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Neogenin

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https://www.readbyqxmd.com/read/27913301/neogenin-regulates-mitochondrial-activity-in-pre-implantation-mouse-embryos
#1
Kyong Hee Choi, Sun Haw Hong, Hye Ran Lee, Hoon Taek Lee, Jae Ho Lee, Sang Jin Lee
No abstract text is available yet for this article.
November 29, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27890825/the-expression-of-chemorepulsive-guidance-receptors-and-the-regenerative-abilities-of-spinal-projecting-neurons-after-spinal-cord-injury
#2
Jie Chen, Cindy Laramore, Michael I Shifman
Spinal cord injury (SCI) in mammals leads to permanent loss of function because axons do not regenerate in the central nervous system (CNS). To date, treatments based on neutralizing inhibitory environmental cues, such as the myelin-associated growth inhibitors and chondroitin sulfate proteoglycans, or on adding neurotrophic factors, have had limited success in enhancing regeneration. Published studies suggested that multiple axon guidance cues (repulsive guidance molecule (RGM) family, semaphorins, ephrins, and netrins) persist in adult animals, and that their expression is upregulated after CNS injury...
November 24, 2016: Neuroscience
https://www.readbyqxmd.com/read/27716118/selective-depletion-of-tumour-suppressors-deleted-in-colorectal-cancer-dcc-and-neogenin-by-environmental-and-endogenous-serine-proteases-linking-diet-and-cancer
#3
Caroline M Forrest, Kara McNair, Maria C J Vincenten, L Gail Darlington, Trevor W Stone
BACKGROUND: The related tumour suppressor proteins Deleted in Colorectal Cancer (DCC) and neogenin are absent or weakly expressed in many cancers, whereas their insertion into cells suppresses oncogenic behaviour. Serine proteases influence the initiation and progression of cancers although the mechanisms are unknown. METHODS: The effects of environmental (bacterial subtilisin) and endogenous mammalian (chymotrypsin) serine proteases were examined on protein expression in fresh, normal tissue and human neuroblastoma and mammary adenocarcinoma lines...
October 6, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27575743/repulsive-guidance-molecule-b-inhibits-renal-cyst-development-through-the-bone-morphogenetic-protein-signaling-pathway
#4
Jiangfeng Liu, Weiling Wang, Ming Liu, Limin Su, Hong Zhou, Yin Xia, Jianhua Ran, Herbert Y Lin, Baoxue Yang
Autosomal dominant polycystic kidney disease (ADPKD) is a monogenetic disease that still lacks effective therapy. Repulsive guidance molecule b (RGMb), a co-receptor for bone morphogenetic proteins (BMPs) and a ligand for neogenin, is expressed in renal tubular epithelial cells. Previous studies showed that RGMb plays negative roles in several types of tumors and prevents the immune system from over activation. The present study was designed to explore the effects of RGMb in ADPKD development. We found that expression of RGMb in kidney was less in PKD mice than wild-type mice...
December 2016: Cellular Signalling
https://www.readbyqxmd.com/read/27430720/netrin-1-augments-chemokinesis-in-cd4-t-cells-in-vitro-and-elicits-a-proinflammatory-response-in-vivo
#5
Leo Boneschansker, Hironao Nakayama, Michele Eisenga, Johannes Wedel, Michael Klagsbrun, Daniel Irimia, David M Briscoe
Netrin-1 is a neuronal guidance cue that regulates cellular activation, migration, and cytoskeleton rearrangement in multiple cell types. It is a chemotropic protein that is expressed within tissues and elicits both attractive and repulsive migratory responses. Netrin-1 has recently been found to modulate the immune response via the inhibition of neutrophil and macrophage migration. However, the ability of Netrin-1 to interact with lymphocytes and its in-depth effects on leukocyte migration are poorly understood...
