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closed-system transfer device

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https://www.readbyqxmd.com/read/29446222/engineering-controls-in-veterinary-oncology-a-survey-of-148-acvim-board-certified-oncologists-and-environmental-surveillance-in-20-specialty-hospitals
#1
K Alexander, N Northrup, D Clarke, H Lindell, T Laver
Engineering controls (EC, facility and equipment barriers between hazards and people) are used to avoid exposure to chemotherapy drugs. In this study, American College of Veterinary Internal Medicine board-certified veterinary oncologists were surveyed about their use of containment primary EC (C-PEC) and supplemental EC (closed system transfer devices, CSTD). The survey was completed by 148 (38%) of practicing diplomates. All used EC. Both C-PEC and CSTD were used at 92% of hospitals; however, US Pharmacopoeial Convention Chapter <800> (USP <800>) standards were met at only 19% of hospitals and oncologists did not know the type of C-PEC at 18% of hospitals...
February 15, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29412837/glucose-lowering-therapies-in-type-2-diabetes-opportunities-and-challenges-for-peptides
#2
REVIEW
Clifford J Bailey
This overview considers the opportunities and challenges that face the use of gluco-regulatory peptides to treat type 2 diabetes. New insulin analogues and formulations are being developed with pharmacokinetic properties to speed-up or prolong transfer from a subcutaneous injection site to the target tissues, or to selectively favour effects on the liver. Alternative routes of insulin administration continue to attract attention, and advances in the integration of glucose monitoring with insulin pump devices are improving miniaturised 'closed loop' artificial pancreas systems...
February 2018: Peptides
https://www.readbyqxmd.com/read/29375015/how-can-the-use-of-closed-system-transfer-devices-to-facilitate-sharing-of-drug-vials-be-optimised-to-achieve-maximum-cost-savings
#3
Peter J Gilbar, Carole R Chambers, Johan Vandenbrouche, Paul Jm Sessink, Timothy G Tyler
No abstract text is available yet for this article.
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29342114/gan-based-laser-wireless-power-transfer-system
#4
Carlo De Santi, Matteo Meneghini, Alessandro Caria, Ezgi Dogmus, Malek Zegaoui, Farid Medjdoub, Boris Kalinic, Tiziana Cesca, Gaudenzio Meneghesso, Enrico Zanoni
The aim of this work is to present a potential application of gallium nitride-based optoelectronic devices. By using a laser diode and a photodetector, we designed and demonstrated a free-space compact and lightweight wireless power transfer system, whose efficiency is limited by the efficiency of the receiver. We analyzed the effect of the electrical load, temperature, partial absorption and optical excitation distribution on the efficiency, by identifying heating and band-filling as the most impactful processes...
January 17, 2018: Materials
https://www.readbyqxmd.com/read/29339374/multicenter-evaluation-of-a-new-closed-system-drug-transfer-device-in-reducing-surface-contamination-by-antineoplastic-hazardous-drugs
#5
Sylvia B Bartel, Timothy G Tyler, Luci A Power
PURPOSE: Results of a study to evaluate the effectiveness of a recently introduced closed system drug-transfer device (CSTD) in reducing surface contamination during compounding and simulated administration of antineoplastic hazardous drugs (AHDs) are reported. METHODS: Wipe samples were collected from 6 predetermined surfaces in compounding and infusion areas of 13 U.S. cancer centers to establish preexisting levels of surface contamination by 2 marker AHDs (cyclophosphamide and fluorouracil)...
January 16, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29295996/development-of-a-genetically-encodable-fret-system-using-fluorescent-rna-aptamers
#6
Mette D E Jepsen, Steffen M Sparvath, Thorbjørn B Nielsen, Ane H Langvad, Guido Grossi, Kurt V Gothelf, Ebbe S Andersen
Fluorescent RNA aptamers are useful as markers for tracking RNA molecules inside cells and for creating biosensor devices. Förster resonance energy transfer (FRET) based on fluorescent proteins has been used to detect conformational changes, however, such FRET devices have not yet been produced using fluorescent RNA aptamers. Here we develop an RNA aptamer-based FRET (apta-FRET) system using single-stranded RNA origami scaffolds. To obtain FRET, the fluorescent aptamers Spinach and Mango are placed in close proximity on the RNA scaffolds and a new fluorophore is synthesized to increase spectral overlap...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29276288/hazardous-drug-contamination-of-drug-preparation-devices-and-staff-a-contamination-study-simulating-the-use-of-chemotherapy-drugs-in-a-clinical-setting
#7
Evan Call, Brian Bill, Chad McLean, Nathan Call, Allyn Bernkopf, Craig Oberg
Background: Hazardous drug contamination (HD) in healthcare environments continues, placing healthcare staff at risk of significantly chronic health problems, despite the use of personal protective equipment (PPE) and closed system transfer device systems (CSTDs). Objective: This study's aim was to determine how HD might spread through touch after handling contaminated vials in simulated pharmacy and nursing environments. Methods: UV fluorescent powder Glo Germ (Glo Germ Co., Moab, UT), composed of melamine resin, was used to simulate HD...
