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https://www.readbyqxmd.com/read/28549061/central-hypothyroidism-a-neglected-thyroid-disorder
#1
REVIEW
Paolo Beck-Peccoz, Giulia Rodari, Claudia Giavoli, Andrea Lania
Central hypothyroidism is a rare and heterogeneous disorder that is characterized by a defect in thyroid hormone secretion in an otherwise normal thyroid gland due to insufficient stimulation by TSH. The disease results from the abnormal function of the pituitary gland, the hypothalamus, or both. Moreover, central hypothyroidism can be isolated or combined with other pituitary hormone deficiencies, which are mostly acquired and are rarely congenital. The clinical manifestations of central hypothyroidism are usually milder than those observed in primary hypothyroidism...
May 26, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28515626/the-history-of-tuberculosis-from-the-first-historical-records-to-the-isolation-of-koch-s-bacillus
#2
REVIEW
I Barberis, N L Bragazzi, L Galluzzo, M Martini
Tuberculosis (TB) is a contagious, infectious disease, due to Mycobacterium tuberculosis (MT) that has always been a permanent challenge over the course of human history, because of its severe social implications. It has been hypothesized that the genus Mycobacterium originated more than 150 million years ago. In the Middle Ages, scrofula, a disease affecting cervical lymph nodes, was described as a new clinical form of TB. The illness was known in England and France as "king's evil", and it was widely believed that persons affected could heal after a royal touch...
March 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28515300/a-novel-a-h7n2-influenza-virus-isolated-from-a-veterinarian-caring-for-cats-in-a-new-york-city-animal-shelter-causes-mild-disease-and-transmits-poorly-in-the-ferret-model
#3
Jessica A Belser, Joanna A Pulit-Penaloza, Xiangjie Sun, Nicole Brock, Claudia Pappas, Hannah M Creager, Hui Zeng, Terrence M Tumpey, Taronna R Maines
In December 2016, a low pathogenic avian influenza (LPAI) A(H7N2) virus was identified as the causative source of an outbreak in a cat shelter in New York City, which subsequently spread to multiple shelters in New York and Pennsylvania. One person with occupational exposure to infected cats became infected with the virus, representing the first LPAI H7N2 human infection in North America since 2003. Considering the close contact that frequently occurs between companion animals and humans, it was critical to assess the relative risk of this novel virus to public health...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28503304/clinico-pathologic-presentation-of-hypersensitivity-pneumonitis-in-egyptian-patients-a-multidisciplinary-study
#4
Dalia Abd El-Kareem, Yosri M Akl, Gina A Nakhla, Ali A Elhindawi, Mahmoud A Eltorky
BACKGROUND: Hypersensitivity pneumonitis (HP) is a common diffuse parenchymal lung disease in Egypt which can be difficult to recognize due to the dynamic symptoms & associated environmental factors. METHODS: Forty-three Egyptian patients were enrolled in this study, presenting with dyspnea and cough, predominant ground-glass opacity (GGO) in high-resolution computed tomography (HRCT) where lung biopsy was needed to establish the diagnosis. RESULTS: The age range was 15 to 60 years...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28490164/contralateral-superior-cerebellar-artery-syndrome-a-consequence-of-brain-herniation
#5
Meysam Mohseni, Zohreh Habibi, Farideh Nejat
Vascular compromise is a well-known consequence of brain herniation syndromes. Transtentorial brain herniation most often involves posterior cerebral arteries. However, isolated involvement of contralateral superior cerebellar artery (SCA) during unilateral impending brain herniation is reported only once and we present another case of this exceedingly rare entity. A 24-year-old man was referred to us with impending herniation due to a multiloculated hydrocephalus, and during the course of illness, he developed an isolated SCA ischemia in the opposite side of the most dilated entrapped horn...
