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https://www.readbyqxmd.com/read/28822705/anti-dermatophyte-activity-of-leguminosae-plants-from-southern-brazil-with-emphasis-on-mimosa-pigra-leguminosae
#1
C B de Morais, M Scopel, G P R Pedrazza, F K da Silva, D F Dalla Lana, M L Tonello, S T S Miotto, M M Machado, L F S De Oliveira, A M Fuentefria, J A S Zuanazzi
BACKGROUND: Intensive prophylactic use of antifungals leads to the increase of drug resistance and the need for new and more effective treatments are real. Plants from Leguminosae family are rich in flavonoids, for which numerous biological activities have been described, including antifungal effects. PURPOSE: To screen methanolic extracts from Leguminosae species looking for alternative sources for antifungal agents (anti-dermatophyte and anti-Candida) and their innocuity...
August 16, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28822512/implications-of-the-2013-acc-aha-cholesterol-guidelines-on-contemporary-clinical-practice-for-patients-with-atherosclerotic-coronary-and-peripheral-arterial-disease
#2
Prasad Gunasekaran, Vinodh Jeevanantham, Suresh Sharma, Rashmi Thapa, Kamal Gupta
BACKGROUND: Cholesterol management guidelines from the American College of Cardiology/American Heart Association (ACC/AHA-2013) recommend fixed statin dosing (dose depends on age ≤ or >75years) compared to the earlier adult treatment panel III (ATPIII) guidelines which recommended specific low-density lipoprotein-cholesterol (LDL-C) targets. Clinical implications of this recommendation are not known. METHODS: We retrospectively compared cholesterol levels and statin utilization across cohorts with coronary artery disease (CAD) (n=9563), peripheral arterial disease (PAD) (n=596) and CAD+PAD (n=975) by applying both guidelines...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28822321/neurostimulation-techniques-in-the-treatment-of-cocaine-dependence-a-review-of-the-literature
#3
REVIEW
Fady Rachid
OBJECTIVE: Cocaine use disorder is a very common condition that represents a substantial public health problem, and no effective pharmacological or psychological therapies have been identified to date. Urgent therapeutic alternatives are therefore needed such as neurostimulation techniques. The purpose of this review is to describe and discuss studies that have evaluated the safety and efficacy of these techniques for the treatment of cocaine dependence. METHODS: The electronic literature on repetitive transcranial magnetic stimulation, theta-burst stimulation, deep transcranial magnetic stimulation, transcranial direct current stimulation, magnetic seizure therapy, electroconvulsive therapy, cranial electro-stimulation, and deep brain stimulation in the treatment of cocaine addiction were reviewed...
August 10, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28822165/-methodological-quality-assessment-of-community-acquired-pneumonia-clinical-practice-guidelines-in-china-based-on-agree-%C3%A2-tool
#4
Ying-Jie Zhi, Xing Liao, Yan-Ming Xie, De-Min Li, Wei Chen, Yao-Long Chen, Ren-Bo Chen, Ya Yuwen, Hong-Chun Zhang, Yong-Yan Wang
This study is aimed to identify and assess the methodological quality of community-acquired pneumonia (CAP) clinical practice guidelines (CPG) in China by using AGREE Ⅱ tool. CNKI, SinoMed, Wanfang, and VIP Chinese databases from database establishment to March 2017 were searched by manual retrieval to collect all the clinical practice guidelines prepared by various associations or organizations, then AGREE Ⅱtool was used to assess them. Data in each CPG were analyzed in terms of six domains, including scope and purpose, participants, rigor, clarity and readability, applicability and editorial independence...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28822054/utility-and-comparative-efficacy-of-recombinant-allergens-versus-allergen-extract
#5
REVIEW
Hardik D Patel, Jeffrey M Chambliss, Meera R Gupta
Allergy immunotherapy (AIT) is the only disease-modifying therapy for the treatment of allergic diseases. Although its efficacy and utility are well-established, the potential for serious adverse events, cumbersome and lengthy treatment protocols, and variability of natural allergen preparations have limited its widespread application. Recent advances in recombinant technology have opened new avenues for the development of AIT vaccines. The purpose of this review is to highlight recent evidence on the use of novel recombinant vaccines and review the mechanisms, efficacy, safety, and limitations of AIT...
