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https://www.readbyqxmd.com/read/29153459/-intrafamilial-disruptive-behaviour-disorders-in-children-and-adolescents-present-data-and-treatment-prospects
#1
E Bousquet, N Franc, C Ha, D Purper-Ouakil
Child-to-parent violence is a form of family violence that is still a well-kept secret. Abused parents can be victims of different types of abuse. Children can use both physical and psychological violence such as financial threats to take control of the home. In this situation, parents often no longer dare to contradict their children by fear of triggering uncontrollable violence. Although the phenomenon recently drew the attention of the media, there is still little knowledge about its prevalence and clinical characteristics...
November 16, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29132413/germacranolide-type-sesquiterpene-lactones-from-smallanthus-sonchifolius-with-promising-activity-against-leishmania-mexicana-and-trypanosoma-cruzi
#2
Jerónimo L Ulloa, Renata Spina, Agustina Casasco, Patricia B Petray, Virginia Martino, Miguel A Sosa, Fernanda M Frank, Liliana V Muschietti
BACKGROUND: Leishmaniasis and Chagas disease are life-threatening illnesses caused by the protozoan parasites Leishmania spp. and Trypanosoma cruzi, respectively. They are known as "neglected diseases" due to the lack of effective drug treatments and the scarcity of research work devoted to them. Therefore, the development of novel and effective drugs is an important and urgent need. Natural products are an important source of bioactive molecules for the development of new drugs. In this study, we evaluated the activity of enhydrin, uvedalin and polymatin B, three sesquiterpene lactones (STLs) isolated from Smallanthus sonchifolius, on Leishmania mexicana (MNYC/BZ/62/M) and Trypanosoma cruzi (Dm28c)...
November 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29107574/high-prevalence-of-salmonella-spp-in-wastewater-reused-for-irrigation-assessed-by-molecular-methods
#3
Paula Santiago, Ana Jiménez-Belenguer, Jorge García-Hernández, Rosa Montes Estellés, Manuel Hernández Pérez, M Angeles Castillo López, María Antonia Ferrús, Yolanda Moreno
Salmonella spp. is one of the most important causal agents of food-borne illness in developed countries and its presence in irrigation water poses a risk to public health. Its detection in environmental samples is not easy when culture methods are used, and molecular techniques such as PCR or ribosomal rRNA probe hybridization (Fluorescent in situ Hybridization, FISH) are outstanding alternatives. The aim of this work was to determine the environmental risk due to the presence of Salmonella spp. in wastewater by culture, PCR and FISH...
October 24, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29102764/treatment-of-malaria-and-related-symptoms-using-traditional-herbal-medicine-in-ethiopia
#4
Sultan Suleman, Takele Beyene Tufa, Dereje Kebebe, Sileshi Belew, Yimer Mekonnen, Fanta Gashe, Seid Musa, Evelien Wynendaele, Luc Duchateau, Bart De Spiegeleer
ETHNOPHARMACOLOGICAL RELEVANCE: Medicinal plants have always been an integral part of different cultures in Ethiopia in the treatment of different illnesses including malaria and related symptoms. However, due to lack of proper documentation, urbanization, drought, acculturation and deforestation, there is an increased risk of losing this traditional knowledge. Hence, the use of the indigenous knowledge should be well documented and validated for potential future use. AIM OF THE STUDY: To gather and document information on medicinal plants which are used in the traditional treatment of malaria and related symptoms in Ethiopia...
November 1, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29056694/inquiring-into-the-gaps-of-campylobacter-surveillance-methods
#5
REVIEW
Maria Magana, Stylianos Chatzipanagiotou, Angeliki R Burriel, Anastasios Ioannidis
Campylobacter is one of the most common pathogen-related causes of diarrheal illnesses globally and has been recognized as a significant factor of human disease for more than three decades. Molecular typing techniques and their combinations have allowed for species identification among members of the Campylobacter genus with good resolution, but the same tools usually fail to proceed to subtyping of closely related species due to high sequence similarity. This problem is exacerbated by the demanding conditions for isolation and detection from the human, animal or water samples as well as due to the difficulties during laboratory maintenance and long-term storage of the isolates...
