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Sylvia B Bartel, Timothy G Tyler, Luci A Power
PURPOSE: Results of a study to evaluate the effectiveness of a recently introduced closed system drug-transfer device (CSTD) in reducing surface contamination during compounding and simulated administration of antineoplastic hazardous drugs (AHDs) are reported. METHODS: Wipe samples were collected from 6 predetermined surfaces in compounding and infusion areas of 13 U.S. cancer centers to establish preexisting levels of surface contamination by 2 marker AHDs (cyclophosphamide and fluorouracil)...
January 16, 2018: American Journal of Health-system Pharmacy: AJHP
Jinlong Jian, Aubryanna Hettinghouse, Chuan-Ju Liu
Multifunctional factor progranulin (PGRN) plays an important role in lysosomes, and its mutations and insufficiency are associated with lysosomal storage diseases, including neuronal ceroid lipofuscinosis and Gaucher disease (GD). The first breakthrough in understanding the molecular mechanisms of PGRN as regulator of lysosomal storage diseases came unexpectedly while investigating the role of PGRN in inflammation. Challenged PGRN null mice displayed typical features of GD. In addition, GRN gene variants were identified in GD patients and the serum levels of PGRN were significantly lower in GD patients...
September 2017: Genes & Diseases
Kazue Hirai
Handling of hazardous drugs in nursing practice, there are risks of a wide variety of occupational exposures such as drug administration, management of spills, care of patients after administration, etc. Using a general infusion set for intravenous administration, there are risk of exposure such as scattering when the bottle needle is spiked into the infusion bag, leakage when priming the infusion line with antineoplastic drug, spillage when removing the side tube. For intravenous administration, use of CSTD for administration is most effective, but in many facilities, a general infusion set is used due to cost considerations...
July 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Hisanaga Nomura
Recently, 1 out of 2 people are diagnosed as cancer, the number of patients who are given chemotherapy increases year by year. As a result, amount of anticancer drugs used also increases. Anticancer drug preparation work is one of pharmacist work. In many hospital, pharmacists prepare anticancer drugs at pharmacy. However, it is enough to take steps to exposure measures at all facilities. According to the United States Pharmacopeial(USP)and the handling standards of hazardous and drugs, there are 3 levels, the first level(safety cabinet), the second level(anticancer agent preparation room in pharmacy) and supplemental engineering control(CSTD)...
July 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Nicolas Simon, Michèle Vasseur, Marine Pinturaud, Marion Soichot, Camille Richeval, Luc Humbert, Michèle Lebecque, Ousseini Sidikou, Christine Barthelemy, Pascal Bonnabry, Delphine Allorge, Bertrand Décaudin, Pascal Odou
BACKGROUND: The objective of this randomized, prospective and controlled study was to investigate the ability of a closed-system transfer device (CSTD; BD-Phaseal) to reduce the occupational exposure of two isolators to 10 cytotoxic drugs and compare to standard compounding devices. METHODS AND FINDINGS: The 6-month study started with the opening of a new compounding unit. Two isolators were set up with 2 workstations each, one to compound with standard devices (needles and spikes) and the other using the Phaseal system...
2016: PloS One
Hisateru Yasui
In Japan, JSCN/JSMO/JASPO Joint Guidelines for Safe Handling of Cancer Chemotherapy Drugs was published in July, 2015. Occupational exposure of hazardous drugs (HD) should be prevented and safely managed by comprehensive team approaches throughout all processes of cancer chemotherapy; preparation, delivery, administration to abandonment of HD. All medical stuffs who deal with HD occupationally should acquire knowledge and skills for safe handling of HD. Understanding of hierarchy control and practical use of BSC, CSTD, PPE are keys for prevention of HD exposure...
May 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Aaron Campigotto, Matthew P Muller, Linda R Taggart, Reem Haj, Elizabeth Leung, Jeya Nadarajah, Larissa M Matukas
Cumulative susceptibility test data (CSTD) are used to guide empirical antimicrobial therapy and to track trends in antibiotic resistance. The Clinical and Laboratory Standards Institute recommends reporting CSTD at least annually and sets the minimum number of isolates per reported organism at 30. To comply, many hospitals combine data from multiple intensive care units (ICUs); however, this may not be appropriate to guide empirical therapy because of variations in patient populations. In this study, susceptibility data for two different ICUs at a tertiary care hospital in Toronto, Canada, were used to create a traditional CSTD report, which combined data from different ICUs, and a rolling-average CSTD report, which pooled 2 years of data for each ICU separately...
