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Copper T

Shu-Wen Sun, Hai-Ling Liu, Yue Zhou, Feng-Bin Wang, Xing-Hua Xia
An electrochemical sensor using ultralight and porous copper-nitrogen doped graphene (CuNRGO) nanocomposite as the electrocatalyst has been constructed to simultaneously determine DNA bases such as guanine (G) and cytosine (C), adenine (A) and thymine (T). The nanocomposite is synthesized by thermally annealing an ice templated structure of graphene oxide (GO) and Cu(phen)2. Due to the unique structure and the presence of Cu(2+)-N active sites, the CuNRGO exhibits outstanding electrocatalytic activity toward the oxidation of free DNA bases...
September 22, 2017: Analytical Chemistry
Caroline N Wolfe Wurtzel, Geoffrey T Burns, Andy F Zhu, Kagan Ozer
PURPOSE: Volar plates positioned at, or distal to, the watershed line have been shown to have a higher incidence of attritional rupture of the flexor pollicis longus (FPL). In this study, we aimed to evaluate the effect of wrist extension and volar tilt on the contact between the plate and the FPL tendon in a cadaver model. We hypothesized that, following volar plate application, loss of native volar tilt increases the contact between the FPL and the plate at lower degrees of wrist extension...
September 16, 2017: Journal of Hand Surgery
Ke Bian, Fangyi Chen, Zachary T Humulock, Qi Tang, Deyu Li
Disturbed metabolism of copper ions can cause diseases, such as Wilson's disease (WD). In this work, we investigated the inhibi-tory effect of Cu(II) ion on the AlkB family DNA repair enzymes in vitro, which are members of the Fe(II)/alpha-ketoglutarate-dependent dioxygenase and include human ALKBH2, ALKBH3, and E. coli AlkB proteins. None of the three proteins were significantly inhibited under normal cellular copper concentrations. But under WD related condition, we observed the activities of all three enzymes were strongly suppressed (from 95...
September 19, 2017: Chemical Research in Toxicology
Richard C Walroth, Kelsey C Miles, James T Lukens, Samantha N MacMillan, Shannon S Stahl, Kyle M Lancaster
Copper/aminoxyl species are proposed as key intermediates in aerobic alcohol oxidation. Several possible electronic structural descriptions of these species are possible, and the present study probes this issue by examining four crystallographically characterized Cu/aminoxyl halide complexes by Cu K-edge, Cu L2,3-edge, and Cl K-edge X-ray absorption spectroscopy. The mixing coefficients between Cu, aminoxyl, and halide orbitals are determined via these techniques with support from density functional theory...
September 18, 2017: Journal of the American Chemical Society
Qianmei Zhang, Wei Wei, Peilin Wang, Liping Zuo, Feng Li, Jin Xu, Xiaobo Xi, Xiaoyong Gao, Guanghui Ma, Hai-Yan Xie
Adoptive T-cell transfer for cancer therapy relies on both effective ex vivo T-cell expansion and in vivo targeting performance. One promising but challenging method for accomplishing this purpose is to construct multifunctional artificial antigen-presenting cells (aAPCs). We herein developed biomimetic magnetosomes as versatile aAPCs, wherein magnetic nanoclusters were coated with azide-engineered leucocyte membranes and then decorated with T-cell stimuli through copper-free click chemistry. These nano aAPCs not only exhibited high performance for antigen-specific cytotoxic T-cell (CTL) expansion and stimulation but also visually and effectively guided reinfused CTLs to tumor tissues through magnetic resonance imaging and magnetic control...
September 20, 2017: ACS Nano
Jacob J Lacharity, Jeremy Fournier, Ping Lu, Artur K Mailyan, Aaron T Herrmann, Armen Zakarian
An asymmetric total synthesis of (+)-6-hydroxythiobinupharidine (1b) and (-)-6-Hydroxythionuphlutine (2b), a set of hemi-aminal containing dimeric sesquiterpenes isolated from yellow water lilies of the Nuphar genus, is described. The central bis-spirocyclic thiolane was forged through the Stevens rearrangement of a sulfonium ylide, generated in-situ from the coupling of a copper carbenoid with a spirocyclic thietane. This strategy diverges both from the proposed biosynthesis1 and previous syntheses of this family of alkaloids,2,3 all of which employ dimerization of symmetric monomers to form the aforementioned central thiolane...
September 15, 2017: Journal of the American Chemical Society
Tomoya Fujie, Shiori Okino, Eiko Yoshida, Chika Yamamoto, Hiroshi Naka, Toshiyuki Kaji
Recent developments have shown that organic-inorganic hybrid molecules have the potential to provide useful tools for analyzing biological systems. In the case of fibrinolysis, which is the phenomenon whereby fibrin is degraded by plasmin that has been converted from plasminogen via tissue plasminogen activator (t-PA) secreted from vascular endothelial cells, we hypothesized that there may be organic-inorganic hybrid molecules that could be used to analyze the mechanisms by which endothelial fibrinolysis is regulated...
