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Silvere Vialet-Chabrand, Adrian Hills, Yizhou Wang, Howard Griffiths, Virgilio L Lew, Tracy Lawson, Michael R Blatt, Simon Rogers
The physical requirement for charge to balance across biological membranes means that the transmembrane transport of each ionic species is interrelated, and manipulating solute flux through any one transporter will affect other transporters at the same membrane, often with unforeseen consequences. The OnGuard systems modeling platform has helped to resolve the mechanics of stomatal movements, uncovering previously unexpected behaviors of stomata. To date, however, the manual approach to exploring model parameter space has captured little formal information about the emergent connections between parameters that define the most interesting properties of the system as a whole...
June 2017: Plant Physiology
Nikolaos Dellios, Ulf Teichgraeber, Robert Chelaru, Ansgar Malich, Ismini E Papageorgiou
AIM: The most ubiquitous chest diagnostic method is the chest radiograph. A common radiographic finding, quite often incidental, is the nodular pulmonary lesion. The detection of small lesions out of complex parenchymal structure is a daily clinical challenge. In this study, we investigate the efficacy of the computer-aided detection (CAD) software package SoftView™ 2.4A for bone suppression and OnGuard™ 5.2 (Riverain Technologies, Miamisburg, OH, USA) for automated detection of pulmonary nodules in chest radiographs...
2017: Journal of Clinical Imaging Science
Calen Frolkis, Dr Robert Gilkeson
Lung Cancer Posters IISESSION TYPE: Original Investigation PosterPRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PMPURPOSE: This restrospective study sought to evaluate a next generation CAD algorithm in the detetion of previously overlooked lung cancer on chest radiographs.METHODS: IRB approval was granted for this retrospective study. Patient consent was waived given the retrospective data collected. Review of 606 patients presented at our Institutional Thoracic Tumor Board was performed. Clinical reports from cross-sectional imaging, pathology, and prior chest Xrays were analyzed...
October 1, 2014: Chest
Anna Błażewicz, Maria Klatka, Wojciech Dolliver, Ryszard Kocjan
A fast, accurate and precise ion chromatography method with pulsed amperometric detection was applied to evaluate a variety of parameters affecting the determination of total iodine in serum and urine of 81 subjects, including 56 obese and 25 healthy Polish children. The sample pretreatment methods were carried out in a closed system and with the assistance of microwaves. Both alkaline and acidic digestion procedures were developed and optimized to find the simplest combination of reagents and the appropriate parameters for digestion that would allow for the fastest, least time consuming and most cost-effective way of analysis...
July 1, 2014: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Yizhou Wang, Adrian Hills, Michael R Blatt
Stomatal transpiration is at the center of a crisis in water availability and crop production that is expected to unfold over the next 20 to 30 years. Global water usage has increased 6-fold in the past 100 years, twice as fast as the human population, and is expected to double again before 2030, driven mainly by irrigation and agriculture. Guard cell membrane transport is integral to controlling stomatal aperture and offers important targets for genetic manipulation to improve crop performance. However, its complexity presents a formidable barrier to exploring such possibilities...
April 2014: Plant Physiology
Yong Wang, Qing Geng, Yuexian Zuo, Xinwen Zhou, Hongzhen Lian, Guangwen Pan
A method for the determination of hydrazine ion in explosion dust of liquid explosive has been established by ion chromatography. The hydrazine ion in an explosion dust sample was extracted with deionized water by sonification and centrifugation. The large molecules and solid particles in supernatant were removed by an OnGuard II RP column and a 0.22 microm filtration membrane, respectively. The filtrate was separated on an IonPac CS-12A column with isocratic elution of 5 mmol/L methanesulfonic acid (MSA). Then 0...
September 2013: Se Pu, Chinese Journal of Chromatography
Michael R Blatt, Yizhou Wang, Nathalie Leonhardt, Adrian Hills
It is widely recognized that the nature and characteristics of transport across eukaryotic membranes are so complex as to defy intuitive understanding. In these circumstances, quantitative mathematical modeling is an essential tool, both to integrate detailed knowledge of individual transporters and to extract the properties emergent from their interactions. As the first, fully integrated and quantitative modeling environment for the study of ion transport dynamics in a plant cell, OnGuard offers a unique tool for exploring homeostatic properties emerging from the interactions of ion transport, both at the plasma membrane and tonoplast in the guard cell...
