keyword
https://read.qxmd.com/read/36370411/identification-and-reduction-of-hazardous-drug-surface-contamination-through-the-use-of-a-novel-closed-system-transfer-device-coupled-with-a-point-of-care-hazardous-drug-detection-system
#1
JOURNAL ARTICLE
Erich Brechtelsbauer
PURPOSE: Minimizing hazardous drug (HD) contamination is critical for protecting the health of healthcare workers (HCWs) and patients. Alarmingly, widespread HD contamination has been documented across a variety of clinical settings. Quantitative wipe sampling presents significant time and cost barriers, resulting in routine monitoring adherence rates around 25%. Closed-system drug transfer devices (CSTDs) and qualitative point-of-care tests can be implemented to overcome these barriers...
March 21, 2023: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/35313703/evaluation-of-three-barrier-type-closed-system-transfer-devices-using-the-2015-niosh-vapor-containment-performance-draft-protocol
#2
JOURNAL ARTICLE
Andrew Szkiladz, Shawn Hegner
Background: Closed System Transfer Devices (CSTD) have been developed to reduce healthcare worker exposure to hazardous drugs during medication handling. To evaluate CSTD performance in preventing the escape of drug vapors, the National Institute for Occupational Safety and Health (NIOSH) developed a 2015 draft testing protocol incorporating two compounding tasks utilizing 70% isopropyl alcohol (IPA) as a medication surrogate. Purpose: The objective of this study was to evaluate the performance of three CSTDs (Chemolock [ICU Medical Inc...
2022: Drugs & Therapy Perspectives
https://read.qxmd.com/read/32854576/development-of-a-simple-compatibility-inspection-method-using-pressure-in-a-bd-phaseal%C3%A2-system-and-hazardous-drug-vials
#3
JOURNAL ARTICLE
Hiromasa Ishimaru, Yasumasa Tsuda, Hidenori Kage, Tomoaki Kawano, Shinji Takayama, Yoshihito Morimoto, Kazumi Goto, Kazuhiro Watanabe
BACKGROUND: Many reports support the use of closed system drug transfer devices (CSTDs) to protect against exposure to hazardous drugs during their preparation. However, leakage may occur if the CSTD fails to maintain hermeticity when fitted into the vial. Our aims were to devise a measure to prevent HD exposure and to develop a test method to verify CSTD function when a BD PhaSeal™ protector is used in HD preparation. METHODS: We selected the BD PhaSeal™ System, which is the most commonly used CSTD device in Japan...
September 2021: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/30296468/use-and-handling-safety-of-mini-spike-2-%C3%A2-chemo-and-puresite-for-safe-chemotherapy-compounding-in-a-hospital-pharmacy
#4
JOURNAL ARTICLE
Silvia Valero García, Nieves Vila Clérigues, Victoria Fornés Ferrer, Eduardo López Briz, Jose Luis Poveda Andrés
We wanted to evaluate the impact of Mini-Spike 2® Chemo + Puresite (MSCP) use on contamination surface levels, professionals' satisfaction and compounding time at pharmacy compared with Phaseal™. Presence of cyclophosphamide (CYP) and 5-fluorouracil (5FU) was evaluated at three sampling times: baseline; after a decontamination procedure and six months after MSCP use for CYP and 5FU compounding. Testing was carried out using an independent laboratory and wipe testing kit. To test compounding time, four different nurses followed the same compounding protocol with each device...
December 2018: Regulatory Toxicology and Pharmacology: RTP
https://read.qxmd.com/read/30089139/a-decontamination-process-adding-a-tensioactive-agent-and-isopropanol-to-a-closed-system-drug-transfer-device-for-better-control-of-isolator-contamination-a-prospective-parallel-study
#5
COMPARATIVE STUDY
Michèle Vasseur, Nicolas Simon, Chloé Picher, Camille Richeval, Marion Soichot, Luc Humbert, Christine Barthélémy, Sandrine Fleury-Souverain, Pascal Bonnabry, Bertrand Décaudin, Delphine Allorge, Pascal Odou
BACKGROUND: Despite the use of closed system drug transfer devices (CSTD), residual contamination from antineoplastic drugs is still detected inside isolators. The aim of this study was to compare the decontamination level obtained using a CSTD + standard cleaning procedure with a CSTD + standard cleaning procedure + specific decontamination procedure. METHODS AND FINDINGS: A comparative and prospective study was carried out in a newly opened compounding unit. Compounding was performed with a CSTD (BD-Phaseal, Becton-Dickinson)...
