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Quinolone adverse effect

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https://www.readbyqxmd.com/read/27843968/moxifloxacin-induced-acute-psychosis-a-case-report-with-literature-review
#1
Faizan Mazhar, Shahzad Akram, Nafis Haider
Third generation quinolones are extensively used to treat a variety of common bacterial infections. Due to their extensive use in clinical practice, an increase in neuropsychiatric events has been reported. We report the case of psychotic symptoms occurs after three doses of moxifloxacin in a healthy adult male with no underlying risk factors. After the discontinuation of moxifloxacin treatment, there was a complete resolution of patient's symptoms. The case draws attention to a rare side effect of a commonly use drug and alert the clinicians to be cautious in those patients that have a baseline risk factors which makes the patient more susceptible to such adverse drug effect...
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27753544/travelers-diarrhea-associated-enterotoxigenic-escherichia-coli-gyra-mutants-and-quinolone-antibiotic-affinity-a-molecular-dynamics-simulation-and-residue-interaction-network-analysis
#2
Kusum Mehla, Jayashree Ramana
Travelers' diarrhea (TD) is one of the most important global health issues among international travelers, especially those traveling to developing countries. Enterotoxigenic Escherichia coli (ETEC) is the most frequently isolated pathogen causing TD. Although TD is self-limiting, it is also severely incapacitating. Ciprofloxacin is one of the standard quinolone antibiotics used in patients with TD. However, the alarming levels of antibiotic resistance have necessitated the urgent need to identify new drugs...
October 18, 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27499793/incidence-rate-and-pattern-of-clinically-relevant-potential-drug-drug-interactions-in-a-large-outpatient-population-of-a-developing-country
#3
Ehsan Nabovati, Hasan Vakili-Arki, Zhila Taherzadeh, Mohammad Reza Saberi, Ameen Abu-Hanna, Saeid Eslami
The objective of this study was to determine incidence rate, type, and pattern of clinically relevant potential drug-drug interactions (pDDIs) in a large outpatient population of a developing country. A retrospective, descriptive cross-sectional study was conducted on outpatients' prescriptions in Khorasan Razavi province, Iran, over 12 months. A list of 25 clinically relevant DDIs, which are likely to occur in the outpatient setting, was used as the reference. Most frequent clinically relevant pDDIs, most common drugs contributing to the pDDIs, and the pattern of pDDIs for each medical specialty were determined...
May 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27453864/recurrent-mania-consequent-to-quinolones-exposure-a-case-report-and-review-of-literature
#4
Swapnajeet Sahoo, Jitender Aneja, Debasish Basu
Antibiotics are the one of the most commonly used group, of drugs, in general medical and surgical practice. The quinolone antibiotics can lead to a range of adverse neuropsychiatric effects with most of the reports due to ciprofloxacin and ofloxacin. Here, we report an interesting and rarely described psychiatric manifestation of recurrent mania following the use of quinolone antibiotics, and briefly review the available literature.
January 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27377275/a-novel-binuclear-copper-complex-incorporating-a-nalidixic-acid-derivative-displaying-a-one-dimensional-coordination-polymeric-structure
#5
F R G Bergamini, M A Ribeiro, P C M L Miranda, A L B Formiga, P P Corbi
The identification of the antibacterial action of nalidixic acid (nx) was central to the development of the quinolone antibacterial compounds. The ability of the nx naphthyridyl ring to interact with and inhibit some proteins has encouraged the investigation of similar structures in the search for more active compounds with less adverse effects. The possibility of structural modification by attachment of other biologically active moieties to the naphthyridyl ring of nx allowed the development of new active antimicrobial molecules...
July 1, 2016: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/27367195/-sensitivity-of-microbial-associations-of-periodontal-lesions-to-antibacterial-agents
#6
I M Makeeva, F Yu Daurova, S F Byakova, E V Ippolitov, M S Gostev, A O Polikushina, E V Shubin
UNLABELLED: The aim of the study was the development of approaches to improve the effectiveness of antibiotic therapy in dental practice on the basis of determining the sensitivity of pathogenic microorganisms to antibiotics of different groups. MATERIAL AND METHODS: The study included determination of the sensitivity of the microbial complexes from wound exudate of periodontal pocket and apical abscess to macrolides, quinolones, penicillins, lincosamides and 5-nitroimidazole...
2016: Stomatologii︠a︡
https://www.readbyqxmd.com/read/27270894/radical-cure-of-experimental-babesiosis-in-immunodeficient-mice-using-a-combination-of-an-endochin-like-quinolone-and-atovaquone
#7
Lauren A Lawres, Aprajita Garg, Vidya Kumar, Igor Bruzual, Isaac P Forquer, