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https://www.readbyqxmd.com/read/28441157/new-role-of-mechanical-assist-device-as-bridge-to-transplant-usa-perspective
#1
Ambreen Mohamed, Natasha Mehta, Howard J Eisen
PURPOSE OF REVIEW: Cardiac transplant remains the gold standard of care for patients with end-stage heart failure. Unfortunately, due to the limited availability of donor hearts in the United States, not all eligible candidates are able to be transplanted. Since the introduction of mechanical assist devices for the treatment of advanced heart failure, patients gain a significant survival benefit while awaiting transplant. With rapidly evolving technology, it is important to appreciate the advances in the current use of mechanical assist devices...
April 24, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28441042/aberrantly-expressed-long-noncoding-rnas-in-recurrent-implantation-failure-a-microarray-related-study
#2
Li-Juan Fan, Hong-Jing Han, Jing Guan, Xiao-Wei Zhang, Qing-Hua Cui, Huan Shen, Cheng Shi
Long noncoding RNAs (lncRNAs) are a class of noncoding RNAs longer than 200 nucleotides. They were long regarded as transcription noise for their low expression and non-protein coding features. Recent published reports indicate that lncRNAs are involved in virtually every aspect of human biology. We aimed to profile the endometrial lncRNA expression pattern in women with recurrent implantation failure (RIF) and predict the function of the genes of the dysregulated lncRNA transcripts. Endometrial samples (24) were collected during window of implantation (14 RIF women and 10 women who conceived after embryo transfer)...
April 25, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28440910/subacute-pyridostigmine-exposure-increases-heart-rate-recovery-and-cardiac-parasympathetic-tone-in-rats
#3
Manushree Bharadwaj, Carey Pope, Michael Davis, Stuart Katz, Christian Cook, Lara Maxwell
Heart rate recovery (HRR) describes the rapid deceleration of heart rate after strenuous exercise and is an indicator of parasympathetic tone. A reduction in parasympathetic tone occurs in patients with congestive heart failure, resulting in prolonged HRR. Acetylcholinesterase inhibitors, such as pyridostigmine, can enhance parasympathetic tone by increasing cholinergic input to the heart. The objective of this study was to develop a rodent model of HRR to test the hypothesis that subacute pyridostigmine administration decreases cholinesterase activity and accelerates HRR in rats...
April 25, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28440568/impact-of-t-wave-amplitude-in-lead-avr-on-predicting-cardiac-events-in-ischemic-and-nonischemic-cardiomyopathy-patients-with-an-implantable-cardioverter-defibrillator
#4
Yoshihiro Tanaka, Tetsuo Konno, Yudai Tamura, Toyonobu Tsuda, Hiroshi Furusho, Masayuki Takamura, Kenji Sakata, Masakazu Yamagishi, Kenshi Hayashi
BACKGROUND: T wave amplitudes during ventricular repolarization in the lead aVR (TAaVR) are shown to be associated with adverse cardiac events in patients with several cardiovascular diseases, such as postmyocardial infarction. However, the utility of TAaVR has not been previously evaluated in patients with cardiomyopathy who have received implantable cardioverter defibrillators (ICD). Patients with ischemic or nonischemic cardiomyopathy (ICM or NICM, respectively) and who received an ICD may experience worsening of their condition due to the introduction of electric shock during treatment...
April 25, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28439819/lengthening-of-the-humerus-with-intramedullary-lengthening-nails-preliminary-report
#5
Julian Fürmetz, Søren Kold, Nikola Schuster, Florian Wolf, Peter H Thaller
Distraction osteogenesis of the humerus with fully implantable lengthening is now possible since the diameter of the available nails was reduced to 10 mm and below. We report on the first intramedullary lengthening cases of the humerus with two different lengthening devices (FITBONE and PRECICE). Two different approaches and implantation techniques were used. We retrospectively reviewed clinical and radiographic data and pointed out results, pitfalls and complications of the procedure. Four adult patients with relevant length discrepancy of the humerus were treated with fully implantable systems in two centers between 2012 and 2015...
