Dinusha C Rajapaksha, Shan L Edirisinghe, Chamilani Nikapitiya, Shs Dananjaya, Hyo-Jung Kwun, Cheol-Hee Kim, Chulhong Oh, Do-Hyung Kang, Mahanama De Zoysa
In this study, Spirulina maxima derived pectin nanoparticles (SmPNPs) were synthesized and multiple biological effects were investigated using in vitro and in vivo models. SmPNPs were not toxic to Raw 264.7 cells and zebrafish embryos up to 1 mg/mL and 200 µg/mL, respectively. SmPNPs upregulated Il 10, Cat, Sod 2, Def 1, Def 2, and Muc 1 in Raw 264.7 cells and tlr2, tlr4b, tlr5b, il1β, tnfα, cxcl8a, cxcl18b, ccl34a.4, ccl34b.4, muc5.1, muc5.2, muc5.3, hamp, cstd, hsp70, cat , and sod1 in the larvae and adult zebrafish, suggesting immunomodulatory activity...
November 7, 2020: Marine Drugs