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Thomas Fransson, Ruchira Chatterjee, Franklin D Fuller, Sheraz Gul, Clemens Weninger, Dimosthenis Sokaras, Thomas Kroll, Roberto Alonso Mori, Uwe Bergmann, Jan Kern, Vittal K Yachandra, Junko Yano
Serial femtosecond crystallography (SFX) using the ultra-short X-ray pulses from a X-ray free-electron laser (XFEL) provides a new way of collecting structural data at room temperature, which also allows for following the reaction in real time after initiating the reaction with a trigger. XFEL experiments are conducted in a shot-by-shot mode as the sample is destroyed and replenished after each X-ray pulse, and therefore monitoring and controlling the data quality by using in situ diagnostic tools is especially important...
June 15, 2018: Biochemistry
Riley D Stewart, Jeffrey Hawel, Daniel French, Drew Bethune, James Ellsmere
BACKGROUND: Achalasia is a chronic disease affecting the myenteric plexus of the esophagus and lower esophageal sphincter. Treatment is aimed at palliating symptoms to improve quality of life. Treatment options for symptom relapse after esophagomyotomy include botox injection, repeat myotomy, per-oral endoscopic myotomy, or pneumatic balloon dilation (PBD). Data demonstrating the safety and efficacy of PBD for recurrence are scarce. With a lack of published data, guidelines have suggested avoiding PBD for recurrent achalasia because of concern for a high risk of perforation...
June 15, 2018: Surgical Endoscopy
Jun Zhang, YongGang Luo, ZhenFeng Zhu, GuiWen Feng, Zhi Sun, XiaoJian Zhang
BACKGROUND: The aim of this study was to investigate and compare the pharmacokinetic (PK) characteristics of mycophenolate mofetil (MMF) capsule and MMF dispersible tablet by detecting the active metabolite of mycophenolic acid (MPA) in Chinese kidney transplant recipients. METHODS: In the prospective, randomized, open-label study, the renal transplant patients were given a multiple-dose of either MMF capsule or MMF dispersible tablet combination with tacrolimus (Tac)...
June 12, 2018: Therapeutic Drug Monitoring
María Elena Alliende, José Antonio Arraztoa, Ulises Guajardo, Fernando Mellado
Objective: To describe and evaluate urinary hormone profiles in the luteal phase. Setting and Patients: Twenty-five healthy fertile women, with regular ovulatory pattern cycles as assessed by temperature and cervical mucus, at a university based center. Methods: Daily urinary hormonal assessment of luteinizing hormone, estrone glucuronide, and pregnanediol glucuronide. This was done during 3 or more cycles, with 78 completed cycles. Samples were analyzed by both crude levels and levels adjusted for the hormone excretion rate...
2018: Frontiers in Public Health
Jaime Camacho, Robert Grand, Niska Blevins, Pranav Sharma, Werner de Riese, James Cammack
Ischemic penile gangrene is an uncommon urologic condition associated with significant morbidity. Etiology of the disease is due to vasculogenic ischemia of the penile tissue. Presented are a series of images from a case of a 51-year-old morbidly obese male truck driver with idiopathic ischemic penile gangrene. The patient was evaluated with penile angiography and treated with urinary diversion via suprapubic catheter placement and serial debridement of the necrotic tissue.
April 2018: Radiology Case Reports
Joseph Caldwell, Hawa Edriss, Kenneth Nugent
Ascites is a debilitating condition affecting patients with end-stage liver disease and advanced abdominal malignancies. Serial paracentesis can reduce symptoms in these patients; indwelling peritoneal catheters provide an alternative approach that allows patients to manage their symptoms at home. A literature search was conducted to identify studies with at least 20 patients published in the last 15 years that reported indwelling catheter placement in patients with chronic ascites. Fourteen studies with 957 patients (687 with malignancy and 270 with cirrhosis) were reviewed...
July 2018: Proceedings of the Baylor University Medical Center
Antoni Xavier Torres-Collado, Ali R Jazirehi
Patients with B-cell non-Hodgkin’s lymphoma (B-NHL) who fail to respond to first-line treatment regimens or develop resistance, exhibit poor prognosis. This signifies the need to develop alternative treatment strategies. CD19-chimeric antigen receptor (CAR) T cell-redirected immunotherapy is an attractive and novel option, which has shown encouraging outcomes in phase I clinical trials of relapsed/refractory NHL. However, the underlying mechanisms of, and approaches to overcome, acquired anti-CD19CAR CD8⁺ T cells (CTL)-resistance in NHL remain elusive...