April 24, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/28439636/kinematic-alignment-is-a-possible-alternative-to-mechanical-alignment-in-total-knee-arthroplasty
#6
Yong Seuk Lee, Stephen M Howell, Ye-Yeon Won, O-Sung Lee, Seung Hoon Lee, Hamed Vahedi, Seow Hui Teo
PURPOSE: A systematic review was conducted to answer the following questions: (1) Does kinematically aligned (KA) total knee arthroplasty (TKA) achieve clinical outcomes comparable to those of mechanically aligned (MA) TKA? (2) How do the limb, knee, and component alignments differ between KA and MA TKA? (3) How is joint line orientation angle (JLOA) changed from the native knee in KA TKA compared to that in MA TKA? METHODS: Nine full-text articles in English that reported the clinical and radiological outcomes of KA TKA were included...
April 24, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28438326/transapical-transcatheter-aortic-valve-implantation-using-the-j-valve-system-a-1-year-follow-up-study
#7
Xiang Luo, Xu Wang, Xuan Li, Xin Wang, Fei Xu, Mingzheng Liu, Bing Yu, Fei Li, Minghui Tong, Wei Wang
OBJECTIVE: Transcatheter aortic valve implantation has become a routine procedure to treat screened inoperable or high-risk patients. In this study, we present the first outcome of echocardiographic midterm using a new second-generation transcatheter aortic valve implantation system, the J-Valve system (Jie Cheng Medical Technologies, Suzhou, China), in patients with aortic stenosis or aortic regurgitation. METHODS: From July 2014 to June 2015, 21 patients with isolated aortic valve disease at high risk for open surgery received transapical transcatheter aortic valve implantation using the J-Valve system...
March 23, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28437660/an-experimental-analysis-of-shell-failure-in-breast-implants
#8
N G Ramião, P S Martins, M L Barroso, D C Santos, A A Fernandes
Breast implant durability and the mechanisms of rupture are important topics in the medical community, for patients, manufactures and regulatory medical agencies. After concerns about the Poly Implant Prosthesis (PIP) implants, the need for understanding the adverse outcomes and the failure mode to improve the breast implants increased. The objective of this research is to analyze and describe the rupture characteristics of failed explanted PIP implants to study the modes and causes of rupture. Eleven explanted PIP implants were analyzed by visual inspection and scanning electron microscopy (SEM)...
April 6, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28437496/novel-solution-for-massive-glenoid-defects-in-shoulder-arthroplasty-a-patient-specific-glenoid-vault-reconstruction-system
#9
David M Dines, Lawrence Gulotta, Edward V Craig, Joshua S Dines
Complex glenoid deformities present the most difficult challenges in shoulder arthroplasty. These deformities may be caused by severe degenerative or congenital deformity, posttraumatic anatomy, tumor, or, in most cases, bone loss after glenoid failure in anatomical total shoulder arthroplasty. Methods of treating severe bone loss have included inlay and onlay bone-graft options with augmented fixation and, in severe cases, salvage hemiarthroplasty with limited goal expectations. Unfortunately, none of these methods has provided consistently satisfactory reproducible results...
