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closed-system transfer device

Pablo Martín Lancharro, Nuria De Castro-Acuña Iglesias, Francisco-Javier González-Barcala, José Domingo Moure González
OBJECTIVE: Provide updated evidence and learn about the actions that must be implemented in order to prevent the occupational exposure to cytostatic drugs. METHOD: A bibliographic search was carried out on the MEDLINE, COCHRANE PLUS and WEB OF SCIENCE databases, with the terms "surface contamination", "cytostatic drug", "drug preparation", "occupational exposure", "safe handling" and "closed-system transfer device", within the 2010-2015 period. RESULTS: Thirteen articles were selected for review...
November 1, 2016: Farmacia Hospitalaria
Eva González-Haba Peña, Silvia Manrique Rodríguez, Ana Mª Herranz Alonso, Patricia Pérez Castán, Mónica Moreno Gálvez, Irene Iglesias Peinado, María Sanjurjo Saez
OBJECTIVES: The level of environmental contamination generated during preparation and administration of hazardous drugs using different valve closed-systems and their combinations was compared. The actual impact on the overall time of preparation of cytostatics and the economic cost of the different modalities were also compared. METHODS: Comparative study of the preparation of fluorescein mixtures with different modalities of valve closed-system combinations. Environmental contamination was detected in critical points of connection, and in splashes produced at any other points...
November 1, 2016: Farmacia Hospitalaria
Wei Xu, Kaiyu Fu, Chaoxiong Ma, Paul W Bohn
Bipolar electrodes (BPE) are electrically floating metallic elements placed in electrified fluids that enable the coupling of anodic and cathodic redox reactions at the opposite ends by electron transfer through the electrode. One particularly compelling application allows electron transfer reactions at one end of a closed BPE to be read out optically by inducing a redox-initiated change in the optical response function of a reporter system at the other end. Here, a BPE-enabled method for electrochemical sensing based on the electrochromic response of a methyl viologen (MV) reporter is developed, characterized, and rendered in a field-deployable format...
October 17, 2016: Analyst
C M Chan, A E Frimberger, A S Moore
Many chemotherapy drugs used in human patients are discarded after single use or within 24 h of reconstitution, as per the manufacturer's product label recommendations. This can be wasteful and costly to veterinary clients. This report reviews the published stability and storage data for 19 injectable chemotherapy drugs commonly used in veterinary medicine. Based on these data, storage procedures are presented, assuming aseptic technique and a closed system drug transfer device (CSDTD) are used for drug preparation and handling...
October 2, 2016: Veterinary and Comparative Oncology
Franco Mangussi, Damián H Zanette
In oscillating mechanical systems, nonlinearity is responsible for the departure from proportionality between the forces that sustain their motion and the resulting vibration amplitude. Such effect may have both beneficial and harmful effects in a broad class of technological applications, ranging from microelectromechanical devices to edifice structures. The dependence of the oscillation frequency on the amplitude, in particular, jeopardizes the use of nonlinear oscillators in the design of time-keeping electronic components...
2016: PloS One
Cunlan Guo, Xi Yu, Sivan Refaely-Abramson, Lior Sepunaru, Tatyana Bendikov, Israel Pecht, Leeor Kronik, Ayelet Vilan, Mordechai Sheves, David Cahen
Charge migration for electron transfer via the polypeptide matrix of proteins is a key process in biological energy conversion and signaling systems. It is sensitive to the sequence of amino acids composing the protein and, therefore, offers a tool for chemical control of charge transport across biomaterial-based devices. We designed a series of linear oligoalanine peptides with a single tryptophan substitution that acts as a "dopant," introducing an energy level closer to the electrodes' Fermi level than that of the alanine homopeptide...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
Hiroki Kurosawa, Hiroki Utsunomiya, Naomi Shiga, Aiko Takahashi, Motomasa Ihara, Masumi Ishibashi, Mitsuo Nishimoto, Zen Watanabe, Hiroyuki Abe, Jin Kumagai, Yukihiro Terada, Hideki Igarashi, Toshifumi Takahashi, Atsushi Fukui, Ryota Suganuma, Masahito Tachibana, Nobuo Yaegashi
STUDY QUESTION: Does a new system-the chip-sensing embryo respiration monitoring system (CERMs)-enable evaluation of embryo viability for potential application in a clinical IVF setting? SUMMARY ANSWER: The system enabled the oxygen consumption rate of spheroids, bovine embryos and frozen-thawed human embryos to be measured, and this rate corresponded to the developmental potential of embryos. WHAT IS ALREADY KNOWN: To date, no reliable and clinically suitable objective evaluation methods for embryos are available, which circumvent the differences in inter-observer subjective view...
