Emma G Guare, Cory M Hale, Jeffrey Sivik, Erik Lehman, Yoshika Inoue, Kevin Rakszawski, Natthapol Songdej, Myles Nickolich, Hong Zheng, Seema Naik, David Claxton, Witold Rybka, Raymond Hohl, Shin Mineishi, Kentaro Minagawa, Catharine I Paules
BACKGROUND: Bacterial prophylaxis with a fluoroquinolone (FQ) during autologous stem cell transplant (ASCT) is common, although not standardized among transplant centers. The addition of doxycycline (doxy) to FQ prophylaxis was previously linked to reduced neutropenic fever and bacteremia in multiple myeloma (MM) patients undergoing ASCT although several confounders were present. We compared the incidence of neutropenic fever and bacteremia between MM patients variably receiving prophylaxis with FQ alone and FQ-doxy during ASCT...
January 25, 2024: Transplant Infectious Disease: An Official Journal of the Transplantation Society