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https://www.readbyqxmd.com/read/29913322/culture-supernatants-of-oral-cancer-cells-induce-impaired-ifn-%C3%AE-production-of-pdcs-partly-through-the-down-regulation-of-tlr-9-expression
#1
Nannan Han, Zun Zhang, Houyu Jv, Jingzhou Hu, Min Ruan, Chenping Zhang
OBJECTIVES: The aim of the present study was to investigate whether tumor-derived supernatants down-regulate the immune function of plasmacytoid dendritic cells (pDCs) in oral cancer and the potential molecular mechanisms of this effect. MATERIALS AND METHODS: Immunohistochemistry (IHC) and flow cytometry were used to detect tumor-infiltrating and peripheral blood pDCs. MTS and flow cytometry were employed to evaluate the immune response of CD4+ T cells. Real-time PCR and ELISA assays were used to identify TLR-7 and TLR-9 expression, IFN-α production and tumor-secreted soluble cytokines...
June 5, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29913134/an-efficient-method-to-evaluate-experimental-factor-influence-on-in-vitro-binding-of-aptamers
#2
Donglin Diao, Na Qiao, Xiao Wu, Jiyuan Li, Xinhui Lou
Nucleic acid-based aptamers are promising alternative to antibodies, however, their selection process (SELEX) is challenging. A number of simulations and few experiments have been reported offering insights into experimental factors (EFs) that govern the effectiveness of the selection process. Though useful, these previous studied were either lack of experimental confirmation, or considered limited EFs. A more efficient experimental method is highly desired. In this study, we developed a fast method that is capable to quantitatively probe the influence of multiple EFs...
June 15, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29913001/efficacy-of-rituximab-vs-tacrolimus-in-pediatric-corticosteroid-dependent-nephrotic-syndrome-a-randomized-clinical-trial
#3
Biswanath Basu, Anja Sander, Birendranath Roy, Stella Preussler, Shilpita Barua, T K S Mahapatra, Franz Schaefer
Importance: Calcineurin inhibitors are an established first-line corticosteroid-sparing therapy for patients with corticosteroid-dependent nephrotic syndrome (CDNS), whereas B-lymphocyte-depleting therapy is mostly used as a rescue for calcineurin inhibitor-resistant cases. The positive efficacy and safety profile of rituximab raises the question of whether it could be used as a first-line alternative to calcineurin inhibitor therapy. Objective: To compare the efficacy of rituximab and tacrolimus in maintaining relapse-free survival among children with CDNS...
June 18, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29912982/discovery-of-a-novel-potent-peptide-agonist-to-adiponectin-receptor-1
#4
Sunghwan Kim, Younho Lee, Jun Woo Kim, Young-Jin Son, Min Jung Ma, Jee-Hyun Um, Nam Doo Kim, Sang Hyun Min, Dong Il Kim, Brian B Kim
Activation of adiponectin receptors (AdipoRs) by its natural ligand, adiponectin has been known to be involved in modulating critical metabolic processes such as glucose metabolism and fatty acid oxidation as demonstrated by a number of in vitro and in vivo studies over last two decades. These findings suggest that AdipoRs' agonists could be developed into a potential therapeutic agent for metabolic diseases, such as diabetes mellitus, especially for type II diabetes, a long-term metabolic disorder characterized by high blood sugar, insulin resistance, and relative lack of insulin...
2018: PloS One
https://www.readbyqxmd.com/read/29912794/intraindividual-and-interindividual-variability-of-olanzapine-trough-concentrations-in-patients-treated-with-the-long-acting-injectable-formulation
#5
Sara Baldelli, Massimo C Mauri, Chiara Di Pace, Silvia Paletta, Alessandra Reggiori, Chiara Rovera, Emilio Clementi, Dario Cattaneo
BACKGROUND: A long-acting injectable (LAI) formulation of olanzapine has been developed as an alternative to oral regimens. A therapeutic range of 20 to 80 ng/mL for oral olanzapine trough concentrations has been proposed. Here, we sought to investigate the intraindividual and interindividual variability of olanzapine concentrations with time in patients on maintenance therapy with the LAI formulation carried out in the routine clinical practice. METHODS: To address this issue, we carried out a retrospective analysis of therapeutic drug monitoring of olanzapine concentrations in 21 schizophrenic patients on maintenance LAI olanzapine...
