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https://www.readbyqxmd.com/read/28110508/on-an-enhanced-rank-preserving-structural-failure-time-model-to-handle-treatment-switch-crossover-and-dropout
#1
Lingling Li, Shijie Tang, Liewen Jiang
It is very challenging to estimate the comparative treatment effect between a treatment therapy and a control therapy on overall survival in the presence of treatment crossover, switch to an alternative non-study therapy, and non-random patient dropout. Existing methods (e.g., intent-to-treat and per-protocol) are known to be biased. We proposed two new estimators to address these analytical challenges and evaluated their performance via a comprehensive simulation study. The new estimators were constructed by combining an enhanced rank-preserving structural failure time model and the inverse probability censoring weighting approach...
January 22, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28110415/antimicrobial-combination-treatment-including-ciprofloxacin-decreased-the-mortality-rate-of-pseudomonas-aeruginosa-bacteraemia-a-retrospective-cohort-study
#2
M Paulsson, A Granrot, J Ahl, J Tham, F Resman, K Riesbeck, F Månsson
Ineffective antimicrobial therapy of Pseudomonas aeruginosa bacteraemia increases mortality. Recent studies have proposed the use of antimicrobial combination therapy composed of a beta-lactam with either ciprofloxacin or tobramycin. To determine if combination therapy correlates to lower mortality and is superior compared to monotherapy, we investigated the effect of antimicrobial treatment regimens on 30-day mortality in a cohort with Pseudomonas aeruginosa bacteraemia. All cases of P. aeruginosa bacteraemia (n = 292) in southwest Skåne County, Sweden (years 2005-2010, adult population 361,112) and the whole county (2011-2012, 966,130) were identified...
January 21, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28110373/experiences-with-surgically-treated-primary-or-secondary-hepatic-sarcoma
#3
René Fahrner, Sandra G C Dennler, Felix Dondorf, Michael Ardelt, Falk Rauchfuss, Utz Settmacher
PURPOSE: Liver resection in hepatic sarcoma is rare, but other alternative treatment options are scarce. Surgery offers the only aggressive approach to achieve a tumour-free state. The aim of this investigation was to evaluate the outcome and survival of these patients at a single hepato-biliary university hospital. METHODS: Between January 2004 and July 2013, 896 anatomical liver resections were performed. Eleven liver resections (1.2%) were performed due to primary hepatic sarcoma or hepatic sarcoma metastases...
January 21, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28110366/atomoxetine-treatment-for-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-adhd-a-comprehensive-meta-analysis-of-outcomes-on-parent-rated-core-symptomatology
#4
REVIEW
Jessica L Gayleard, Matthew P Mychailyszyn
Attention-Deficit/Hyperactivity Disorder (ADHD) impacts a significant number of children and adolescents and often leads to deleterious functional impairment. Psychostimulant medication has historically been the first line of pharmacological intervention, though recent years have seen greater attention paid to non-stimulant alternatives. The objective of the present study was to conduct the most comprehensive meta-analysis to date evaluating the efficacy of atomoxetine in reducing core symptomatology of ADHD according to parent report...
January 21, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/28110193/effects-of-polyphenol-compounds-melanin-on-nafld-nash-prevention
#5
Natalia Belemets, Nazarii Kobyliak, Oleksandr Virchenko, Tetyana Falalyeyeva, Tsyryuk Olena, Petro Bodnar, Oleksiy Savchuk, Tetyana Galenova, Martin Caprnda, Luis Rodrigo, Lubomir Skladany, Delian Delev, Radka Opatrilova, Peter Kruzliak, Tetyana Beregova, Lyudmyla Ostapchenko
BACKGROUND: One of the pathogenic mechanisms of the progression non-alcoholic liver disease (NAFLD) to nonalcoholic steatohepatitis (NASH) is the accumulation of reactive oxygen species (ROS). So, antioxidant therapy is necessary for successful treatment of the liver injury. We have paid attention to melanin produced by yeast Nadsoniella nigra strain X-1 as novel antioxidant and anti-inflammatory agents with low toxicity. In current study we aimed to investigate the preventive effect of melanin on the monosodium glutamate (MSG) induced NAFLD model in rats...