May 15, 2014: Journal of Plant Physiology
Lorena De Ausen, Erik F DeFreitas, Latisha Littleton, Michael Lustik
PURPOSE: A study of leakage from selected closed-system transfer devices (CSTDs) under experimental conditions is described. METHODS: Three CSTDs (the ChemoClave, OnGuard, and PhaSeal systems) were tested. Nine manufacturer-trained oncology pharmacists and pharmacy technicians volunteered to participate in an experiment to determine the degree of leakage of a liquid test agent (a radioactive technetium isotope [(99m)Tc] diluted in normal saline) during CSTD-assisted transfer of liquid from vials to syringes per standard practices...
April 1, 2013: American Journal of Health-system Pharmacy: AJHP
Ronald D Novak, Nicholas J Novak, Robert Gilkeson, Bahar Mansoori, Gunhild E Aandal
This study aimed to compare the diagnostic effectiveness of computer-aided detection (CAD) software (OnGuard™ 5.2) in combination with hardware-based bone suppression (dual-energy subtraction radiography (DESR)), software-based bone suppression (SoftView™, version 2.4), and standard posteroanterior images with no bone suppression. A retrospective pilot study compared the diagnostic performance of two commercially available methods of bone suppression when used with commercially available CAD software. Chest images from 27 patients with computed tomography (CT) and pathology-proven malignant pulmonary nodules (8-34 mm) and 25 CT-negative patient controls were used for analysis...
August 2013: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
Michael R Blatt, Adrian Hills, Zhong-Hua Chen, Yizhou Wang, Maria Papanatsiou, Vigilio L Lew
Much of the 70% of global water usage associated with agriculture passes through stomatal pores of plant leaves. The guard cells, which regulate these pores, thus have a profound influence on photosynthetic carbon assimilation and water use efficiency of plants. We recently demonstrated how quantitative mathematical modeling of guard cells with the OnGuard modeling software yields detail sufficient to guide phenotypic and mutational analysis. This advance represents an all-important step toward applications in directing "reverse-engineering" of guard cell function for improved water use efficiency and carbon assimilation...
January 2013: Plant Signaling & Behavior
Seth Kligerman, Ling Cai, Charles S White
PURPOSE: The purpose of the study was to determine whether computer-aided detection (CAD) can improve a radiologist's ability to detect lung cancers previously missed on a chest radiograph (CXR). MATERIALS AND METHODS: Eighty-one cases of lung cancer previously missed on CXR were collected, along with the CXRs of 215 age-matched and emphysema-matched controls without lung cancer. Tumor subtlety was scored from 1 (very subtle) to 5 (very obvious) by expert thoracic radiologists...
July 2013: Journal of Thoracic Imaging
Katja T Rinne, Matthias Saurer, Kathrin Streit, Rolf T W Siegwolf
RATIONALE: Isotope analysis of carbohydrates is important for improved understanding of plant carbon metabolism and plant physiological response to the environment. High-performance liquid chromatography/isotope ratio mass spectrometry (HPLC/IRMS) for direct compound-specific δ(13)C measurements of soluble carbohydrates has recently been developed, but the still challenging sample preparation and the fact that no single method is capable of separating all compounds of interest hinder its wide-spread application...
September 30, 2012: Rapid Communications in Mass Spectrometry: RCM
Yong Wang, Bo Wu, Houbin Lian, Chaoou Shi
A method for the determination of glyphosate in human blood by ion chromatography was established. The protein in heart blood from a corpse was precipitated with acetonitrile. The large molecules and Cl(-) in the supernatant were removed by a Dionex OnGuard II RP column and a Dionex OnGuard II Ag column, respectively. The filtrate was separated on an IonPac AS-19 column with KOH solution as eluent produced online by an eluent generator (EG). A suppressor with external water mode and a conductivity detector for the detection were used...
