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Pharmacy admixing

Jamin Engel, Nicole Lazar
To support compounding of products that are sterile and chemically stable, beyond use dating of admixtures must include a thorough evaluation of appropriate resources. In most instances, resources provide documentation of a specific compounded admixture, at a specific concentration and storage parameters, that does not coincide with current operations or patient-specific requirements. To meet the operational demands of a pharmacy, institutions employ a referenced guideline approach to guide decision making for safe sterile admixing...
September 2016: Hospital Pharmacy
M Javed, T Wright, M Murison
No abstract text is available yet for this article.
January 2015: Annals of the Royal College of Surgeons of England
Yasuaki Ohtsubo, Keizo Ishimito, Momoe Tanioka, Keiko Uchiumi, Naoko Fujimoto, Tadashi Ishimitsu, Yutaka Uchida, Akira Kamiya
A checking system was developed for risk management of injectable anticancer drug use. Because the dosage and administration of injectable anticancer drugs vary with each patient, checking the prescription and aseptic i.v. admixing can be markedly complicated and time-consuming for pharmacists. The system we investigated in this study provided real-time checking of dosage, drip infusion rate, dosing periods, and dosing-free periods. The prescription parameters for this check included height, weight, body surface area, the medical history of each patient, the patient's ICD10 code' and disease indication from the package insert...
June 2002: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
S Hotoda, T Aoyama, A Sato, Y Yamamura, K Nakajima, K Nakamura, H Sato, T Iga
We quantitatively studied factors influencing the environment cleanliness for intravenous hyperalimentation (IVH) admixing. The environment cleanliness was evaluated by measuring the counts of particles (> 0.5 micron) and bacteria floating in 1 ft3 of the air inside the clean room (23.6 m3) and in the clean bench built in the department of pharmacy, The University of Tokyo Hospital in 1998. The number of particles at the center of the clean room during IVH admixing by 4 pharmacists was higher than that at the medicine passing area (150 +/- 50/ft3 vs...
December 1999: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
R C Rogers, M D Lee, S G McNeeley, J H Encalade, M K Ryan
Clindamycin and gentamicin are frequently prescribed by obstetricians and gynecologists (OB-GYN) for various pelvic infections in women. These two antibiotics maintain chemical stability when admixed in a small-volume parenteral. The institution of an admixture policy that recommends combining these agents when both drugs are prescribed in OB-GYN patients would decrease the frequency of administration, improve patient convenience, reduce risk of administration errors and intravenous line contamination, and reduce costs of antibiotic therapy...
July 1987: Hospital Pharmacy
D Matanin, K Carlson, B Bonace
This study was designed to assist the hospital pharmacy administrator in assessing personnel and staffing requirements for a pharmacy chemotherapy admixture service. Time study data was collected on 250 consecutive new and refill chemotherapy admixtures. Both pharmacists and technicians admixed during the 32-day study period. Protective clothing and a vertical hood were utilized. The admixtures were divided into three categories depending on the drug's original packaging (ampul or vial) and the delivery system used for the final solution (syringe or IV bag)...
July 1984: Hospital Pharmacy
H Kishi, A Yamaji, K Kataoka, Y Fujii, K Nishikawa, N Ohnishi, E Hiraoka, A Okada, C W Kim
Studies were undertaken to determine rational dosages of vitamin A and E during long-term total parenteral nutrition (TPN). Four kinds of vitamin prescriptions containing different amounts of vitamin A and E were prepared from commercially available products and/or hospital pharmacy products. Patients were divided into four groups according to the vitamin prescription used. Plasma vitamin levels of different patient groups were determined by a modified fluorimetric method and were compared with those of a normal subject group...
September 1981: JPEN. Journal of Parenteral and Enteral Nutrition
T V Nguyen, J C Theiss, T S Matney
The Salmonella reversion test was used to measure the mutagenic activities of urine concentrates from individuals preparing cancer chemotherapy agents for i.v. administration. Longitudinal studies were performed in which the total urine produced in 24-hr periods was collected, starting on a Sunday at 7 p.m. after a duty-free weekend and extending over an 8-day period. There was no detectable increase in mutagenic activity in the urine concentrates of three pharmacy administrators who had no contact with these drugs...
November 1982: Cancer Research
J B Freeman, R Fairfull-Smith, G H Rodman, D M Bernstein, A B Gazzaniga, M Gersovitz
A multicenter study was conducted to compare a new peripheral intravenously given solution containing 3 per cent amino acids, 3 per cent glycerol and a complete pattern of maintenance electrolytes--ProcalAmine--with an isonitrogenous amino acid control solution--FreAmine III--in patients undergoing elective gastrointestinal or vascular operations. Fifty-two patients received the control solution and 48 patients received the experimental solution in a double-blind, randomized trial for five consecutive postoperative days...
May 1983: Surgery, Gynecology & Obstetrics
D C Weil, P M Arnow
Many hospital pharmacies are reluctant to store admixed parenteral fluids longer than 24 to 48 h because of concern about possible microbial contamination. We evaluated the safety of prolonged refrigerated storage of admixtures by culturing mixtures in 471 bags prepared routinely in a hospital pharmacy and stored at 4 degrees C for up to 15 days. Low-level contamination (1 CFU per bag) was found in 3 of 253 solutions of saline and/or glucose into which nonantibiotic additives had been injected. None of 171 saline and/or glucose solutions with antibiotic additives or 47 parenteral nutrition fluids was culture positive...
September 1988: Journal of Clinical Microbiology
K E Edwards, J R Allen, M J Miller, R Yogev, P C Hoffman, R Klotz, S Marubio, E Burkholder, T Williams, A T Davis
Enterobacter aerogenes bacteremia associated with the infusion of contaminated admixed intravenous (IV) fluid occurred in seven patients in a pediatric hospital over a five-day period. Clinical illness was characterized by spiking fever in all patients. The temporal clustering of cases allowed for rapid recognition of the problem. The primary control measure was the prompt replacement of the IV fluids, although IV antibiotics were also administered. Hospital pharmacy practices for admixing IV solutions should follow published recommendations to minimize this source of potential contamination of fluids...
September 1978: Pediatrics
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