April 2016: Journal of Clinical Microbiology
Joshua Cox, Vonni Speed, Sara O'Neal, Terry Hasselwander, Candice Sherwood, Stephen F Eckel, William C Zamboni
Background Even while following best practices, surface exposures of hazardous drugs (HDs) are high and numerous. Thus, it is important to develop new products to reduce the surface contamination of HDs. Hazardous Drug Clean (HDClean™) was developed to decontaminate and remove HDs from various types of surfaces and overcome the problems associated with other cleaning products. Methods HDClean was evaluated to remove mock surface exposures of HDs (docetaxel, paclitaxel, ifosfamide, cyclophosphamide, 5-FU, and cisplatin) from various types of surfaces...
March 2017: Journal of Oncology Pharmacy Practice
Bingduo Zhou, Fengying Wu, Lin Yuan, Zhulei Miao, Shengliang Zhu
Background. Huachansu, the sterilized water extract of Bufo bufo gargarizans toad skin, is used in China to alleviate the side-effects and enhance the therapeutic effect of chemotherapy in advanced non-small-cell lung cancer (NSCLC). We conducted a meta-analysis to assess Huachansu's efficacy. Methods. We extensively searched electronic databases (CENTRAL, EMBASE, MEDLINE, CBM, Cochrane Library, CNKI, CEBM, WFDP, CSCD, CSTD, and IPA) for randomized controlled trials containing Huachansu plus chemotherapy as the test group and chemotherapy as the control group...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
Nongthombam Premananda Singh, Sharad Gokhale
Air quality exposure assessment using personal exposure sampling or direct measurement of spatiotemporal air pollutant concentrations has difficulty and limitations. Most statistical methods used for estimating spatiotemporal air quality do not account for the source characteristics (e.g. emissions). In this study, a prediction method, based on the lognormal probability distribution of hourly-average-spatial concentrations of carbon monoxide (CO) obtained by a CALINE4 model, has been developed and validated in an urban traffic corridor...
December 15, 2015: Science of the Total Environment
Cheryl A Thompson
No abstract text is available yet for this article.
June 15, 2015: American Journal of Health-system Pharmacy: AJHP
K Kicenuik, N Northrup, A Dawson, J Locke, J A Villamil, J Chretin, G Sfiligoi, C Clifford, M Rosenberg, T Hamilton, R Regan, M Parsons-Doherty, C Mallett, J Philibert, J Impellizeri, E Hofmeister
This prospective experimental simulation study evaluated the efficiency, ease of use (EOU) and cost of administering chemotherapy with two closed system transfer devices (CSTD, Equashield™ and PhaSeal(®) ) and no CSTD. Forty-six veterinary technicians (VT) working in oncology specialty practices were timed during chemotherapy administration simulated with water and a model canine limb 10 times with each system and with no CSTD. EOU and likelihood of recommending each system were rated by VT using visual analog scales...
March 2017: Veterinary and Comparative Oncology
Yohei Ikeno, Daisuke Arii, Hirofumi Nakajima, Kunihiko Murooka, Michio Nojima, Akio Kidokoro
The closed-system transfer device (CSTD), which is used to prevent the exposure of medical staff to anticancer drugs, has been reported to allow safe preparation and administration of these drugs to patients. At many medical institutions, however, the use of such devices is limited to select anticancer drugs. This could be attributable to the longer preparation time compared to the conventional injection technique with a syringe and needle, as well as the fact that the anticancer drugs are too expensive to be covered by the remuneration available for medical services...
May 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Paul J M Sessink, Jason Trahan, Joseph W Coyne
PURPOSE: In a follow-up to a previous study, surface contamination with the antineoplastic drug cyclophosphamide was compared in 30 US hospital pharmacies from 2004 to 2010 following preparation with standard drug preparation techniques or the PhaSeal closed system drug transfer device (CSTD). METHODS: Wipe samples were taken from biological safety cabinet (BSC) surfaces, BSC airfoils (the front leading edge of the BSC), floors in front of BSCs, and countertops in the pharmacy, and they were analyzed for contamination with cyclophosphamide...
