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https://www.readbyqxmd.com/read/27900092/primary-orbital-precursor-t-cell-lymphoblastic-lymphoma-report-of-a-unique-case
#1
Lisa Stenman, Marta Persson, Fredrik Enlund, Erik Clasen-Linde, Göran Stenman, Steffen Heegaard
Primary T-cell lymphoblastic lymphoma (T-LBL) in the eye region is very rare. The present study described a unique case of T-LBL involving the extraocular muscles. A 22-year-old male patient presented with a 3-week history of headache, reduced visual acuity and edema of the left eye. Clinical examination revealed left-sided exophthalmus, periorbital edema, chemosis, and reduced motility of the left eye. A magnetic resonance imaging scan revealed thickening of the left orbital muscles and a positron emission tomography-computed tomography scan also demonstrated activity in a subclavicular lymph node...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27881629/risk-of-fractures-after-stroke-results-from-the-ontario-stroke-registry
#2
Moira K Kapral, Jiming Fang, Shabbir M H Alibhai, Peter Cram, Angela M Cheung, Leanne K Casaubon, Marla Prager, Melissa Stamplecoski, Brennan Rashkovan, Peter C Austin
OBJECTIVE: To determine the risk of fractures after stroke. METHODS: Using the Ontario Stroke Registry, we identified a population-based sample of consecutive patients seen in the emergency department or hospitalized with stroke (n = 23,751) or TIA (n = 11,240) at any of 11 stroke centers in Ontario, Canada, and discharged alive between July 1, 2003, and March 31, 2012. We compared the risk of low-trauma fractures in patients with stroke vs those with TIA using propensity score methods to adjust for differences in baseline factors...
November 23, 2016: Neurology
https://www.readbyqxmd.com/read/27879514/primary-cutaneous-t-cell-lymphomas-showing-gamma-delta-%C3%AE-%C3%AE-phenotype-and-predominantly-epidermotropic-pattern-are-clinicopathologically-distinct-from-classic-primary-cutaneous-%C3%AE-%C3%AE-t-cell-lymphomas
#3
E Dean Merrill, Rose Agbay, Roberto N Miranda, Phyu P Aung, Michael T Tetzlaff, Ken H Young, Jonathan L Curry, Priyadharsini Nagarajan, Doina Ivan, Victor G Prieto, L Jeffrey Medeiros, Madeleine Duvic, Carlos A Torres-Cabala
Primary cutaneous gamma-delta (γδ) T-cell lymphoma is a rare disease that typically involves the dermis and subcutis. Cases of primary cutaneous T-cell lymphomas showing γδ phenotype and predominantly epidermotropic pattern (EγδTCL) are not well defined. In this series, cases of primary cutaneous T-cell lymphomas showing γδ phenotype were reviewed and classified as predominantly epidermotropic (EγδTCL) when >75% of lymphoma cells resided in the epidermis or predominantly dermal and/or subcutaneous (DSγδTCL)...
November 22, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27836976/stress-granule-induction-after-brain-ischemia-is-independent-of-eukaryotic-translation-initiation-factor-eif-2%C3%AE-phosphorylation-and-is-correlated-with-a-decrease-in-eif4b-and-eif4e-proteins
#4
María Irene Ayuso, Emma Martínez-Alonso, Ignacio Regidor, Alberto Alcázar
Stress granules (SGs) are cytoplasmic ribonucleoprotein aggregates that are directly connected with the translation-initiation arrest response to cellular stresses. Translation inhibition (TI) is observed in transient brain ischemia, condition which induces persistent TI even after reperfusion, i.e., when blood flow is restored, and causes delayed neuronal death (DND) in selective vulnerable regions. We previously described a connection between TI and DND in the hippocampal cornu ammonis 1 (CA1) in an animal model of transient brain ischemia...
November 11, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27835656/the-association-of-peri-procedural-blood-transfusion-with-morbidity-and-mortality-in-patients-undergoing-percutaneous-lower-extremity-vascular-interventions-insights-from-bmc2-vic
#5
Peter K Henke, Yeo Jung Park, Sachinder Hans, Paul Bove, Robert Cuff, Andris Kazmers, Theodore Schreiber, Hitinder S Gurm, P Michael Grossman
OBJECTIVE: To determine the predictors of periprocedural blood transfusion and the association of transfusion on outcomes in high risk patients undergoing endoluminal percutaneous vascular interventions (PVI) for peripheral arterial disease. METHODS/RESULTS: Between 2010-2014 at 47 hospitals participating in a statewide quality registry, 4.2% (n = 985) of 23,273 patients received a periprocedural blood transfusion. Transfusion rates varied from 0 to 15% amongst the hospitals in the registry...
