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https://www.readbyqxmd.com/read/29058228/maldi-imaging-mass-spectrometry-of-n-glycans-and-tryptic-peptides-from-the-same-formalin-fixed-paraffin-embedded-tissue-section
#1
Peggi M Angel, Anand Mehta, Kim Norris-Caneda, Richard R Drake
Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a unique and well developed tool for probing the protein content of formalin-fixed, paraffin-embedded tissue (FFPE). Integral to this approach is the application of trypsin, and more recently peptide N-glycosidase F, to release tryptic peptides or N-glycans from tissue and report localization of distinct species. This is typically done on serial or adjacent tissue sections, and there is an emerging need to understand the colocalized protein population linked to the exact same regions of N-glycans...
October 21, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29057395/parallelizing-affinity-propagation-using-graphics-processing-units-for-spatial-cluster-analysis-over-big-geospatial-data
#2
Xuan Shi
Introduced in 2007, affinity propagation (AP) is a relatively new machine learning algorithm for unsupervised classification that has seldom been applied in geospatial applications. One bottleneck is that AP could hardly handle large data, and a serial computer program would take a long time to complete an AP calculation. New multicore and manycore computer architectures, combined with application accelerators, show promise for achieving scalable geocomputation by exploiting task and data levels of parallelism...
2017: Proc Annu Conf GeoComput
https://www.readbyqxmd.com/read/29057016/what-would-i-know-about-mercy-faith-and-optimistic-expectancies-among-african-americans
#3
Jacqueline S Mattis, Wizdom Powell, Nyasha A Grayman, Yohance Murray, Yasmin C Cole-Lewis, Janelle R Goodwill
A small body of research has begun to explore the association between faith and optimism among African Americans. However, missing from the extant work is an examination of the extent to which traditional indices of religious commitment work together with beliefs about God to shape optimism. The present study examines the utility of indices of social location, religious commitment (i.e., early and current religious service attendance, subjective religiosity), belief about the quality of one's relationship with God (i...
March 2017: Race and Social Problems
https://www.readbyqxmd.com/read/29056302/single-pass-four-throw-pupilloplasty-postoperative-mydriasis-and-fundus-visibility-in-pseudophakic-eyes
#4
Dhivya Ashok Kumar, Amar Agarwal, Maheswari Srinivasan, Jyothi Narendrakumar, Akshaya Mohanavelu, Keerthana Krishnakumar
PURPOSE: To analyze the pharmacological mydriasis and the consequent fundus visibility after single-pass 4-throw pupilloplasty in pseudophakic eyes. SETTING: Dr. Agarwal's Eye Hospital, Chennai, India. DESIGN: Comparative case series. METHODS: Patients with bilateral pseudophakia with single-pass 4-throw pupilloplasty in 1 eye (study) and no single-pass 4-throw in the fellow eye (control) were included. The pupil measurements were analyzed before and after the instillation of mydriatics (tropicamide 0...
October 19, 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29055760/giant-coronary-artery-pseudoaneurysm-formed-after-septal-artery-perforation-during-retrograde-percutaneous-coronary%C3%A2-intervention-a-conservative-strategy-with-serial-cardiac-computed-tomographic-imaging
#5
Umihiko Kaneko, Yoshifumi Kashima, Daitaro Kanno, Tsutomu Fujita
No abstract text is available yet for this article.
October 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29055748/sex-and-dose-dependent-abuse-liability-of-repeated-subanesthetic-ketamine-in-rats
#6
Kristin J Schoepfer, Caroline E Strong, Samantha K Saland, Katherine N Wright, Mohamed Kabbaj
RATIONALE: Subanesthetic ketamine (KET) elicits rapid, robust, but transient antidepressant effects. KET's antidepressant actions can be augmented and maintained for a longer duration when repeatedly delivered. However, KET is recreationally abused, raising long-term treatment safety concerns. Women are more likely than men to seek treatment for depression, escalate from casual to compulsive drug use, and are more sensitive to antidepressants. Similarly, female rodents are more sensitive than males to KET's rapid antidepressant-like behavioral effects; dose-response thresholds in these assays equal 2...