August 18, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28822020/polysomnographic-determinants-of-requirement-for-advanced-positive-pressure-therapeutic-options-for-obstructive-sleep-apnea
#6
Anupama Gupta, Garima Shukla
BACKGROUND: A small percentage of adult patients with severe obstructive sleep apnea (OSA) has been recognized to be extraordinarily difficult to treat with conventional continuous or Bi-level positive airway pressure (together referred to as PAP) therapy. AIM AND OBJECTIVES: The aim of this study was to determine polysomnographic (PSG) characteristics, which may help predict the requirement for advanced therapeutic options for OSA. METHODS: Consecutive patients who underwent PAP titration at our sleep laboratory over a 2-year period were included...
August 18, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28821972/non-deformed-singular-and-non-singular-exponential-type-potentials
#7
J J Pe Na, G Ovando, J Morales, J García-Ravelo
The canonical transformation method applied to the Schrödinger equation to transform it into a second-order differential equation of hypergeometric-type is presented. Starting from there, those exactly solvable multiparameter exponential-type (ME-T) potentials with hypergeometric wavefunctions that belong to the families of radial (singular) and one-dimensional (non-singular) potentials, are obtained. Furthermore, we show how the choice of the involved parameters leads, as particular cases, to different deformed or non-deformed potential models already used in the study of electronic properties of diatomic molecules...
August 18, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28821936/minimally-invasive-plate-augmentation-in-the-treatment-of-long-bone-non-unions
#8
Ki-Chul Park, Chang-Wug Oh, Joon-Woo Kim, Kyeong-Hyeon Park, Jong-Keon Oh, Il-Hyung Park, Hee-Soo Kyung, Jeong Heo
INTRODUCTION: Exchange nailing is most acceptable for treating hypertrophic non-union of the long bones, requiring the removal of previously fixed implant. However, its main effect of mechanical stabilization is controversial in non-isthmal area. We hypothesized that minimally invasive plate augmentation over the non-union site may have a better option, without the need of bone grafting or removing pre-existing implants. MATERIALS AND METHODS: Seventeen patients with hypertrophic non-union of the long bones between 2010 and 2014 on radiography who previously underwent intramedullary (IM) nailing or plate osteosynthesis for long-bone fractures were included...
August 18, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28821832/development-of-enhanced-ethanol-ablation-as-an-alternative-to-surgery-in-treatment-of-superficial-solid-tumors
#9
Robert Morhard, Corrine Nief, Carlos Barrero Castedo, Fangyao Hu, Megan Madonna, Jenna L Mueller, Mark W Dewhirst, David F Katz, Nirmala Ramanujam
While surgery is at the foundation of cancer treatment, its access is limited in low-income countries. Here, we describe development of a low-cost alternative therapy based on intratumoral ethanol injection suitable for resource-limited settings. Although ethanol-based tumor ablation is successful in treating hepatocellular carcinomas, the necessity for multiple treatments, injection of large fluid volumes, and decreased efficacy in treatment of non-capsulated tumors limit its applicability. To address these limitations, we investigated an enhanced ethanol ablation strategy to retain ethanol within the tumor through the addition of ethyl cellulose...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821752/hybrid-nitric-oxide-donor-and-its-carrier-for-the-treatment-of-peripheral-arterial-diseases
#10
Duong Q Le, Aneetta E Kuriakose, Dat X Nguyen, Kytai T Nguyen, Suchismita Acharya
Nitric oxide (NO) has been known to promote physiological angiogenesis to treat peripheral arterial diseases (PAD) by increasing the vascular endothelial growth factor (VEGF) level in endothelial cells (ECs) and preventing platelet adherence and leukocyte chemotaxis. However, the ongoing ischemic event during peripheral ischemia produces superoxide and diminishes the NO bioavailability by forming toxic peroxynitrite anion. Here we disclose an efficacious hybrid molecule 4-(5-Amino-1,2,3-oxadiazol-3-yl)-2,2,6,6-tetramethyl-1-piperidinol (SA-2) containing both antioxidant and NO donor functionalities that provide a therapeutic level of NO necessary to promote angiogenesis and to protect ECs against hydrogen peroxide-induced oxidative stress...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821620/arjunolic-acid-a-peroxisome-proliferator-activated-receptor-alpha-agonist-regresses-cardiac-fibrosis-by-inhibiting-non-canonical-tgf-%C3%AE-signaling
#11
Trisha Bansal, Emeli Chatterjee, Jasdeep Singh, Arjun Ray, Bishwajit Kundu, V Thankamani, Shantanu Sengupta, Sagartirtha Sarkar
Cardiac hypertrophy and associated heart fibrosis remain a major cause of death worldwide. Phytochemicals have gained attention as alternative therapeutics for managing cardiovascular diseases. These include the extract from the plant Terminalia arjuna which is a popular cardioprotectant and may prevent or slow progression of pathological hypertrophy to heart failure. Here, we investigated the mode of action of a principal bioactive T. arjuna compound, arjunolic acid (AA) in ameliorating hemodynamic load-induced cardiac fibrosis and identified its intracellular target...
