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https://www.readbyqxmd.com/read/29046045/comparative-study-of-clinical-and-radiographic-outcomes-of-high-tibial-osteotomy-in-patients-with-kissing-lesions-and-non-kissing-lesions
#1
Oog-Jin Shon, Sang-Jin Park, Bum-Jin Shim, Dong-Yeol Lee
Purpose: High Outerbridge grade lesions of the articular cartilage have been associated with poor outcomes of high tibial osteotomy (HTO). However, there has been no report on the efficacy of HTO in the presence of kissing lesions. The purpose of this study was to compare clinical and radiographic outcomes of HTO between kissing lesion and non-kissing lesion groups. Materials and Methods: Of the patients with medial compartment osteoarthritis and varus deformity treated with HTO between 2007 and 2012, 21 cases with kissing lesions and 22 cases without kissing lesions were selected...
October 19, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/29045810/a-novel-next-generation-sequencing-assay-as-an-alternative-to-currently-available-methods-for-hepatitis-c-virus-genotyping
#2
G Dirani, E Paesini, E Mascetra, P Farabegoli, B Dalmo, B Bartolini, A R Garbuglia, M R Capobianchi, V Samri
Chronic HCV infection is one of the leading causes of liver-related death and in many countries it is a primary reason for having a liver transplant. HCV genotype identification has long been used in the clinical practice, since different genotypes have different response rates and required different doses and durations of IFN/RBV treatment; moreover both the frequency and the pattern of resistance to different Direct-Acting Antivirals (DAAs) classes are subtype specific. Hence the necessity to make an accurate HCV subtyping becomes a fundamental tool to optimize current and future clinical management of HCV infected subjects...
October 15, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/29045804/matrine-induced-g0-g1-arrest-and-apoptosis-in-human-acute-t-cell-lymphoblastic-leukemia-t-all-cells
#3
Aslı Tetik Vardarlı, Zekeriya Düzgün, Ceren Erdem, Burçin Tezcanli Kaymaz, Zuhal Eroglu, Vildan Bozok Çetintas
Matrine, a natural product extracted from the root of Sophora flavescens, is a promising alternative drug in different types of cancer. Here, we aimed to investigate the therapeutic effects and underlying molecular mechanisms of matrine on human acute lymphoblastic leukemia (ALL) cell line, CCRF-CEM. Cell viability and IC50 values were determined by WST-1 cell cytotoxicity assay. Cell cycle distribution and apoptosis rates were analyzed by flow cytometry. Expression patterns of 44 selected miRNAs and 44 RNAs were analyzed by quantitative reverse transcription polymerase chain reaction (qRT-PCR) using the Applied Biosystems 7500 Fast Real-Time PCR System...
October 18, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29045684/lean-management-to-support-choosing-wisely-in-healthcare-the-first-evidence-from-a-systematic-literature-review
#4
Maria Crema, Chiara Verbano
Purpose: Choosing Wisely (CW) is an emergent approach to identify and reduce unnecessary care, such as tests and treatments that do not add value for patients and may even cause harm. The purpose of this paper is to investigate whether and how Lean Healthcare Management (LHM) can support CW objectives, focusing on customer needs and on waste elimination. Data sources: A systematic literature review has been performed in Scopus, PubMed and Web of Science. Study selection: Peer reviewed articles published in English language have been selected...
October 17, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29044860/effects-of-exenatide-twice-daily-exenatide-once-weekly-or-insulin-in-patients-with-type-2-diabetes-and-baseline-hba1c-%C3%A2-10-0-two-pooled-analyses-including-20-randomised-controlled-trials
#5
Robert S Busch, James Ruggles, Jenny Han, Elise Hardy
AIMS: Patients with advanced type 2 diabetes (T2D) and high glycated haemoglobin (HbA1c) values can be difficult to treat because of their severe metabolic disease. This pooled analysis examined the treatment effects of exenatide twice daily (BID), exenatide once weekly (QW) and insulin in patients with high baseline HbA1c (≥10.0%). METHODS: This post hoc analysis used pooled data from 12 and 8 randomised controlled trials of exenatide BID and exenatide QW, respectively...
