Tiffany Y Sia, Anna Maio, Yelena M Kemel, Kanika S Arora, Sushmita B Gordhandas, Ryan M Kahn, Erin E Salo-Mullen, Margaret A Sheehan, Prince Rainier Tejada, Chaitanya Bandlamudi, Qin Zhou, Alexia Iasonos, Rachel N Grisham, Roisin E O'Cearbhaill, William P Tew, Kara Long Roche, Oliver Zivanovic, Yukio Sonoda, Ginger J Gardner, Dennis S Chi, Alicia J Latham, Maria I Carlo, Yonina R Murciano-Goroff, Marie Will, Michael F Walsh, Mark E Robson, Diana L Mandelker, Michael F Berger, Nadeem R Abu-Rustum, Carol L Brown, Kenneth Offit, Jada G Hamilton, Carol Aghajanian, Britta Weigelt, Zsofia K Stadler, Ying L Liu
PURPOSE: To evaluate rates of germline pathogenic/likely pathogenic variants (PVs) and genetic counseling by ancestry in patients with epithelial ovarian cancer (EOC). METHODS: Patients with pathologically confirmed EOC who underwent clinical tumor-normal sequencing from January 1, 2015, to December 31, 2020, inclusive of germline analysis of ≥76 genes were included. Patients with newly identified PVs were referred for Clinical Genetics Service (CGS) counseling...
September 2023: JCO Precision Oncology