August 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28821365/can-low-dose-of-ketamine-reduce-the-need-for-morphine-in-renal-colic-a-double-blind-randomized-clinical-trial
#12
Saeed Abbasi, Nader Bidi, Babak Mahshidfar, Peyman Hafezimoghadam, Mahdi Rezai, Mani Mofidi, Davood Farsi
BACKGROUND: The combination of morphine with low doses of ketamine (MK) has been utilized in the Emergency Department (ED) compared with morphine and placebo (MP) for the treatment of acute pain in few studies. The purpose of this study was to compare the effect of MP with MK for the treatment of severe pain with renal colic of patients who had been referred to the ED. METHODS: This study is a double blind randomized clinical trial on patients with severe renal colic pain who were referred to the ED...
August 14, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28821160/leuconostoc-mesenteroides-derived-anticancer-pharmaceuticals-hinder-inflammation-and-cell-survival-in-colon-cancer-cells-by-modulating-nf-%C3%AE%C2%BAb-akt-pten-mapk-pathways
#13
Sepideh Zununi Vahed, Abolfazl Barzegari, Yalda Rahbar Saadat, Ali Goreyshi, Yadollah Omidi
Promising results from different studies on the effect of probiotics in cancer prevention and therapy have so far been reported. However, the molecular mechanism of the interaction of probiotics with cancer cells is yet to be fully understood. In the present study, Leuconostoc mesenteroides was isolated from traditional dairy products, and its probiotic characteristics were determined. HT-29 cells were treated with conditioned-medium of designated bacteria and the cell apoptosis was studied at cellular and molecular level using DAPI staining, flow cytometry, DNA ladder assays, and real-time quantitative-PCR (q-PCR)...
August 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28821011/the-photodynamic-action-of-pheophorbide-a-induces-cell-death-through-oxidative-stress-in-leishmania-amazonensis
#14
Nathielle Miranda, Hélito Volpato, Jean Henrique da Silva Rodrigues, Wilker Caetano, Tânia Ueda-Nakamura, Sueli de Oliveira Silva, Celso Vataru Nakamura
Leishmaniasis is a disease caused by hemoflagellate protozoa, affecting millions of people worldwide. The difficulties of treating patients with this parasitosis include the limited efficacy and many side effects of the currently available drugs. Therefore, the search for new compounds with leishmanicidal action is necessary. Photodynamic therapy has been studied in the medical field because of its selectivity, utilizing a combination of visible light, a photosensitizer compound, and singlet oxygen to reach the area of treatment...
August 11, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28820996/exploring-ozonation-as-treatment-alternative-for-methiocarb-and-formed-transformation-products-abatement
#15
A Cruz-Alcalde, C Sans, S Esplugas
Despite the high toxicity and resistance to conventional water treatments exhibited by methiocarb (MC), there are no reports regarding the degradation of this priority pesticide by means of alternative purification technologies. In this work, the removal of MC by means of ozonation was studied for the first time, employing a multi-reactor methodology and neutral pH conditions. The second-order rate constants of MC reaction with molecular ozone (O3) and formed hydroxyl radicals (OH·) were determined to be 1...