January 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28110155/first-in-man-study-with-a-novel-pegylated-recombinant-human-insulin-like-growth-factor-i
#6
H Kletzl, A Guenther, A Höflich, C Höflich, J Frystyk, R F Staack, E Schick, C Wandel, N Bleich, F Metzger
OBJECTIVE: This study is a first time assessment of safety and tolerability, pharmacokinetics, and pharmacodynamics of RO5046013 in human, in comparison with unmodified rhIGF-I. DESIGN: The study was conducted as a single-center, randomized, double-blinded, placebo-controlled, single ascending dose, parallel group study in a clinical research unit in France. A total of 62 healthy volunteers participated in this clinical trial. RO5046013 was given as single subcutaneous injection, or as intravenous infusion over 48h, at ascending dose levels...
January 10, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28109989/low-glycemic-index-treatment-for-seizure-control-in-angelman-syndrome-a-case-series-from-the-center-for-dietary-therapy-of-epilepsy-at-the-massachusetts-general-hospital
#7
Olivia R Grocott, Katherine S Herrington, Heidi H Pfeifer, Elizabeth A Thiele, Ronald L Thibert
The low glycemic index treatment, a dietary therapy that focuses on glycemic index and reduced carbohydrate intake, has been successful in reducing seizure frequency in the general epilepsy population. Epilepsy is a common feature of Angelman syndrome and seizures are often refractory to multiple medications, especially in those with maternal deletions. Dietary therapy has become a more frequently used option for treating epilepsy, often in combination with other antiepileptic drugs, due to its efficacy and favorable side effect profile...
January 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28109978/structural-brain-alteration-in-survivors-of-acute-lymphoblastic-leukemia-with-chemotherapy-treatment-a-voxel-based-morphometry-and-diffusion-tensor-imaging-study
#8
Liwei Zou, Lianzi Su, Jiajia Xu, Li Xiang, Longsheng Wang, Zhimin Zhai, Suisheng Zheng
OBJECTIVE: To assess structural brain changes in survivors of acute lymphoblastic leukemia (ALL) with chemotherapy treatment by combining voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS). METHODS: 28 ALL patients (mean age: 40.71±8.58 years, years since diagnosis: 7-38) and 20 age-matched control subjects (mean age: 42.95±6.39 years) selected in this study with 3D T1 and diffusion tensor imaging acquired on a 3.0T Siemens MRI scanner. The ALL group had a history of chemotherapy treatment and off-therapy at least for 3 years was enrolled...
January 18, 2017: Brain Research
https://www.readbyqxmd.com/read/28109962/endothelial-permeability-and-hemostasis-in-septic-shock-results-from-the-process-trial
#9
Peter Hou, Michael Filbin, Henry Wang, Long Ngo, David T Huang, William C Aird, Donald M Yealy, Derek C Angus, John A Kellum, Nathan I Shapiro
BACKGROUND: We studied patients from the Protocolized Care in Early Septic Shock (ProCESS) trial to determine: the effects of alternative resuscitation strategies on circulating markers of endothelial cell permeability and hemostasis, and; the association between biomarkers and mortality. METHODS: Prospective study of biomarkers of endothelial cell permeability (vegf, sflt-1, ang-2) and hemostasis (vwf, thrombomodulin, tpa) in 605 of the 1341 ProCESS participants in a derivation cohort and 305 in validation...
January 18, 2017: Chest
https://www.readbyqxmd.com/read/28109894/pregnancy-outcomes-following-direct-uterine-fibroid-thermal-ablation-a-review-of-the-literature
#10
REVIEW
Julia Keltz, Mark Levie, Scott Chudnoff
The objective of this review is to describe the reproductive outcomes of women after radiofrequency volumetric thermal ablation (RFVTA) of fibroids or magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU). This is a literature review of the current case reports of reproductive outcomes following direct fibroid thermal ablation at multiple academic and private centers throughout the world. A literature search was performed using PubMed and Medline. All publications that included data of women who underwent radiofrequency fibroid ablation or magnetic resonance-guided high-intensity focused ultrasound of fibroids and subsequently conceived were included...