October 17, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29044340/renouncement-of-renal-replacement-therapy-withdrawal-and-refusal
#6
José Andrade Moura, Ana Flávia de Souza Moura, José Hermógenes Rocco Suassuna
Renouncement of renal replacement therapy (RRT) is a medical dilemma. This review covers the concept, the magnitude, the prognosis, and discusses strategies and management approaches about this subject in patients with CKD and AKI. Evidence suggests that refusal is more frequent and carries a more guarded prognosis than withdrawal of RRT. When RRT is not expected to be beneficial in terms of survival or quality of life, conservative treatment and palliative care are alternatives. We review the historical evolution of guidelines about renouncement of RRT and palliative care, and highlight the absence of specific recommendations in Brazil...
July 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29044326/in-vitro-antiparasitic-activity-and-chemical-composition-of-the-essential-oil-from-protium-ovatum-leaves-burceraceae
#7
Elisângela B B Estevam, Isabella P B DE Deus, Vanessa P DA Silva, Elizabeth A J DA Silva, Cassia C F Alves, José Milton Alves, Cristiane M Cazal, Lizandra G Magalhães, Mariana C Pagotti, Viviane R Esperandim, Alex F Souza, Mayker L D Miranda
Leishmaniasis and trypanosomiasis are globally widespread parasitic diseases which have been responsible for high mortality rates. Since drugs available for their treatment are highly hepatotoxic, nephrotoxic and cardiotoxic, adherence to therapy has been affected. Thus, the search for new, more effective and safer drugs for the treatment of these diseases is necessary. Natural products have stood out as an alternative to searching for new bioactive molecules with therapeutic potential. In this study, the chemical composition and antiparasitic activity of the essential oil from Protium ovatum leaves against trypomastigote forms of Trypanosoma cruzi and the promastigote forms of Leishmania amazonensis were evaluated...
October 16, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29044265/a-comprehensive-review-of-the-health-perspectives-of-resveratrol
#8
REVIEW
Abdur Rauf, Muhammad Imran, Hafiz Ansar Rasul Suleria, Bashir Ahmad, Dennis G Peters, Mohammad S Mubarak
Many natural products present in our diet, including flavonoids, can prevent the progression of cancer and other diseases. Resveratrol, a natural polyphenol present in various fruits and vegetables, plays an important role as a therapeutic and chemopreventive agent used in the treatment of various illnesses. It exhibits effects against different types of cancer through different pathways. It additionally exerts antidiabetic, anti-inflammatory, and anti-oxidant effects in a variety of cell types. Furthermore, the cardiovascular protective capacities of resveratrol are associated with multiple molecular targets and may lead to the development of novel therapeutic strategies for atherosclerosis, ischemia/reperfusion, metabolic syndrome, and heart failure...
October 18, 2017: Food & Function
https://www.readbyqxmd.com/read/29044153/tripalmitin-nanoparticle-formulations-significantly-enhance-paclitaxel-antitumor-activity-against-breast-and-lung-cancer-cells-in-vitro
#9
María Carmen Leiva, Raúl Ortiz, Rafael Contreras-Cáceres, Gloria Perazzoli, Iryna Mayevych, Juan Manuel López-Romero, Francisco Sarabia, Jose Manuel Baeyens, Consolación Melguizo, Jose Prados
Paclitaxel (PTX) is one of the drugs of choice in the treatment of breast and lung cancer. However, its severe side effects, including mielosuppression, cardiotoxicity and neurotoxicity, frequently cause treatment to be discontinued. Solid lipid nanoparticles (NPs) of glyceril tripalmitate (tripalmitin) loaded with PTX (Tripalm-NPs-PTX) including modifications by the addition of hexa(ethylene glycol), β-cyclodextrin and macelignan were developed. All NPs-PTX formulations displayed excellent hemocompatibility and significantly enhanced PTX antitumor activity in human breast (MCF7, MDAMB231, SKBR3 and T47D) and lung (A549, NCI-H520 and NCI-H460) cancer cells...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044140/therapeutic-potential-of-bifidobacterium-breve-strain-a1-for-preventing-cognitive-impairment-in-alzheimer-s-disease