August 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27341639/loss-and-gain-of-function-approach-to-investigate-early-cell-fate-determinants-in-preimplantation-mouse-embryos
#6
Jae H Lee, Yong Ii Cho, Sung S Choi, Hae-Won Kim, Churl K Min, Sang J Lee
Gene silencing and overexpression techniques are instrumental for the identification of genes involved in embryonic development. Direct target gene modification in preimplantation embryos provides a means to study the underlying mechanisms of genes implicated in, for instance, cellular differentiation into the trophectoderm (TE) and the inner cell mass (ICM). Here, we describe a protocol that examines the role of neogenin as an authentic receptor for initial cell fate determination in preimplantation mouse embryos...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27225772/neogenin-promotes-bmp2-activation-of-yap-and-smad1-and-enhances-astrocytic-differentiation-in-developing-mouse-neocortex
#7
Zhihui Huang, Dong Sun, Jin-Xia Hu, Fu-Lei Tang, Dae-Hoon Lee, Ying Wang, Guoqing Hu, Xiao-Juan Zhu, Jiliang Zhou, Lin Mei, Wen-Cheng Xiong
UNLABELLED: Neogenin, a DCC (deleted in colorectal cancer) family receptor, is highly expressed in neural stem cells (NSCs). However, its function in NSCs remains to be explored. Here we provide in vitro and in vivo evidence for neogenin's function in NSCs to promote neocortical astrogliogenesis, but not self-renewal or neural differentiation. Mechanistically, neogenin in neocortical NSCs was required for BMP2 activation of YAP (yes associated protein). The active/nuclear YAP stabilized phospho-Smad1/5/8 and was necessary for BMP2 induction of astrocytic differentiation...
May 25, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27143755/rgmb-and-neogenin-control-cell-differentiation-in-the-developing-olfactory-epithelium
#8
Joseph Wai Keung Kam, Emilie Dumontier, Christopher Baim, Alexandra C Brignall, David Mendes da Silva, Mitra Cowan, Timothy E Kennedy, Jean-François Cloutier
Cellular interactions are key for the differentiation of distinct cell types within developing epithelia, yet the molecular mechanisms engaged in these interactions remain poorly understood. In the developing olfactory epithelium (OE), neural stem/progenitor cells give rise to odorant-detecting olfactory receptor neurons (ORNs) and glial-like sustentacular (SUS) cells. Here, we show in mice that the transmembrane receptor neogenin (NEO1) and its membrane-bound ligand RGMB control the balance of neurons and glial cells produced in the OE...
May 1, 2016: Development
https://www.readbyqxmd.com/read/27072365/neogenin-facilitates-the-induction-of-hepcidin-expression-by-hemojuvelin-in-the-liver
#9
Ningning Zhao, Julia E Maxson, Richard H Zhang, Mastura Wahedi, Caroline A Enns, An-Sheng Zhang
Hemojuvelin (HJV) regulates iron homeostasis by direct interaction with bone morphogenetic protein (BMP) ligands to induce hepcidin expression through the BMP signaling pathway in the liver. Crystallography studies indicate that HJV can simultaneously bind to both BMP2 and the ubiquitously expressed cell surface receptor neogenin. However, the role of the neogenin-HJV interaction in the function of HJV is unknown. Here we identify a mutation in HJV that specifically lowers its interaction with neogenin. Expression of this mutant Hjv in the liver of Hjv(-/-) mice dramatically attenuated its induction of BMP signaling and hepcidin mRNA, suggesting that interaction with neogenin is critical for the iron regulatory function of HJV...
June 3, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27029596/neogenin-recruitment-of-the-wave-regulatory-complex-maintains-adherens-junction-stability-and-tension
#10
Natalie K Lee, Ka Wai Fok, Amanda White, Nicole H Wilson, Conor J O'Leary, Hayley L Cox, Magdalene Michael, Alpha S Yap, Helen M Cooper
To maintain tissue integrity during epithelial morphogenesis, adherens junctions (AJs) must resist the mechanical stresses exerted by dynamic tissue movements. Junctional stability is dependent on actomyosin contractility within the actin ring. Here we describe a novel function for the axon guidance receptor, Neogenin, as a key component of the actin nucleation machinery governing junctional stability. Loss of Neogenin perturbs AJs and attenuates junctional tension. Neogenin promotes actin nucleation at AJs by recruiting the Wave regulatory complex (WRC) and Arp2/3...
2016: Nature Communications
https://www.readbyqxmd.com/read/26839325/quantification-of-hepcidin-related-iron-accumulation-in-the-rat-liver
#11
Preethne Böser, Yulia Mordashova, Mark Maasland, Isabel Trommer, Helga Lorenz, Mathias Hafner, Dietmar Seemann, Bernhard K Mueller, Andreas Popp
Hepcidin was originally detected as a liver peptide with antimicrobial activity and it functions as a central regulator in the systemic iron metabolism. Consequently suppression of hepcidin leads to iron accumulation in the liver. AbbVie developed a monoclonal antibody ([mAb]; repulsive guidance molecule [RGMa/c] mAb) that downregulates hepcidin expression by influencing the RGMc/bone morphogenetic protein (BMP)/neogenin receptor complex and causes iron deposition in the liver. In a dose range finding study with RGMa/c mAb, rats were treated with different dose levels for a total of 4 weekly doses...