October 18, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29055625/coronary-artery-calcium-progression-is%C3%A2-associated-with-coronary-plaque-volume-progression-results-from-a-quantitative-semiautomated-coronary%C3%A2-artery%C3%A2-plaque-analysis
#7
Indre Ceponiene, Rine Nakanishi, Kazuhiro Osawa, Mitsuru Kanisawa, Negin Nezarat, Sina Rahmani, Kendall Kissel, Michael Kim, Eranthi Jayawardena, Alexander Broersen, Pieter Kitslaar, Matthew J Budoff
OBJECTIVES: The aim of this study was to determine whether coronary artery calcium (CAC) progression was associated with coronary plaque progression on coronary computed tomographic angiography. BACKGROUND: CAC progression and coronary plaque characteristics are associated with incident coronary heart disease. However, natural history of coronary atherosclerosis has not been well described to date, and the understanding of the association between CAC progression and coronary plaque subtypes such as noncalcified plaque progression remains unclear...
October 14, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29055395/the-neural-signature-of-emotional-memories-in-serial-crimes
#8
Philippe Chassy
Neural plasticity is the process whereby semantic information and emotional responses are stored in neural networks. It is hypothesized that the neural networks built over time to encode the sexual fantasies that motivate serial killers to act should display a unique, detectable activation pattern. The pathological neural watermark hypothesis posits that such networks comprise activation of brain sites that reflect four cognitive components: autobiographical memory, sexual arousal, aggression, and control over aggression...
October 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29054943/non-infectious-aortitis-in-an-immunosuppressed-renal-transplant-recipient-with-iga-nephropathy
#9
Charlotte M Snead, Stephen C Crockett, Phillippa K Bailey
A 54-year-old woman presented with atypical chest pain, fever and malaise. She was immunosuppressed with three agents following a living-donor kidney transplant 1 year previously. Her native kidney failure was secondary to biopsy-demonstrated crescentic IgA nephropathy, with systemic involvement. A CT pulmonary angiogram revealed an inflammatory cuff of soft tissue around the descending thoracic aorta suggesting aortitis. Inflammatory markers were elevated. Given her immunosuppression, the patient was screened extensively for infective causes and was empirically commenced on intravenous meropenem...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054922/protein-turnover-measurements-in-human-serum-by-serial-immunoaffinity-lc-ms-ms
#10
Vahid Farrokhi, Xiaoying Chen, Hendrik Neubert
BACKGROUND: The half-life of target proteins is frequently an important parameter in mechanistic pharmacokinetic and pharmacodynamic (PK/PD) modeling of biotherapeutics. Clinical studies for accurate measurement of physiologically relevant protein turnover can reduce the uncertainty in PK/PD model-based predictions, for example, of the therapeutic dose and dosing regimen in first-in-human clinical trials. METHODS: We used a targeted mass spectrometry work flow based on serial immunoaffinity enrichment of multiple human serum proteins from a [5,5,5-(2)H3]-L-leucine tracer pulse-chase study in healthy volunteers...
October 20, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29053369/effects-of-message-framing-on-influenza-vaccination-understanding-the-role-of-risk-disclosure-perceived-vaccine-efficacy-and-felt-ambivalence
#11
Sungsu Kim, Ivanka Pjesivac, Yan Jin
The current study examined the effects of framing in promotional health messages on intention to vaccinate against seasonal influenza virus. The findings of an experimental study (N = 86) indicated that exposure to both benefits and side effects of vaccination (gain-framed with risk disclosure message) led to lower intention to receive the flu vaccine. This relationship was mediated by both perceived vaccine efficacy and felt ambivalence in a serial order, revealing the underlying psychological mechanisms important for understanding health-related behaviors...