#10
Yodai Kobayashi, Hirosuke Sugahara, Kousuke Shimada, Eri Mitsuyama, Tetsuya Kuhara, Akihito Yasuoka, Takashi Kondo, Keiko Abe, Jin-Zhong Xiao
It has previously been shown that the consumption of probiotics may have beneficial effects not only on peripheral tissues but also on the central nervous system and behavior via the microbiota-gut-brain axis, raising the possibility that treatment with probiotics could be an effective therapeutic strategy for managing neurodegenerative disorders. In this study, we investigated the effects of oral administration of Bifidobacterium breve strain A1 (B. breve A1) on behavior and physiological processes in Alzheimer's disease (AD) model mice...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044005/analysis-on-the-treatment-and-prevention-of-epidemic-conjunctivitis-in-108-cases
#11
Guangli Sun, Gang Su, Yanhui Bai, Huiqin Yang
To explore the treatment method and preventive measures on epidemic keratoconjunctivitis. 108 patients with epidemic keratoconjunctivitis who received treatment in our hospital from January, 2015 to September, 2015.were selected. These patients were treated with interferon eye drops, Ganciclovir ophthalmic gel, and alternating eye treatment of tobramycin-dexamethasone eye drops and diclofenac sodium eye drops. Meanwhile, health education was also performed among patients, so as to promote the recovery of the disease as soon as possible and to prevent the spread of the disease Among the 108 patients, there were 101 patients recovered...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29043907/prescription-pattern-and-awareness-of-disease-and-treatment-in-patients-of-parkinson-s-disease
#12
Raakhi K Tripathi, Sandip V Kapse, Anirudha V Potey
AIM: This cross-sectional study aimed to evaluate the prescription pattern, awareness of disease and treatment in patients with Parkinson's disease (PD). MATERIALS & METHODS: A total of 100 PD patients, attending a tertiary care hospital in Mumbai were included. Prescriptions were analyzed and awareness was evaluated using a questionnaire. RESULTS: The mean number of anti-Parkinson agents (APA) prescribed was 1.52 ± 0.65. Number of APA strongly correlated with disease duration (ρ = 0...
October 18, 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29043803/identification-of-privileged-antichlamydial-natural-products-by-a-ligand-based-strategy
#13
Elina Karhu, Janne Isojärvi, Pia Vuorela, Leena Hanski, Adyary Fallarero
The obligate intracellular pathogen Chlamydia pneumoniae remains a difficult target for antimicrobial therapy. Owing to the permeability barrier placed by bacterial and host vacuolar membranes, as well as the propensity of the bacterium for persistent infections, treatment failures are common. Despite the urgent need for new antichlamydial compounds, their discovery is challenged by the technically demanding assay procedures and lack of validated targets. An alternative strategy of using naturally occurring compounds and their derivatives against C...
October 18, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29043596/short-term-prospective-questionnaire-study-of-early-postoperative-quality-of-life-after-colorectal-endoscopic-submucosal-dissection
#14
Fumihiko Nakamura, Yutaka Saito, Shin Haruyama, Masau Sekiguchi, Masayoshi Yamada, Taku Sakamoto, Takeshi Nakajima, Seiichiro Yamamoto, Yoshitaka Murakami, Hideki Ishikawa, Takahisa Matsuda
BACKGROUND: Endoscopic submucosal dissection (ESD) has become popular as an alternative to laparoscopy-assisted colectomy (LAC) for early colorectal cancer. AIM: To validate postoperative quality of life (QOL) based on subjective symptoms of patients from questionnaire survey. METHODS: We prospectively enrolled patients planned to undergo ESD for adenoma or Tis/T1a cancer at our institution between December 2011 and January 2013. Controls were prospectively enrolled LAC patients diagnosed with T1b cancer...