July 19, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/28993809/characterization-of-a-multidrug-resistant-salmonella-enterica-serovar-heidelberg-outbreak-strain-in-commercial-turkeys-colonization-transmission-and-host-transcriptional-response
#6
Bradley L Bearson, Shawn M D Bearson, Torey Looft, Guohong Cai, Daniel C Shippy
In recent years, multidrug-resistant (MDR) Salmonella enterica serovar Heidelberg (S. Heidelberg) has been associated with numerous human foodborne illness outbreaks due to consumption of poultry. For example, in 2011, an MDR S. Heidelberg outbreak associated with ground turkey sickened 136 individuals and resulted in 1 death. In response to this outbreak, 36 million pounds of ground turkey were recalled, one of the largest meat recalls in U.S. HISTORY: To investigate colonization of turkeys with an MDR S...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28973011/zika-beyond-the-americas-travelers-as-sentinels-of-zika-virus-transmission-a-geosentinel-analysis-2012-to-2016
#7
Karin Leder, Martin P Grobusch, Philippe Gautret, Lin H Chen, Susan Kuhn, Poh Lian Lim, Johnnie Yates, Anne E McCarthy, Camilla Rothe, Yasuyuki Kato, Emmanuel Bottieau, Kristina Huber, Eli Schwartz, William Stauffer, Denis Malvy, Marc T M Shaw, Christophe Rapp, Lucille Blumberg, Mogens Jensenius, Perry J J van Genderen, Davidson H Hamer
BACKGROUND: Zika virus (ZIKV) was first isolated in Africa; decades later, caused large outbreaks in the Pacific, and is considered endemic in Asia. We aim to describe ZIKV disease epidemiology outside the Americas, the importance of travelers as sentinels of disease transmission, and discrepancies in travel advisories from major international health organizations. METHODS AND FINDINGS: This descriptive analysis using GeoSentinel Surveillance Network records involves sixty-four travel and tropical medicine clinics in 29 countries...
2017: PloS One
https://www.readbyqxmd.com/read/28931453/molecular-characterization-and-distribution-of-plasmodium-matutinum-a-common-avian-malaria-parasite
#8
Gediminas Valkiūnas, Mikas Ilgūnas, Dovilė Bukauskaitė, Vaidas Palinauskas, Rasa Bernotienė, Tatjana A Iezhova
Species of Plasmodium (Plasmodiidae, Haemosporida) are widespread and cause malaria, which can be severe in avian hosts. Molecular markers are essential to detect and identify parasites, but still absent for many avian malaria and related haemosporidian species. Here, we provide first molecular characterization of Plasmodium matutinum, a common agent of avian malaria. This parasite was isolated from a naturally infected thrush nightingale Luscinia luscinia (Muscicapidae). Fragments of mitochondrial, apicoplast and nuclear genomes were obtained...
November 2017: Parasitology
https://www.readbyqxmd.com/read/28918832/streptococcus-anginosus-group-bacterial-infections
#9
Tasaduq Fazili, Scott Riddell, Deanna Kiska, Tim Endy, Luca Giurgea, Calden Sharngoe, Waleed Javaid
BACKGROUND: The Streptococcus anginosus group (SAG) causes a variety of infections in adults. To better understand the burden of SAG infections and their associated morbidity and mortality, we conducted a retrospective analysis of these infections in adults at a tertiary care center. METHODS: A retrospective review of all cultures positive for SAG in adults and a corresponding review of the patients' medical records were conducted at a tertiary care facility in central New York...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28915435/an-overview-of-systematic-reviews-on-the-public-health-consequences-of-social-isolation-and-loneliness
#10
REVIEW
N Leigh-Hunt, D Bagguley, K Bash, V Turner, S Turnbull, N Valtorta, W Caan
OBJECTIVES: Social isolation and loneliness have been associated with ill health and are common in the developed world. A clear understanding of their implications for morbidity and mortality is needed to gauge the extent of the associated public health challenge and the potential benefit of intervention. STUDY DESIGN: A systematic review of systematic reviews (systematic overview) was undertaken to determine the wider consequences of social isolation and loneliness, identify any differences between the two, determine differences from findings of non-systematic reviews and to clarify the direction of causality...
September 12, 2017: Public Health
https://www.readbyqxmd.com/read/28902609/knee-extension-loss-secondary-to-a-cyclops-like-gouty-tophus-a-case-report-and-literature-review
#11
Michael Doany, Nicole Lopez, Andrew Rokito
While gouty arthritis of the knee is not uncommon, associated mechanical block to extension is a rarely seen complication. This report presents a unique case of extension loss due to a single, isolated intra-articular gouty tophus. Only a few similar reports have been described in the literature involving cases that are often initially suspected to be related to inherent structural knee pathology as opposed to a systemic condition or illness.
