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https://www.readbyqxmd.com/read/28734785/impact-of-magnetic-stirring-on-stainless-steel-integrity-effect-on-biopharmaceutical-processing
#1
Christopher Thompson, Kelly Wilson, Yoen Joo Kim, Min Xie, William K Wang, Michaela Wendeler
Stainless steel containers are widely used in the pharmaceutical and biopharmaceutical industry for the storage of buffers, process intermediates, and purified drug substance. They are generally held to be corrosion resistant, biocompatible, and non-reactive, although it is well established that trace amounts of metal ions can leach from stainless steel equipment into biopharmaceutical products. We report here that the use of stainless steel containers in conjunction with magnetic stirring bars leads to significantly aggravated metal contamination, consisting both of metal particles and significantly elevated metal ions in solution, the degree of which is several orders of magnitude higher than described for static conditions...
July 19, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28734263/study-of-the-influencing-factors-of-the-blood-levels-of-toxic-elements-in-africans-from-16-countries
#2
Luis Alberto Henríquez-Hernández, Octavio P Luzardo, Luis D Boada, Cristina Carranza, José Luis Pérez Arellano, Ana González-Antuña, Maira Almeida-González, Carlos Barry-Rodríguez, Manuel Zumbado, María Camacho
Africa's economy is growing faster than any other continent and it has been estimated that the middle class in Africa now exceeds 350 million people. This has meant a parallel increase in the importation of consumer goods and in the implementation of communication and information technologies (ICT), but also in the generation of large quantities of e-waste. However, inadequate infrastructure development remains a major constraint to the continent's economic growth and these highly toxic residues are not always adequately managed...
July 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28726753/antimicrobial-properties-of-selected-copper-alloys-on-staphylococcus-aureus-and-escherichia-coli-in-different-simulations-of-environmental-conditions-with-vs-without-organic-contamination
#3
Anna Różańska, Agnieszka Chmielarczyk, Dorota Romaniszyn, Agnieszka Sroka-Oleksiak, Małgorzata Bulanda, Monika Walkowicz, Piotr Osuch, Tadeusz Knych
Background: Hospital equipment made from copper alloys can play an important role in complementing traditional methods of disinfection. Aims of the study: The aim of this study was to assess the dynamics of the antimicrobial properties of selected copper alloys in different simulations of environmental conditions (with organic contamination vs. without organic contamination), and to test alternatives to the currently used testing methods. Materials and Methods: A modification of Japanese standard JIS Z 2801 as well as Staphylococcus aureus (SA) and Escherichia coli (EC) suspended in NaCl vs...
July 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28724453/decrease-in-vancomycin-resistant-enterococcus-colonization-after-extensive-renovation-of-a-unit-dedicated-to-the-treatment-of-hematologic-malignancies-and-hematopoietic-stem-cell-transplantation
#4
Clyde D Ford, Michaela A Gazdik Stofer, Jana Coombs, Bert K Lopansri, Brandon J Webb, Gabriela Motyckova, Finn Bo Petersen
OBJECTIVE While a direct relation between hospital construction and concomitant infection rates has been clearly established, few data are available regarding the environmental decontamination effects of renovation in which surfaces are replaced and regarding subsequent infection incidence. DESIGN Retrospective clinical study with vancomycin-resistant Enterococcus (VRE) molecular strain typing and environmental cultures. SETTING A regional referral center for acute leukemia and hematopoietic stem-cell transplantation...
July 20, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28722484/consumer-perceptions-of-the-safety-of-ready-to-eat-foods-in-retail-food-store-settings
#5
Katrina Levine, Mary Yavelak, John B Luchansky, Anna C S Porto-Fett, Benjamin Chapman
To better understand how consumers perceive food safety risks in retail food store settings, a survey was administered to 1,041 nationally representative participants who evaluated possible food safety risks depicted in selected photographs and self-reported their perceptions, attitudes, and behaviors. Participants were shown 12 photographs taken at retail stores portraying either commonly perceived or actual food safety contributing factors, such as cross-contamination, product and equipment temperatures, worker hygiene, and/or store sanitation practices...
