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https://www.readbyqxmd.com/read/28917718/olfactory-toxicity-in-rats-following-manganese-chloride-nasal-instillation-a-pilot-study
#1
Melanie L Foster, Deepa B Rao, Taylor Francher, Samantha Traver, David C Dorman
Following inhalation, manganese travels along the olfactory nerve from the olfactory epithelium (OE) to the olfactory bulb (OB). Occupational exposure to inhaled manganese is associated with changes in olfactory function. This pilot study evaluated two related hypotheses: (a) intranasal manganese administration increases OE and OB manganese concentrations; and (b) intranasal manganese exposure impairs performance of previously trained rats on a go-no-go olfactory discrimination (OD) task. Male Fischer 344 rats were trained to either lever press ("go") in response to a positive conditioned stimulus (CS+: vanillin) or to do nothing ("no go") when a negative conditioned stimulus (CS-: amyl acetate) was present...
September 13, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28913318/modified-anterior-craniofacial-osteotomy-using-partial-nasal-bone-division-and-reconstruction-in-frontoethmoidal-sinus-meningioma
#2
Eon Ju Park, Hong Il Kim, Jin Hyung Park, Hyung Suk Yi
Typical transcranial approaches are insufficient for adequate visualization and resection of skull base tumors. Different approaches with multiple modifications have been attempted. Here, we describe a new approach for a lesion that is central and hard to treat by conventional craniotomy and successful reconstruction with calvarial bone graft and titanium mesh plate. A 69-year-old female patient presented with recurrent meningioma. The tumor had invaded the frontal lobe, right supraorbital rim, and ethmoidal bone...
June 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28905843/orbital-dermatofibrosarcoma-protuberans-with-frontal-and-ethmoid-sinus-involvement-a-case-report-and-brief-review-of-literature
#3
Deepti Sharma, Garima Singh, Neha Kakkar, Vidya Jha
Dermatofibrosarcoma protuberans is a soft tissue sarcoma that is dermal in origin. The incidence is <0.1% of all malignancies and 1% of soft tissue sarcoma. Most commonly, it involves trunk (62%) followed by extremities (25%) and head and neck (13%). It is a slow growing tumor with locally aggressive behavior. Here, a 50-year-old female diagnosed with orbital dermatofibrosarcoma developed extra-axial component in right frontal region even on chemotherapy. Hence, the bad prognostic factors are yet to be established in dermatofibrosarcoma protuberans...
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28900497/pretreatment-nomograms-for-local-and-regional-recurrence-after-radical-radiation-therapy-for-primary-nasopharyngeal-carcinoma
#4
Fo-Ping Chen, Li Lin, Zhen-Yu Qi, Guan-Qun Zhou, Rui Guo, Jiang Hu, Ai-Hua Lin, Jun Ma, Ying Sun
Background: The aim of this study was to build nomograms to predict local recurrence (LR) and regional recurrence (RR) in patients with nasopharyngeal carcinoma (NPC) underwent intensity-modulated radiation therapy (IMRT). Patients and Methods : A total of 1811 patients with non-metastatic NPC treated with IMRT (with or without chemotherapy) between October 2009 and February 2012 at our center were involved for building the nomograms. Nomograms for LR-free rate and RR-free rate at 3- and 5- year were generated as visualizations of Cox proportional hazards regression models, and validated using bootstrap resampling, estimating discrimination and calibration...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28893971/computed-tomographic-assessment-of-equine-maxillary-cheek-teeth-anatomical-relationships-and-paranasal-sinus-volumes
#5
Tiziana Liuti, Richard Reardon, Paddy M Dixon
Disorders affecting the equine maxillary cheek teeth and paranasal sinuses are relatively common, but limited objective information is available on the dimensions and relationships of these structures in horses of different ages. The aims of this study were to assess age-related changes in the positioning and anatomical relationships of the individual maxillary cheek teeth with the infraorbital canal and maxillary septum and the volumes of the individual sinus compartments. CT and gross examination were performed on 60 normal equine cadaver heads that were aged by their dentition...