May 2017: Bulletin of the Hospital for Joint Diseases
https://www.readbyqxmd.com/read/28890518/a-case-of-imported-dengue-fever-from-burkina-faso-to-japan-in-october-2016
#12
Takehiro Hashimoto, Satoshi Kutsuna, Takahiro Maeki, Shigeru Tajima, Saho Takaya, Yuichi Katanami, Kei Yamamoto, Nozomi Takeshita, Kayoko Hayakawa, Yasuyuki Kato, Shuzo Kanagawa, Norio Ohmagari
Dengue fever remains underreported in Africa due to lack of awareness among healthcare providers, the presence of other febrile illnesses, and insufficient laboratory testing. We present a case of imported dengue fever from Burkina Faso to Japan, where an outbreak of dengue was reported on October 18, 2016. The phylogenetic analysis revealed that the isolate from our patient belonged to a distinct of sylvatic dengue viruses, suggesting that dengue viruses have been maintained in the mosquitoes and human cycles in Burkina Faso for more than 30 years...
September 11, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28884123/deviation-of-the-fecal-stream-in-colonic-bowel-segments-results-in-increased-numbers-of-isolated-lymphoid-follicles-in-the-submucosal-compartment-in-a-novel-murine-model-of-diversion-colitis
#13
Annabel Kleinwort, Paula Döring, Christine Hackbarth, Claus-Dieter Heidecke, Tobias Schulze
INTRODUCTION: Diversion colitis is a significant health problem due to its high incidence in patients with diverting enterostomy. This mucosal inflammation presents characteristic histopathological features allowing for the differentiation of this entity from other inflammatory bowel diseases. The pathophysiology of this disease remains ill-defined, in part due to the lack of appropriate animal models. The present study was performed in order to develop and characterize a murine model of diversion colitis...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28883819/immunogenicity-of-dna-vaccine-against-h5n1-containing-extended-kappa-b-site-in-vivo-study-in-mice-and-chickens
#14
Patrycja Redkiewicz, Anna Stachyra, Róz A Sawicka, Katarzyna Bocian, Anna Góra-Sochacka, Piotr Kosson, Agnieszka Sirko
Influenza is one of the most important illnesses in the modern world, causing great public health losses each year due to the lack of medication and broadly protective, long-lasting vaccines. The development of highly immunogenic and safe vaccines is currently one of the major problems encountered in efficient influenza prevention. DNA vaccines represent a novel and powerful alternative to the conventional vaccine approaches. To improve the efficacy of the DNA vaccine against influenza H5N1, we inserted three repeated kappa B (κB) motifs, separated by a 5-bp nucleotide spacer, upstream of the cytomegalovirus promoter and downstream of the SV40 late polyadenylation signal...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28878022/drusen-in-patient-derived-hipsc-rpe-models-of-macular-dystrophies
#15
Chad A Galloway, Sonal Dalvi, Sandy S C Hung, Leslie A MacDonald, Lisa R Latchney, Raymond C B Wong, Robyn H Guymer, David A Mackey, David S Williams, Mina M Chung, David M Gamm, Alice Pébay, Alex W Hewitt, Ruchira Singh
Age-related macular degeneration (AMD) and related macular dystrophies (MDs) are a major cause of vision loss. However, the mechanisms underlying their progression remain ill-defined. This is partly due to the lack of disease models recapitulating the human pathology. Furthermore, in vivo studies have yielded limited understanding of the role of specific cell types in the eye vs. systemic influences (e.g., serum) on the disease pathology. Here, we use human induced pluripotent stem cell-retinal pigment epithelium (hiPSC-RPE) derived from patients with three dominant MDs, Sorsby's fundus dystrophy (SFD), Doyne honeycomb retinal dystrophy/malattia Leventinese (DHRD), and autosomal dominant radial drusen (ADRD), and demonstrate that dysfunction of RPE cells alone is sufficient for the initiation of sub-RPE lipoproteinaceous deposit (drusen) formation and extracellular matrix (ECM) alteration in these diseases...