July 19, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28718270/salmonella-infection-amongst-food-workers-in-lahore
#6
Sajjad Ullah, Saira Bashir, Akif Qasim
This descriptive observational study was conducted at Pathology lab Jinnah hospital, Lahore, January 2013 to October 2015. We include all the food workers in different restaurants, slaughters, inn, recreation centre and bakeries of Lahore for the purpose to identify the salmonella infection, we used Typhoid IgGI/IgM Rapid test device methods (Serum/Plasma), is a lateral flow chromatographic immunoassay technique were calculated. We analysed 1025 individuals, 62 (6%) were found positive for the said diseases out of which 14 (1...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28699005/study-of-chlordecone-desorption-from-activated-carbons-and-subsequent-dechlorination-by-reduced-cobalamin
#7
Ronald Ranguin, Axelle Durimel, Reeka Karioua, Sarra Gaspard
Since 1972, the French departments of Guadeloupe and Martinique have intensively used organochlorinated pesticides such as chlordecone (CLD) and hexachlorocyclohexane (HCH) isomers to prevent the proliferation of banana weevil (Cosmopolite sordidus). These molecules are stable in the environment, leading to a continuous contamination of soils, water, and food chain in the banana-producing areas. In these polluted areas, water treatment plants are equipped with activated carbon (AC) filters. In order to improve treatment of CLD-contaminated waters by AC, CLD adsorption and desorption kinetic studies are carried out using different ACs produced from sugar cane bagasse as adsorbents and subsequent CLD degradation is performed using reduced vitamin B12 (VB12)...
July 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28698763/wolf-s-panniculitis
#8
Anastasiya Atanasova Chokoeva, Georgi Tchernev
A 28-year-old male patient, presented with a one-week history of pain and itching on the skin of the left upper leg. Erythematous indurated, warm and painful on palpation, subcutaneous plaques and nodules were clinically observed, affecting the skin of the left upper leg, within a recent black-wolf tattoo. The diagnosis of traumatic panniculitis with superposed bacterial infection, provoked by a wolf tattoo was made. The patient underwent 7-days systemic antibiotic treatment regimen and topical application of iodine povidone unguent under occlusion for 7 days...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28695189/risk-of-fungal-infection-to-dental-patients
#9
Jaqueline Lopes Damasceno, Rafael Aparecido Dos Santos, Amir Horiquini Barbosa, Luciana Assirati Casemiro, Regina Helena Pires, Carlos Henrique Gomes Martins
Fungi can cause various diseases, and some pathogenic fungi have been detected in the water of dental equipment. This environment offers suitable conditions for fungal biofilms to emerge, which can facilitate mycological contamination. This study verified whether the water employed in the dental units of two dental clinics at the University of Franca was contaminated with fungi. This study also evaluated the ability of the detected fungi to form biofilms. The high-revving engine contained the largest average amount of fungi, 14...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28688340/pesticide-tailwater-deeply-treated-by-tubular-porous-electrode-reactor-tper-purpose-for-discharging-and-cost-saving
#10
Yonghao Zhang, Kajia Wei, Anlin Xu, Weiqing Han, Xiuyun Sun, Jiansheng Li, Jinyou Shen, Lianjun Wang
Pesticide tailwater often contains residual and toxic contaminants of triazole fungicides (TFs) due to their poor biodegradability which will do great harm to local aquatic systems. For this case, a novel electrochemical reactor (TPER) equipped a tubular porous RuO2-Sb2O5-SnO2 electrode was assembled and then employed to deeply treat pesticide tailwater. Characterizations of the electrode studied by SEM, EDS and XRD analysis indicated that it owns a porous structure and a compact and crack-free surface. Influence of the porous structure on electrochemical property was examined by cyclic voltammetry and normal pulse voltammetry...