February 2016: Toxicologic Pathology
https://www.readbyqxmd.com/read/26721439/repulsive-guidance-molecule-a-suppresses-angiogenesis
#12
Kana Harada, Yuki Fujita, Toshihide Yamashita
The repulsive guidance molecule-a (RGMa) is a membrane-associated glycoprotein that has diverse functions in the developing and adult central nervous system. Here, we show that RGMa suppresses new blood vessel formation. Treatment of human umbilical artery endothelial cells (HUAEC) on Matrigel with recombinant RGMa inhibits vascular endothelial growth factor (VEGF)-induced and VEGF-independent tubular formation and migration. RGMa enhances adhesion presumably through dephosphorylation of focal adhesion kinase (FAK) at tyrosine-397...
January 22, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26659141/draxin-from-neocortical-neurons-controls-the-guidance-of-thalamocortical-projections-into-the-neocortex
#13
Yohei Shinmyo, M Asrafuzzaman Riyadh, Giasuddin Ahmed, Iftekhar Bin Naser, Mahmud Hossain, Hirohide Takebayashi, Hiroshi Kawasaki, Kunimasa Ohta, Hideaki Tanaka
The thalamocortical tract carries sensory information to the neocortex. It has long been recognized that the neocortical pioneer axons of subplate neurons are essential for thalamocortical development. Herein we report that an axon guidance cue, draxin, is expressed in early-born neocortical neurons, including subplate neurons, and is necessary for thalamocortical development. In draxin(-/-) mice, thalamocortical axons do not enter the neocortex. This phenotype is sufficiently rescued by the transgenic expression of draxin in neocortical neurons...
2015: Nature Communications
https://www.readbyqxmd.com/read/26651291/lrig2-negatively-regulates-ectodomain-shedding-of-axon-guidance-receptors-by-adam-proteases
#14
Susan van Erp, Dianne M A van den Heuvel, Yuki Fujita, Ross A Robinson, Anita J C G M Hellemons, Youri Adolfs, Eljo Y Van Battum, Anna M Blokhuis, Marijn Kuijpers, Jeroen A A Demmers, Håkan Hedman, Casper C Hoogenraad, Christian Siebold, Toshihide Yamashita, R Jeroen Pasterkamp
Many guidance receptors are proteolytically cleaved by membrane-associated metalloproteases of the ADAM family, leading to the shedding of their ectodomains. Ectodomain shedding is crucial for receptor signaling and function, but how this process is controlled in neurons remains poorly understood. Here, we show that the transmembrane protein Lrig2 negatively regulates ADAM-mediated guidance receptor proteolysis in neurons. Lrig2 binds Neogenin, a receptor for repulsive guidance molecules (RGMs), and prevents premature Neogenin shedding by ADAM17 (TACE)...
December 7, 2015: Developmental Cell
https://www.readbyqxmd.com/read/26518331/unmasking-a-novel-disease-gene-neo1-associated-with-autism-spectrum-disorders-by-a-hemizygous-deletion-on-chromosome-15-and-a-functional-polymorphism
#15
Wai-Kwan Siu, Ching-Wan Lam, Wei-Wei Gao, Hei-Man Vincent Tang, Dong-Yan Jin, Chloe Miu Mak
BACKGROUND: Autism spectrum disorders (ASD) are neurodevelopmental disorders with a high degree of heritability, but the genetic basis is exceedingly heterogeneous. Microdeletions of chromosome 15q24 have been demonstrated to be recurrent genomic alterations in ASD patients. Of interest, neuronal migration genes are of particular relevance to the pathogenesis of ASD. NEO1 is located in 15q24 and encodes for neogenin, a membrane receptor involved in cortical interneuron migration and axon guidance...