May 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28387014/weak-by-the-machines-muscle-motor-protein-dysfunction-a-side-effect-of-intensive-care-unit-treatment
#6
REVIEW
O Friedrich, S Diermeier, L Larsson
Intensive care interventions involve periods of mechanical ventilation, sedation and complete mechanical silencing of patients. Critical illness myopathy (CIM) is an ICU-acquired myopathy that is associated with limb muscle weakness, muscle atrophy, electrical silencing of muscle and motor proteinopathy. The hallmark of CIM is a preferential muscle myosin loss due to increased catabolic and reduced anabolic activity. The ubiquitin proteasome pathway plays an important role, apart from recently identified novel mechanisms affecting non-lysosomal protein degradation or autophagy...
April 7, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28382808/weaning-of-neurological-early-rehabilitation-patients-from-mechanical-ventilation-a-retrospective-observational-study
#7
Jens D Rollnik, Joachim K Krauss, Christoph Gutenbrunner, Claus Wallesch, Thomas Münte, Martin Stangel
BACKGROUND: There is little known about the factors influencing the weaning process of long-term mechanically ventilated patients in the neurological early rehabilitation. AIM: To identify salient clinical and neurophysiological variables with impact upon weaning from mechanical ventilation during neurological and neurosurgical early rehabilitation. DESIGN: Observational, retrospective data analysis. POPULATION: A sample of 65 mechanically ventilated neurological and neurosurgical early rehabilitation patients of the BDH-Clinic Hessisch Oldendorf in Northern Germany...
April 4, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28377064/the-ulysses-syndrome-an-eponym-identifies-a-psychosomatic-disorder-in-modern-migrants
#8
Raffaella Bianucci, Philippe Charlier, Antonio Perciaccante, Donatella Lippi, Otto Appenzeller
Due to civil wars, violence and persecutions, between 2015 and 2016, more than 1.4 million people, from the Middle East and Africa, fled their counties and migrated to Europe. The vast majority of migrants, who have already experienced enormous level of stressors, are faced with dangerous, often lethal, migratory journeys. Those who survive are exposed to adaptation stressors such as different languages, isolation, lack of work opportunities, diminished social status and a sense of failure in the new countries of residence...
April 1, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28375030/aminoglycosides-against-carbapenem-resistant-enterobacteriaceae-in-the-critically-ill-the-pitfalls-of-aminoglycoside-susceptibility
#9
Alexandre P Zavascki, Brandon O Klee, Jürgen B Bulitta
The emergence of carbapenem-resistant Enterobacteriaceae (CRE) has brought aminoglycosides to the frontline since an aminoglycoside may be the only antimicrobial to which CRE isolates show in vitro susceptibility. The appropriateness of aminoglycoside-based therapies for severe infections by CRE is discussed considering the current breakpoints and recent pharmacokinetic (PK) studies in critically ill patients. Areas covered: Many aminoglycoside-susceptible CRE isolates present minimal inhibitory concentrations (MICs) at or slightly below the breakpoint of amikacin or gentamicin...
April 17, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28366291/the-power-in-being-together-for-young-adults-who-have-heart-disease-the-photoshoot-experience
#10
Robyn Gallagher, Ellen Potter, Linda Thomson Mangnall, Laila Ladak, Patrick Gallagher, Lis Neubeck
OBJECTIVES: The study aimed to determine perceived motivations and benefits of photoshoot participation for young adults who have heart disease. BACKGROUND: Feeling isolated and different can have lifelong affects on quality of life in heart disease survivors. Photoshoots, where people create a photographic image of themselves, promote positive interpretation of their cardiac illness experience, but participant experiences remain under-investigated. METHODS: Young adult heart disease support group members completing a photoshoot were interviewed and data were thematically analyzed...