2018: PloS One
https://read.qxmd.com/read/30041583/application-of-the-2015-proposed-niosh-vapor-containment-performance-protocol-for-closed-system-transfer-devices-used-during-pharmacy-compounding-and-administration-of-hazardous-drugs
#6
JOURNAL ARTICLE
Charlotte M Forshay, Shawn O Streeter, Stephanie A Salch, Stephen F Eckel
PURPOSE: The National Institute for Occupational Safety and Health (NIOSH) released a proposed protocol in 2015 to evaluate the vapor containment abilities of closed system transfer device technologies in order to provide meaningful comparisons between products. This study assessed the vapor containment ability of closed system transfer devices when following the methodology as outlined by the 2015 NIOSH proposed protocol. METHODS: This study evaluated six closed system transfer device brands following the draft NIOSH vapor containment protocol...
July 2019: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/29958506/comparison-of-closed-system-transfer-devices-for-turnaround-time-and-ease-of-use
#7
COMPARATIVE STUDY
Zubeir A Nurgat, Myer Lawrence, Tusneem A Elhassan, Mohammad Al Nahedh, Mohamed Ashour, Dina Alaboura, Abdulrazaq S Al-Jazairi, Ahmed Al-Jedai
OBJECTIVE/PURPOSE: The primary purpose of this study was to compare three closed-system transfer devices with differing mechanical interfaces for their suitability for adoption into our daily practice. The secondary purpose was to use the results of this study to support the selection of one of the closed-system transfer devices, which would suit both the pharmacy and nursing staff at our institution, furthermore promoting the enculturation of international recommendations into our clinical practice...
July 2019: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/29582940/closed-system-drug-transfer-devices-plus-safe-handling-of-hazardous-drugs-versus-safe-handling-alone-for-reducing-exposure-to-infusional-hazardous-drugs-in-healthcare-staff
#8
REVIEW
Kurinchi Selvan Gurusamy, Lawrence Mj Best, Cynthia Tanguay, Elaine Lennan, Mika Korva, Jean-François Bussières
BACKGROUND: Occupational exposure to hazardous drugs can decrease fertility and result in miscarriages, stillbirths, and cancers in healthcare staff. Several recommended practices aim to reduce this exposure, including protective clothing, gloves, and biological safety cabinets ('safe handling'). There is significant uncertainty as to whether using closed-system drug-transfer devices (CSTD) in addition to safe handling decreases the contamination and risk of staff exposure to infusional hazardous drugs compared to safe handling alone...
March 27, 2018: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/29510165/pre-and-post-intervention-study-of-antiblastic-drugs-contamination-surface-levels-at-a-pharmacy-department-compounding-area-using-a-closed-system-drug-transfer-device-and-a-decontamination-process
#9
JOURNAL ARTICLE
Silvia Valero, Eduardo López-Briz, Nieves Vila, Antonio Solana, Mar Melero, Jose Luis Poveda
Assuring healthcare workers security on Hazardous Drugs (HD) compounding is critical in healthcare settings. Our study aims to demonstrate that the use of a Close System drug Transfer Device (CSTD) PhaSeal™ added to a decontamination process reduces antiblastic surface contamination levels in the Compounding Area (CA) of our Pharmacy Department (PD). We selected cyclophosphamide, 5-fluorouracil and iphosphamide to be evaluated. Testing was carried out with a wipe kit and quantified by an independent laboratory...
June 2018: Regulatory Toxicology and Pharmacology: RTP
https://read.qxmd.com/read/27391697/effectiveness-of-a-closed-system-transfer-device-in-reducing-surface-contamination-in-a-new-antineoplastic-drug-compounding-unit-a-prospective-controlled-parallel-study
#10
JOURNAL ARTICLE
Nicolas Simon, Michèle Vasseur, Marine Pinturaud, Marion Soichot, Camille Richeval, Luc Humbert, Michèle Lebecque, Ousseini Sidikou, Christine Barthelemy, Pascal Bonnabry, Delphine Allorge, Bertrand Décaudin, Pascal Odou
BACKGROUND: The objective of this randomized, prospective and controlled study was to investigate the ability of a closed-system transfer device (CSTD; BD-Phaseal) to reduce the occupational exposure of two isolators to 10 cytotoxic drugs and compare to standard compounding devices. METHODS AND FINDINGS: The 6-month study started with the opening of a new compounding unit. Two isolators were set up with 2 workstations each, one to compound with standard devices (needles and spikes) and the other using the Phaseal system...