October 2016: Human Reproduction
Deng-Tai Wen, Lan Zheng, Liu Ni, Hui Wang, Yue Feng, Min Zhang
The CG9940 gene, which encodes the NAD(+) synthase protein in Drosophila, is conserved in human, zebra fish, and mosquito. NAD(+) synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). Both the CG9940 and exercise are closely relative to NAD(+) level, and NAD(+) plays important roles not only in energy metabolism and mitochondrial functions but also in aging...
October 2016: Experimental Gerontology
M B Wheeler, M Rubessa
The in vitro production (IVP) of mammalian embryos is central to several areas of biotechnology. Further, the use of in vitro embryo manipulation is expanding as new applications emerge. ART finds direct applications in increasing the genetic quality of livestock, producing transgenic animals, cloning, artificial insemination, reducing disease transmission, preserving endangered germplasm, producing chimeric animals for disease research and treating infertility. Whereas new techniques such as nuclear transfer and ICSI are now commonly used, basic embryo culture procedures remain the limiting step to the development of these techniques...
July 14, 2016: Molecular Human Reproduction
Enrique P Blair, Steven A Corcelli, Craig S Lent
Molecular quantum-dot cellular automata is a computing paradigm in which digital information is encoded by the charge configuration of a mixed-valence molecule. General-purpose computing can be achieved by arranging these compounds on a substrate and exploiting intermolecular Coulombic coupling. The operation of such a device relies on nonequilibrium electron transfer (ET), whereby the time-varying electric field of one molecule induces an ET event in a neighboring molecule. The magnitude of the electric fields can be quite large because of close spatial proximity, and the induced ET rate is a measure of the nonequilibrium response of the molecule...
July 7, 2016: Journal of Chemical Physics
Nicolas Simon, Michèle Vasseur, Marine Pinturaud, Marion Soichot, Camille Richeval, Luc Humbert, Michèle Lebecque, Ousseini Sidikou, Christine Barthelemy, Pascal Bonnabry, Delphine Allorge, Bertrand Décaudin, Pascal Odou
BACKGROUND: The objective of this randomized, prospective and controlled study was to investigate the ability of a closed-system transfer device (CSTD; BD-Phaseal) to reduce the occupational exposure of two isolators to 10 cytotoxic drugs and compare to standard compounding devices. METHODS AND FINDINGS: The 6-month study started with the opening of a new compounding unit. Two isolators were set up with 2 workstations each, one to compound with standard devices (needles and spikes) and the other using the Phaseal system...
2016: PloS One
Tao Tang, Jing Tian, Daijun Zhong, Chengyu Fu
A rate feed forward control-based sensor fusion is proposed to improve the closed-loop performance for a charge couple device (CCD) tracking loop. The target trajectory is recovered by combining line of sight (LOS) errors from the CCD and the angular rate from a fiber-optic gyroscope (FOG). A Kalman filter based on the Singer acceleration model utilizes the reconstructive target trajectory to estimate the target velocity. Different from classical feed forward control, additive feedback loops are inevitably added to the original control loops due to the fact some closed-loop information is used...
2016: Sensors
Philippe Garrigue, Marc Montana, Christophe Ventre, Amandine Savry, Laurence Gauthier-Villano, Pascale Pisano, Bertrand Pourroy
Closed-system transfer devices enhance the drug handlers' protection against hazardous drugs exposure by prohibiting the escape of liquid or vapor from the system. PhaSeal (Becton Dickinson), a reference closed-system transfer device, includes a vial protector with an expansion chamber, and an injector with an enclosed needle. VialShield (CareFusion) is another more recent closed-system transfer device including an expansion-chamber and a non-return valve, designed to be used in association with Texium (CareFusion), a closed, needle-free male luer with its preassembled syringe...
