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Oncology admixing

Liping Liu, Scott W Aesif, Benjamin R Kipp, Jesse S Voss, Silver Daniel, Marie Christine Aubry, Jennifer M Boland
Ciliated muconodular papillary tumors (CMPTs) are rare peripheral lung lesions, characterized by papillary architecture and ciliated columnar cells admixed with mucinous cells and basal cells. They often have prominent surrounding intra-alveolar mucin, which can lead to diagnostic confusion with mucinous adenocarcinoma. Recognition of the ciliated component is the key to diagnosis of CMPT. The literature contains few reported cases to date, all occurring in East-Asian patients. Although follow-up data are limited, CMPT seems to be an indolent tumor with very good prognosis, leading some to question whether it is a reactive or hamartomatous lesion...
July 22, 2016: American Journal of Surgical Pathology
Rémy Brossel, Alexandre Yahi, Stéphane David, Laura Moreno Velasquez, Jean-Marc Guinebretière
In the past ten years, many studies have shown that malignant tissue has been "normalized" in vitro using mechanical signals. We apply the principles of physical oncology (or mechanobiology) in vivo to show the effect of a "constraint field" on tumor growth. The human breast cancer cell line, MDA MB 231, admixed with ferric nanoparticles was grafted subcutaneously in Nude mice. The magnetizable particles rapidly surrounded the growing tumor. Two permanent magnets located on either side of the tumor created a gradient of magnetic field...
2016: PloS One
Karla Claudio-Campos, Carmelo Orengo-Mercado, Jessicca Y Renta, Muriel Peguero, Ricardo García, Gabriel Hernández, Susan Corey, Carmen L Cadilla, Jorge Duconge
Puerto Ricans are a unique Hispanic population with European, Native American (Taino), and higher West African ancestral contributions than other non-Caribbean Hispanics. In admixed populations, such as Puerto Ricans, genetic variants can be found at different frequencies when compared to parental populations and uniquely combined and distributed. Therefore, in this review, we aimed to collect data from studies conducted in healthy Puerto Ricans and to report the frequencies of genetic polymorphisms with major relevance in drug response...
December 2015: Drug Metabolism and Personalized Therapy
Denis Dupoiron, Hélène Richard, Vincent Chabert-Desnot, Catherine Devys, Pierre Leynia, Michèle Boisdron-Celle
OBJECTIVES: Ziconotide is often administered in combination with other analgesics via an intrathecal pump. Studies have established that ziconotide is stable when delivered alone in high concentrations. No stability data are available, however, for ziconotide given in low concentrations and/or with other analgesics as usually occurs in clinical oncology practice. The objective of this study was to assess the in vitro stability of ziconotide alone and combined with other analgesics in intrathecal pumps at 37 °C, as well as in syringes at 5 °C, to evaluate conditions for storing and transporting preparations...
July 2014: Neuromodulation: Journal of the International Neuromodulation Society
Vijayalakshmi Ananthanarayanan, Yi Pan, Maria Tretiakova, Mahul B Amin, Liang Cheng, Jonathan I Epstein, David J Grignon, Donna E Hansel, Rafael E Jimenez, Jesse K McKenney, Rodolfo Montironi, Esther Oliva, Adeboye O Osunkoya, Priya Rao, Victor E Reuter, Jae Y Ro, Steven S Shen, John R Srigley, Toyonori Tsuzuki, Jorge L Yao, Tatjana Antic, Michael Haber, Jerome B Taxy, Gladell P Paner
Current oncology guidelines and clinical trials consider giving adjuvant chemotherapy to bladder cancer patients with at least microscopic perivesical tissue invasion (MPVTI) (≥pT3a) on cystectomy. The boundary of muscularis propria (MP) and perivesical tissue is commonly ill defined, and hence, when the tumor involves the interface, interpretation of MPVTI is likely to be subjective. In this study, 20 sets of static images that included 1 nontumoral bladder wall for defining MP-perivesical tissue boundary and 19 bladder cancer cases equivocal for MPVTI with confounding factors were sent to 17 expert genitourinary pathologists for review...
February 2014: American Journal of Surgical Pathology
Osama E Rahma, Ed Ashtar, Malgorzata Czystowska, Marta E Szajnik, Eva Wieckowski, Sarah Bernstein, Vincent E Herrin, Mortada A Shams, Seth M Steinberg, Maria Merino, William Gooding, Carmen Visus, Albert B Deleo, Judith K Wolf, Jeffrey G Bell, Jay A Berzofsky, Theresa L Whiteside, Samir N Khleif
PURPOSE: Peptide antigens have been administered by different approaches as cancer vaccine therapy, including direct injection or pulsed onto dendritic cells; however, the optimal delivery method is still debatable. In this study, we describe the immune response elicited by two vaccine approaches using the wild-type (wt) p53 vaccine. EXPERIMENTAL DESIGN: Twenty-one HLA-A2.1 patients with stage III, IV, or recurrent ovarian cancer overexpressing the p53 protein with no evidence of disease were treated in two cohorts...