January 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28109864/microsurgical-posterolateral-foraminotomy-on-patients-with-adult-isthmic-spondylolisthesis
#11
Han Soo Chang
BACKGROUND: Currently, the standard surgical treatment for adult isthmic spondylolisthesis consists of various techniques of arthrodesis supplemented with instrumentation. The superiority of this strategy, however, has not been irrefutably proven. Considering the risk associated with the instrumentation surgery, we may justifiably examine a less invasive approach. METHODS: We describe a series of nine patients with adult isthmic spondylolisthesis, in whom we microsurgically decompressed the responsible nerve root in the intervertebral foramen through the posterolateral inter-muscular approach...
January 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28109630/analytical-model-for-the-design-of-in-situ-horizontal-permeable-reactive-barriers-hprbs-for-the-mitigation-of-chlorinated-solvent-vapors-in-the-unsaturated-zone
#12
Iason Verginelli, Oriana Capobianco, Niels Hartog, Renato Baciocchi
In this work we introduce a 1-D analytical solution that can be used for the design of horizontal permeable reactive barriers (HPRBs) as a vapor mitigation system at sites contaminated by chlorinated solvents. The developed model incorporates a transient diffusion-dominated transport with a second-order reaction rate constant. Furthermore, the model accounts for the HPRB lifetime as a function of the oxidant consumption by reaction with upward vapors and its progressive dissolution and leaching by infiltrating water...
January 10, 2017: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/28109602/strategies-to-gain-body-condition-score-in-pasture-based-dairy-cows-during-late-lactation-and-the-far-off-nonlactating-period-and-their-interaction-with-close-up-dry-matter-intake
#13
J R Roche, A Heiser, M D Mitchell, M A Crookenden, C G Walker, J K Kay, M Vailati Riboni, J J Loor, S Meier
In pasture-based systems, cows are generally thinner at the end of lactation than cows fed total mixed rations and, as a result, over-feeding of metabolizable energy (ME) during the far-off nonlactating period is a standard management policy to achieve optimum calving body condition score (BCS). An alternative would be to manage cows to gain BCS through late lactation, such that cows ended lactation close to optimum calving BCS and maintenance of BCS through to calving. We sought to quantify the effect of moderate or excessive ME intakes during the far-off nonlactating period in cows that had been managed to gain or maintain BCS through late lactation and whether the far-off management strategy interacted with close-up level of feeding...
January 18, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28109381/endovascular-technique-for-repair-of-descending-thoracic-aortic-aneurysm-after-coarctation-operation
#14
Heike Baumgarten, John J Squiers, William T Brinkman, Javier Vasquez
The incidence of aneurysm after open surgical repair of coarctation is 11% to 24%. If the condition is left untreated, fatal rupture may occur. Thoracic endovascular aortic repair (TEVAR) has been reported as a feasible and safe alternative to open surgical repeated procedures in this context. However, TEVAR might be challenging because of the proximity of the pathologic condition to the supraaortic vessels and the ongoing presence of the coarctation. We report a unique case of a 48-year old man undergoing TEVAR because of aortic aneurysm after previous surgical coarctation treatment and successful closure of the coarctation with a vascular plug device...
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28108978/treatment-of-complicated-urinary-tract-infection-and-acute-pyelonephritis-by-short-course-intravenous-levofloxacin-750%C3%A2-mg-day-or-conventional-intravenous-oral-levofloxacin-500%C3%A2-mg-day-prospective-open-label-randomized-controlled-multicenter-non-inferiority
#15
Hong Ren, Xiao Li, Zhao-Hui Ni, Jian-Ying Niu, Bin Cao, Jie Xu, Hong Cheng, Xiao-Wen Tu, Ai-Min Ren, Ying Hu, Chang-Ying Xing, Ying-Hong Liu, Yan-Feng Li, Jun Cen, Rong Zhou, Xu-Dong Xu, Xiao-Hui Qiu, Nan Chen
OBJECTIVE: To compare the efficacy and safety of short-course intravenous levofloxacin (LVFX) 750 mg with a conventional intravenous/oral regimen of LVFX 500 mg in patients from China with complicated urinary tract infections (cUTIs) and acute pyelonephritis (APN). METHODS: This was a prospective, open-label, randomized, controlled, multicenter, non-inferiority clinical trial. Patients with cUTI and APN were randomly assigned to a short-course therapy group (intravenous LVFX at750 mg/day for 5 days) or a conventional therapy group (intravenous/oral regimen of LVFX at 500 mg/day for 7-14 days)...