April 2012: Se Pu, Chinese Journal of Chromatography
Tingting Zhang, Mingli Ye, Zhongyang Hu, Guangwen Pan, Lina Liang, Shuchao Wu
A new method for the determination of five cations (sodium, ammonium, potassium, magnesium and calcium) in wines and beverages was developed and validated based on capillary ion chromatography. With a capillary ion exchange column (IonPac CS12A, 250 mm x 0.4 mm, 8 microm) and 18 mmol/L methanesulfonic acid (MSA) elution, the five cations can be well separated in 15 min. After suppression with a capillary suppressor (CCES 300), the background was much decreased, and the sensitivities of the cations were greatly improved...
April 2012: Se Pu, Chinese Journal of Chromatography
Adrian Hills, Zhong-Hua Chen, Anna Amtmann, Michael R Blatt, Virgilio L Lew
Stomatal guard cells play a key role in gas exchange for photosynthesis while minimizing transpirational water loss from plants by opening and closing the stomatal pore. Foliar gas exchange has long been incorporated into mathematical models, several of which are robust enough to recapitulate transpirational characteristics at the whole-plant and community levels. Few models of stomata have been developed from the bottom up, however, and none are sufficiently generalized to be widely applicable in predicting stomatal behavior at a cellular level...
July 2012: Plant Physiology
Zhong-Hua Chen, Adrian Hills, Ulrike Bätz, Anna Amtmann, Virgilio L Lew, Michael R Blatt
The dynamics of stomatal movements and their consequences for photosynthesis and transpirational water loss have long been incorporated into mathematical models, but none have been developed from the bottom up that are widely applicable in predicting stomatal behavior at a cellular level. We previously established a systems dynamic model incorporating explicitly the wealth of biophysical and kinetic knowledge available for guard cell transport, signaling, and homeostasis. Here we describe the behavior of the model in response to experimentally documented changes in primary pump activities and malate (Mal) synthesis imposed over a diurnal cycle...
July 2012: Plant Physiology
Ayushi D, Arijit Sengupta, Sangita D Kumar, A G Kumbhar, G Venkateswaran
A simple, rapid and accurate method for the determination of monoethanolamine (MEA) in PHWR steam-water circuits has been developed. MEA is added in the feed water to provide protection against corrosion while hydrazine is added to scavenge dissolved oxygen. The quantitative determination of MEA in presence of hydrazine was accomplished using derivatization ion chromatography with conductometric detection in nonsuppressed mode. A Metrosep cation 1-2 analytical column and a Metrosep cartridge were used for cation separation...
2011: International Journal of Analytical Chemistry
Moulay Meziane, Nancy A Obuchowski, Omar Lababede, Michael L Lieber, Michael Philips, Peter Mazzone
OBJECTIVE: The primary objective of our study was to compare the effect of a chest radiography computer-aided detection (CAD) system on the follow-up recommendations of chest radiologists, general radiologists, and pulmonologists. MATERIALS AND METHODS: A chest radiography CAD system (RapidScreen 1.1) that has been approved by the U.S. Food and Drug Administration (FDA) and a second-generation version of the system (OnGuard 3.0) not yet approved by the FDA were applied to single frontal radiographs of 200 patients at high risk for lung cancer...
May 2011: AJR. American Journal of Roentgenology
Moulay Meziane, Peter Mazzone, Eric Novak, Michael L Lieber, Omar Lababede, Michael Phillips, Nancy A Obuchowski
PURPOSE: There are few computer-aided detection (CAD) systems that are available for the detection of nodules on chest radiographs. We evaluated the performance of a Food and Drug Administration-approved system and 3 of its subsequent versions to determine their potential to improve readers' accuracy. MATERIALS AND METHODS: We tested the performance of 4 generations of CAD software programs, RapidScreen 1.1 and OnGuard 3.0, 4.0, and 5.0 (Riverain Medical), for their ability to detect lung cancer on a sample of 100 patients with and 100 patients without nodules...
January 2012: Journal of Thoracic Imaging
Jing Li, Yu Wang, Lina Liang
The contents of iodide and thiocyanate are important detection items in powdered milk quality testing. Due to the complexity of the powdered milk matrix, chromatographic analysis is easily subjected to interference. Acclaim Mixed-Mode WAX-1 column incorporated both hydrophobic and weak anion-exchange properties was used to separate iodide and thiocyanate from interfering substances in powdered milk matrix, and detected by Ultraviolet (UV) detection. After powdered milk was dissolved in water, the protein was precipitated by acetonitrile...
April 2010: Se Pu, Chinese Journal of Chromatography
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