adenomatous polyposis coli), and these mutations cause constitutive activation of the Wnt-to-β-catenin pathway in the intestinal epithelium. Because Wnt-β-catenin signaling is required for homeostasis and regeneration of the adult intestinal epithelium, therapeutic targeting of this pathway is challenging. We found that genetic activation of the cytokine-stimulated pathway mediated by the receptor gp130, the associated Jak (Janus kinase) kinases, and the transcription factor Stat3 (signal transducer and activator of transcription 3) was required for intestinal regeneration in response to irradiation-induced damage in wild-type mice and for tumorigenesis in Apc-mutant mice...
September 30, 2014: Science Signaling
https://read.qxmd.com/read/24792576/egfr-and-her2-exert-distinct-roles-on-colon-cancer-cell-functional-properties-and-expression-of-matrix-macromolecules
#36
JOURNAL ARTICLE
Maria-Ioanna Ellina, Panagiotis Bouris, Alexios J Aletras, Achilleas D Theocharis, Dimitris Kletsas, Nikos K Karamanos
BACKGROUND: ErbB receptors, EGFR and HER2, have been implicated in the development and progression of colon cancer. Several intracellular pathways are mediated upon activation of EGFR and/or HER2 by EGF. However, there are limited data regarding the EGF-mediated signaling affecting functional cell properties and the expression of extracellular matrix macromolecules implicated in cancer progression. METHODS: Functional assays, such as cell proliferation, transwell invasion assay and migration were performed to evaluate the impact of EGFR/HER2 in constitutive and EGF-treated Caco-2 cells...
August 2014: Biochimica et Biophysica Acta
https://read.qxmd.com/read/24682388/aloperine-induces-g2-m-phase-cell-cycle-arrest-and-apoptosis-in-hct116-human-colon-cancer-cells
#37
JOURNAL ARTICLE
Li Zhang, Yanxin Zheng, Hongzhu Deng, Lei Liang, Juan Peng
Aloperine (ALO) is a quinolizidine alkaloid extracted from the leaves of Sophora alopecuroides (S. alopecuroides) and possesses anti-inflammatory, anti-allergenic, antitumor, and antiviral effects. In this study, when compared with seven other types of alkaloids extracted from S. alopecuroides, ALO treatment produced the most potent effects against HCT116 colon cancer cell types. ALO inhibited proliferation and induced apoptosis in HCT116 cells in a dose- and time-dependent manner as detected by MTT, clonogenic survival, and flow cytometric assays...
June 2014: International Journal of Molecular Medicine
https://read.qxmd.com/read/24398427/therapeutic-inhibition-of-jak-activity-inhibits-progression-of-gastrointestinal-tumors-in-mice
#38
JOURNAL ARTICLE
Emma Stuart, Michael Buchert, Tracy Putoczki, Stefan Thiem, Ryan Farid, Joachim Elzer, Dennis Huszar, Paul M Waring, Toby J Phesse, Matthias Ernst
Aberrant activation of the latent transcription factor STAT3 and its downstream targets is a common feature of epithelial-derived human cancers, including those of the gastrointestinal tract. Mouse models of gastrointestinal malignancy implicate Stat3 as a key mediator of inflammatory-driven tumorigenesis, in which its cytokine/gp130/Janus kinase (Jak)-dependent activation provides a functional link through which the microenvironment sustains tumor promotion. Although therapeutic targeting of STAT3 is highly desirable, such molecules are not available for immediate clinical assessment...
February 2014: Molecular Cancer Therapeutics
https://read.qxmd.com/read/24195509/incb018424-induces-apoptotic-cell-death-through-the-suppression-of-pjak1-in-human-colon-cancer-cells
#39
JOURNAL ARTICLE
H J An, E K Choi, J S Kim, S W Hong, J H Moon, J S Shin, S H Ha, K P Kim, Y S Hong, J L Lee, E K Choi, J S Lee, D H Jin, T W Kim
Janus kinase (JAK) is one of the main upstream activators of signal transducers and activators of transcription (STAT) that are constitutively activated in various malignancies and are associated with cell growth, survival, and carcinogenesis. Here, we investigated the role of JAKs in colorectal cancer in order to develop effective therapeutic targets for INCB018424, which is the first JAK1/2 inhibitor to be approved by FDA. After examining the basal expression levels of phospho-JAK1 and phospho-JAK2, we measured the effects of INCB018424 on the phosphorylation of JAK1/2 using western blot analysis...
2014: Neoplasma
https://read.qxmd.com/read/24098947/rkip-phosphorylation-and-stat3-activation-is-inhibited-by-oxaliplatin-and-camptothecin-and-are-associated-with-poor-prognosis-in-stage-ii-colon-cancer-patients
#40
JOURNAL ARTICLE
Sam Cross-Knorr, Shaolei Lu, Kimberly Perez, Sara Guevara, Kate Brilliant, Claudio Pisano, Peter J Quesenberry, Murray B Resnick, Devasis Chatterjee
BACKGROUND: A major obstacle in treating colorectal cancer (CRC) is the acquired resistance to chemotherapeutic agents. An important protein in the regulation of cancer cell death and clinical outcome is Raf kinase inhibitor protein (RKIP). In contrast, activated signal transducer and activator of transcription 3 (STAT3) is a protein that promotes tumor cell survival by inhibiting apoptosis and has an important role in cancer progression in many of cancer types. The aim of this study was to evaluate the regulation of RKIP and STAT3 after treatment with clinically relevant chemotherapeutic agents (camptothecin (CPT) and oxaliplatin (OXP)) and the cytokine interleukin-6 (IL-6) in HCT116 colon cancer cells as well as evaluate the association between RKIP and STAT3 with clinical outcome of Stage II colon cancer patients...
2013: BMC Cancer
keyword
keyword
104178
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.