August 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28820697/case-report-treatment-of-widespread-nodular-post-kala-azar-dermal-leishmaniasis-with-extended-dose-liposomal-amphotericin-b-in-bangladesh-a-series-of-four-cases
#16
Ariful Basher, Shomik Maruf, Proggananda Nath, Md Golam Hasnain, Muhammod Abdul Mukit, Azim Anuwarul, Fatima Aktar, Rupen Nath, Afm Akhtar Hossain, Abul Hasnat Milton, Dinesh Mondal, Abul Khair Mohammad Sumsuzzaman, Ridwanur Rahman, Mohammad Abul Faiz
Post kala-azar dermal leishmaniasis (PKDL) is a skin manifestation which usually appears after visceral leishmaniasis. It is now proved that PKDL patients serve as a reservoir for anthropometric leishmanial transmission. Hence, to achieve the kala-azar elimination target set by the World Health Organization in the Indian Subcontinent, PKDL cases should be given priority. The goal of treatment for PKDL should be early reepithelizlization and rapid cure, but unfortunately this has been difficult to achieve, especially for patients with severe lesions...
August 14, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28820681/efficacy-safety-and-cost-effectiveness-of-thermotherapy-in-the-treatment-of-leishmania-donovani-induced-cutaneous-leishmaniasis-a-randomized-controlled-clinical-trial
#17
Wardha F Refai, Nayani P Madarasingha, Buthsiri Sumanasena, Sudath Weerasingha, Amala De Silva, Rohini Fernandopulle, Abhay R Satoskar, Nadira D Karunaweera
Leishmania donovani causes cutaneous leishmaniasis (CL) in Sri Lanka. Standard treatment is multiple, painful doses of intralesional sodium stibogluconate (IL-SSG). Treatment failures are increasingly reported, hence the need to investigate alternatives. Efficacy, safety, and cost-effectiveness of thermotherapy were assessed for the first time for L. donovani CL. A single blinded noninferiority randomized controlled trial was conducted on new laboratory-confirmed CL patients with single lesions (N = 213). Selected patients were randomly assigned to 1) test group (N = 98; single session of radiofrequency-induced heat therapy (RFHT) given at 50°C for 30 seconds) and 2) control group (N = 115; 1-3 mL IL-SSG given weekly, until cure/10 doses)...
August 14, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28820462/wettability-investigations-and-wet-transfer-enhancement-of-large-area-cvd-graphene-on-aluminum-nitride
#18
Marius Knapp, René Hoffmann, Volker Cimalla, Oliver Ambacher
The two-dimensional and virtually massless character of graphene attracts great interest for radio frequency devices, such as surface and bulk acoustic wave resonators. Due to its good electric conductivity, graphene might be an alternative as a virtually massless electrode by improving resonator performance regarding mass-loading effects. We report on an optimization of the commonly used wet transfer technique for large-area graphene, grown via chemical vapor deposition, onto aluminum nitride (AlN), which is mainly used as an active, piezoelectric material for acoustic devices...
August 18, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28820231/interventions-for-treating-persistent-pain-in-survivors-of-torture
#19
REVIEW
Emma Baird, Amanda C de C Williams, Leslie Hearn, Kirstine Amris
BACKGROUND: Persistent (chronic) pain is a frequent complaint in survivors of torture, particularly but not exclusively pain in the musculoskeletal system. Torture survivors may have no access to health care; where they do, they may not be recognised when they present, and the care available often falls short of their needs. There is a tendency in state and non-governmental organisations' services to focus on mental health, with poor understanding of persistent pain, while survivors may have many other legal, welfare, and social problems that take precedence over health care...
August 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28819961/-bioresorbable-scaffolds-in-the-treatment-of-coronary-artery-disease-expert-consensus-statement-of-the-association-of-cardiovascular-interventions-of-the-polish-cardiac-society-acvi-pcs
#20
Krzysztof Reczuch, Krzysztof Milewski, Wojciech Wąsek, Łukasz Rzeszutko, Wojciech Wojakowski, Michał Hawranek, Adrian Włodarczak, Tomasz Pawłowski, Janusz Kochman, Sławomir Dobrzycki, Marek Grygier, Andrzej Ochała, Jarosław Wójcik, Maciej Lesiak, Dariusz Dudek, Jacek Legutko
Bioresorbable scaffold coated with antimitotic drug is the latest development in the coronary stents technology. The concept of temporary scaffolding and natural vessel healing after angioplasty is a very attractive alternative to conventional metal stents. The results of the first observational studies have confirmed their ultimate biodegradation. Newest results of randomised trials and registries in broader clinical and anatomical indications also revealed the limitations of the first generation of scaffolds...
2017: Kardiologia Polska
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