keyword
MENU ▼
Read by QxMD icon Read
search

Adrenal function and sepsis

keyword
https://www.readbyqxmd.com/read/28666938/death-of-adrenocortical-cells-during-murine-acute-t-cruzi-infection-is-not-associated-with-tnf-r1-signaling-but-mostly-with-the-type-ii-pathway-of-fas-mediated-apoptosis
#1
Ana R Pérez, Flavia Lambertucci, Florencia B González, Eduardo A Roggero, Oscar A Bottasso, Juliana de Meis, Maria T Ronco, Silvina R Villar
Earlier studies from our laboratory demonstrated that acute experimental Trypanosoma cruzi infection promotes an intense inflammation along with a sepsis-like dysregulated adrenal response characterized by normal levels of ACTH with raised glucocorticoid secretion. Inflammation was also known to result in adrenal cell apoptosis, which in turn may influence HPA axis uncoupling. To explore factors and pathways which may be involved in the apoptosis of adrenal cells, together with its impact on the functionality of the gland, we carried out a series of studies in mice lacking death receptors, such as TNF-R1 (C57BL/6-(Tnfrsf1a tm1Imx) or TNF-R1(-/-)) or Fas ligand (C57BL/6 Fas-deficient lpr mice), undergoing acute T...
June 27, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28567296/thyrotoxicosis-leading-to-adrenal-crises-reveals-primary-bilateral-adrenal-lymphoma
#2
Catarina Roque, Ricardo Fonseca, Carlos Tavares Bello, Carlos Vasconcelos, António Galzerano, Sância Ramos
Primary adrenal lymphoma is a rare malignancy. It frequently presents bilaterally and with symptoms of adrenal insufficiency. Amiodarone may induce secondary organ dysfunction, and thyrotoxicosis develops in 15% of cases. The symptomatology of both conditions is nonspecific, especially in the elderly, and a high suspicion index is necessary for appropriate diagnosis. A 78-year-old female presented to the emergency department with confusion, nausea and vomiting. She had recently been to the emergency department with urinary tract infection, vomiting and acute hypochloremic hyponatremia...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28406323/the-inhibiting-effect-of-intravenous-anesthesia-on-adrenal-gland-functions-under-the-sepsis-condition
#3
Te Wang, Changdong Liu, Pihong Wei, Lili Lv, Zaiqi Yang
This study aims to explore the effect of intravenous anesthesia on the adrenal gland functions of rats with sepsis as well as on their lungs and adrenal gland tissues in order to provide a theoretical reference for the cure of sepsis. Female Sprague Dawley (SD) rats were taken as the research objects in this study. Venous channels of rats were constructed by catheterization through the external jugular vein, and the cecal ligation and puncture technique was adopted to duplicate the sepsis rat models. The level of tumor necrosis factor-α (TNF-α) in serum was detected using enzyme-linked immunosorbent assay (ELISA), and necrocytosis was observed by the fluorescent staining method...
April 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28393725/level-of-adrenomedullin-in-cases-with-adrenal-defficiency-and-its-relation-to-mortality-in-patients-with-sepsis
#4
Baran Balcan, Şehnaz Olgun, Türkay Akbaş, Emel Eryüksel, Sait Karakurt
Introduction: The aim of this study was to determine the prognostic value of adrenomedullin, after evaluation of adrenal function in sepsis patients. We also evaluated other prognostic factors such as APACHE II score, proBNP, and CRP and their prediction in mortality. Materials and Methods: This is a prospective, observational study. We enrolled 48 patients, who were admitted to the intensive care unit due to sepsis according to surviving sepsis campaign criteria...