March 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/26395479/phenotypic-analysis-of-mice-completely-lacking-netrin-1
#16
Andrea R Yung, Allison M Nishitani, Lisa V Goodrich
Netrin 1 (Ntn1) is a multifunctional guidance cue expressed in the ventricular zone and floor plate of the embryonic neural tube. Although Ntn1 is best known for acting as an axon guidance cue through Dcc and neogenin receptors, it is also thought to regulate neuronal survival and blood vessel development through Unc5 family receptors. However, the Ntn1 gene trap mutant mouse does not display all the phenotypes predicted from in vitro assays or analyses of mice lacking predicted receptors. Since the gene trap strain still produces wild-type Ntn1 protein, it is unclear whether the absence of phenotypes reflects the activity of alternative cues or of residual Ntn1...
November 1, 2015: Development
https://www.readbyqxmd.com/read/26390805/inhibition-of-human-placental-endothelial-cell-proliferation-and-angiogenesis-by-netrin-4
#17
M Dakouane-Giudicelli, S Brouillet, W Traboulsi, A Torre, G Vallat, S Si Nacer, M Vallée, J J Feige, N Alfaidy, P de Mazancourt
INTRODUCTION: Netrin-4 is a secreted member of the laminin-related protein family, known to be involved in axonal guidance and endothelial cell survival, proliferation, and migration. We have recently reported the cellular localization of netrin-4 and its receptor neogenin in human first trimester and term placenta. A strong expression of netrin-4 was observed in trophoblast and in endothelial cells, suggesting a potential role of this protein in placental angiogenesis. In relation to human pregnancy, it has been reported that circulating netrin-4 were increased in fetal umbilical cord blood of intrauterine growth restriction IUGR compared to normal pregnancy suggesting an adverse effect of this protein on placental and fetal development...
November 2015: Placenta
https://www.readbyqxmd.com/read/26292756/%C3%AF-secretase-and-larg-mediate-distinct-rgma-activities-to-control-appropriate-layer-targeting-within-the-optic-tectum
#18
P Banerjee, H Harada, N G Tassew, J Charish, D Goldschneider, V A Wallace, S Sugita, P Mehlen, P P Monnier
While a great deal of progress has been made in understanding the molecular mechanisms that regulate retino-tectal mapping, the determinants that target retinal projections to specific layers of the optic tectum remain elusive. Here we show that two independent RGMa-peptides, C- and N-RGMa, activate two distinct intracellular pathways to regulate axonal growth. C-RGMa utilizes a Leukemia-associated RhoGEF (LARG)/Rho/Rock pathway to inhibit axonal growth. N-RGMa on the other hand relies on ϒ-secretase cleavage of the intracellular portion of Neogenin to generate an intracellular domain (NeICD) that uses LIM-only protein 4 (LMO4) to block growth...
March 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/26257176/complete-loss-of-netrin-1-results-in-embryonic-lethality-and-severe-axon-guidance-defects-without-increased-neural-cell-death
#19
Jenea M Bin, Dong Han, Karen Lai Wing Sun, Louis-Philippe Croteau, Emilie Dumontier, Jean-Francois Cloutier, Artur Kania, Timothy E Kennedy
Netrin-1 regulates cell migration and adhesion during the development of the nervous system, vasculature, lung, pancreas, muscle, and mammary gland. It is also proposed to function as a dependence ligand that inhibits apoptosis; however, studies disagree regarding whether netrin-1 loss-of-function mice exhibit increased cell death. Furthermore, previously studied netrin-1 loss-of-function gene-trap mice express a netrin-1-β-galactosidase protein chimera with potential for toxic gain-of-function effects, as well as a small amount of wild-type netrin-1 protein...
August 18, 2015: Cell Reports
https://www.readbyqxmd.com/read/26116534/netrin-1-induces-the-migration-of-schwann-cells-via-p38-mapk-and-pi3k-akt-signaling-pathway-mediated-by-the-unc5b-receptor
#20
Jianwei Lv, Xiaolei Sun, Jianxiong Ma, Xinlong Ma, Yang Zhang, Fengbo Li, Yanjun Li, Zhihu Zhao
Schwann cells (SCs) play an essentially supportive role in the regeneration of injured peripheral nerve system (PNS). As Netrin-1 is crucial for the normal development of nervous system (NS) and can direct the process of damaged PNS regeneration, our study was designed to determine the role of Netrin-1 in RSC96 Schwann cells (an immortalized rat Schwann cell line) proliferation and migration. Our studies demonstrated that Netrin-1 had no effect on RSC96 cells proliferation, while significantly promoted RSC96 cells migration...
August 14, 2015: Biochemical and Biophysical Research Communications
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