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Submucosal cleft palate

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https://www.readbyqxmd.com/read/27526237/perforation-with-submucosal-cleft-palate-in-a-previously-undiagnosed-adult-patient
#1
Şeyda Güray Evin, Mehtap Karamese, Osman Akdag, Muhammed Nebil Selimoglu, Zekeriya Tosun
Perforation with a submucosal cleft palate (SMCP) is a rare condition with a limited number of cases reported in the literature. However, most described cases include neonates and infants, but not cases due to trauma or infection. Here, we present a case of an adult patient with SMCP with a perforation of the palate who was undiagnosed. In light of this case, diagnosis and treatment of perforation in SMCP are presented. A new diagram that can be used in the management of these patients with velopharyngeal insufficiency is proposed...
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27391507/congenital-fistula-of-the-hard-palate-with-submucosal-cleft-palate
#2
Yong Lu, Wei Han
No abstract text is available yet for this article.
July 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/26322171/molecular-basis-of-cleft-palates-in-mice
#3
REVIEW
Noriko Funato, Masataka Nakamura, Hiromi Yanagisawa
Cleft palate, including complete or incomplete cleft palates, soft palate clefts, and submucosal cleft palates, is the most frequent congenital craniofacial anomaly in humans. Multifactorial conditions, including genetic and environmental factors, induce the formation of cleft palates. The process of palatogenesis is temporospatially regulated by transcription factors, growth factors, extracellular matrix proteins, and membranous molecules; a single ablation of these molecules can result in a cleft palate in vivo...
August 26, 2015: World Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26080188/congenital-lateral-cleft-palate-of-unknown-etiology
#4
Ahmet Kahraman, Serdar Yüce, Ömer Faruk Koçak, Yasin Canbaz, Dağhan Işik
The term cleft palate (CP) refers to midline defects extending from the prealveolar ark to the uvula, and these defects present with varying degrees. CP may be complete, incomplete, unilateral, bilateral, or submucosal. It is often observed with cleft lip (CL). In various studies, the incidence of isolated CP has been reported as 1.3 to 25.3 per 1000 births. As a result of deterioration of the anatomical structure of the palate, illnesses such as regurgitation, respiratory tract infections, otitis, and speech disorders may occur...
June 2015: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/25684075/use-of-hyperdry-amniotic-membrane-in-operations-for-cleft-palate-a-study-in-rats
#5
COMPARATIVE STUDY
Hiroaki Tsuno, Makoto Noguchi, Motonori Okabe, Kei Tomihara, Toshiko Yoshida, Toshio Nikaido
The growth of maxillary bone and the development of dentition are often impaired in patients who have had pushback operations for repair of a cleft palate. There has been considerable discussion about the most suitable technique or material used in such repairs to resolve the problem. Hyperdry amniotic membrane, a new preservable material derived from human amnion, has recently been introduced in several procedures. We have evaluated its use during pushback surgery in animal studies to try to correct the inhibition of growth and development of the maxilla...
April 2015: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/25468463/long-term-speech-outcomes-following-late-cleft-palate-repair-using-the-modified-furlow-technique
#6
Christina M Pasick, Paul L Shay, Carrie A Stransky, Cynthia B Solot, Marilyn A Cohen, Oksana A Jackson
OBJECTIVES: Published reports and previous studies from our institution have reported worse overall speech results, including significantly higher rates of persistent articulation errors, in patients undergoing palatoplasty at age >18 months. This study further investigates the effects of late repair on long term speech outcomes. METHODS: A retrospective review was performed of non-syndromic patients undergoing primary palatoplasty at age >18 months between 1980 and 2006 at our institution...
December 2014: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/25230004/19q13-32-microdeletion-syndrome-three-new-cases
#7
Angela Castillo, Nancy Kramer, Charles E Schwartz, Judith H Miles, Barbara R DuPont, Jill A Rosenfeld, John M Graham
A previous report described a unique phenotype associated with an apparently de novo 732 kb 19q13.32 microdeletion, consisting of intellectual disability, facial asymmetry, ptosis, oculomotor abnormalities, orofacial clefts, cardiac defects, scoliosis and chronic constipation. We report three unrelated patients with developmental delay and dysmorphic features, who were all found to have interstitial 19q13.32 microdeletions of varying sizes. Both the previously reported patient and our Patient 1 with a larger, 1...
November 2014: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/25003402/a-35-year-experience-with-syndromic-cleft-palate-repair-operative-outcomes-and-long-term-speech-function
#8
Marten N Basta, Jason Silvestre, Carrie Stransky, Cynthia Solot, Marilyn Cohen, Donna McDonald-McGinn, Elaine Zackai, Richard Kirschner, David W Low, Peter Randall, Don LaRossa, Oksana A Jackson
BACKGROUND: Associated comorbidities can put syndromic patients with cleft palate at risk for poor speech outcomes. Reported rates of velopharyngeal insufficiency (VPI) vary from 8% to 64%, and need for secondary VPI surgery from 23% to 64%, with few studies providing long-term follow-up. The purpose of this study was to describe our institutional long-term experience with syndromic patients undergoing cleft palatoplasty. METHODS: A retrospective review was conducted of all patients with syndromic diagnoses undergoing primary Furlow palatoplasty from 1975 to 2011...