June 14, 2018: Cancers
James D Turner, Sean W Dobson, Daryl S Henshaw, Christopher J Edwards, Robert S Weller, Jon W Reynolds, Gregory B Russell, Jonathan D Jaffe
BACKGROUND: Peripheral nerve blockade is used to provide analgesia for patients undergoing total knee arthroplasty. This study compared a single-injection adductor canal block (SACB) with adjuvants to continuous adductor canal blockade (CACB). The hypothesis was that the 2 groups would have equivalent analgesia at 30 hours after neural blockade. METHODS: This was a double-blinded, randomized, controlled, equivalency trial. Sixty patients were randomized to either the SACB group (20 mL of 0...
May 24, 2018: Journal of Arthroplasty
Rongshuang Yuan, Xue Tao, Shuang Liang, Yan Pan, Li He, Jinghui Sun, Ju Wenbo, Xiangyan Li, Jianguang Chen, Chunmei Wang
AIM: Schisandra chinensis is a well-known traditional Chinese medicine used mainly as a recipe for hepatoprotection. Modern researches have revealed that the hepatoprotection is related to its lignans and crude polysaccharide. In this study, we examined the effect and mechanism of Schisandra chinensis acidic polysaccharide (SCAP) on the liver injury induced by ethanol. MAIN METHODS: SCAP was extracted with water extraction and ethanol precipitation. Liver injury models of both mice and HepG2 cells were produced by ethanol...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Doaa M Mokhtar
Fish liver is considered as a key organ that controls various life functions. The cellular and stromal elements of liver of eighteen specimens of adult grass carp were investigated by light- and electron- microscopy and enzyme histochemistry. The liver was formed of two lobes with a long process extended from the right lobe. Serial paraffin section of the liver identified different kinds of vascular- biliary structures as follows: 1) pancreatic-venous-biliary-arteriolar tracts (P-VBAT); 2) venous-biliary-arteriolar tracts, (VBAT); 3) pancreatic-venous-biliary tracts (P-VBT); 4) venous-biliary tracts (VBT); 5) venous-arteriolar tracts (VAT); 6) isolated veins named as venous tracts (VT); 7) isolated bile ducts, named as biliary tracts (BT); 8) biliary-arteriolar tracts (BAT); 9) pancreatic-biliary tracts (P-BT); 10) pancreatic- venous tracts (P-VT)...
June 6, 2018: Micron: the International Research and Review Journal for Microscopy
Mareike Clos, Tobias Sommer, Signe L Schneider, Michael Rose
During incidental learning statistical regularities are extracted from the environment without the intention to learn. Acquired implicit memory of these regularities can affect behavior in the absence of awareness. However, conscious insight in the underlying regularities can also develop during learning. Such emergence of explicit memory is an important learning mechanism that is assumed to involve prediction errors in the striatum and to be dopamine-dependent. Here we directly tested this hypothesis by manipulating dopamine levels during incidental learning in a modified serial reaction time task (SRTT) featuring a hidden regular sequence of motor responses in a placebo-controlled between-group study...
2018: PloS One
Hsieh Fushing, Shan-Yu Liu, Yin-Chen Hsieh, Brenda McCowan
Data generated from a system of interest typically consists of measurements on many covariate features and possibly multiple response features across all subjects in a designated ensemble. Such data is naturally represented by one response-matrix against one covariate-matrix. A matrix lattice is an advantageous platform for simultaneously accommodating heterogeneous data types: continuous, discrete and categorical, and exploring hidden dependency among/between features and subjects. After each feature being individually renormalized with respect to its own histogram, the categorical version of mutual conditional entropy is evaluated for all pairs of response and covariate features according to the combinatorial information theory...
2018: PloS One
Enrico Munari, Giulio Rossi, Giuseppe Zamboni, Gianluigi Lunardi, Marcella Marconi, Marco Sommaggio, George J Netto, Mohammad O Hoque, Matteo Brunelli, Guido Martignoni, Michael C Haffner, Francesca Moretta, Maria C Pegoraro, Alberto Cavazza, Giuseppina Samogin, Vanna Furlan, Francesca R Mariotti, Paola Vacca, Lorenzo Moretta, Giuseppe Bogina
Pembrolizumab is the only programmed cell death 1/programmed death-ligand 1 inhibitor for treatment of patients with non-small cell lung cancer, with a companion diagnostic assay, the 22C3 PharmDx. Although in many studies 22C3 and Ventana's SP263 appear to yield overlapping results, they show discrepancies at clinically relevant cutoffs (1% and 50%). We provide a solid comparison between 22C3 and SP263 assays in a large cohort of non-small cell lung cancer cases taking into account interobserver variability between trained pathologists who are used to either clone in their clinical practice...