March 2016: International Journal of Pharmaceutical Compounding
Cassidy Blundell, Emily R Tess, Ariana S R Schanzer, Christos Coutifaris, Emily J Su, Samuel Parry, Dongeun Huh
During human pregnancy, the fetal circulation is separated from maternal blood in the placenta by two cell layers - the fetal capillary endothelium and placental trophoblast. This placental barrier plays an essential role in fetal development and health by tightly regulating the exchange of endogenous and exogenous materials between the mother and the fetus. Here we present a microengineered device that provides a novel platform to mimic the structural and functional complexity of this specialized tissue in vitro...
August 2, 2016: Lab on a Chip
Hongwei Fu, Shengyuan Yan, Yichao Wang, Dongmei Gu, Xue Li, Guifang Yang, Yunde Liu
BACKGROUND: In China, one laboratory usually owns more than one diagnostic device or reagent kit measuring the same analyte and this situation causes great troubles for quality control and traceability. To determine if the different devices yield equivalent results, the correlation coefficients and predicted bias between three distinct bio-chemistry analyzers in our lab were evaluated. METHODS: 40 analytes were detected and used to evaluate method performance and comparability of results between different analyzers...
2016: Clinical Laboratory
Elizabeth Meade
There is a lack of research and consensus on the long-term risks of occupational exposure to monoclonal antibodies. There is, however, some risk to health professionals who are involved in their preparation and administration. This article discusses the use of closed-system drug transfer devices to minimise exposure, and touches on the importance of aseptic techniques, personal protective equipment, and appropriate education and training for health professionals.
September 2015: British Journal of Nursing: BJN
N De Munck, F Belva, H Van de Velde, G Verheyen, D Stoop
STUDY QUESTION: Does closed oocyte vitrification in an oocyte donation programme have an impact on obstetric and neonatal outcome? SUMMARY ANSWER: Obstetric and neonatal outcomes after closed system vitrification of donor oocytes appear to be reassuring. WHAT IS KNOWN ALREADY: The use of fresh oocytes has not been proved to be superior to the use of vitrified donor oocytes in terms of survival, embryo development and clinical pregnancies. Those studies used open devices to prove the non-superiority...
May 2016: Human Reproduction
Ramon Fuentes, Pablo Navarro, Aldo Curiqueo, Nicolas E Ottone
The electromagnetic articulograph (EMA) is a device that can collect movement data by positioning sensors at multiple points, measuring displacements of the structure in real time, as well as the acoustics and mechanics of speech using a microphone connected to the measurement system. The aim of this study is to describe protocols for the generation, measurement and visualization of mandibular border and functional movements in the three spatial planes (frontal, sagittal and horizontal) using the EMA. The EMA has transmitter coils that determine magnetic fields to collect information about movements from sensors located on different structures (tongue, palate, mouth, incisors, skin, etc...
2015: International Journal of Clinical and Experimental Medicine
Sandra Gómez-Álvarez, Begoña Porta-Oltra, Marta Hernandez-Griso, Francisca Pérez-Labaña, Mónica Climente-Martí
OBJECTIVE: to assess the impact of two closed-system drug transfer device on the local and environmental contamination and preparation times in the process of preparation of parenteral chemotherapy compared to the standard system. METHOD: prospective observational study. Two different closed- systems providers, Care Fusion® and Icu Medical®, were compared to standard preparation. 15 nurses of Pharmacy Department prepared 5 preparations each one, one with the standard procedure and four using closed-systems...
January 2016: Farmacia Hospitalaria
David I de Pomerai, Nooria Iqbal, Ivan Lafayette, Archana Nagarajan, Mehri Kaviani Moghadam, April Fineberg, Tom Reader, Steve Greedy, Chris Smartt, David W P Thomas
Potential health effects of radiofrequency (RF) radiation from mobile phones arouse widespread public concern. RF fields from handheld devices near the brain might trigger or aggravate brain tumors or neurodegenerative diseases such as Parkinson's disease (PD). Aggregation of neural α-synuclein (S) is central to PD pathophysiology, and invertebrate models expressing human S have helped elucidate factors affecting the aggregation process. We have recently developed a transgenic strain of Caenorhabditis elegans carrying two S constructs: SC tagged with cyan (C) blue fluorescent protein (CFP), and SV with the Venus (V) variant of yellow fluorescent protein (YFP)...
February 2016: Bioelectromagnetics
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