March 30, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28359131/-sports-injuries-and-illnesses-of-the-german-national-team-during-the-2016-olympic-summer-games-in-rio-de-janeiro
#11
Casper Grim, Thilo Hotfiel, Martin Engelhardt, Syndey Plewinski, Olav Spahl, Bernd Wolfarth
Background This article aims to survey and describe the injuries and illnesses of the German Team during the 2016 Olympic Games in Rio de Janeiro. Methods Through an electronic documentation system, injuries and illnesses requiring treatment were recorded and evaluated. An injury or illness was defined as any physical symptom that required medical attention and impaired participation in training and/or competition. The classification distinguished between type of injury (acute or overload), region and type of illness (infections, skin, allergy, etc...
January 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/28348804/cytolethal-distending-toxin-producing-escherichia-coli-strains-causing-severe-diarrhoea-in-young-mexican-children
#12
Mario Meza-Segura, Mussaret Bano Zaidi, Samantha Maldonado-Puga, Jazmin Huerta-Cantillo, Lucia Chavez-Dueñas, Fernando Navarro-Garcia, Teresa Estrada-Garcia
Introduction. Cytolethal distending toxins (CDTs), encoded by cdt genes, have DNase activity leading to cellular and nuclear distension, resulting in irreversible cell cycle arrest and apoptosis of target cells. cdt-positive Escherichia coli strains have been isolated from children with diarrhoea. There is, however, scant information on the prevalence and clinical presentation of diarrhoeal disease caused by these strains. Furthermore, toxin production of cdt-positive strains is rarely confirmed. We report five young children with diarrhoea caused by CDT-producing E...
February 2017: JMM Case Reports
https://www.readbyqxmd.com/read/28333181/candida-auris-candidaemia-in-indian-icus-analysis-of-risk-factors
#13
Shivaprakash M Rudramurthy, Arunaloke Chakrabarti, Raees A Paul, Prashant Sood, Harsimran Kaur, Malini R Capoor, Anupma J Kindo, Rungmei S K Marak, Anita Arora, Raman Sardana, Shukla Das, Deepinder Chhina, Atul Patel, Immaculata Xess, Bansidhar Tarai, Pankaj Singh, Anup Ghosh
Objectives: To identify the risk factors associated with Candida auris candidaemia, as this fungus now poses a global threat. Methods: We performed a subgroup analysis of a previously reported study of 27 Indian ICUs. The clinical data of candidaemia cases due to C. auris and other Candida species were compared to determine significant risk factors associated with C. auris infection. Results: Of the 1400 candidaemia cases reported earlier, 74 (5...
June 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28328650/exosomes-in-critical-illness
#14
Nora Terrasini, Vincenzo Lionetti
OBJECTIVE: Exosomes are small, cell-released vesicles (40-100 nm in size) with the potential to transfer proteins, lipids, small RNAs, messenger RNAs, or DNA between cells via interstitial fluids. Due to their role in tissue homeostasis, exosomes have emerged as a new type of therapeutic and diagnostic (theranostic) tool in the noninvasive assessment of organ response to injury or treatment and in the development of reliable organ-protective intensive therapy. Our review provides current insights into the role of exosomes in the personalized management of injury and repair responses in critical illness...
June 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28327177/intestinal-t-lymphocyte-homing-is-associated-with-gastric-emptying-and-epithelial-barrier-function-in-critically-ill-a-prospective-observational-study
#15
Christian Greis, Zohal Rasuly, Rolf A Janosi, Lambros Kordelas, Dietrich W Beelen, Tobias Liebregts
BACKGROUND: Impaired gastric emptying is common in critically ill patients. Intestinal dysmotility, a major cause of feed intolerance, may foster infectious complications due to mucosal barrier disruption. However, little is known about gut-directed immune activation, intestinal barrier function and its association with impaired gastric emptying in critically ill patients at ICU admission. METHODS: We conducted a prospective observational study at two tertiary care medical ICUs...