2016: PloS One
https://read.qxmd.com/read/27323425/safe-cytotoxic-drug-preparation-using-closed-system-transfer-device-technical-and-practical-evaluation-of-a-new-device-vialshield-texium-comparatively-to-a-reference-one-phaseal
#11
COMPARATIVE STUDY
Philippe Garrigue, Marc Montana, Christophe Ventre, Amandine Savry, Laurence Gauthier-Villano, Pascale Pisano, Bertrand Pourroy
Closed-system transfer devices enhance the drug handlers' protection against hazardous drugs exposure by prohibiting the escape of liquid or vapor from the system. PhaSeal (Becton Dickinson), a reference closed-system transfer device, includes a vial protector with an expansion chamber, and an injector with an enclosed needle. VialShield (CareFusion) is another more recent closed-system transfer device including an expansion-chamber and a non-return valve, designed to be used in association with Texium (CareFusion), a closed, needle-free male luer with its preassembled syringe...
March 2016: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/25864458/treatment-time-ease-of-use-and-cost-associated-with-use-of-equashield%C3%A2-phaseal-%C3%A2-or-no-closed-system-transfer-device-for-administration-of-cancer-chemotherapy-to-a-dog-model
#12
COMPARATIVE STUDY
K Kicenuik, N Northrup, A Dawson, J Locke, J A Villamil, J Chretin, G Sfiligoi, C Clifford, M Rosenberg, T Hamilton, R Regan, M Parsons-Doherty, C Mallett, J Philibert, J Impellizeri, E Hofmeister
This prospective experimental simulation study evaluated the efficiency, ease of use (EOU) and cost of administering chemotherapy with two closed system transfer devices (CSTD, Equashield™ and PhaSeal® ) and no CSTD. Forty-six veterinary technicians (VT) working in oncology specialty practices were timed during chemotherapy administration simulated with water and a model canine limb 10 times with each system and with no CSTD. EOU and likelihood of recommending each system were rated by VT using visual analog scales...
March 2017: Veterinary and Comparative Oncology
https://read.qxmd.com/read/24917007/-verification-of-reduction-in-preparation-time-and-cost-of-cyclophosphamide-when-using-the-closed-system-drug-transfer-device
#13
JOURNAL ARTICLE
Yohei Ikeno, Daisuke Arii, Hirofumi Nakajima, Kunihiko Murooka, Michio Nojima, Akio Kidokoro
The closed-system transfer device (CSTD), which is used to prevent the exposure of medical staff to anticancer drugs, has been reported to allow safe preparation and administration of these drugs to patients. At many medical institutions, however, the use of such devices is limited to select anticancer drugs. This could be attributable to the longer preparation time compared to the conventional injection technique with a syringe and needle, as well as the fact that the anticancer drugs are too expensive to be covered by the remuneration available for medical services...
May 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/24598373/syringe-plunger-contamination-by-hazardous-drugs-a-comparative-study
#14
COMPARATIVE STUDY
Stephen T Smith, Mark C Szlaczky
AIM: The purpose of this study was to perform a comparative cyclophosphamide contamination level test with Becton Dickinson® syringe plungers with Phaseal® Closed System Transfer Devices and Equashield® syringe plungers under routine oncological compounding conditions. METHOD: The ChemoGlo™ sampling kit and analysis services were used to test for cyclophosphamide contamination levels on the syringe plungers of Becton Dickinson® Phaseal and Equashield® syringes that underwent cycles of drug transfer in a Forma Class II, 2A Biological Safety Cabinet...
October 2014: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/24421463/reduction-in-surface-contamination-with-cyclophosphamide-in-30-us-hospital-pharmacies-following-implementation-of-a-closed-system-drug-transfer-device
#15
JOURNAL ARTICLE
Paul J M Sessink, Jason Trahan, Joseph W Coyne
PURPOSE: In a follow-up to a previous study, surface contamination with the antineoplastic drug cyclophosphamide was compared in 30 US hospital pharmacies from 2004 to 2010 following preparation with standard drug preparation techniques or the PhaSeal closed system drug transfer device (CSTD). METHODS: Wipe samples were taken from biological safety cabinet (BSC) surfaces, BSC airfoils (the front leading edge of the BSC), floors in front of BSCs, and countertops in the pharmacy, and they were analyzed for contamination with cyclophosphamide...