September 11, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28872506/an-aneurysmal-bone-cyst-in-the-skull-base
#6
Sangjun Kim, Dong Won Jung, Min Gyoung Pak, Young Jin Song, Woo Yong Bae
An aneurysmal bone cyst (ABC) is believed to be attributable to intraosseous circulatory disturbance. An ABC is a vascular tumor of the bone caused by bony expansion after partial vascular occlusion and congestion. Most ABCs are found in adolescents (approximately 75% of ABCs are observed in patients under 20 years of age). The most common ABC sites are the long bones of the limbs, the vertebrae, and the cranial bone. Aneurysmal bone cysts in the skull base or ethmoid sinus have been but rarely reported worldwide...
September 1, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28860916/dermis-fat-graft-for-pediatric-exenteration-challenging-but-rewarding
#7
Himika Gupta, Deepa Nair, Aliasgar Moiyadi, Prathamesh Pai
Orbital exenteration is a destructive and disfiguring surgery and involves removal of the entire orbital contents, soft tissue and often lids as well. We report a case of an eight month old female, with malignant orbital teratoma who underwent lid sparing exenteration for the destructive, locally advanced disease. Three month post surgery she developed recurrence with intracranial extension as well as socket infection with pus discharge. Repeat surgery involved a multispeciality approach for removal of the tumor which was abutting the cavernous sinus posteriorly and ethmoid sinus medially, apart from filling the entire bony orbit...
July 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28859993/on-ciprofloxacin-concentration-in-chronic-rhinosinusitis
#8
José Gameiro Dos Santos, Rosário Figueirinhas, José P Liberal, João C Almeida, Joana Sousa, Amílcar Falcão, Corália Vicente, João Paço, Cecília A Sousa
OBJECTIVE: Considering that all the evidence indicates that chronic rhinosinusitis without nasal polyps (CRSsNP) and chronic rhinosinusitis with nasal polyps (CRSwNP) are distinct entities, the aim of this study was to compare the concentrations obtained in plasma and in sinonasal mucosa with oral and nasal topical ciprofloxacin, in patients with and without nasal polyps, without evaluating the effectiveness of the use of an antibiotic. METHODS: Prospective clinical study with single-blind randomization...
August 28, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28859706/outcomes-of-sinonasal-squamous-cell-carcinoma-with-and-without-association-of-inverted-papilloma-a-multi-institutional-analysis
#9
Brian C Lobo, Brian D'Anza, Janice L Farlow, Dennis Tang, Troy D Woodard, Jonathan Y Ting, Raj Sindwani
INTRODUCTION: Sinonasal squamous cell carcinoma (SCC) accounts for <1% of all malignancies but represents 70% of sinonasal cancer. Up to 10% of SCCs are associated with inverted papilloma (IPSCC). Studies that compare patients, treatment, and outcomes of SCC and IPSCC are absent in the literature. METHODS: A retrospective review of patients with SCC and those with IPSCC at Cleveland Clinic and Indiana University from 1995 to 2015. The records were analyzed for demographics, tumor characteristics, treatment, and outcomes...
September 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28859244/significance-of-human-papillomavirus-positivity-in-sinonasal-squamous-cell-carcinoma
#10
Suat Kılıç, Sarah S Kılıç, Emilie S Kim, Soly Baredes, Omar Mahmoud, Stacey T Gray, Jean Anderson Eloy
BACKGROUND: The role of human papillomavirus (HPV) in sinonasal squamous cell carcinoma (SNSCC) is not well understood. METHODS: The National Cancer Database was queried for cases of SNSCC with known HPV status. Demographics, socioeconomic variables, TNM stage, histology, grade, treatment modalities, and overall survival (OS) through 5 years were compared between HPV-positive and HPV-negative tumors. Cox proportional hazard regression analyses were performed. RESULTS: Seven hundred seventy (770) cases were identified; 526 were HPV-negative (68...