2016: PloS One
https://www.readbyqxmd.com/read/27749929/rabies-virus-infection-induces-the-formation-of-stress-granules-closely-connected-to-the-viral-factories
#6
Jovan Nikolic, Ahmet Civas, Zoé Lama, Cécile Lagaudrière-Gesbert, Danielle Blondel
Stress granules (SGs) are membrane-less dynamic structures consisting of mRNA and protein aggregates that form rapidly in response to a wide range of environmental cellular stresses and viral infections. They act as storage sites for translationally silenced mRNAs under stress conditions. During viral infection, SG formation results in the modulation of innate antiviral immune responses, and several viruses have the ability to either promote or prevent SG assembly. Here, we show that rabies virus (RABV) induces SG formation in infected cells, as revealed by the detection of SG-marker proteins Ras GTPase-activating protein-binding protein 1 (G3BP1), T-cell intracellular antigen 1 (TIA-1) and poly(A)-binding protein (PABP) in the RNA granules formed during viral infection...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27699280/ptb-and-tiar-binding-to-insulin-mrna-3-and-5-utrs-implications-for-insulin-biosynthesis-and-messenger-stability
#7
Rikard G Fred, Syrina Mehrabi, Christopher M Adams, Nils Welsh
OBJECTIVES: Insulin expression is highly controlled on the posttranscriptional level. The RNA binding proteins (RBPs) responsible for this result are still largely unknown. METHODS AND RESULTS: To identify RBPs that bind to insulin mRNA we performed mass spectrometry analysis on proteins that bound synthetic oligonucloetides mimicing the 5'- and the 3'-untranslated regions (UTRs) of rat and human insulin mRNA in vitro. We observed that the RBPs heterogeneous nuclear ribonucleoprotein (hnRNP) U, polypyrimidine tract binding protein (PTB), hnRNP L and T-cell restricted intracellular antigen 1-related protein (TIA-1-related protein; TIAR) bind to insulin mRNA sequences, and that the in vitro binding affinity of these RBPs changed when INS-1 cells were exposed to glucose, 3-isobutyl-1-methylxanthine (IBMX) or nitric oxide...
September 2016: Heliyon
https://www.readbyqxmd.com/read/27639281/the-primary-immune-response-to-vaccinia-virus-vaccination-includes-cells-with-a-distinct-cytotoxic-effector-cd4-t-cell-phenotype
#8
C Mee Ling Munier, David van Bockel, Michelle Bailey, Susanna Ip, Yin Xu, Sheilajen Alcantara, Sue Min Liu, Gareth Denyer, Warren Kaplan, Kazuo Suzuki, Nathan Croft, Anthony Purcell, David Tscharke, David A Cooper, Stephen J Kent, John J Zaunders, Anthony D Kelleher
BACKGROUND: Smallpox was eradicated by a global program of inoculation with Vaccinia virus (VV). Robust VV-specific CD4 T-cell responses during primary infection are likely essential to controlling VV replication. Although there is increasing interest in cytolytic CD4 T-cells across many viral infections, the importance of these cells during acute VV infection is unclear. METHODS: We undertook a detailed functional and genetic characterization of CD4 T-cells during acute VV-infection of humans...
October 17, 2016: Vaccine
https://www.readbyqxmd.com/read/27612448/primary-rare-anaplastic-large-cell-lymphoma-alk-positive-in-small-intestine-case-report-and-review-of-the-literature
#9
Qinghua Cao, Fang Liu, Shurong Li, Ni Liu, Lihui Li, Changzhao Li, Tingsheng Peng
BACKGROUND: Primary anaplastic large cell lymphoma, ALK positive in small intestine is clinically rare and the clinical, radiological and pathological information are generally not available. Here, we report a case of 32-year-old male with ALK positive anaplastic large cell lymphoma at the junction of jejunum and ileum, and highlight the clinicopathological features and the differential diagnosis of this type lymphoma. CASE PRESENTATION: The patient presented with right middle abdominal mass for 1 month with sporadic pain...
2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27612012/t-cell-restricted-intracellular-antigen-1-facilitates-mitochondrial-fragmentation-by-enhancing-the-expression-of-mitochondrial-fission-factor
#10
Hyosun Tak, Jung Woo Eun, Jihye Kim, So Jung Park, Chongtae Kim, Eunbyul Ji, Heejin Lee, Hoin Kang, Dong-Hyung Cho, Kyungbun Lee, Wook Kim, Suk Woo Nam, Eun Kyung Lee
Mitochondrial morphology is dynamically regulated by the formation of small fragmented units or interconnected mitochondrial networks, and this dynamic morphological change is a pivotal process in normal mitochondrial function. In the present study, we identified a novel regulator responsible for the regulation of mitochondrial dynamics. An assay using CHANG liver cells stably expressing mitochondrial-targeted yellow fluorescent protein (mtYFP) and a group of siRNAs revealed that T-cell intracellular antigen protein-1 (TIA-1) affects mitochondrial morphology by enhancing mitochondrial fission...