October 20, 2017: Health Communication
https://www.readbyqxmd.com/read/29051929/fully-chip-embedded-automation-of-a-multi-step-lab-on-a-chip-process-using-a-modularized-timer-circuit
#12
Junsu Kang, Donghyeon Lee, Young Jin Heo, Wan Kyun Chung
For highly-integrated microfluidic systems, an actuation system is necessary to control the flow; however, the bulk of actuation devices including pumps or valves has impeded the broad application of integrated microfluidic systems. Here, we suggest a microfluidic process control method based on built-in microfluidic circuits. The circuit is composed of a fluidic timer circuit and a pneumatic logic circuit. The fluidic timer circuit is a serial connection of modularized timer units, which sequentially pass high pressure to the pneumatic logic circuit...
October 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29051328/how-does-sevoflurane-induction-followed-by-a-ketamine-maintenance-infusion-affect-intraocular-pressure-establishment-of-an-anaesthetic-protocol-for-paediatric-glaucoma-examinations-under-anaesthesia
#13
Jessica Gwendoline van der Walt, Francois Roodt, Christopher Tinley
Accurate measurement of intraocular pressure (IOP) is essential in paediatric glaucoma management. Children require serial measurements and examination under anaesthesia (EUA). Most anaesthetic agents reduce IOP, and the ideal time to measure IOP under anaesthesia is questionable. STUDY PURPOSE: To determine the effect of sevoflurane induction, followed by intravenous ketamine infusion on IOP, in children undergoing EUA for glaucoma or suspected glaucoma, and to establish the earliest time point at which reliable, repeatable IOP measurements can be obtained under anaesthesia...
October 19, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29051003/spontaneous-regeneration-of-nerve-fiber-and-irreversibility-of-corporal-smooth-muscle-fibrosis-after-cavernous-nerve-crush-injury-evidence-from-serial-transmission-electron-microscopy-and-intracavernous-pressure
#14
Yi-No Wu, Kuo-Chiang Chen, Chun-Hou Liao, Han-Sun Chiang
OBJECTIVES: To determine the pathophysiological progresses following bilateral cavernous nerve crushing (BCNC) injury, as an index for a treatment point and establishment of adequate treatment strategies for neurogenic erectile dysfunction (ED). METHODS: Thirty-six rats were assigned to 1 of 6 groups, and BCNC or sham surgery was performed. Functional testing and ultrastructural analyses were performed immediately and at 7, 14, 21, and 28 d after the cavernous nerve (CN) injury (n = 6)...
October 16, 2017: Urology
https://www.readbyqxmd.com/read/29050921/the-phenomena-of-mechanical-interaction-of-segments-of-hypertrophied-myocardium
#15
REVIEW
Alexander Balakin, Daniil Kuznetsov, Yuri Protsenko
The main aims of adaptation mechanisms of heart contractility are to regulate the stroke volume and optimize the global heart function. These mechanisms manifest themselves in hearts of healthy animals and in hearts with severe hypertrophy in different ways. Severe right ventricle hypertrophy was induced by single treatment with monocrotaline. Young rats of both sexes were used to prevent influences of sex hormones on the development of right ventricular hypertrophy. Serial duplex method is used as a model of interaction of two ventricular wall segments...
October 16, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29050685/renal-function-changes-following-left-ventricular-assist-device-implantation
#16
Usama A Daimee, Meng Wang, Anna Papernov, Saadia Sherazi, Scott McNitt, Himabindu Vidula, Leway Chen, Jeffrey D Alexis, Valentina Kutyifa
Limited data assessing the clinical significance of post-left ventricular assist device (LVAD) in renal function are available. We aimed to investigate the impact of changes in renal function after LVAD implantation on subsequent long-term outcomes. We followed 184 patients with HeartMate II LVADs implanted between May 2008 and November 2014. Serial assessment of renal function, was performed at baseline and at day 1, day 7, 1 month, 3 months, 6 months, 1 year, and 2 years after implantation. Effects of 1-month GFR and changes in GFR from baseline to 1 month on long-term mortality and hospital re-admission were evaluated...