August 31, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28845040/surgical-anatomy-for-the-endoscopic-endonasal-approach-to-the-ventrolateral-skull-base
#11
Kenichi Oyama, Shigeyuki Tahara, Toshio Hirohata, Yudo Ishii, Daniel M Prevedello, Ricardo L Carrau, Sebastien Froelich, Akira Teramoto, Akio Morita, Akira Matsuno
The authors describe the surgical anatomy for the endoscopic endonasal approach (EEA) to the ventrolateral skull base. The ventrolateral skull base can be divided into two segments: the upper lateral and lower lateral skull base. The upper lateral skull base includes the cavernous sinus and the orbit, while the lower lateral skull base includes the petrous apex, Meckel's cave, parapharyngeal space, infratemporal fossa, etc. To gain access to the upper lateral skull base, a simple opening of the ethmoid sinus provides sufficient exposure of this area...
August 25, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28837389/basaloid-adenocarcinoma-of-the-lacrimal-sac-a-rare-entity-and-approach-to-management
#12
Alison B Huggins, Mary A Stefanyszyn, Gurston Nyquist, Michael P Rabinowitz
Presented is a rare case of basaloid adenocarcinoma of the lacrimal sac. Low grade features of this malignancy permitted a conservative surgical approach to maximize functional and cosmetic outcomes. This is retrospective case description of a single 77-year-old-female patient who underwent a dacryocystorhinostomy with silicone tubes at an outside hospital for epiphora, but was referred to the Wills Eye Hospital Oculoplastics Department for a lacrimal sac biopsy showing low-grade carcinoma with basaloid features...
August 24, 2017: Orbit
https://www.readbyqxmd.com/read/28830313/characteristics-of-sinonasal-fibrous-dysplasia-experience-from-a-single-department
#13
Chen Duan, Qi Dai, Quan Liu, Hongmeng Yu
OBJECTIVES: We summarized the characteristics of fibrous dysplasia patients in our department to obtain clinical data on this disease. METHODS: We retrospectively reviewed 28 patients who were diagnosed with sinonasal fibrous dysplasia based on pathological examination results from March 2012 to February 2017 in our department. RESULTS: The 28 patients included 16 females and 12 males, and the median age was 31.5 (range, 7-69) years. The three most common symptoms were nasal obstruction (25%), impaired vision (21%) and headache (18%)...
August 22, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28806382/orbital-cellulitis-following-orbital-blow-out-fracture
#14
Je Yeon Byeon, Hwan Jun Choi
Orbital cellulitis and abscess have been described in the literature as complication that usually occur secondary to infection in the maxillary, ethmoidal, and frontal sinuses. If left untreated, it can lead to blindness, cavernous sinus thrombosis, meningitis, or cerebral abscess. Orbital fractures are a common sequela of blunt orbital trauma, but are only rarely associated with orbital cellulitis. So, the authors present rare orbital cellulitis after orbital blow-out fracture. A 55-year-old Asian complains of severe orbital swelling and pain on the left side...
August 10, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28798926/rare-case-of-cryptogenic-brain-abscess-caused-by-raoultella-ornithinolityca
#15
Marianna Luongo
Cerebral abscess is a potentially fatal neurosurgical condition, despite improvements in technology, new antimicrobial agents and modern neurosurgical instruments and techniques. I report the case of a 64-year-old woman, affected by a right frontobasal brain abscess, compressing the homolateral frontal horn of lateral ventricle, with a second mass partially occupying the right orbital cavity. She presented also with inflammatory sinusopathy involving the right maxillary, ethmoid and frontal sinuses. After 14 d of clinical observation and antimicrobial therapy, the patient received a computed tomography scan, which showed growth of the cerebral mass, with a ring of peripheral contrast enhancement and surrounding edema...