September 9, 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27601594/neoadjuvant-chemotherapy-of-ovarian-cancer-results-in-three-patterns-of-tumor-infiltrating-lymphocyte-response-with-distinct-implications-for-immunotherapy
#11
Charlotte S Lo, Sanaz Sanii, David R Kroeger, Katy Milne, Aline Talhouk, Derek S Chiu, Kurosh Rahimi, Patricia A Shaw, Blaise A Clarke, Brad H Nelson
PURPOSE: Some forms of chemotherapy can enhance anti-tumor immunity through immunogenic cell death, resulting in increased T cell activation and tumor infiltration. Such effects could potentially sensitize tumors to immunotherapies, including checkpoint blockade. We investigated whether platinum- and taxane-based chemotherapy for ovarian cancer induces immunological changes consistent with this possibility. METHODS: Matched pre- and post-neoadjuvant chemotherapy tumor samples from 26 high-grade serous carcinoma (HGSC) patients were analyzed by immunohistochemistry (IHC) for a large panel of immune cells and associated factors...
September 6, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27596159/association-of-polymorphisms-in-genes-of-factors-involved-in-regulation-of-splicing-of-cystic-fibrosis-transmembrane-conductance-regulator-mrna-with-acute-respiratory-distress-syndrome-in-children-with-pneumonia
#12
Francesca Perez-Marques, Pippa Simpson, Ke Yan, Michael W Quasney, Nadine Halligan, Daniel Merchant, Mary K Dahmer
BACKGROUND: Previous work has demonstrated a strong association between lung injury in African American children with pneumonia and a polymorphic (TG)mTn region in cystic fibrosis transmembrane conductance (CFTR) involved in the generation of a nonfunctional CFTR protein lacking exon 9. A number of splicing factors that regulate the inclusion/exclusion of exon 9 have been identified. The objective of this study was to determine whether genetic variants in these splicing factors were associated with acute respiratory distress syndrome (ARDS) in children with pneumonia...
2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27564014/primary-intestinal-extranodal-natural-killer-t-cell-lymphoma-nasal-type-a-comprehensive-clinicopathological-analysis-of-55-cases
#13
Bao-Hua Yu, Ruo-Hong Shui, Wei-Qi Sheng, Chao-Fu Wang, Hong-Fen Lu, Xiao-Yan Zhou, Xiong-Zeng Zhu, Xiao-Qiu Li
PURPOSE: To investigate the clinicopathological features, survival and prognostic factors of primary intestinal extranodal natural killer/T-cell lymphoma, nasal type (PI-ENKTCL). METHODS: Clinical and histological characteristics of PI-ENKTCL cases were retrospectively evaluated. Immunohistochemical phenotype and status of Epstein-Barr virus (EBV) and T-cell receptor (TCR) gene rearrangement were examined. The overall survival and prognostic parameters were also analyzed...
2016: PloS One
https://www.readbyqxmd.com/read/27470997/systematic-evaluation-of-multiple-immune-markers-reveals-prognostic-factors-in-ovarian-cancer
#14
Phillip P Santoiemma, Carolina Reyes, Li-Ping Wang, Mike W McLane, Michael D Feldman, Janos L Tanyi, Daniel J Powell
OBJECTIVE: Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Several factors prognostic for survival have been identified including the presence of certain lymphocyte markers. Tumor-infiltrating lymphocytes (TILs), particularly cytotoxic CD8+ TILs, have been shown to be most favorable for prognosis in ovarian cancer, although other immune cells including CD3+ T-cells, CD4+ T-cells, and B-cells have also demonstrated survival benefits. Although data for these markers exists, results are not uniform in the literature...