September 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28366151/-level-of-adrenomedullin-in-cases-with-adrenal-defficiency-and-its-relation-to-mortality-in-patients-with-sepsis
#5
Baran Balcan, Şehnaz Olgun, Türkay Akbaş, Emel Eryüksel, Sait Karakurt
Introduction: The aim of this study was to determine the prognostic value of adrenomedullin, after evaluation of adrenal function in sepsis patients. We also evaluated other prognostic factors such as APACHE II score, proBNP, and CRP and their prediction in mortality. Materials and Methods: This is a prospective, observational study. We enrolled 48 patients, who were admitted to the intensive care unit due to sepsis according to surviving sepsis campaign criteria...
September 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28018291/adrenal-gland-microenvironment-and-its-involvement-in-the-regulation-of-stress-induced-hormone-secretion-during-sepsis
#6
REVIEW
Waldemar Kanczkowski, Mariko Sue, Stefan R Bornstein
Survival of all living organisms depends on maintenance of a steady state of homeostasis, which process relies on its ability to react and adapt to various physical and emotional threats. The defense against stress is executed by the hypothalamic-pituitary-adrenal axis and the sympathetic-adrenal medullary system. Adrenal gland is a major effector organ of stress system. During stress, adrenal gland rapidly responds with increased secretion of glucocorticoids (GCs) and catecholamines into circulation, which hormones, in turn, affect metabolism, to provide acutely energy, vasculature to increase blood pressure, and the immune system to prevent it from extensive activation...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27833904/surgical-treatment-after-failed-primary-correction-of-urogenital-sinus-in-female-patients-with-virilizing-congenital-adrenal-hyperplasia-are-good-results-possible
#7
Maria Helena Palma Sircili, Tania Sartori Sanchez Bachega, Guiomar Madureira, Larissa Gomes, Berenice Bilharinho Mendonca, Francisco Tibor Dénes
PURPOSE: Genital reconstruction in female patients with virilizing congenital adrenal hyperplasia (CAH) is very challenging. Our aim was to evaluate the techniques employed to treat complications after failure of primary urogenital sinus (UGS) surgery, as well as the result of these reoperations. PATIENTS AND METHODS: Twenty girls with virilizing CAH who were previously submitted to genitoplasty in our service and elsewhere had recurrent UGS stenosis and vaginal introitus stenosis that required surgical treatment...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27540247/application-of-pharmaceutical-knowledge-to-the-unconventional-use-of-a-rarely-used-anaesthetic-agent
#8
Caroline Cole
CASE SUMMARY: A 6 yr old 45 kg child with severe Cushinoid features was admitted to PICU with probable hypertensive encephalopathy. She presented with increasing headaches, vomiting and seizures becoming unresponsive with a GCS of 3. She was profoundly hypertensive and her cortisol levels were significantly elevated (>2000 nmol/L). Rapid reduction in cortisol levels was required to stabilise her condition prior to surgery. Etomidate is the only readily available intravenous preparation which reliably suppresses adrenocortical function...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27103538/the-pituitary-adenylate-cyclase-activating-polypeptide-pacap-protects-adrenal-function-in-septic-rats-administered-etomidate
#9
Na Liu, Yu Zhang, Jun-Yu Xiong, Shan Liu, Jie Zhu, Shen Lv
BACKGROUND: Both hyperinflammation during sepsis and etomidate can suppress adrenal function. In this study, we explored whether treatment with pituitary adenylate cyclase-activating polypeptide (PACAP) relieves adrenal suppression in cecal ligation and puncture (CLP)-induced septic rats. MATERIALS AND METHODS: Female Sprague-Dawley rats were randomly divided into five groups (n=7 per group), including the sham group, sepsis group (CLP group), sepsis and etomidate group (CLP+ETO group), PACAP group, and etomidate alone group (ETO group)...
August 2016: Neuropeptides
https://www.readbyqxmd.com/read/26942021/a-case-of-waterhouse-friderichsen-syndrome-resulting-from-an-invasive-pneumococcal-infection-in-a-patient-with-a-hypoplastic-spleen
#10
Kazumasa Emori, Nobuhiro Takeuchi, Junichi Soneda
A 50-year-old male was brought to our emergency department by ambulance with complaints of pain and numbness in both legs. At arrival, purple spots were evident on his neck and face. Examination of the vital sign indicated septic shock. Laboratory data and blood gas analysis revealed disseminated intravascular coagulation, multiple organ failure, and metabolic acidosis. Peripheral blood smears revealed Howell-Jolly bodies, indicating decreased splenic function. A rapid urinary pneumococcal antigen test was also found to be positive...