July 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28768937/definitive-surgical-treatment-of-osteomalacia-induced-by-skull-base-tumor-and-determination-of-the-half-life-of-serum-fibroblast-growth-factor-23
#16
Taijun Hana, Shota Tanaka, Hirofumi Nakatomi, Masaaki Shojima, Seiji Fukumoto, Masako Ikemura, Nobuhito Saito
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome often associated with fibroblast growth factor 23 (FGF23)-producing tumors such as phosphaturic mesenchymal tumor, mixed connective tissue variant (PMTMCT) affecting the bone and soft tissue. We experienced a patient with progressive bone and muscle pain due to FGF23-related TIO. Venous sampling had strongly suggested the anterior skull base as a source of FGF23, which led to the discovery of a small tumor in the ethmoid sinus extending intracranially...
August 2, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28767609/sinonasal-renal-cell-like-adenocarcinoma-a-unique-variant-of-primary-clear-cell-carcinoma-of-the-head-and-neck-the-first-reported-case-in-korea
#17
Nah-Ihm Kim, Jung-In Yang, Sung-Sun Kim, Ji-Shin Lee, Sang-Chul Lim, Shin Jung, Jae-Hyuk Lee, Kyung-Sub Moon, Kyung-Hwa Lee
RATIONALE: Primary sinonasal renal cell-like adenocarcinoma (SNRCLA) is a rare and unique neoplasm. PATIENT CONCERNS: A 63-year-old man presented with repeated epistaxis, nasal obstruction and hyposmia of 2-month duration. Radiological studies revealed a mass of the left ethmoid sinus involving anterior skull base. DIAGNOSIS: The patient was treated with craniofacial resection, bifrontal craniotomy combined with an endonasal endoscopic approach...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28760714/giant-fronto-ethmoidal-osteoma-selection-of-an-optimal-surgical-procedure
#18
Maria Humeniuk-Arasiewicz, Grażyna Stryjewska-Makuch, Małgorzata A Janik, Bogdan Kolebacz
INTRODUCTION: Osteomas of the paranasal sinuses are benign bone tumours that produce clinical signs depending on their size and location. In most reported cases large tumours are excised by an external approach or in conjunction with an endoscopic technique. Endoscopic treatment of such tumours is a huge challenge for the operator. OBJECTIVE: Determine the optimal surgical approach by analysing giant osteomas of the frontal and ethmoidal sinuses in the literature...
July 17, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28755036/a-pilot-study-for-segmentation-of-pharyngeal-and-sino-nasal-airway-subregions-by-automatic-contour-initialization
#19
Bala Chakravarthy Neelapu, Om Prakash Kharbanda, Viren Sardana, Abhishek Gupta, Srikanth Vasamsetti, Rajiv Balachandran, Shailendra Singh Rana, Harish Kumar Sardana
PURPOSE: The objective of the present study is to put forward a novel automatic segmentation algorithm to segment pharyngeal and sino-nasal airway subregions on 3D CBCT imaging datasets. METHODS: A fully automatic segmentation of sino-nasal and pharyngeal airway subregions was implemented in MATLAB programing environment. The novelty of the algorithm is automatic initialization of contours in upper airway subregions. The algorithm is based on boundary definitions of the human anatomy along with shape constraints with an automatic initialization of contours to develop a complete algorithm which has a potential to enhance utility at clinical level...
July 28, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28749846/three-dimensional-radiologic-study-on-index-measurement-of-endonasal-endoscopic-optic-nerve-decompression
#20
Yao Zhao, Haobo Duan, Jianming Liu, Kailiang Cheng, Yingying Han, Youqiong Li
OBJECTIVE: To provide the radiologic basis for the clinical application of endonasal endoscopic optic nerve decompression (EEOND). METHODS: CTA images were used to observe the optic canal (OC) and related structures of 60 patients (120 sides) with normal nasal, paranasal sinuses, OC, and other related structures. RESULTS: Optic canal could be classified as: the canal (10 sides, 8.33%), the semicanal (25 sides, 20.83%), the impression (49 sides, 40...
September 2017: Journal of Craniofacial Surgery
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