October 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29043576/submucosal-tunneling-endoscopic-resection-for-the-treatment-of-gastrointestinal-submucosal-tumors-originating-from-the-muscularis-propria-layer
#15
Chen Du, Enqiang Linghu
Surgical resection and endoscopic resection comprise two alternative options for the treatment of submucosal tumors (SMTs) originating from the muscularis propria (MP) layer. Endoscopic resection is minimally invasive compared with surgical resection. Conventional non-tunneling techniques, such as endoscopic submucosal dissection (ESD), endoscopic submucosal excavation (ESE), and endoscopic full-thickness resection (EFR) have been demonstrated to be safe and effective. However, these techniques fail to maintain the integrity of the mucosa and induce high risk of perforation, infection, and postoperative strictures...
October 17, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29043388/isolation-and-potential-biocementation-of-calcite-precipitation-inducing-bacteria-from-colombian-buildings
#16
Sandra M Montaño-Salazar, Juan Lizarazo-Marriaga, Pedro F B Brandão
Microbiological induced calcium carbonate or calcite precipitation (MICP) has become a highly researched issue due to its multiple applications in the construction industry, being a promising alternative with a great biotechnological importance. In this work, potential calcite precipitation inducing bacteria were isolated from mortar and concrete samples of different buildings at the National University of Colombia. Eighteen crystal-precipitating strains were recovered in Urea-CaCl2 solid medium. The 16S rRNA gene sequencing identified isolates as Arthrobacter, Psychrobacillus and Rhodococcus genera...
October 17, 2017: Current Microbiology
https://www.readbyqxmd.com/read/29043356/cationic-amphiphilic-zn-porphyrin-with-high-antifungal-photodynamic-potency
#17
Sara Moghnie, Artak Tovmasyan, James Craik, Ines Batinic-Haberle, Ludmil Benov
Photodynamic therapy (PDT) is a promising alternative approach particularly attractive for treatment of localized fungal infections. It is based on compounds, photosensitizers (PSs), which when excited with visible light, generate reactive species that ultimately cause cell death. Such species have short lifespans; as a consequence, efficiency and selectivity of the PDT treatment depend mainly on the properties of the PSs. This study is the first to explore the effect of cationic porphyrin-based photosensitizers on Saccharomyces cerevisiae, a member of the fungus kingdom...
October 18, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29043001/effect-of-pingchuan-guben-decoction-on-patients-with-chronic-obstructive-pulmonary-disease-results-from-a-randomized-comparative-effectiveness-research-trial
#18
Cheng-Liang Qian, Rong Fan
Chronic obstructive pulmonary disease (COPD) is known to be a systemic low-grade ongoing inflammation exerting major health and economic burden worldwide. Complementary and alternative medicines, such as Traditional Chinese Medicine, are widely used for the treatment of patients with COPD. The present study was designed to investigate the efficacy of Pingchuan Guben decoction on patients with COPD through a double-blinded, open-labeled, randomized controlled trial. A total of 86 patients were randomly assigned to two groups, with 43 patients in the intervention group and 43 cases in the control group...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042957/ursolic-acid-inhibits-breast-cancer-growth-by-inhibiting-proliferation-inducing-autophagy-and-apoptosis-and-suppressing-inflammatory-responses-via-the-pi3k-akt-and-nf-%C3%AE%C2%BAb-signaling-pathways-in-vitro
#19
Juan Luo, Yan-Ling Hu, Hong Wang
Breast cancer, which is the second leading cause of cancer-associated mortality in women worldwide, develops from breast tissue. Chemotherapy is the most commonly used therapy to treat breast cancer. However, a number of natural plant-derived products have been suggested as alternative therapies to treat different types of cancer, such as breast cancer. The aim of the present study was to determine the anti-tumor effects of ursolic acid and its effect on apoptosis and inflammation in breast cancer cells. The anti-cancer effects of ursolic acid were evaluated in vitro using flow cytometry, western blotting and reverse transcription-quantitative polymerase chain reaction...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042865/additional-corticosteroids-or-alternative-antibiotics-for-the-treatment-of-macrolide-resistant-mycoplasma-pneumoniae-pneumonia
#20
EDITORIAL
Eun-Ae Yang, Kyung-Yil Lee
No abstract text is available yet for this article.
August 2017: Korean Journal of Pediatrics
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