October 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27460788/internalized-tau-sensitizes-cells-to-stress-by-promoting-formation-and-stability-of-stress-granules
#15
Cecilia A Brunello, Xu Yan, Henri J Huttunen
Stress granules are membrane-less RNA- and RNA-binding protein-containing complexes that are transiently assembled in stressful conditions to promote cell survival. Several stress granule-associated RNA-binding proteins have been associated with neurodegenerative diseases. In addition, a close link was recently identified between the stress granule core-nucleating protein TIA-1 and Tau. Tau is a central pathological protein in Alzheimer's disease and other tauopathies, and misfolded, aggregated Tau is capable of propagating pathology via cell-to-cell transmission...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27445489/alk-positive-anaplastic-large-cell-lymphoma-with-soft-tissue-involvement-in-a-young-woman
#16
Kehai Gao, Hongtao Li, Caihong Huang, Huazhuang Li, Jun Fang, Chen Tian
INTRODUCTION: Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma that has strong expression of CD30. ALCL can sometimes involve the bone marrow, and in advanced stages, it can produce destructive extranodal lesions. But anaplastic large cell lymphoma kinase (ALK)+ ALCL with soft tissue involvement is very rare. CASE REPORT: A 35-year-old woman presented with waist pain for over 1 month. The biopsy of soft tissue lesions showed that these cells were positive for ALK-1, CD30, TIA-1, GranzymeB, CD4, CD8, and Ki67 (90%+) and negative for CD3, CD5, CD20, CD10, cytokeratin (CK), TdT, HMB-45, epithelial membrane antigen (EMA), and pan-CK, which identified ALCL...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27428734/a-clinicopathologic-study-of-lennert-lymphoma-and-possible-prognostic-factors-the-importance-of-follicular-helper-t-cell-markers-and-the-association-with-angioimmunoblastic-t-cell-lymphoma
#17
Daisuke Kurita, Hiroaki Miyoshi, Noriaki Yoshida, Yuya Sasaki, Seiichi Kato, Daisuke Niino, Yasuo Sugita, Yoshihiro Hatta, Masami Takei, Makoto Makishima, Koichi Ohshima
Lennert lymphoma (LeL) is a variant of peripheral T-cell lymphoma, not otherwise specified. Few clinicopathologic studies have investigated LeL, which is a rare disease. Here, we analyzed the clinicopathologic features of 26 patients with LeL to identify potential prognostic factors. Neoplastic cells positive for CD4, CD8, CD4/CD8, TIA-1, and granzyme B were observed in 21 (80.8%), 4 (15.4%), 1 (3.8%), 4 (15.3%), and 0 (0.0%) patients, respectively. Regarding follicular helper T-cell (TFH) markers, neoplastic cells positive for programmed cell death-1 (PD-1), CXCL13, CD10, and BCL6 were observed in 14 (53...
September 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27412902/no-decline-in-the-risk-of-stroke-following-incident-atrial-fibrillation-since-2000-in-the-community-a-concerning-trend
#18
Alanna M Chamberlain, Robert D Brown, Alvaro Alonso, Bernard J Gersh, Jill M Killian, Susan A Weston, Véronique L Roger
BACKGROUND: While atrial fibrillation is a recognized risk factor for stroke, contemporary data on trends in stroke incidence after the diagnosis of atrial fibrillation are scarce. METHODS AND RESULTS: Olmsted County, MN residents with incident atrial fibrillation or atrial flutter (collectively referred to as AF) from 2000 to 2010 were identified. Cox regression determined associations of year of AF diagnosis with ischemic stroke and transient ischemic attack (TIA) occurring through 2013...
June 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27402301/indolent-t-cell-lymphoproliferative-disease-of-the-gastro-intestinal-tract-following-treatment-with-adalimumab-in-resistant-crohn-s-colitis
#19
Natalia Edison, Hila Belhanes-Peled, Yuval Eitan, Yifat Guthmann, Yelena Yeremenko, Mark Raffeld, Irit Elmalah, Philippe Trougouboff
We report a case of intestinal indolent T-cell lymphoproliferative disease (TCLPD) occurring after the initiation of Tumor Necrosis Factor-α (TNF-α) inhibitor therapy for resistant Crohn's disease. A prominent T-cell infiltrate positive for CD8, TIA-1, TCR-βF1 was associated with the foci of active inflammation. T-Cell Receptor (TCR) gene clonality studies (BIOMED-2) demonstrated monoclonality. After the TNF-α inhibitor treatment was withdrawn, the T-cell infiltrates regressed, but two years later, the same monoclonal T-cell infiltrate reappeared at the only site of active inflammation...
July 8, 2016: Human Pathology
https://www.readbyqxmd.com/read/27371730/long-noncoding-rna-malat1-promotes-aggressive-pancreatic-cancer-proliferation-and-metastasis-via-the-stimulation-of-autophagy
#20
Le Li, Hua Chen, Yue Gao, Yong-Wei Wang, Guang-Quan Zhang, Shang-Ha Pan, Liang Ji, Rui Kong, Gang Wang, Yue-Hui Jia, Xue-Wei Bai, Bei Sun
Recently, pancreatic ductal adenocarcinoma (PDAC) has emerged as one of the most aggressive malignant tumors with the worst prognosis. Previous studies have demonstrated that long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is increased in pancreatic cancer and is identified as a diagnostic biomarker. Nonetheless, the molecular mechanism of elevated MALAT1 levels and tumor aggressiveness remains unknown. In this study, MALAT1 was found to be highly expressed in PDAC tissues, and elevated expression was associated with poorer prognoses...
September 2016: Molecular Cancer Therapeutics
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