2017: Journal of Toxicological Sciences
Alessandro Aliprandi, Tiago Moreira, Cosimo Anichini, Marc-Antoine Stoeckel, Matilde Eredia, Ugo Sassi, Matteo Bruna, Carlos Pinheiro, César A T Laia, Sara Bonacchi, Paolo Samorì
This study reports a novel green chemistry approach to assemble copper-nanowires/reduced-graphene-oxide hybrid coatings onto inorganic and organic supports. Such films are robust and combine sheet resistances (<30 Ω sq(-1) ) and transparencies in the visible region (transmittance > 70%) that are rivalling those of indium-tin oxide. These electrodes are suitable for flexible electronic applications as they show a sheet resistance change of <4% after 10 000 bending cycles at a bending radius of 1.0 cm, when supported on polyethylene terephthalate foils...
September 13, 2017: Advanced Materials
Corey H Yu, Nan Yang, Jameson Bothe, Marco Tonelli, Sergiy Nokhrin, Natalia V Dolgova, Lelita T Braiterman, Svetlana Lutsenko, Oleg Y Dmitriev
The human transporter ATP7B delivers copper to the biosynthetic pathways and maintains copper homeostasis in the liver. Mutations in ATP7B cause the potentially fatal hepato-neurological disorder Wilson disease. The activity and intracellular localization of ATP7B are regulated by copper, but the molecular mechanism of this regulation is largely unknown. We show that the copper chaperone Atox1, which delivers copper to ATP7B, and the group of the first three metal binding domains (MBD1-3) are central to the activity regulation of ATP7B...
September 12, 2017: Journal of Biological Chemistry
Christopher P Favazza, Heidi A Edmonson, Chi Ma, Yunhong Shu, Joel P Felmlee, Robert E Watson, Krzysztof R Gorny
PURPOSE: To assess risks of RF-heating of a vagus nerve stimulator (VNS) during 1.5T prostate MRI using body coil transmit and to compare these risks with those associated with MRI head exams using a transmit/receive head coil. METHODS: Spatial distributions of radio-frequency (RF) B1 fields generated by transmit/receive (T/R) body and head coils were empirically assessed along the long axis of a 1.5 T MRI scanner bore. Measurements were obtained along the center axis of the scanner and laterally offset by 15 cm (body coil) and 7 cm (head coil)...
September 7, 2017: Medical Physics
Q N Pham, M T Barako, J Tice, Y Won
Delivering liquid through the void spaces in porous metals is a daunting challenge for a variety of emerging interface technologies ranging from battery electrodes to evaporation surfaces. Hydraulic transport characteristics of well-ordered porous media are governed by the pore distribution, porosity, and morphology. Much like energy transport in polycrystalline solids, hydraulic transport in semi-ordered porous media is predominantly limited by defects and grain boundaries. Here, we report the wicking performances for porous copper inverse opals having pore diameters from 300 to 1000 nm by measuring the capillary-driven liquid rise...
September 5, 2017: Scientific Reports
O Kuzmina, N H Hassan, L Patel, C Ashworth, E Bakis, A J P White, P A Hunt, T Welton
Solvatochromic transition metal (TM)-complexes with weakly associating counter-anions are often used to evaluate traditional neutral solvent and anion coordination ability. However, when employed in ionic liquids (IL) many of the common assumptions made are no longer reliable. This study investigates the coordinating ability of weakly coordinating IL anions in traditional solvents and within IL solvents employing a range of solvatochromic copper complexes. Complexes of the form [Cu(acac)(tmen)][X] (acac = acetylacetonate, tmen = tetramethylethylenediamine) where [X](-) = [ClO4](-), Cl(-), [NO3](-), [SCN](-), [OTf](-), [NTf2](-) and [PF6](-) have been synthesised and characterised both experimentally and computationally...
September 28, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Ignacio T Vargas, Diego A Fischer, Marco A Alsina, Juan P Pavissich, Pablo A Pastén, Gonzalo E Pizarro
Corrosion of copper pipes may release high amounts of copper into the water, exceeding the maximum concentration of copper for drinking water standards. Typically, the events with the highest release of copper into drinking water are related to the presence of biofilms. This article reviews this phenomenon, focusing on copper ingestion and its health impacts, the physicochemical mechanisms and the microbial involvement on copper release, the techniques used to describe and understand this phenomenon, and the hydrodynamic effects...