September 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29050516/human-bone-marrow-mesenchymal-stromal-cell-derived-osteoblasts-promote-the-expansion-of-hematopoietic-progenitors-through-beta-catenin-and-notch-signaling-pathways
#17
Matthew Michalicka, Gavin Boisjoli, Suria Jahan, Owen Hovey, Emily Doxtator, Ahmad Abu-Khader, Roya Pasha, Nicolas Pineault
Coculture of hematopoietic stem cells (HSC) with primary stromal cells from HSC niches supports the maintenance and expansion of HSC and progenitors ex vivo. However, a major drawback is the availability of primary human samples for research and clinical applications. We investigated the use of in vitro derived osteoblasts as a new source of feeder cells and characterized the molecular pathways that mediate their growth promoting activities. First, we compared the growth and differentiation modulating activities of mesenchymal stromal cells (MSC)-derived osteoblasts (M-OST) to that of their undifferentiated precursor on umbilical cord blood (UCB) progenitors...
October 19, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29050203/loss-of-egr1-a-human-del5q-gene-accelerates-bcr-abl-driven-chronic-myelogenous-leukemia
#18
Silvia Maifrede, Andrew Magimaidas, Xiaojin Sha, Kaushiki Mukherjee, Dan A Liebermann, Barbara Hoffman
There is substantial evidence that early growth response-1 (Egr1) gene, a zinc-finger transcription factor, behaves as a tumor suppressor in leukemia. This includes reports from this laboratory that constitutive Egr1 overrides leukemia conferred by deregulated c-Myc or E2F-1 in the M1 myeloid leukemic cell line by promoting differentiation. To investigate the effect of Egr1 on the initiation and progression of Chronic Myelogenous Leukemia (CML), lethally irradiated syngeneic wild type mice were reconstituted with bone marrow (BM) from either wild type or Egr1 null mice transduced with a 210-kD BCR-ABL-expressing MSCV-retrovirus (bone marrow transplantation {BMT})...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049339/reliability-of-transcardiopulmonary-thermodilution-cardiac-output-measurement-in-experimental-aortic-valve-insufficiency
#19
Martin Petzoldt, Constantin J Trepte, Jan Ridder, Stefan Maisch, Philipp Klapsing, Jan F Kersten, Hans Peter Richter, Jens C Kubitz, Daniel A Reuter, Matthias S Goepfert
BACKGROUND: Monitoring cardiac output (CO) is important to optimize hemodynamic function in critically ill patients. The prevalence of aortic valve insufficiency (AI) is rising in the aging population. However, reliability of CO monitoring techniques in AI is unknown. The aim of this study was to investigate the impact of AI on accuracy, precision, and trending ability of transcardiopulmonary thermodilution-derived COTCPTD in comparison with pulmonary artery catheter thermodilution COPAC...
2017: PloS One
https://www.readbyqxmd.com/read/29049078/hearts-and-minds-real-life-cardiotoxicity-with-clozapine-in-psychosis
#20
George Joy, Eromona Whiskey, Mark Bolstridge, Alejandro Porras-Segovia, Theresa A McDonagh, Carla M Plymen, Sukhi S Shergill
BACKGROUND: Schizophrenia has a 1% prevalence in the population; 30% of these patients are treatment refractory. Clozapine is the only drug licensed to treat treatment refractory psychosis, but concerns about potential adverse effects result in only a proportion of eligible patients being treated. Although a well-documented neutropenia risk is mitigated by routine blood testing, cardiac toxicity is a commonly cited reason to discontinue clozapine treatment. However, there is little data on the real-life cardiac outcomes in those receiving clozapine treatment...
October 19, 2017: Journal of Clinical Psychopharmacology
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