2016: Case Reports in Critical Care
https://www.readbyqxmd.com/read/26821337/ultrasonographic-approach-to-diagnosis-of-fetal-inflammatory-response-syndrome-a-tool-for-at-risk-fetuses
#11
REVIEW
Salvatore Andrea Mastrolia, Offer Erez, Giuseppe Loverro, Edoardo Di Naro, Adi Yehuda Weintraub, Dan Tirosh, Joel Baron, Reli Hershkovitz
Preterm parturition is a syndrome that may result from many underlying mechanisms. Infection and inflammation are the prominent ones. Intrauterine infection and inflammation have an effect akin to sepsis, and that is similar to systemic inflammatory response in adults. Indeed, there is evidence to support the association of a fetal inflammatory response syndrome (FIRS) to systemic infection and inflammation. The utilization of invasive procedures for the prenatal diagnosis of FIRS is associated with a risk for complications resulting from the invasive method...
July 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26491861/mortality-of-septic-mice-strongly-correlates-with-adrenal-gland-inflammation
#12
Carla Jennewein, Nguyen Tran, Waldemar Kanczkowski, Lars Heerdegen, Ajith Kantharajah, Stefan Dröse, Stefan Bornstein, Bertram Scheller, Kai Zacharowski
OBJECTIVES: Sepsis and septic shock are commonly present in the ICU and accompanied by significant morbidity, mortality, and cost. The frequency of secondary adrenal insufficiency in sepsis remains open to debate and a challenge to identify and treat appropriately. Animal models of sepsis using genetic or surgical initiation of adrenal insufficiency resulted in increased mortality, but the mechanisms are still unclear. The present study investigates the impact of adrenal inflammation in septic mice challenged with cecal ligation and puncture...
April 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/26308430/corticosteroid-therapy-benefits-septic-mice-with-adrenal-insufficiency-but-harms-septic-mice-without-adrenal-insufficiency
#13
COMPARATIVE STUDY
Junting Ai, Ling Guo, Zhong Zheng, Shu-Xia Wang, Bing Huang, Xiang-An Li
OBJECTIVES: Corticosteroid therapy is frequently used in septic patients given the rationale that there is an increased demand for corticosteroid in sepsis, and up to 60% of severe septic patients experience adrenal insufficiency. However, the efficacy of corticosteroid therapy and whether the therapy should be based on the results of adrenal function testing are highly controversial. The lack of an adrenal insufficiency animal model and our poor understanding of the pathogenesis caused by adrenal insufficiency present significant barriers to address this long-standing clinical issue...
November 2015: Critical Care Medicine
https://www.readbyqxmd.com/read/26261663/an-autopsy-case-of-pneumococcal-waterhouse-friderichsen-syndrome-with-possible-functional-asplenia-hyposplenia
#14
Yukiko Hata, Takashi Chiba, Maki Ohtani, Shin Ishizawa, Naoki Nishida
We report an autopsy case of rapid progressive Waterhouse-Friderichsen syndrome (WFS) associated with Streptococcus pneumonia infection in a previously healthy man. Although he once visited a hospital about 6 hours before death, the both physical and serological examination did not show any sign of overwhelming infection. Autopsy showed massive adrenal hemorrhage without inflammation, and showed proliferation of gram positive cocci and microthrombosis in the vessels of many organs. The pathological change of respiratory tract was extremely minimal...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26226342/corticosteroids-in-pediatric-shock-a-call-to-arms
#15
Kusum Menon, Hector R Wong
OBJECTIVE: To identify the issues needing to be resolved to design, implement, and complete a definitive randomized controlled trial of adjunctive corticosteroid use in children with septic shock. DESIGN: Pediatric studies from MEDLINE (1946 to January 2015) and Embase (1947 to January 2015) that addressed adrenal function or steroid use in critically ill children with systemic inflammatory response syndrome, sepsis, or septic shock were reviewed and their relevant points discussed...