December 2014: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/24865192/microdeletions-involving-chromosomes-12-and-22-associated-with-syndromic-duane-retraction-syndrome
#9
Khaled K Abu-Amero, Altaf A Kondkar, Darren T Oystreck, Arif O Khan, Thomas M Bosley
BACKGROUND: Duane retraction syndrome (DRS) is the most common of the congenital cranial dysinnervation disorders (CCDDs). CCDDs can be monogenic or chromosomal in origin. Identification of the genetic cause(s) in patients and families with DRS facilitates definitive diagnosis and provides insights into these developmental errors. MATERIALS AND METHODS: This study described a young girl with DRS on the left and several additional developmental abnormalities. Clinical examination including neuroimaging, sequencing of candidate genes associated with DRS, and array comparative genomic hybridization (array CGH) were performed...
September 2014: Ophthalmic Genetics
https://www.readbyqxmd.com/read/24790293/hormonal-and-genetical-assessment-of-a-japanese-girl-with-weaver-syndrome
#10
Yoko Miyoshi, Masako Taniike, Ikuko Mohri, Sotaro Mushiake, Shigeo Nakajima, Naomichi Matsumoto, Keiichi Ozono
We report a case of Japanese girl with a rare disorder of Weaver syndrome, which was characterized by overgrowth with advanced and disharmonic bone age, craniofacial abnormalities, developmental delay, metaphyseal flaring of the long bones and camptodactyly. The patient was delivered at 38 weeks of gestation with a length of 54.2 cm (+ 2.6 SD), a weight of 3805 g (+ 2.5 SD) and an occipitofrontal circumference (OFC) of 35.0 cm (+ 1.1 SD). She manifested hypertonia and flexion contractures in the first few years...
2004: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/24607194/surgical-considerations-in-22q11-2-deletion-syndrome
#11
REVIEW
Richard E Kirschner, Adriane L Baylis
The 22q11.2 deletion syndrome (22q11DS) may be associated with several palatal abnormalities, including overt cleft palate, submucosal cleft palate, palatopharyngeal disproportion, and velar hypotonia. The syndrome is the genetic disorder most commonly associated with velopharyngeal dysfunction (VPD). The complex causes of VPD in affected patients combine with the complexity of associated medical disorders to render surgical management of the velopharynx particularly challenging. Optimization of surgical outcomes requires precision in diagnosis, surgical management, and multidisciplinary care...
April 2014: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/24373587/powered-instrumentation-for-transnasal-endoscopic-partial-adenoidectomy-in-children-with-submucosal-cleft-palate
#12
Sherif M Askar, Amal S Quriba
OBJECTIVES: Partial adenoidectomy is the selective removal of the obstructing part of adenoid tissue, thus relieves obstruction symptoms and preserves the velopharyngeal valve action. Patients with palatal dysfunction are candidates for the technique. This study describes the use of microdebrider, transnasally (guided by the nasal endoscope) to perform partial adenoidectomy in patients with submucosal cleft palate, who presented with adenoidal hypertrophy and also it discusses its effects on nasal obstruction and speech...
February 2014: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/23851744/alteration-of-maxillary-and-mandibular-growth-of-adult-patients-with-unoperated-isolated-cleft-palate
#13
COMPARATIVE STUDY
Yunqiang Yang, Yeke Wu, Yifei Gu, Qijian Yang, Bing Shi, Qian Zheng, Yan Wang
OBJECTIVE: The objective of this study was to investigate the effects of cleft palate itself on the growth of maxilla and mandible. PATIENTS AND METHODS: Fifty-two adult female patients with unoperated isolated cleft palate and 52 adult female individuals with normal occlusion were included in our study. Computer software was used for lateral cephalometry measurement. Manual measurement was performed for dental cast measurements, and sample t test analysis was applied to analyze the differences between the 2 groups using SPSS 17...
July 2013: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/23707152/a-25-year-review-of-cases-with-submucous-cleft-palate
#14
Tomito Oji, Yoshiaki Sakamoto, Hisao Ogata, Ikkei Tamada, Kazuo Kishi
OBJECTIVES: To evaluate the effect of diagnostic and operative time on velopharyngeal closure in submucosal cleft palate (SMCP). METHODS: SMCP patients treated at the Keio University School of Medicine from 1986 to 2011 were enrolled as subjects. Clinical data were obtained, including patient sex, age at diagnosis, and operative age, occasion of diagnosis, accompanying deformities, speech test results before and 6 months after palatoplasty, and pharyngeal flap usage after palatoplasty...