September 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/29136298/tuning-the-f%C3%A3-rster-resonance-energy-transfer-through-self-assembly-approach-for-efficient-white-light-emission-in-aqueous-medium
#8
Pragyan Pallavi, Bahadur Sk, Palak Ahir, Abhijit Patra
A simple and cost-effective methodology employing environmentally benign substances for the fabrication of white-light emitting materials is important for practical applications in the field of lighting and display devices. Designing of purely organic-based white-light emitting system with high quantum efficiency in the aqueous medium is an unmet challenge. With this objective, a new class of pyridoindole based hydrophobic fluorophore 6,7,8,9-tetrapropylpyrido[1,2-a]indole-10-carbaldehye (TPIC) was introduced...
November 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29073136/a-bacterial-toxin-antitoxin-module-is-the-origin-of-inter-bacterial-and-inter-kingdom-effectors-of-bartonella
#9
Alexander Harms, Marius Liesch, Jonas Körner, Maxime Québatte, Philipp Engel, Christoph Dehio
Host-targeting type IV secretion systems (T4SS) evolved from conjugative T4SS machineries that mediate interbacterial plasmid transfer. However, the origins of effectors secreted by these virulence devices have remained largely elusive. Previous work showed that some effectors exhibit homology to toxins of bacterial toxin-antitoxin modules, but the evolutionary trajectories underlying these ties had not been resolved. We previously reported that FicT toxins of FicTA toxin-antitoxin modules disrupt cellular DNA topology via their enzymatic FIC (filamentation induced by cAMP) domain...
October 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29061556/impact-of-an-electronic-monitoring-intervention-to-improve-adherence-to-inhaled-medication-in-patients-with-asthma-and-chronic-obstructive-pulmonary-disease-study-protocol-for-a-randomized-controlled-trial
#10
Claudia Gregoriano, Thomas Dieterle, Selina Dürr, Isabelle Arnet, Kurt E Hersberger, Jörg D Leuppi
BACKGROUND: Despite progress in pharmacological and non-pharmacological treatment in recent years, the burden of disease among patients with asthma and chronic obstructive pulmonary disease (COPD) is high and patients are frequently hospitalized due to exacerbations. Reasons for uncontrolled diseases are manifold, but are often associated with poor inhalation technique and non-adherence to the prescribed treatment plan. This causes substantial mortality, morbidity, and costs to the healthcare system...
October 23, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29041769/high-mechanical-bandwidth-fiber-coupled-fabry-perot-cavity
#11
Erika Janitz, Maximilian Ruf, Yannik Fontana, Jack Sankey, Lilian Childress
Fiber-based optical microcavities exhibit high quality factor and low mode volume resonances that make them attractive for coupling light to individual atoms or other microscopic systems. Moreover, their low mass should lead to excellent mechanical response up to high frequencies, opening the possibility for high bandwidth stabilization of the cavity length. Here, we demonstrate a locking bandwidth of 44 kHz achieved using a simple, compact design that exploits these properties. Owing to the simplicity of fiber feedthroughs and lack of free-space alignment, this design is inherently compatible with vacuum and cryogenic environments...
August 21, 2017: Optics Express
https://www.readbyqxmd.com/read/28981323/a-strategy-for-formulating-regulation-on-cstds
#12
Allison Field, Gemma Hughes, Sarah Rowland
This article identifies what steps need to be taken to ensure the mandatory use of closed system transfer devices by all health professionals involved in the hazardous drug journey.
September 6, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28981322/the-need-for-national-mandatory-guidance-on-cstds
#13
Elizabeth Meade, Alison Simons, Samantha Toland
Closed system transfer devices play a vital role in reducing health professionals' risk of exposure to hazardous drugs. Although recommended as a first line of defence against contamination, they are not widely used. Clear mandatory national guidance is needed to address this.
September 6, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28874560/ultrafast-fluorescent-decay-induced-by-metal-mediated-dipole-dipole-interaction-in-two-dimensional-molecular-aggregates
#14
Qing Hu, Dafei Jin, Jun Xiao, Sang Hoon Nam, Xiaoze Liu, Yongmin Liu, Xiang Zhang, Nicholas X Fang
Two-dimensional molecular aggregate (2DMA), a thin sheet of strongly interacting dipole molecules self-assembled at close distance on an ordered lattice, is a fascinating fluorescent material. It is distinctively different from the conventional (single or colloidal) dye molecules and quantum dots. In this paper, we verify that when a 2DMA is placed at a nanometric distance from a metallic substrate, the strong and coherent interaction between the dipoles inside the 2DMA dominates its fluorescent decay at a picosecond timescale...