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912782/a-randomized-triple-blind-trial-of-cardiac-shock-wave-therapy-on-exercise-tolerance-and-symptoms-in-patients-with-stable-angina-pectoris
#6
Evgeny Shkolnik, Greta Burneikaite, Gabrielius Jakutis, Mikhail Scherbak, Gitana Zuoziene, Birute Petrauskiene, Ekaterina Trush, Yury Vasyuk, Aleksandras Laucevicius, Jelena Celutkiene
BACKGROUND: Despite major advances in managing coronary artery disease and continuous research on alternative techniques to enhance myocardial perfusion and reduce symptoms, coronary artery disease is still one of the leading causes of adult disability worldwide. Cardiac shock-wave therapy (CSWT) has shown promising results in the amelioration of myocardial ischemia in experimental studies; however, clinical results are limited to single-center, mostly uncontrolled and underpowered trials...
June 16, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29912738/aortic-valve-in-valve-in-externally-mounted-bioprosthesis-a-safe-treatment-option-for-bioprosthetic-structural-valve-dysfunction
#7
Anson W Cheung, Jian Ye, Danny Dvir, David A Wood, John G Webb
OBJECTIVE: Aortic valve-in-valve implantation for prosthetic valve dysfunction is a good alternative to reoperative valve replacement. There are some limitations to this approach including the risk of coronary occlusion, patient prosthesis mismatch, and valve malposition. The incidence of coronary occlusion is higher in aortic valve-in-valve than de novo aortic stenosis cases. Multiple factors can contribute to this complication, and the type of bioprosthesis has been implicated. METHODS: We examined our experience of 80 aortic valve-in-valve cases with internally and externally mounted leaflet valves...
June 15, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29912729/in-vitro-effects-of-the-fs50-protein-from-salivary-glands-of-xenopsylla-cheopis-on-voltage-gated-sodium-channel-activity-and-motility-of-mda-mb-231-human-breast-cancer-cells
#8
Bei Zhang, Zhenghui Deng, Baishuang Zeng, Shilong Yang, Xin Chen, Xueqing Xu, Jiguo Wu
Voltage-gated sodium channel activity enhances the motility and oncogene expression of metastasic cancer cells that express a neonatal alternatively spliced form of the NaV1.5 isoform. We reported previously that FS50, a salivary protein from Xenopsylla cheopis, showed inhibitory activity against the NaV1.5 channel when assayed in HEK 293T cells and antiarrhythmia effects on rats and monkeys after induction of arrhythmia by BaCl2. This study aims to identify the effect of FS50 on voltage-gated sodium channel activity and the motility of MDA-MB-231 human breast cancer cells in vitro...
June 16, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29912546/extraordinary-corrosion-protection-from-polymer-clay-nanobrick-wall-thin-films
#9
Eric J Schindelholz, Erik David Spoerke, Hai-Duy Nguyen, Jaime C Grunlan, Shuang Qin, Daniel C Bufford
Metals across all industries demand anti-corrosion surface treatments and drive a continual need for high-performing and low-cost coatings. Here we demonstrate polymer-clay nanocomposite thin films as a new class of transparent conformal barrier coatings for protection in corrosive atmospheres. Films assembled via layer-by-layer deposition, as thin as 90 nm, are shown to reduce copper corrosion rates by >1000x in an aggressive H2S atmosphere. These multilayer nanobrick wall coatings hold promise as high-performing anti-corrosion treatment alternatives to costlier, more toxic, and less scalable thin films, such as graphene, hexavalent chromium, or atomic layer deposited metal oxides...
June 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29912481/osseointegration-of-zirconia-implants-with-3-varying-surface-textures-and-a-titanium-implant-a-histological-and-micro-ct-study
#10
Paweł Kubasiewicz-Ross, Jakub Hadzik, Marzena Dominiak
BACKGROUND: Zirconium - a bioinert metal - in comparison with titanium implants, offers a variety of potential advantages for use in the esthetic area of dentistry due to its tooth-like color. Zirconium dental implants are considered to be an alternative method of treatment to conventional titanium dental implants for patients with a thin gingival biotype. OBJECTIVES: This study was designed to study the bone tissue response to new zirconia implants with modified surfaces in comparison with commercially available titanium dental implants and commercially available zirconia implants...
