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Isolation due to illness

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https://www.readbyqxmd.com/read/28647923/foodborne-illness-outbreak-investigation-in-a-high-profile-sports-club
#1
Kwendy Cavanagh, Travers Johnstone, Essi Huhtinen, Zeina Najjar, Peter Lorentzos, Craig Shadbolt, John Shields, Leena Gupta
A foodborne illness outbreak involving an elite sports team was investigated by a public health unit in Sydney, Australia. An epidemiological association was established between gastrointestinal illness and the consumption of food supplied by an external caterer, with a lamb meal most strongly associated with illness. Genetically identical Salmonella isolates were identified from clinical specimens, residual food items, and an environmental swab taken from the catering premises. The training schedule and other club operations were significantly affected by this outbreak...
December 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28638321/membrane-guanylate-cyclase-catalytic-subdomain-structure-and-linkage-with-calcium-sensors-and-bicarbonate
#2
Sarangan Ravichandran, Teresa Duda, Alexandre Pertzev, Rameshwar K Sharma
Membrane guanylate cyclase (MGC) is a ubiquitous multi-switching cyclic GMP generating signaling machine linked with countless physiological processes. In mammals it is encoded by seven distinct homologous genes. It is a single transmembrane spanning multi-modular protein; composed of integrated blocks and existing in homo-dimeric form. Its core catalytic domain (CCD) module is a common transduction center where all incoming signals are translated into the production of cyclic GMP, a cellular signal second messenger...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28632089/older-lesbians-receiving-home-care-formal-and-informal-dimensions-of-caregiving
#3
Sandra S Butler
Older lesbians face the triple jeopardy of ageism, sexism, and heterosexism, and their experiences are largely invisible. This qualitative, exploratory study examines the formal and informal caregiving experiences of 20 lesbians, 65 and older, who had utilized home care services due to acute illness or chronic disabilities. Half of those not partnered reported some level of isolation from support networks. Nearly all study participants eventually found home care workers with whom they were satisfied and even quite connected...
March 1, 2017: Journal of Women & Aging
https://www.readbyqxmd.com/read/28625989/rapid-high-throughput-identification-of-anthrax-causing-and-emetic-bacillus-cereus-group-genome-assemblies-using-btyper-a-computational-tool-for-virulence-based-classification-of-bacillus-cereus-group-isolates-using-nucleotide-sequencing-data
#4
Laura M Carroll, Jasna Kovac, Rachel A Miller, Martin Wiedmann
The Bacillus cereus group comprises nine species, several of which are pathogenic. Differentiating between isolates that may cause disease and those that do not is a matter of public health and economic importance, but can be particularly challenging due to the high genomic similarity of the group. To this end, we have developed BTyper, a computational tool that employs a combination of (i) virulence gene-based typing, (ii) multi-locus sequence typing (MLST), (iii) panC clade typing, and (iv) rpoB allelic typing to rapidly classify B...
June 16, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28625941/meditation-and-successful-aging-can-meditative-practices-counteract-age-related-cognitive-decline
#5
Marco Sperduti, Dominique Makowski, Philippe Blondé, Pascale Piolino
Life expectancy is constantly increasing in the developed countries due to medical, hygiene and socio-economic advances. Unfortunately, a longer life not always corresponds to a healthier life. Indeed, aging is associated with growing risk factors for illness associated with societal conditions (isolation, maltreatment), and neurodegenerative diseases. Even normal aging is associated with a cognitive decline that can hinder independence and quality of life of elderly. Thus, one major societal challenge is to build policies that support people of all ages to maintain a maximum health and functional capacity throughout their lives...
June 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28590234/a-porcine-enterovirus-g-associated-with-enteric-disease-contains-a-novel-papain-like-cysteine-protease
#6
Todd P Knutson, Binu T Velayudhan, Douglas G Marthaler
Identification of unknown pathogens in pigs displaying enteric illness is difficult due to the large diversity of bacterial and viral species found within faecal samples. Current methods often require bacterial or viral isolation, or testing only a limited number of known species using quantitative PCR analysis. Herein, faeces from two 25-day-old piglets with diarrhoea from Texas, USA, were analysed by metagenomic next-generation sequencing to rapidly identify possible pathogens. Our analysis included a bioinformatics pipeline of rapid short-read classification and de novo genome assembly which resulted in the identification of a porcine enterovirus G (EV-G), a complete genome with substantial nucleotide differences (>30 %) among current sequences, and a novel non-structural protein similar in sequence to the Torovirus papain-like cysteine protease (PLpro)...
June 8, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28578555/infections-due-to-acinetobacter-baumannii-in-the-icu-treatment-options
#7
Joseph P Lynch, George G Zhanel, Nina M Clark
Bacteria within the genus Acinetobacter (principally A. baumannii-calcoaceticus complex [ABC]) are gram-negative coccobacilli that may cause nosocomial infections in critically ill or debilitated patients (particularly ventilator-associated pneumonia and infections of the bloodstream, urinary tract, and wounds). Treatment of Acinetobacter infections is difficult, as Acinetobacter spp. are intrinsically resistant to multiple antimicrobial agents, and have a remarkable ability to acquire new resistance determinants via mechanisms that include plasmids, transposons, integrons, and resistance islands...