January 20, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28108911/traditional-chinese-medicine-for-modern-treatment-of-parkinson-s-disease
#16
REVIEW
Lu Han, Yuan-Hong Xie, Rong Wu, Chen Chen, Yan Zhang, Xiao-Ping Wang
Parkinson's disease (PD) is a chronic and progressive degenerative disorder of brain commonly seen among the elderly. As conventionally medical therapy is of limited relief and potential side effects, complementary and alternative medicine (CAM) has attracted growing public and professional attention. Therapies such as acupuncture, musical/rhythmic therapy and deep brain stimulation have been gradually proved positively in clinic. In this review, we retrospected the scientific or evidence-based-medicine advances of application and research for modern treatment of PD by CAM, especially traditional Chinese medicine in categories...
January 20, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28108798/augmented-perineal-urethrostomy-using-a-dorsal-buccal-mucosal-graft-bi-institutional-study
#17
Jessica DeLong, Kurt McCammon, Leandro Capiel, Augustín Rovegno, Jeremy B Tonkin, Gerald Jordan, Ramón Virasoro
PURPOSE: To present our technique and outcomes for perineal urethrostomy augmented with a dorsal onlay buccal mucosa graft (BMG). Results from initial series and collaboration from an international center are included. METHODS: A retrospective chart review of all adult patients who underwent urethral reconstruction with perineal urethrostomy utilizing a buccal mucosal graft between January 1, 2002 and January 1, 2013 was performed. All surgeries were performed by three surgeons using the same technique (GHJ, KAM, and RV)...
January 20, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28108735/fertility-sparing-uterine-lesion-resection-for-young-women-with-gestational-trophoblastic-neoplasias-single-institution-experience
#18
Xiaoyu Wang, Junjun Yang, Jie Li, Jun Zhao, Tong Ren, Fengzhi Feng, Xirun Wan, Yang Xiang
PURPOSE: To evaluate the oncological safety and pregnant outcomes of fertility-sparing uterine lesion resection in treating gestational trophoblastic neoplasias. RESULTS: After the treatment of surgery and chemotherapy, all the patients achieved complete remission. With a median follow-up time of 44 months (range, 6-188), 3 patients (3.85%) relapsed within 3-26 months. Multivariate analysis showed that tumor size was the independent risk factor of recurrence and the cutoff value was 4...
January 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28108729/comparative-omega-3-fatty-acid-enrichment-of-egg-yolks-from-first-cycle-laying-hens-fed-flaxseed-oil-or-ground-flaxseed
#19
I J Ehr, M E Persia, E A Bobeck
When laying hen diets are enriched with omega-3 polyunsaturated fatty acids to generate value-added eggs for human consumption markets, concentrations of alpha-linolenic (ALA), eicosapentaenoic (EPA), and docosahexaenoic acids (DHA) in the yolk can reach 250 mg/50 g whole egg. Flaxseed, a rich source of ALA, is commonly used for omega-3 enrichment; however, the impact of dietary flaxseed source (extracted oil vs. milled seed) on fatty acid transfer to egg yolk in laying hens is unknown. Therefore, transfer of ALA, EPA, and DHA into egg yolk from extracted flaxseed oil or milled flaxseed was evaluated in Hy-Line W-36 laying hens over an 8-week feeding period (25 to 33 wk old)...
January 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/28108686/use-of-mechanical-insufflation-exsufflation-devices-for-airway-clearance-in-subjects-with-neuromuscular-disease
#20
REVIEW
Catherine Auger, Vanessa Hernando, Hubert Galmiche
The aim of this systematic review is to examine the benefit/risk ratio of the use of mechanical insufflation-exsufflation (MI-E) devices for airway clearance in patients with neuromuscular diseases. A search was conducted for relevant studies in MEDLINE, the Cochrane Library, and the Health Technology Assessment Database using the main key words: cough, airway clearance, in-exsufflation. The search limits were studies published in English and French between 1970 and 2014 (literature watch until December 2015)...
February 2017: Respiratory Care
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