March 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28437353/evaluation-of-the-modern-luque-trolley-construct-for-the-treatment-of-early-onset-scoliosis-using-a-gliding-implant-in-an-immature-animal-model
#10
Jean A Ouellet, Catherine E Ferland, Karina Klein, Guillaume Racloz, Karina Klein, Henning Richter, Thomas Steffen, Brigitte von Rechenberg
STUDY DESIGN: This was an experimental animal study. OBJECTIVE: To determine biological compatibility, stability, and growth potential of the Trolley Gliding Vehicle (TGV) used in a novel surgical technique for guided spinal growth. SUMMARY OF BACKGROUND DATA: Current treatments for early-onset scoliosis maintaining spinal growth consist of posteriorly based spinal constructs requiring repetitive lengthening. Such interventions have a high rate of complications...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28437352/effect-and-strategy-of-1-stage-interrupted-2-level-transpedicular-wedge-osteotomy-for-correcting-severe-kyphotic-deformities-in-ankylosing-spondylitis
#11
Yongfei Zhao, Yan Wang, Zheng Wang, Xuesong Zhang, Keya Mao, Yonggang Zhang
STUDY DESIGN: Prospective study. OBJECTIVE: To investigate the safety, outcome, and strategy of the 1-stage interrupted 2-level transpedicular wedge osteotomy for correcting the severe kyphotic deformity in ankylosing spondylitis (AS). SUMMARY OF BACKGROUND DATA: There has been a large series in the literature reporting on results of osteotomy for the correction of kyphotic deformity secondary to AS. However, few articles have reported, in detail, the plan, design, strategy, and effect of 1-stage interrupted 2-level transpedicular wedge osteotomy for the correction of severe kyphotic deformity in AS...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28436055/implantation-window-and-angiogenesis
#12
Mostafa Peyvandi Karizbodagh, Bahman Rashidi, Amirhossein Sahebkar, Aria Masoudifar, Hamed Mirzaei
In recent decades, infertility is one of the health problems worldwide. One of the most crucial events in reproductive period is implantation window (IW). In the time after IW period, the embryo cannot connect to the endometrium; therefore the most critical issue for successful implantation is timely entrance of embryo to the uterine cavity during the IW. Implantation failure is responsible for many cases of infertility and is the most important limiting factor for achieving a successful outcome using the assisted reproductive techniques (ART)...
April 24, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28435571/outcome-of-skeletal-reconstructive-surgery-for-metastatic-bone-tumours-in-the-femur
#13
N H Mohamed-Haflah, Y Kassim, I Zuchri, W Zulmi
INTRODUCTION: The role of surgery in skeletal metastasis is to reduce morbidity and improve the quality of life in terminally ill patients. We report our experience with patients who underwent skeletal reconstructive surgery for metastatic bone tumour of the femur. MATERIALS AND METHODS: Twenty nine operations for skeletal metastasis of the femur performed in our centre between 2009 and 2015 were included in this study. We evaluated the choice of implant, complications, survival rate and functional outcome...
March 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28435557/internal-fixation-of-transverse-patella-fractures-using-cannulated-cancellous-screws-with-anterior-tension-band-wiring
#14
I Khan, M Y Dar, S Rashid, M F Butt
Aims: To evaluate the effectiveness and safety of anterior tension band wiring technique using two cannulated cancellous screws in patients with transverse (AO34-C1) or transverse with mildly comminuted (AO34-C2) patellar fractures. Materials and Methods: This is a prospective study of 25 patients with transverse fracture or transverse fracture with mildly comminuted patella fractures. All the patients were treated with open reduction and internal fixation using two parallel cannulated screws and 18G stainless steel wire as per the tension band principle...
July 2016: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28435004/improvements-in-left-ventricular-diastolic-mechanics-after-parachute-device-implantation-in-patients-with-ischemia-heart-failure-a-cardiac-ct-study
#15
Chun-Ho Yun, Jing-Yi Sun, Barry Templin, Shih-Hsuan Lin, Kuan-Ming Chen, Tung-Hsin Wu, Chung-Lieh Hung, Chun-Chieh Liu, Hsi-Hsien Hsu, Mohamad Amer Alaiti, Anas Fares, Anthony DeCicco, Hiram G Bezerra
BACKGROUND: Percutaneous ventricular restoration therapy using left ventricle (LV) partitioning Parachute device has emerged as a clinical treatment option for LV apical aneurysm post extensive anterior myocardial infarction (AMI). We assessed changes of diastolic mechanics and accompanied functional improvements following LV parachute device implantation by cardiac computed tomography (CCT). METHODS AND RESULTS: CCT data from 28 patients in the pre- and post-implantation of LV parachute device implantation...