September 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28867170/assessment-of-pit-latrines-in-a-peri-urban-community-in-kwazulu-natal-south-africa-as-a-source-of-antibiotic-resistant-e-coli-strains
#16
Lorika S Beukes, Tracy L B King, Stefan Schmidt
Due to the frequent use of antibiotics and recurring illnesses related to multidrug-resistant (MDR) bacteria in South Africa, we determined if MDR Escherichia coli were present in pit latrine fecal sludge samples obtained from a peri-urban community in KwaZulu-Natal, South Africa. The abundance of E. coli in pit latrine samples was established using a most probable number (MPN) method with species confirmation done using biochemical tests and polymerase chain reaction (PCR). Forty-four randomly selected E. coli pit latrine isolates were further characterized, using the European committee on antimicrobial susceptibility testing (EUCAST) disk diffusion method to establish antibiotic resistance profiles for these E...
November 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28835578/altered-immune-responses-in-broiler-chicken-husbandry-workers-and-their-association-with-endotoxin-exposure
#17
Ravi Gautam, Yong Heo, GyeongDong Lim, EunSeob Song, Katharine Roque, JaeHee Lee, YeonGyeong Kim, AhRang Cho, SoJung Shin, ChangYul Kim, GiHwan Bang, JiYun Bahng, HyoungAh Kim
Exposure to bioaerosols in indoor animal farms associates with respiratory illnesses, but little is known about the immune modulation to chicken farmers. This study aimed to compare the general immunity of chicken farmers with those of control subjects with non-agricultural jobs. Blood taken from the farmers and controls was subjected to plasma IgE and IgG subclass measurements. Isolated peripheral blood mononuclear cells (PBMC) were stimulated and cytokine production was measured. Indoor total and respirable dust levels and their endotoxin (LPS) and aflatoxin (AF) levels in the farms were measured...
August 22, 2017: Industrial Health
https://www.readbyqxmd.com/read/28826328/refugee-and-immigrant-women-s-experience-of-postpartum-depression-a-meta-synthesis
#18
Carolyn L Tobin, Pam Di Napoli, Cheryl Tatano Beck
The aim of this work is to synthesize qualitative research on refugee and immigrant women's experiences of postpartum depression (PPD) to gain insight into the unique needs of this group of women. This population is more at risk of developing PPD due to a complexity of issues including pre- and postmigratory stressors; however, there is currently little research on this topic available to health care providers and policy makers. Thirteen articles met inclusion criteria, and five themes emerged from the meta-synthesis: (a) suffering in solitude, (b) the invisible illness, (c) cultural conceptualizations, (d) barriers to help seeking, and (e) facilitators of help seeking...
January 1, 2017: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
https://www.readbyqxmd.com/read/28804559/microrna-1907-enhances-atherosclerosis-associated-endothelial-cell-apoptosis-by-suppressing-bcl-2
#19
Jin Zhao, Shu-Lin Ou, Wei-You Wang, Chang Yan, Lu-Xiang Chi
Injury and endothelial cell apoptosis are hall marks of atherosclerosis (AS). However, the mechanisms underlying its pathogenesis remain ill-defined. Recent evidence of a role for microRNAs in AS-associated endothelial cell apoptosis encouraged us to address this question. Here, AS was developed in ApoE (-/-) mice supplied with a high-fat diet (HFD), compared to ApoE (-/-) mice supplied with a normal diet (ND). Mouse endothelial cells were isolated from the aortic arch using flow cytometry based on their expression of CD31...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28799681/genomic-and-clinical-evidence-uncovers-the-enterohepatic-species-helicobacter-valdiviensis-as-a-potential-human-intestinal-pathogen
#20
Pablo Fresia, Ronald Jara, Rafael Sierra, Ignacio Ferrés, Gonzalo Greif, Gregorio Iraola, Luis Collado
BACKGROUND: Helicobacter valdiviensis is a recently described enterohepatic species isolated from wild bird's fecal samples. Currently, its pathogenic potential and clinical significance are unknown mainly due to the lack of whole-genome sequences to compare with other helicobacters and the absence of specific screenings to determine its prevalence in humans. MATERIALS AND METHODS: The species type strain (WBE14(T) ) was whole-genome-sequenced, and comparative analyses were carried out including the genomes from other Helicobacter species to determine the exact phylogenetic position of H...
August 11, 2017: Helicobacter
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