March 2012: Cancer Immunology, Immunotherapy: CII
Aimee Danette Ruder, Douglas Lamont Smith, Michael Thornton Madsen, Frederic Henry Kass
BACKGROUND: The John Marsh Cancer Center is an ambulatory oncology clinic located in Hagerstown, MD. In 2004, a clinical oncology pharmacist was hired to help manage therapies and control cost. The objective was to evaluate clinical interventions, consultations and cost savings by the clinical oncology pharmacist. METHODS: This was a retrospective descriptive analysis of clinical interventions by the clinical oncology pharmacist from September 4, 2004 to October 27, 2006...
December 2011: Journal of Oncology Pharmacy Practice
A Saleem, E O Aboagye, J C Matthews, P M Price
PURPOSE: This study aimed to evaluate the utility of plasma pharmacokinetic analyses of anti-cancer agents from data obtained during positron emission tomography (PET) oncology studies of radiolabelled anti-cancer agents. PATIENTS AND METHODS: Thirteen patients were administered fluorine-18 radiolabelled 5-FU ([(18)F]5-FU) admixed with 5-FU, corresponding to a total 5-FU dose of 380-407 mg/m2 (eight patients) and 1 mg/m2 (five patients). Nine patients received 2...
April 2008: Cancer Chemotherapy and Pharmacology
Margaret S Brandwein-Gensler, Beverly Y Wang, Mark L Urken
Spindle cells are not routinely encountered in the context of thyroid pathology and are most often present in anaplastic thyroid carcinoma, medullary thyroid carcinoma, and benign conditions such as Riedel struma or de Quervain granulomatous thyroiditis. Only a few publications have reported papillary thyroid carcinoma admixed with a prominent spindle cell component. While these tumors are clearly distinct from anaplastic thyroid carcinoma, prognostication as to their oncologic potential is not yet established...
January 2004: Archives of Pathology & Laboratory Medicine
N R Frühauf, O Dumpich, C P Kaudel, S Kasimir-Bauer, K J Oldhafer
The clinical use of leukocyte adhesion filters is based on differentiated depletion of blood cells, although most of the mechanisms of filtration are still unclear. There is also evidence that leukocyte adhesion filters can remove disseminated tumour cells from patients' blood. The following proves this observation and consists of three parts: in the first part we analysed the depletion capacity of the LeucotrapWB filter medium (Pall) in an employed small-scale model for the cell line HT29 (colorectal origin) in phosphate-buffered saline (PBS) solution...
March 2001: Perfusion
T D Sievers, M A Lagan, S B Bartel, C Rasco, P J Blanding
The objective of this study was to describe the variation in preparation and administration of cyclophosphamide, mesna, and hydration for the treatment of childhood malignancies within clinical trial protocol documents. All cyclophosphamide-containing cooperative group (Pediatric Oncology Group) protocols that were open at Dana-Farber Cancer Institute in April 1998 were evaluated. Among the 14 active protocols, there were 23 unique cyclophosphamide regimens. Marked variation existed in infusion rate, fluid type, and volume used for admixing cyclophosphamide and mesna, as defined in the "Treatment" section of the protocols that we evaluated...
January 2001: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
R J Zaino, R J Kurman, V L Brunetto, C P Morrow, R C Bentley, J O Cappellari, P Bitterman
Papillary endometrioid or villoglandular adenocarcinoma (VGA) is a relatively common type of endometrial adenocarcinoma, but studies describing its behavior have yielded conflicting results. Patients with a component of VGA were identified in a review of 819 women entered in a Gynecology Oncology Group Study (Protocol 33) of clinical stages I and II endometrial adenocarcinoma. Cases with coexisting foci of serous or clear cell carcinoma were excluded from further consideration. Of the 61 cases that formed the study sample, there were 24 with pure villoglandular differentiation and 37 who were admixed with typical endometrioid adenocarcinoma (EA)...
November 1998: American Journal of Surgical Pathology
Y Takei, G S Pearl
Ultrastructural studies of yolk sac tumors (YST) have generally demonstrated the resemblance of this neoplasm to the primitive human yolk sac. However, these studies have failed to explain the common occurrence of mixed germ cell tumors with yolk sac elements. This report describes the ultrastructural features of a suprasellar YST. This tumor resembled those previously described. Also demonstrated, however, was the presence of primitive germ cells admixed within the neoplasm. A new schema is proposed based on these observations for the interrelationship of germ cell tumors, which may explain the common occurrence of mixed germ cell tumors...
November 1, 1981: Cancer
V V Joshi, A B Cantor, G Altshuler, E W Larkin, J S Neill, J J Shuster, C T Holbrook, F A Hayes, R P Castleberry
To develop consistency in terminology and pathologic criteria, the authors reviewed the literature and 213 cases of neuroblastic tumors (NT) registered with Pediatric Oncology Group (POG) protocols 8104 and 8441. The patients were given standardized therapy stratified according to POG stage and patient age, and four or more histologic sections of primary tumor resected before therapy were available in each of these 213 cases. All stages were represented. The recommended nomenclature combines conventional terms and criteria with those used by Bove and McAdams and Shimada et al...
April 15, 1992: Cancer
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