June 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/28685328/generation-of-domestic-waste-electrical-and-electronic-equipment-on-fernando-de-noronha-island-qualitative-and-quantitative-aspects
#11
Dhiego Raphael Rodrigues Araujo, José Diego de Oliveira, Vanice Fragoso Selva, Maisa Mendonça Silva, Simone Machado Santos
The accelerated growth trajectory of waste electrical and electronic equipment (WEEE) is a matter of concern for governments worldwide. In developing countries, the problem is more complex because municipal waste management is still a challenge for municipalities. Fernando de Noronha Island, an environmentally protected area, has a transfer station for solid waste before it is sent to the final destination abroad, which is different waste management model to most urban areas. In order to check the specifics of management of WEEE, this study aimed to qualitatively and quantitatively evaluate the generation of this type of waste on the main island of Fernando de Noronha, taking into consideration aspects related to consumption habits and handling of waste...
July 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28668741/cost-benefit-analysis-of-copper-recovery-in-remediation-projects-a-case-study-from-sweden
#12
Yevheniya Volchko, Jenny Norrman, Lars Rosén, Karin Karlfeldt Fedje
Contamination resulting from past industrial activity is a problem throughout the world and many sites are severely contaminated by metals. Advances in research in recent years have resulted in the development of technologies for recovering metal from metal-rich materials within the framework of remediation projects. Using cost-benefit analysis (CBA), and explicitly taking uncertainties into account, this paper evaluates the potential social profitability of copper recovery as part of four remediation alternatives at a Swedish site...
June 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28666130/tracking-of-listeria-monocytogenes-in-meat-establishment-using-whole-genome-sequencing-as-a-food-safety-management-tool-a-proof-of-concept
#13
Ivan Nastasijevic, Dubravka Milanov, Branko Velebit, Vesna Djordjevic, Craig Swift, Anais Painset, Brankica Lakicevic
Repeated Listeria outbreaks particularly associated with Ready-To-Eat (RTE) delicatessen meat products have been reported annually at global level. The most frequent scenario that led to foodborne outbreaks was the post-thermal treatment cross-contamination of deli meat products during slicing and modified atmosphere packaging (MAP). The precondition for such cross contamination is the previous introduction of Listeria into meat processing facilities and subsequent colonization of the production environment, associated with formation of biofilms resilient to common sanitation procedures regularly applied in meat establishments...
June 20, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28650715/transfer-of-bacteriophage-ms2-and-fluorescein-from-n95-filtering-facepiece-respirators-to-hands-measuring-fomite-potential
#14
Tyler M Brady, Amanda L Strauch, Claudia M Almaguer, George Niezgoda, Ronald E Shaffer, Patrick L Yorio, Edward M Fisher
Contact transmission of pathogens from personal protective equipment is a concern within the healthcare industry. During public health emergency outbreaks, resources become constrained and the reuse of personal protective equipment, such as N95 filtering facepiece respirators, may be needed. This study was designed to characterize the transfer of bacteriophage MS2 and fluorescein between filtering facepiece respirators and the wearer's hands during three simulated use scenarios. Filtering facepiece respirators were contaminated with MS2 and fluorescein in droplets or droplet nuclei...
June 26, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28650137/how-to-manage-the-biological-risk-in-a-dental-clinic-state-of-the-art-and-future-perspectives
#15
Matteo Saccucci, Gaetano Ierardo, Carmela Protano, Matteo Vitali, Antonella Polimeni
Dental Personnel (DP) may be exposed to pathogens during dental treatment, either through contact contaminated equipment, or with blood and respiratory secretion. On the other hand, health care professionals are constantly exposed to pathogens and opportunists in their work environment. Consequently, the dental healthcare environment is connected with the risk of exposure to biological agents both for patients and dental workers, and involves a wide number of microorganisms that can be present in biological matrices (gingival fluids, saliva, blood), contaminated and/or non-sanitized surfaces, water used in the dental unit, or emitted by patients suffering or carrier of a transmissible disease...