September 5, 2017: Materials
Diana A Iovan, Alexandra T Wrobel, Arthur A McClelland, Austin B Scharf, Guy A Edouard, Theodore A Betley
We report the isolation of a room temperature stable dipyrromethene Cu(O2) complex featuring a side-on O2 coordination. Reactivity studies highlight the unique ability of the dioxygen adduct for both hydrogen-atom abstraction and acid/base chemistry towards phenols, demonstrating that side-on superoxide species can be reactive entities.
September 14, 2017: Chemical Communications: Chem Comm
Anna V Vologzhanina, Varvara V Avdeeva, Mikhail I Buzin, Artem O Dmitrienko, Pavel V Dorovatovskii, Elena A Malinina, Nikolay T Kuznetsov, Evgenia D Voronova, Yan V Zubavichus
A series of salts and complexes containing trans- and iso-isomers of octadecahydro-eicosaborate [B20H18]2- dianion is synthesized and characterized using FTIR and 11B NMR spectroscopies and X-ray diffraction techniques. Both isomers are found to act as four-, bi- or zero-dentate ligands in reactions with copper(II), silver(I) and lead(II) through apical and/or equatorial boron atoms. Solid-state photo- and thermoinitiated reactions of octadecahydro-eicosaborate isomerization and solvent cleavage occurring in these compounds in a single-crystal-to-single-crystal manner are studied in situ...
September 4, 2017: Chemistry: a European Journal
Wilco van der Lugt, Sjoerd M Euser, Jacob P Bruin, Jeroen W Den Boer, Jimmy T Walker, Sebastian Crespi
Legionella continues to be a problem in water systems. This study investigated the influence of different shower mixer faucets, and the influence of the presence of cast iron rust from a drinking water system on the growth of Legionella. The research is conducted using a model of a household containing four drinking water systems. All four systems, which contained standard plumbing components including copper pipes and a water heater, were filled with unchlorinated drinking water. Furthermore, all systems had three different shower faucets: (A) a stainless-steel faucet, (B) a brass-ceramic faucet, and (C) a brass thermostatic faucet...
August 18, 2017: International Journal of Hygiene and Environmental Health
Huria Ibrahim, Hiba Farah, Amal Zein Eddin, Samih Isber, Rabih Sultan
Metal electrodeposition systems display tree-like structures with extensive ramification and a fractal character. Electrolysis is not a necessary route for the growth of such dendritic metal deposits. We can grow beautiful ramification patterns via a simple redox reaction. We present here a study of silver (Ag) deposits from the reduction of Ag(+) in (AgNO3) solution by metallic copper. The experiments are carried out in discotic geometry, in a Petri dish hosting a thin AgNO3 solution film. A variety of deposited structures and patterns is obtained at different Ag(+) concentrations, yet with essentially the same fractal dimension averaged at 1...
August 2017: Chaos
Ian Diner, Jeromy Dooyema, Marla Gearing, Lary C Walker, Nicholas T Seyfried
The benzothiazole-aniline derivative Pittsburgh Compound B (PiB) is the prototypical amyloid affinity probe developed for the in vivo positron emission tomography (PET) detection of amyloid beta (Aβ) deposits in Alzheimer's disease (AD). Specific high-affinity binding sites for PiB have been found to vary among AD cases with comparable Aβ load, and they are virtually absent on human-sequence Aβ deposits in animal models, none of which develop the full phenotype of AD. PiB thus could be an informative probe for studying the pathobiology of Aβ, but little is known about the localization of PiB binding at the molecular or structural level...
September 22, 2017: Bioconjugate Chemistry
Lionel Chapus, Pierre Aubertin, Suzanne Joiret, Ivan T Lucas, Emmanuel Maisonhaute, Alexa Courty
We present here new substrates for Surface Enhanced Raman Spectroscopy (SERS). The synthesis of colloidal nanoparticles through organometallic route allowed to obtain gold, silver or copper nanoparticles of well-controlled shapes and sizes (between 5 and 12 nm in diameter). The organization of these nanoparticles into large-scale 3D superlattices produces a very large number of "hot spots" at the origin of the signal enhancement. Each superlattice was studied individually in order to correlate its optical and SERS properties to its thickness, to the nanoparticle sizes and to the interparticle distance...
September 1, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Rawan Eid, David R Zhou, Nagla T T Arab, Eric Boucher, Paul G Young, Craig A Mandato, Michael T Greenwood
The induction of Programmed Cell Death (PCD) requires the activation of complex responses involving the interplay of a variety of different cellular proteins, pathways, and processes. Uncovering the mechanisms regulating PCD requires an understanding of the different processes that both positively and negatively regulate cell death. Here we have examined the response of normal as well as PCD resistant yeast cells to different PCD inducing stresses. As expected cells expressing the pro-survival human 14-3-3β/α sequence show increased resistance to numerous stresses including copper and rapamycin...
2017: PloS One
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