March 2013: Hospital Pharmacy
Lorena De Ausen, Erik F DeFreitas, Latisha Littleton, Michael Lustik
PURPOSE: A study of leakage from selected closed-system transfer devices (CSTDs) under experimental conditions is described. METHODS: Three CSTDs (the ChemoClave, OnGuard, and PhaSeal systems) were tested. Nine manufacturer-trained oncology pharmacists and pharmacy technicians volunteered to participate in an experiment to determine the degree of leakage of a liquid test agent (a radioactive technetium isotope [(99m)Tc] diluted in normal saline) during CSTD-assisted transfer of liquid from vials to syringes per standard practices...
April 1, 2013: American Journal of Health-system Pharmacy: AJHP
Paul J M Sessink, Thomas H Connor, James A Jorgenson, Timothy G Tyler
PURPOSE: Surface contamination with the antineoplastic drugs cyclophosphamide, ifosfamide, and 5-fluorouracil was compared in 22 US hospital pharmacies following preparation with standard drug preparation techniques or the PhaSeal® closed-system drug transfer device (CSTD). METHODS: Wipe samples were taken from biological safety cabinet (BSC) surfaces, BSC airfoils, floors in front of BSCs, and counters and analyzed for contamination with cyclophosphamide, ifosfamide, and 5-fluorouracil...
March 2011: Journal of Oncology Pharmacy Practice
Roland Ritter, Martin Scheringer, Matthew MacLeod, Urs Schenker, Konrad Hungerbühler
BACKGROUND: Human milk and blood are monitored to detect time trends of persistent organic pollutants (POPs) in humans. It is current practice to use log-linear regression to fit time series of averaged cross-sectional biomonitoring data, here referred to as cross-sectional trend data (CSTD). OBJECTIVE: The goals of our study are to clarify the interpretation of half-lives derived from fitting exponential functions to declining CSTD and to provide a method of estimating human elimination half-lives from CSTD collected in a postban situation...
August 2009: Environmental Health Perspectives
Peng Guo, Xue-Yuan Dong, Ke-Wen Zhao, Xiaodong Sun, Qunna Li, Jin-Tang Dong
Kruppel-like factor 5 (KLF5) is implicated in human breast cancer by frequent genomic deletion and expressional deregulation, but the molecular mechanisms by which KLF5 affects breast tumorigenesis are still unknown. This study was conducted to examine whether and how KLF5 affects the function of estrogen receptor (ER) in breast cancer cells. Using different cell lines, we found that restored expression of KLF5 inhibited estrogen-promoted cell proliferation in ER-positive MCF-7 and T-47D cell lines but had no effect on ER-negative SK-BR-3 cells...
January 1, 2010: International Journal of Cancer. Journal International du Cancer
Funda Gul Koseoglu, Nina Tuncel, Adem Unal Kizildag, Melahat Garipagaoglu, Mustafa Adli, Cagatay Andic
PURPOSE: The aim of this study was to investigate the setup accuracy for patients undergoing postmastectomy radiotherapy using electronic portal imaging. MATERIALS AND METHODS: Ten patients undergoing radiotherapy via tangent (TG), supraclavicular-axillary (SA), and internal mammary (IM) fields were included. To explore the setup accuracy, distances between chosen landmarks were taken as reference parameters (RPs). The difference between measured RPs on simulation films and electronic portal images (EPIs) was calculated as the setup error...
February 2007: Radiation Medicine
Bruce R Harrison, Byron G Peters, Michael R Bing
PURPOSE: A comparison was conducted of the levels of surface contamination with two commonly used antineoplastic drugs, cyclophosphamide and fluorouracil, on countertops, floors, and hood surfaces in three oncology pharmacies following preparation with standard hazardous drug (HD) preparation techniques, or a closed-system drug transfer device (CSTD) in conjunction with standard HD preparation techniques, or a CSTD in conjunction with standard HD preparation techniques but prepared on a countertop outside the biological safety cabinet (BSC)...
September 15, 2006: American Journal of Health-system Pharmacy: AJHP
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