June 2017: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28570918/purification-of-leucocin-a-for-use-on-wieners-to-inhibit-listeria-monocytogenes-in-the-presence-of-spoilage-organisms
#8
Danielle R Balay, Ramana V Dangeti, Kamaljit Kaur, Lynn M McMullen
The aims of this study were to improve the method for purification of leucocin A to increase yield of peptide and to evaluate the efficacy of leucocin A and an analogue of leucocin A (leucocin N17L) to inhibit the growth of Listeria monocytogenes on wieners in the presence of spoilage organisms. Leucocin A was produced by Leuconostoc gelidum UAL187 and purified with a five-fold increase in yield; leucocin N17L was synthesized replacing asparagine at residue 17 with leucine. Five strains of L. monocytogenes associated with foodborne illness were used to assess bacteriocin efficacy in vitro and in situ...
May 24, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28560174/pediatric-huaiyangshan-virus-infection-a-case-report-with-literature-review
#9
Chun-Hui Zhu, Dong Xu, Wei Liu, Di Guo, Qin Ning, Guang Chen
To define the clinical manifestations and laboratory characteristics of pediatric severe fever with thrombocytopenia syndrome (SFTS) case caused by a novel bunyavirus. we retrospectively analyzed a pediatric case of viral SFTS in a 13 year old successfully managed and confirmed to be due to the novel bunyavirus now referred to as Huaiyangshan virus. A literature review of related cases was performed.Our pediatric case was a 13.3-year-old middle school student no underlying disease. Major clinical features included a fever with chills, headache, and dizziness...
2017: IDCases
https://www.readbyqxmd.com/read/28557348/the-toxic-mode-of-action-of-cyclic-lipodepsipeptide-fusaricidins-produced-by-paenibacillus-polymyxa-toward-mammalian-cells
#10
Raimo Mikkola, Maria A Andersson, Pavel Grigoriev, Mari Heinonen, Mirja S Salkinoja-Salonen
AIMS: The toxic strains of Paenibacillus polymyxa were isolated from buildings connected to ill health symptoms. Our aim was to identify the toxic compounds of Paenibacillus polymyxa and describe their toxic actions. METHODS AND RESULTS: The toxins of Paenibacillus polymyxa were purified and analysed by HPLC and mass spectrometry. Toxic fusaricidins A and B, and LI-F05a with mass ions at m/z 883.7, 897.6, and 897.6, respectively, were found. Cytotoxicity of purified fusaricidins A and B were measured using boar sperm, porcine tubular kidney epithelial and murine fibroblast cells...
May 29, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28549061/central-hypothyroidism-a-neglected-thyroid-disorder
#11
REVIEW
Paolo Beck-Peccoz, Giulia Rodari, Claudia Giavoli, Andrea Lania
Central hypothyroidism is a rare and heterogeneous disorder that is characterized by a defect in thyroid hormone secretion in an otherwise normal thyroid gland due to insufficient stimulation by TSH. The disease results from the abnormal function of the pituitary gland, the hypothalamus, or both. Moreover, central hypothyroidism can be isolated or combined with other pituitary hormone deficiencies, which are mostly acquired and are rarely congenital. The clinical manifestations of central hypothyroidism are usually milder than those observed in primary hypothyroidism...
May 26, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28515626/the-history-of-tuberculosis-from-the-first-historical-records-to-the-isolation-of-koch-s-bacillus
#12
REVIEW
I Barberis, N L Bragazzi, L Galluzzo, M Martini
Tuberculosis (TB) is a contagious, infectious disease, due to Mycobacterium tuberculosis (MT) that has always been a permanent challenge over the course of human history, because of its severe social implications. It has been hypothesized that the genus Mycobacterium originated more than 150 million years ago. In the Middle Ages, scrofula, a disease affecting cervical lymph nodes, was described as a new clinical form of TB. The illness was known in England and France as "king's evil", and it was widely believed that persons affected could heal after a royal touch...