July 2013: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/23121717/a-candidate-gene-approach-to-identify-modifiers-of-the-palatal-phenotype-in-22q11-2-deletion-syndrome-patients
#15
COMPARATIVE STUDY
Josine C C Widdershoven, Mark Bowser, Molly B Sheridan, Donna M McDonald-McGinn, Elaine H Zackai, Cynthia B Solot, Richard E Kirschner, Frits A Beemer, Bernice E Morrow, Marcella Devoto, Beverly S Emanuel
OBJECTIVE: Palatal anomalies are one of the identifying features of 22q11.2 deletion syndrome (22q11.2DS) affecting about one third of patients. To identify genetic variants that increase the risk of cleft or palatal anomalies in 22q11.2DS patients, we performed a candidate gene association study in 101 patients with 22q11.2DS genotyped with the Affymetrix genome-wide human SNP array 6.0. METHODS: Patients from Children's Hospital of Philadelphia, USA and Wilhelmina Children's Hospital Utrecht, The Netherlands were stratified based on palatal phenotype (overt cleft, submucosal cleft, bifid uvula)...
January 2013: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/22987620/haploinsufficiency-of-stk11-and-neighboring-genes-cause-a-contiguous-gene-syndrome-including-peutz-jeghers-phenotype
#16
Sarah Scollon, Kirsty McWalter, Keith Abe, Jeremy King, Kevin Kimata, Thomas P Slavin
We report on clinical and molecular findings of a 15-year-old female referred to our genetics clinic for a diagnostic evaluation due to mild developmental delay, submucosal cleft palate, and seizure disorder. Chromosomal microarray technology revealed a cancer predisposition due to a terminal deletion on chromosome 19p that includes the tumor suppressor gene STK11. In addition to abnormal lip pigmentation on exam, further diagnostic workup with upper and lower gastrointestinal screening confirmed polyps consistent with Peutz-Jeghers syndrome...
November 2012: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/22565874/alloderm-revision-for-failed-pharyngoplasty
#17
David A Kelly, Christina Plikatitis, David Blalock, Louis C Argenta, Lisa R David
Velopharyngeal insufficiency (VPI) occurs in more than 20% of patients with a cleft palate after primary palatoplasty. Surgical treatment focuses on pharyngoplasty to narrow the nasopharyngeal space and to decrease the distance needed for palatal closure. Persistent VPI after pharyngoplasty affects more than 20% of patients.From September 2007 to December 2009, 16 children (10 boys and 6 girls) with a mean age of 9.5 years (4-15 years) underwent surgical revision using an AlloDerm sling for persistent VPI after at least 1 previous failed pharyngoplasty...
May 2012: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/22404912/an-unusual-accessory-mandible-and-a-submucosal-cleft-palate-a-case-report-and-review-of-the-literature
#18
REVIEW
Ali Borzabadi-Farahani, John Gross, Pedro A Sanchez-Lara, Stephen L-K Yen
An accessory mandible is a rare congenital anomaly that requires multidisciplinary management. This case report describes a female patient with an unusual accessory mandible, a dysplastic overgrowth of bone, containing teeth that extended from the midsymphyseal region. A submucosal cleft palate and cleft of the lower lip were also present. Her treatment plan took a staged approach with initial surgical resection of the accessory bone and teeth. The second stage, still in the planning phase, will correct the secondary deformity of an anterior open bite and will restore the missing lower anterior teeth...
May 2013: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/22371266/tbx1-regulates-oral-epithelial-adhesion-and-palatal-development
#19
Noriko Funato, Masataka Nakamura, James A Richardson, Deepak Srivastava, Hiromi Yanagisawa
Cleft palate, the most frequent congenital craniofacial birth defect, is a multifactorial condition induced by the interaction of genetic and environmental factors. In addition to complete cleft palate, a large number of human cases involve soft palate cleft and submucosal cleft palate. However, the etiology of these forms of cleft palate has not been well understood. T-box transcriptional factor (Tbx) family of transcriptional factors has distinct roles in a wide range of embryonic differentiation or response pathways...
June 1, 2012: Human Molecular Genetics
https://www.readbyqxmd.com/read/22075323/a-case-of-an-extremely-large-accessory-bone-with-unusual-sutures-and-foramina-parietalia-permagna-in-multiple-premature-craniosynostoses
#20
Sarah E Hanninger, Anton H Schwabegger
BACKGROUND: Within the entity of craniofacial malformations premature craniosynostoses represent the majority of cases. They originate from disturbances in the ossification process, resulting in an osseous closure of cranial sutures ahead of time. Depending on severity and number of the affected sutures, a local or general growth inhibition of the skull follows. In the rare instance of accessory bones along these affected sutures, they may interfere with diagnostics and therapy. PATIENT: This clinical report describes the case of a seven-month-old male infant with multiple craniosynostoses, an extraordinary large accessory median calvarial bone, two foramina parietalia permagna and a submucosal cleft palate...
October 2012: Journal of Cranio-maxillo-facial Surgery
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