June 12, 2018: American Journal of Surgical Pathology
Anna Elizabeth McRee, Thomas N Tully, Javier G Nevarez, Hugues Beaufrere, Melanie Ammersbach, Stephen D Gaunt, Rory G Fuller, L Michael Romero
  Increased glucocorticoids cause a characteristic stress leukogram in mammalian taxa. It is assumed that avians exhibit a similar response, but to date, there have been no controlled studies to correlate serial endogenous corticosterone levels to hematologic values. An established flock of 18 Hispaniolan Amazon parrots ( Amazona ventralis) was used as a model in a crossover study. The treatment group was subjected to the stress of transport, restraint, and common clinical procedures with serial blood samples collected at 20-min intervals for hematology and corticosterone levels; the control group was sampled at the same intervals...
June 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
S O Edeki, M E Adeosun, G O Akinlabi, O M Ofuyatan
In the Nigeria economy, cocoa production has been of great importance. This buttresses the fact that cocoa as a product is the leading agricultural export of Nigeria, leaving the country currently as the world fourth largest producer of cocoa, after Ivory Coast, Indonesia and Ghana and the third largest exporter, after Ivory Coast and Ghana. Hence, there is need for the agricultural sector expansion, effective predictive models and reliable price mechanism. This article examines tonnes of cocoa production dataset of the Nigeria agricultural sector for the period of twenty-four (24) years spanning between 1993 to 2016...
June 2018: Data in Brief
Olga H Toro-Salazar, Ji Hyun Lee, Kia N Zellars, Paige E Perreault, Kathryn C Mason, Zhu Wang, Kan N Hor, Eileen Gillan, Caroline J Zeiss, Daniel M Gatti, Brooke T Davey, Shelby Kutty, Bruce T Liang, Francis G Spinale
Background: Anthracycline induced cardiomyopathy is a major cause of mortality and morbidity among pediatric cancer survivors. It has been postulated that oxidative stress induction and inflammation may play a role in the pathogenesis of this process. Accordingly, the present study performed an assessment of biomarker profiles and functional imaging parameters focused upon potential early determinants of anthracycline induced cardiomyopathy. Methods: Patients (10-22 years) were prospectively enrolled between January 2013 and November 2014...
2018: Cardio-Oncology
Andrew D Smith, Charles Duffy, Andrew D Goodman
Background: Although cognitive dysfunction is a leading cause of disability and poor quality of life in patients with multiple sclerosis (MS), it is infrequently tested in routine clinical evaluation. Development of a cognitive testing paradigm that captured MS-related cognitive dysfunction and could be obtained in a routine clinical setting may increase surveillance and recognition of cognitive dysfunction. Objectives: This was a pilot study to determine if Cognivue could find cognitive performance differences between patients with MS and healthy controls (HC)...
April 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Anta Seck, Khaly Bane, Amadou Diop, Diouma Ndiaye, Seydina O Niang, Babacar Touré
Context: Enterococcus faecalis is the most common bacteria found in infected root canals. Aim: The purpose of this study was to evaluate the effect of the mono instrument (wave-one® ) on the reduction of E. faecalis in root canals. Materials and Methods: Thirty-two human monoroot teeth were used. After sterilization by autoclave, the teeth were infected by E. faecalis and incubated for 24 h. Each tooth underwent sampling before and after the root canal shaping...
May 2018: Journal of Conservative Dentistry: JCD
Paul Kligfield, Fabio Badilini, Isabelle Denjoy, Saeed Babaeizadeh, Elaine Clark, Johan De Bie, Brian Devine, Fabrice Extramiana, Gianluca Generali, Richard Gregg, Eric Helfenbein, Jan Kors, Remo Leber, Peter Macfarlane, Pierre Maison-Blanche, Ian Rowlandson, Ramun Schmid, Martino Vaglio, Gerard van Herpen, Joel Xue, Brian Young, Cynthia L Green
BACKGROUND: Automated measurements of electrocardiographic (ECG) intervals by current-generation digital electrocardiographs are critical to computer-based ECG diagnostic statements, to serial comparison of ECGs, and to epidemiological studies of ECG findings in populations. A previous study demonstrated generally small but often significant systematic differences among 4 algorithms widely used for automated ECG in the United States and that measurement differences could be related to the degree of abnormality of the underlying tracing...
June 2018: American Heart Journal
Rishikesh Bajagain, Yoonsu Park, Seung-Woo Jeong
This study evaluated surface foam spraying technology, which avoids disturbing the soil, to deliver chemical oxidant and oil-degrading microbes to unsaturated soil for 30 days. Hydrogen peroxide foam was sprayed once onto diesel contaminated soil for oxidation of soil total petroleum hydrocarbon (TPH). Periodic bioaugmentation foam was sprayed every three days for biodegradation of soil TPH. Foam spraying employing oxidation-bioaugmentation serial application significantly reduced soil TPH concentrations to 550 mg·kg-1 from an initial 7470 mg·kg-1 ...
June 1, 2018: Science of the Total Environment
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