June 23, 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28649046/transgenerational-endocrine-disruption-and-neurotoxicity-in-zebrafish-larvae-after-parental-exposure-to-binary-mixtures-of-decabromodiphenyl-ether-bde-209-and-lead
#16
Lianguo Chen, Xianfeng Wang, Xiaohua Zhang, Paul K S Lam, Yongyong Guo, James C W Lam, Bingsheng Zhou
Polybrominated diphenyl ethers (PBDEs) and heavy metals are two key groups of electric and electronic equipment contaminants. Despite their co-occurrence in aquatic environments, their combined effects remain largely unknown, particularly under a chronic exposure regime. In the present study, adult zebrafish (Danio rerio) were exposed to environmentally relevant concentrations of BDE-209 and lead (Pb), or their binary mixtures, for 3 months. After chronic parental exposure, increased transfer of BDE-209 and Pb to the offspring eggs was activated in the coexposure groups, with BDE-197 being the predominant PBDE congener, indicating the dynamic metabolism of BDE-209 in parental zebrafish...
June 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28646246/identification-of-particles-in-raw-materials
#17
Kathryn Lee, Markus Lankers, Oliver Valet
Raw materials need to be of a certain quality with respect to physical and chemical composition. They also need to have no contaminants in the form of particles because these could get into the product or indicate the raw materials are not pure enough to make a good quality product. When particles are found, it is important to identify their chemical and elemental composition to correct any process errors that can cause them and to have acceptable quality of the final product. Sources of materials can be the environment, process equipment and processing, and packaging...
June 23, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28643881/virucides-in-apiculture-persistence-of-surrogate-enterovirus-under-simulated-field-conditions
#18
Jana Prodělalová, Hana Malenovská, Romana Moutelíková, Dalibor Titěra
BACKGROUND: Honeybee viruses were recognized among the most important factors leading to colony losses worldwide. Colony food and faeces were regarded as possible source of infectious viruses able to contaminate environment and equipment of apiaries. Thus, methods for elimination of viruses are required. No cell culture assay for testing the effect of disinfectants on honeybee viruses is available yet. Therefore, surrogate virus was employed for testing of iodophor- and peracetic acid-based disinfectants efficacy in combination with six organic contaminants at +6 °C and +22 °C...
June 23, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28643098/-importance-of-wound-irrigation-solutions-and-fluids-with-antiseptic-effects-in-therapy-and-prophylaxis-update-2017
#19
REVIEW
Christian Willy, Catharina Scheuermann-Poley, Marcus Stichling, Thomas von Stein, Axel Kramer
INTRODUCTION: Despite the use of modern antibiotics as well as complex perioperative, intraoperative and postoperative prophylactic measures, the rate of surgical site infections (SSI) could not be significantly reduced. The introduction of biocompatible antiseptic drugs with a high microbiocidal effect provided a successful alternative for infection prevention and therapy, particularly in a time of increasing occurrence of multi-drug resistant pathogens. Hence, questions about the risk-benefit ratio of antiseptic wound irrigation solutions, the prophylactic use of wound irrigation solutions for the reduction of SSI and the effect of negative pressure wound therapy combined with instillation (NPWTi) need to be answered...
July 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28641137/real-time-pcr-methods-for-the-detection-of-blown-pack-spoilage-causing-clostridium-species-c-estertheticum-c-gasigenes-and-c-ruminantium
#20
Rachael Reid, Catherine M Burgess, Evonne McCabe, Séamus Fanning, Paul Whyte, Joe Kerry, Declan Bolton
A set of real-time PCR methods for the detection of C. estertheticum, C. gasigenes and C. ruminantium, the causative agents of blown pack spoilage (BPS) in vacuum packaged beef, was developed. Robust validation of the sensitivity and specificity was carried out in the three matrices (beef meat drip, wet environmental swabs and dry environmental swabs) as encountered in our testing laboratory and against Clostridium strains (n=76) and non-Clostridium strains (n=36). It was possible to detect 4-5 spores per ml for C...
June 3, 2017: Meat Science
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