September 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28855476/validation-of-simultaneous-analytical-method-of-veterinary-drugs-in-foods-using-new-automatic-pretreatment-equipment
#15
Yoichi Yatsukawa, Daisuke Kusuno, Takahiro Matsuda, Kazuhiro Kobayashi, Tetsuro Ohba
New automatic pretreatment equipment (FASVED; Food Automatic Analytical Systems for Veterinary Drugs) was developed. FASVED consists of ten main units: reagent dispenser, homogenizer, transfer hand, lid opening/closing device, centrifugal separator, pipette, shaker, column purification device, centrifugal evaporator and cooling device, and it is capable of freely combining operations by these units. A validation study was performed on two methods for determination of 178 veterinary drugs in livestock products, swine muscle, egg and shrimp, according to the method validation guideline of the Ministry of Health, Labour and Welfare of Japan...
2017: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/28841099/survey-of-guidelines-and-current-practices-for-safe-handling-of-antineoplastic-and-other-hazardous-drugs-used-in-24-countries
#16
Patricia I Mathias, Barbara A MacKenzie, Christine A Toennis, Thomas H Connor
Purpose A survey of guidelines and current practices was conducted to examine the safe handling procedures for antineoplastic and other hazardous drugs that are used in 24 countries including the Americas, Europe, the Mideast, Far East, and Australia. Methods Subject experts were asked to complete a brief survey regarding safe handling guidelines and practices for hazardous drugs in their countries. Questions addressed practices for handling monoclonal antibodies, the use of closed-system transfer devices, medical surveillance practices, and measurements of compliance with existing guidelines...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28839127/multi-orbital-charge-transfer-at-highly-oriented-organic-metal-interfaces
#17
Giovanni Zamborlini, Daniel Lüftner, Zhijing Feng, Bernd Kollmann, Peter Puschnig, Carlo Dri, Mirko Panighel, Giovanni Di Santo, Andrea Goldoni, Giovanni Comelli, Matteo Jugovac, Vitaliy Feyer, Claus Michael Schneidery
The molecule-substrate interaction plays a key role in charge injection organic-based devices. Charge transfer at molecule-metal interfaces strongly affects the overall physical and magnetic properties of the system, and ultimately the device performance. Here, we report theoretical and experimental evidence of a pronounced charge transfer involving nickel tetraphenyl porphyrin molecules adsorbed on Cu(100). The exceptional charge transfer leads to filling of the higher unoccupied orbitals up to LUMO+3. As a consequence of this strong interaction with the substrate, the porphyrin's macrocycle sits very close to the surface, forcing the phenyl ligands to bend upwards...
August 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28750540/electrochromic-sensor-for-multiplex-detection-of-metabolites-enabled-by-closed-bipolar-electrode-coupling
#18
Wei Xu, Kaiyu Fu, Paul W Bohn
Biosensors based on converting electrochemical signals into optical readouts are attractive candidates as low-cost, high-throughput sensor platforms. Here, we described a closed bipolar electrode (CBE)-based two-cell electrochromic device for sensing multiple metabolites, using the simultaneous detection of lactate, glucose, and uric acid as a model system. In the two-cell configuration, an analytical cell contains a redox mediator combined with a specific oxidase, e.g., lactate oxidase, glucose oxidase, or uricase, to form an electrochemical mediator-electrocatalyst pair that supports redox cycling...
July 28, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28745439/a-double-stimuli-responsive-fluorescent-center-for-monitoring-of-food-spoilage-based-on-dye-covalently-modified-eumofs-from-sensory-hydrogels-to-logic-devices
#19
Xiao-Yu Xu, Xiao Lian, Ji-Na Hao, Chi Zhang, Bing Yan
Unsafe food is a huge threat to human health and the economy, and detecting food spoilage early is an ongoing and imperative need. Herein, a simple and effective strategy combining a fluorescence sensor and one-to-two logic operation is designed for monitoring biogenic amines, indicators of food spoilage. Sensors (methyl red@lanthanide metal-organic frameworks (MR@EuMOFs)) are created by covalently modifying MR into NH2 -rich EuMOFs, which have a high quantum yield (48%). A double-stimuli-responsive fluorescence center is produced via energy transfer from the ligands to Eu(3+) and MR...
July 26, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28714119/high-performance-polymers-sandwiched-with-chemical-vapor-deposited-hexagonal-boron-nitrides-as-scalable-high-temperature-dielectric-materials
#20
Amin Azizi, Matthew R Gadinski, Qi Li, Mohammed Abu AlSaud, Jianjun Wang, Yi Wang, Bo Wang, Feihua Liu, Long-Qing Chen, Nasim Alem, Qing Wang
Polymer dielectrics are the preferred materials of choice for power electronics and pulsed power applications. However, their relatively low operating temperatures significantly limit their uses in harsh-environment energy storage devices, e.g., automobile and aerospace power systems. Herein, hexagonal boron nitride (h-BN) films are prepared from chemical vapor deposition (CVD) and readily transferred onto polyetherimide (PEI) films. Greatly improved performance in terms of discharged energy density and charge-discharge efficiency is achieved in the PEI sandwiched with CVD-grown h-BN films at elevated temperatures when compared to neat PEI films and other high-temperature polymer and nanocomposite dielectrics...
July 17, 2017: Advanced Materials
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