June 18, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29912463/the-veterans-health-administration-s-traumatic-brain-injury-screen-and-evaluation-service-delivery-insights
#11
D Helen Moore, Gail Powell-Cope, Heather G Belanger
Background: In recognition of the incidence of traumatic brain injuries (TBIs) in the Iraq and Afghanistan conflicts, the Department of Veterans Affairs (VA) has, since 2007, examined returning U.S. service members for symptoms of TBI, a pre-condition for VA treatment of TBI. This study characterizes "Traumatic Brain Injury screen" service delivery, according to the barrier and facilitator viewpoints of those experiencing the delivery. Methods: The purposeful sample comprised both Veteran patient and VA staff participants in the TBI screen program (n = 64), including patients (n = 14), health care providers (n = 38), and key informants (n = 12)...
April 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29912422/age-and-outcomes-following-guided-de-escalation-of-antiplatelet-treatment-in-acute-coronary-syndrome-patients-undergoing-percutaneous-coronary-intervention-results-from-the-randomized-tropical-acs-trial
#12
Dirk Sibbing, Lisa Gross, Dietmar Trenk, Claudius Jacobshagen, Tobias Geisler, Martin Hadamitzky, Béla Merkely, Róbert Gábor Kiss, András Komócsi, Radoslaw Parma, Stephan B Felix, Franz-Josef Neumann, Jörg Hausleiter, Monika Baylacher, Lukasz Koltowski, Julinda Mehilli, Kurt Huber, Zenon Huczek, Dániel Aradi, Steffen Massberg
Aims: Guided de-escalation of P2Y12-inhibitor treatment was recently identified as an effective alternative treatment strategy in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention. Safety and efficacy of this strategy may differ in relation to patient's age. This pre-specified analysis of the TROPICAL-ACS trial aimed to assess the impact of age on clinical outcomes following guided de-escalation of antiplatelet treatment in ACS patients. Methods and results: Patients were randomly assigned in a 1:1 fashion to either standard treatment with prasugrel for 12 months (control group) or to a guided de-escalation regimen (1 week prasugrel followed by 1 week clopidogrel and platelet function testing guided maintenance therapy with clopidogrel or prasugrel from day 14 after hospital discharge; guided de-escalation group)...
June 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29912401/challenges-to-reshape-the-future-of-type-1-diabetes-research
#13
David Bleich, David H Wagner
Context: Immunotherapy trials to prevent type 1 diabetes have been unsuccessful for more than fifteen years. Understanding pitfalls and knowledge gaps in the immunology of type 1 diabetes should lead us in new directions that will yield better trial outcomes. A proposal is made for precision medicine trial design in future type 1 diabetes studies. Evidence Acquisition: High quality peer-reviewed basic science and clinical research trials for type 1 diabetes were used in this Perspectives article...
June 14, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29912346/a-unidimensional-diffusion-model-applied-to-uremic-toxin-kinetics-in-haemodiafiltration-treatments
#14
Miquel Gomez, Francisco Maduell
Kinetic modelling in haemodialysis is usually based upon the resolution of volume-defined compartment models. The interaction among these compartments is described by purely diffusive processes. In this paper we present an alternative kinetic model for uremic toxins in post-dilutional haemodiafiltration treatments by means of a unidimensional diffusion equation. A wide range of solutes such as urea, creatinine, $\beta _{2}$-microglobulin, myoglobin and prolactin were studied by imposing appropriate boundary and initial conditions in a virtual [0,1] domain...
June 15, 2018: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/29912180/an-alternative-culture-method-to-maintain-genomic-hypomethylation-of-mouse-embryonic-stem-cells-using-mek-inhibitor-pd0325901-and-vitamin-c
#15
Cuiping Li, Weiyi Lai, Hailin Wang
Embryonic stem (ES) cells have the potential to differentiate into any of the three germ layers (endoderm, mesoderm, or ectoderm), and can generate many lineages for regenerative medicine. ES cell culture in vitro has long been the subject of widespread concerns. Classically, mouse ES cells are maintained in serum and leukemia inhibitory factor (LIF)-containing medium. However, under serum/LIF conditions, cells show heterogeneity in morphology and the expression profile of pluripotency-related genes, and are mostly in a metastable state...