March 22, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28302528/association-between-enteric-protozoan-parasites-and-gastrointestinal-illness-among-hiv-and-tuberculosis-infected-individuals-in-the-chowke-district-southern-mozambique
#16
María José Irisarri-Gutiérrez, Marta Hernández-de Mingo, Aida de Lucio, Horacio Gil, Lucía Morales, Raimundo Seguí, Edy Nacarapa, Carla Muñoz-Antolí, Fernando Jorge Bornay-Llinares, José Guillermo Esteban, David Carmena
Human immune deficiency virus (HIV) and tuberculosis (TB) infections remain major public health issues globally, particularly in sub-Saharan Africa. Impairment of both cell-mediated and humoral immunity by HIV and/or TB infections may limit the host's defences against other pathogens, including the diarrheagenic protozoan Cryptosporidium spp., Giardia intestinalis, and Entamoeba histolytica. During September-December 2015 a cross-sectional study was conducted to assess the prevalence and molecular diversity of these enteric parasites among HIV- and/or TB-infected patients at a medical reference centre in Chowke district, southern Mozambique...
June 2017: Acta Tropica
https://www.readbyqxmd.com/read/28293231/isolation-of-francisella-tularensis-and-yersinia-pestis-from-blood-cultures-by-plasma-purification-and-immunomagnetic-separation-accelerates-antibiotic-susceptibility-determination
#17
Ronit Aloni-Grinstein, Ofir Schuster, Shmuel Yitzhaki, Moshe Aftalion, Sharon Maoz, Ida Steinberger-Levy, Raphael Ber
The early symptoms of tularemia and plague, which are caused by Francisella tularensis and Yersinia pestis infection, respectively, are common to other illnesses, resulting in a low index of suspicion among clinicians. Moreover, because these diseases can be treated only with antibiotics, rapid isolation of the bacteria and antibiotic susceptibility testing (AST) are preferable. Blood cultures of patients may serve as a source for bacteria isolation. However, due to the slow growth rates of F. tularensis and Y...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28278252/complement-inhibition-by-sarcoptes-scabiei-protects-streptococcus-pyogenes-an-in-vitro-study-to-unravel-the-molecular-mechanisms-behind-the-poorly-understood-predilection-of-s-pyogenes-to-infect-mite-induced-skin-lesions
#18
Pearl M Swe, Lindsay D Christian, Hieng C Lu, Kadaba S Sriprakash, Katja Fischer
BACKGROUND: On a global scale scabies is one of the most common dermatological conditions, imposing a considerable economic burden on individuals, communities and health systems. There is substantial epidemiological evidence that in tropical regions scabies is often causing pyoderma and subsequently serious illness due to invasion by opportunistic bacteria. The health burden due to complicated scabies causing cellulitis, bacteraemia and sepsis, heart and kidney diseases in resource-poor communities is extreme...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28262659/-the-lived-experience-of-patients-with-heart-transplantation-a-phenomenological-study
#19
Younghui Hwang, Myungsun Yi
PURPOSE: The purpose of this study was to describe the lived experience of patients with heart transplantation in Korea. METHODS: Individual indepth interviews and a focus group interview were used to collect the data from nine patients who had heart transplantations in 2015. All interviews were audio-taped and verbatim transcripts were made for the analysis. Data were analyzed using Colaizzi's phenomenological method. RESULTS: Among the nine participants, eight were men...
February 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28262654/-difficulties-in-caring-for-psychiatric-patient-as-experienced-by-non-psychiatric-nurses
#20
Jaewon Joung, Mi Young Jang, Jihyun Shim, Yoonhi Ko, Sung Hee Shin
PURPOSE: The purpose of this study was to identify non-psychiatric nurses' difficulties in caring for patients with mental illness. METHODS: Data were collected from eighteen general medical-surgical nurses working at a university hospital in Seoul, Korea. This study involved two focus group discussions and three in-depth individual interviews. All interviews were recorded and transcribed as they were spoken, and data were analyzed using qualitative content analysis...
February 2017: Journal of Korean Academy of Nursing
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