March 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28515300/a-novel-a-h7n2-influenza-virus-isolated-from-a-veterinarian-caring-for-cats-in-a-new-york-city-animal-shelter-causes-mild-disease-and-transmits-poorly-in-the-ferret-model
#13
Jessica A Belser, Joanna A Pulit-Penaloza, Xiangjie Sun, Nicole Brock, Claudia Pappas, Hannah M Creager, Hui Zeng, Terrence M Tumpey, Taronna R Maines
In December 2016, a low pathogenic avian influenza (LPAI) A(H7N2) virus was identified as the causative source of an outbreak in a cat shelter in New York City, which subsequently spread to multiple shelters in New York and Pennsylvania. One person with occupational exposure to infected cats became infected with the virus, representing the first LPAI H7N2 human infection in North America since 2003. Considering the close contact that frequently occurs between companion animals and humans, it was critical to assess the relative risk of this novel virus to public health...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28503304/clinico-pathologic-presentation-of-hypersensitivity-pneumonitis-in-egyptian-patients-a-multidisciplinary-study
#14
Dalia Abd El-Kareem, Yosri M Akl, Gina A Nakhla, Ali A Elhindawi, Mahmoud A Eltorky
BACKGROUND: Hypersensitivity pneumonitis (HP) is a common diffuse parenchymal lung disease in Egypt which can be difficult to recognize due to the dynamic symptoms & associated environmental factors. METHODS: Forty-three Egyptian patients were enrolled in this study, presenting with dyspnea and cough, predominant ground-glass opacity (GGO) in high-resolution computed tomography (HRCT) where lung biopsy was needed to establish the diagnosis. RESULTS: The age range was 15 to 60 years...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28490164/contralateral-superior-cerebellar-artery-syndrome-a-consequence-of-brain-herniation
#15
Meysam Mohseni, Zohreh Habibi, Farideh Nejat
Vascular compromise is a well-known consequence of brain herniation syndromes. Transtentorial brain herniation most often involves posterior cerebral arteries. However, isolated involvement of contralateral superior cerebellar artery (SCA) during unilateral impending brain herniation is reported only once and we present another case of this exceedingly rare entity. A 24-year-old man was referred to us with impending herniation due to a multiloculated hydrocephalus, and during the course of illness, he developed an isolated SCA ischemia in the opposite side of the most dilated entrapped horn...
May 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28387014/weak-by-the-machines-muscle-motor-protein-dysfunction-a-side-effect-of-intensive-care-unit-treatment
#16
REVIEW
O Friedrich, S Diermeier, L Larsson
Intensive care interventions involve periods of mechanical ventilation, sedation and complete mechanical silencing of patients. Critical illness myopathy (CIM) is an ICU-acquired myopathy that is associated with limb muscle weakness, muscle atrophy, electrical silencing of muscle and motor proteinopathy. The hallmark of CIM is a preferential muscle myosin loss due to increased catabolic and reduced anabolic activity. The ubiquitin proteasome pathway plays an important role, apart from recently identified novel mechanisms affecting non-lysosomal protein degradation or autophagy...
April 7, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28382808/weaning-of-neurological-early-rehabilitation-patients-from-mechanical-ventilation-a-retrospective-observational-study
#17
Jens D Rollnik, Joachim K Krauss, Christoph Gutenbrunner, Claus Wallesch, Thomas Münte, Martin Stangel
BACKGROUND: There is little known about the factors influencing the weaning process of long-term mechanically ventilated patients in the neurological early rehabilitation. AIM: To identify salient clinical and neurophysiological variables with impact upon weaning from mechanical ventilation during neurological and neurosurgical early rehabilitation. DESIGN: Observational, retrospective data analysis. POPULATION: A sample of 65 mechanically ventilated neurological and neurosurgical early rehabilitation patients of the BDH-Clinic Hessisch Oldendorf in Northern Germany...
April 4, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28377064/the-ulysses-syndrome-an-eponym-identifies-a-psychosomatic-disorder-in-modern-migrants
#18
Raffaella Bianucci, Philippe Charlier, Antonio Perciaccante, Donatella Lippi, Otto Appenzeller
Due to civil wars, violence and persecutions, between 2015 and 2016, more than 1.4 million people, from the Middle East and Africa, fled their counties and migrated to Europe. The vast majority of migrants, who have already experienced enormous level of stressors, are faced with dangerous, often lethal, migratory journeys. Those who survive are exposed to adaptation stressors such as different languages, isolation, lack of work opportunities, diminished social status and a sense of failure in the new countries of residence...
April 1, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28375030/aminoglycosides-against-carbapenem-resistant-enterobacteriaceae-in-the-critically-ill-the-pitfalls-of-aminoglycoside-susceptibility
#19
Alexandre P Zavascki, Brandon O Klee, Jürgen B Bulitta
The emergence of carbapenem-resistant Enterobacteriaceae (CRE) has brought aminoglycosides to the frontline since an aminoglycoside may be the only antimicrobial to which CRE isolates show in vitro susceptibility. The appropriateness of aminoglycoside-based therapies for severe infections by CRE is discussed considering the current breakpoints and recent pharmacokinetic (PK) studies in critically ill patients. Areas covered: Many aminoglycoside-susceptible CRE isolates present minimal inhibitory concentrations (MICs) at or slightly below the breakpoint of amikacin or gentamicin...
June 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28366291/the-power-in-being-together-for-young-adults-who-have-heart-disease-the-photoshoot-experience
#20
Robyn Gallagher, Ellen Potter, Linda Thomson Mangnall, Laila Ladak, Patrick Gallagher, Lis Neubeck
OBJECTIVES: The study aimed to determine perceived motivations and benefits of photoshoot participation for young adults who have heart disease. BACKGROUND: Feeling isolated and different can have lifelong affects on quality of life in heart disease survivors. Photoshoots, where people create a photographic image of themselves, promote positive interpretation of their cardiac illness experience, but participant experiences remain under-investigated. METHODS: Young adult heart disease support group members completing a photoshoot were interviewed and data were thematically analyzed...
March 30, 2017: Heart & Lung: the Journal of Critical Care
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