June 1, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29911919/innovative-treatment-for-pes-cavovarus-a-pilot-study-of-13-children
#16
Ignacio Sanpera, Guillem Frontera-Juan, Julia Sanpera-Iglesias, Laura Corominas-Frances
Background and purpose - Pes cavovarus (PCV) is a complex deformity, frequently related to neurological conditions and associated with foot pain, callosities, and walking instability. The deformity has the tendency to increase during growth. Orthotic treatment is ineffective and surgery may be troublesome. We present the preliminary results of a new mini-invasive surgical technique for correction of this foot deformity. Patients and methods - We operated on 13 children (24 feet), age 7-13 years. In 7 children the deformity was neurological in origin...
June 18, 2018: Acta Orthopaedica
https://www.readbyqxmd.com/read/29911917/cost-minimization-analysis-of-alemtuzumab-compared-to-fingolimod-and-natalizumab-for-the-treatment-of-active-relapsing-remitting-multiple-sclerosis-in-the-netherlands
#17
M A Piena, M Heisen, L W Wormhoudt, J van Wingerden, S T F M Frequin, B M J Uitdehaag
AIM: In active relapsing remitting multiple sclerosis (RRMS) patients requiring second-line treatment, the Dutch National Health Care Institute (ZiN) has not stated a preference for either alemtuzumab, fingolimod or natalizumab. Our aim was to give healthcare decision-makers insight into the differences in cost accumulation over time between alemtuzumab - with a unique, non-continuous treatment schedule - and fingolimod and natalizumab for second-line treatment of active RRMS patients in the Netherlands...
June 18, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29911684/insurance-companies-fighting-the-peer-review-empire-without-any-validity-the-case-for-addiction-and-pain-modalities-in-the-face-of-an-american-drug-epidemic
#18
K Blum, W Jacobs, E J Modestino, N DiNubile, D Baron, T McLaughlin, D Siwicki, I Elman, M Moran, E R Braverman, P K Thanos, R D Badgaiyan
The United States are amid an opioid overdose epidemic; we are challenged to provide non-addicting/non-pharmacological alternatives to assist in pain attenuation. There are proven strategies available to manage chronic pain effectively without opioids. Utilization review providers for insurance companies often ignore medicine based scientific peer-reviewed studies that warn against the chronic use of opioid medications, as well as the lack of evidence to support long-term use of opioids for pain. This paradigm must change if we are to indeed change the drug-embracing culture in American chronic pain management...
October 4, 2018: SEJ Surg Pain
https://www.readbyqxmd.com/read/29911654/coping-with-painful-sex-development-and-initial-validation-of-the-champ-sexual-pain-coping-scale
#19
Ida K Flink, Johanna Thomtén, Linnéa Engman, Stina Hedström, Steven J Linton
Background and purpose Recurrent vulvar pain is a common and debilitating condition which has received remarkably little attention in pain research. For instance, little is known about how these women cope with sexual activities, and there are no structured assessment tools. The purpose of this study was to explore coping strategies in this group, with a view to develop a measure to assess how women with vulvar pain cope with sexual activities. Methods The current study is based on a subsample from a longitudinal study about vulvar pain in a student sample consisting of women between 18 and 35 years old (N = 964)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911581/real-time-ultrasound-guided-infraorbital-nerve-block-to-treat-trigeminal-neuralgia-using-a-high-concentration-of-tetracaine-dissolved-in-bupivacaine
#20
Kenichi Takechi, Amane Konishi, Kotaro Kikuchi, Shiho Fujioka, Tomomi Fujii, Toshihiro Yorozuya, Koh Kuzume, Takumi Nagaro
Background Trigeminal neuralgia is a neuropathic disorder characterized by episodes of intense pain in the face. Drug therapy is the first choice of treatment. However, in cases where drug therapy are contraindicated due to side effects, patients can get pain relief from lengthy neurosurgical procedures. Alternatively, a peripheral trigeminal nerve block can be easily performed in an outpatient setting. Therefore it is a useful treatment option for the acute paroxysmal period of TN in patients who cannot use drug therapy...
December 29, 2017: Scandinavian Journal of Pain
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