October 2015: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/25961232/glucocorticoid-signaling-in-cardiac-disease
#16
Rongqin Ren, John A Cidlowski
As major mediators of stress regulation, glucocorticoids have an essential role in maintaining cardiovascular homeostasis under both physiological and pathological conditions. The release of glucocorticoids into the peripheral circulation is adjusted by the hypothalamic-pituitary-adrenal axis in response to various pathological challenges such as sepsis, starvation, and psychological stress. Clinically, dysregulation of the glucocorticoid-mediated signaling as a result of either excess ligand or receptor hypersensitivity is connected with the progression of unfavorable cardiovascular events such as cardiac hypertrophy, atherosclerosis, and coronary artery disease...
December 1, 2010: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/25560635/diminished-adrenal-sensitivity-to-endogenous-and-exogenous-adrenocorticotropic-hormone-in-critical-illness-a-prospective-cohort-study
#17
Margriet F C de Jong, Nienke Molenaar, Albertus Beishuizen, A B Johan Groeneveld
INTRODUCTION: Adrenal dysfunction may represent critical illness-related corticosteroid insufficiency (CIRCI), as evidenced by a diminished cortisol response to exogenous adrenocorticotropic hormone (ACTH), but this concept and its clinical significance remain highly controversial. We studied the adrenal response to exogenous ACTH as a function of the endogenous cortisol-to-ACTH ratio, a measure of adrenal sensitivity, and of clinical variables, during critical illness and recovery from the acute phase...
2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/25543020/the-role-of-adrenal-gland-microenvironment-in-the-hpa-axis-function-and-dysfunction-during-sepsis
#18
REVIEW
Waldemar Kanczkowski, Mariko Sue, Kai Zacharowski, Martin Reincke, Stefan R Bornstein
Sepsis and septic shock in response to bacterial or viral infections remain the major health problem worldwide. Despite decades of intensive research and improvements in medical care, severe sepsis is associated with high mortality. Rapid activation of the adrenal gland glucocorticoid and catecholamine production is a fundamental component of the stress response and is essential for survival of the host. However, in many critically ill patients this homeostatic function of the adrenal gland is often impaired...
June 15, 2015: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/25450963/mouse-models-of-sepsis-elicit-spontaneous-action-potential-discharge-and-enhance-intracellular-ca2-signaling-in-postganglionic-sympathetic-neurons
#19
M K Lukewich, A E Lomax
Sepsis is a severe systemic inflammatory disorder that rapidly activates the sympathetic nervous system to enhance catecholamine secretion from postganglionic sympathetic neurons and adrenal chromaffin cells. Although an increase in preganglionic drive to postganglionic sympathetic tissues has been known to contribute to this response for quite some time, only recently was it determined that sepsis also has direct effects on adrenal chromaffin cell Ca2+ signaling and epinephrine release. In the present study, we characterized the direct effects of sepsis on postganglionic sympathetic neuron function...
January 22, 2015: Neuroscience
https://www.readbyqxmd.com/read/25365720/reversible-increase-in-maximal-cortisol-secretion-rate-in-septic-shock
#20
Richard I Dorin, Clifford R Qualls, David J Torpy, Ronald M Schrader, Frank K Urban
OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency. We sought to assess adrenocortical function using computer-assisted numerical modeling methodology to characterize and compare maximal cortisol secretion rate and free cortisol half-life in septic shock, sepsis, and healthy control subjects. DESIGN: Post hoc analysis of previously published total cortisol, free cortisol, corticosteroid-binding globulin, and albumin concentration data...
March 2015: Critical Care Medicine
keyword
keyword
104177
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"