April 20, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28434697/poor-outcomes-of-irrigation-and-debridement-in-acute-periprosthetic-joint-infection-with-antibiotic-impregnated-calcium-sulfate-beads
#16
Michael A Flierl, Brian M Culp, Kamil T Okroj, Bryan D Springer, Brett R Levine, Craig J Della Valle
BACKGROUND: One proposed strategy to increase the success of irrigation and debridement with implant retention for the treatment of acute periprosthetic joint infection (PJI) is the use of dissolvable antibiotic-impregnated calcium sulfate beads to provide a local depot of antibiotics. The purpose of this study was to evaluate the outcome of such an approach. METHODS: Thirty-two patients with acute hematogenous (18 patients; 1 bilateral) or acute postoperative (14 patients) PJIs who underwent irrigation and debridement with implant retention and addition of antibiotic-impregnated calcium sulfate beads were retrospectively reviewed...
March 29, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28434694/a-prospective-randomized-trial-of-mini-incision-posterior-and-2-incision-total-hip-arthroplasty-minimum-5-year-follow-up
#17
Robert A Sershon, Matthew W Tetreault, Craig J Della Valle
BACKGROUND: We previously described the results of a randomized controlled trial of mini-posterior vs 2-incision total hip arthroplasty and were unable to demonstrate significant differences in early outcomes. As less-invasive anterior approaches remain popular, the purpose of this report was to re-examine the outcomes at a minimum 5-year follow-up. METHODS: Seventy-two patients undergoing primary total hip arthroplasty were randomized to a mini-posterior or 2-incision approach...
March 23, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28434426/attitudes-of-orthopedic-specialists-toward-effects-of-medical-device-purchasing
#18
Myriam Lingg, Everth Merida-Herrera, Kaspar Wyss, Luis Durán-Arenas
OBJECTIVES: The aim of this study was to assess viewpoints of end-users concerning the purchasing process of high-risk medical devices and to discuss the relevance of health technology assessments (HTAs) at the hospital level and other potential areas for improvement of purchasing processes. METHODS: We used a cross-sectional study and assessed the attitudes and thoughts of orthopedic specialists. The study took place between June and October 2015 in Mexico. RESULTS: We collected data from 187 orthopedic surgeons...
April 24, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28433509/transcutaneous-aortic-valve-implantation-using-the-carotid-artery-access-feasibility-and-clinical-outcomes
#19
Zacharenia Kallinikou, Alexandre Berger, Patrick Ruchat, Gregory Khatchatourov, Isabelle Fleisch, Branislav Korkodelovic, Emmanuel Henchoz, René-Andréas Marti, Stéphane Cook, Mario Togni, Jean-Jacques Goy
BACKGROUND: Transcarotid access is an alternative route for transcutaneous aortic valve implantation (TAVI) in patients with impossible transfemoral access. AIMS: We evaluated the safety, effectiveness and early and late clinical outcomes of CoreValve(®) implantation via the common carotid artery. METHODS: Eighteen patients (10 men, 8 women; mean age 84±5 years) at high surgical risk (mean EuroSCORE II 16±13%) with significant peripheral artery disease underwent TAVI via common carotid artery access under general anaesthesia...
April 19, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28433451/prospective-randomized-study-comparing-two-cephalomedullary-nails-for-elderly-intertrochanteric-fractures-zimmer-natural-nail-versus-proximal-femoral-nail-antirotation-ii
#20
Young-Soo Shin, Jin-Eon Chae, Tae-Wook Kang, Seung-Beom Han
OBJECTIVES: Although both clinical and biomechanical studies suggest that cephalomedullary implants have a mechanical advantage over extramedullary implants, a high rate of complications or implant failure remains in elderly patients with osteoporosis. In an attempt to address some of these challenges, new implants with improved designs named proximal femoral nail antirotation II (PFNA II) and Zimmer natural nail (ZNN) were developed for elderly patients. Although the PFNA II reportedly has good clinical outcomes, it is unclear which implant achieves better safety and efficacy for treating intertrochanteric hip fractures...
April 13, 2017: Injury
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