March 2013: Hospital Pharmacy
https://read.qxmd.com/read/23975556/cost-savings-realized-by-use-of-the-phaseal-%C3%A2-closed-system-transfer-device-for-preparation-of-antineoplastic-agents
#16
JOURNAL ARTICLE
Michael S Edwards, Dominic A Solimando, Franklin R Grollman, Janet L Pang, Ashley H Chasick, Charlene M Hightman, Anthony D Johnson, Maxine G Mickens, Lorenzo M Preston
PURPOSE: Medication cost is a major factor associated with increasing health care costs in the United States. Expenditures for prescription drugs in 2013 are estimated to be $283.7 billion. Closed system transfer devices are widely used for preparation of hazardous drugs. Reports indicate the Phaseal(®) closed system transfer device maintains sterility in vials for 7 days, suggesting the unused portion of single-use vials could be salvaged. This study was done to determine whether using a closed system transfer device to extend the beyond-use date of single-use vials of antineoplastic medications would result in a measurable cost saving...
December 2013: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/23853750/impact-of-closed-system-drug-transfer-device-on-exposure-of-environment-and-healthcare-provider-to-cyclophosphamide-in-japanese-hospital
#17
JOURNAL ARTICLE
Tomohiro Miyake, Takuya Iwamoto, Manabu Tanimura, Masahiro Okuda
In spite of current recommended safe handling procedures, the potential for the exposure of healthcare providers to hazardous drugs exists in the workplace. A reliance on biological safety cabinets to provide total protection against the exposure to hazardous drugs is insufficient. Preventing workplace contamination is the best strategy to minimize cytotoxic drug exposure in healthcare providers. This study was conducted to compare surface contamination and personnel exposure to cyclophosphamide before and after the implementation of a closed-system drug transfer device, PhaSeal, under the influence of cleaning according to the Japanese guidelines...
December 2013: SpringerPlus
https://read.qxmd.com/read/23515515/leakage-from-closed-system-transfer-devices-as-detected-by-a-radioactive-tracer
#18
JOURNAL ARTICLE
Lorena De Ausen, Erik F DeFreitas, Latisha Littleton, Michael Lustik
PURPOSE: A study of leakage from selected closed-system transfer devices (CSTDs) under experimental conditions is described. METHODS: Three CSTDs (the ChemoClave, OnGuard, and PhaSeal systems) were tested. Nine manufacturer-trained oncology pharmacists and pharmacy technicians volunteered to participate in an experiment to determine the degree of leakage of a liquid test agent (a radioactive technetium isotope [(99m)Tc] diluted in normal saline) during CSTD-assisted transfer of liquid from vials to syringes per standard practices...
April 1, 2013: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/23072203/use-of-a-closed-system-drug-transfer-device-phaseal-and-impact-on-preparation-time
#19
JOURNAL ARTICLE
J Sánchez-Rubio Ferrández, M C Lozano, I Iglesias, L Sánchez-Rubio Ferrández, B Rodríguez Vargas, R Moreno Díaz
PhaSeal is a closed-system drug transfer device which has demonstrated to protect against occupational exposure to antineoplastic agents. Our aim was to assess the impact of the incorporation of PhaSeal on the processing time of chemotherapy. The study was a prospective simulation study which compared the processing times with the traditional open-system technique and using the closed-transfer system. Four experienced pharmacy technicians prepared six batches with each method simulating simple chemotherapy admixture operations...
September 2012: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/21862686/multiple-test-assessment-of-devices-to-protect-healthcare-workers-when-administering-cytotoxic-drugs-to-patients
#20
COMPARATIVE STUDY
Thomas Queruau Lamerie, Laurent Carrez, Bertrand Décaudin, Lucie Bouchoud, Jean-François Goossens, Christine Barthélémy, Pascal Bonnabry, Pascal Odou
PURPOSE: Evaluation of containment safety devices designed and introduced to protect preparers and administrators of hazardous drugs, through a multiple-test assessment. METHODS: Six devices were compared: (1) Kis1 gravity-fed infusion set (Doran International, France), (2) Tevadaptor Spike Port Adapter (Teva Pharma AG, France), (3) Phaseal Infusion Adapter C100 (Carmel Pharma AB, France), (4) Codan Connect Z (Codan, France), (5) Pchimx with or without a cap (Doran International, France), and (6) Clave extension set 011-H1225 with or without Spiros (Hospira, France)...
June 2012: Journal of Oncology Pharmacy Practice
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