David D Berg, Stephen D Wiviott, Benjamin M Scirica, Thomas A Zelniker, Erica L Goodrich, Petr Jarolim, Ofri Mosenzon, Avivit Cahn, Deepak L Bhatt, Lawrence A Leiter, Darren K McGuire, John P H Wilding, Per Johanson, Anna Maria Langkilde, Itamar Raz, Eugene Braunwald, Marc S Sabatine, David A Morrow
OBJECTIVE: Heart failure (HF) is an impactful complication of type 2 diabetes mellitus (T2DM). We aimed to develop and validate a risk score for hospitalization for HF (HHF) incorporating biomarkers and clinical factor(s) in patients with T2DM. RESEARCH DESIGN AND METHODS: We derived a risk score for HHF using clinical data, high-sensitivity troponin T (hsTnT), and N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) from 6,106 placebo-treated patients with T2DM in SAVOR-TIMI 53 (Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus-Thrombolysis in Myocardial Infarction 53)...
November 2021: Diabetes Care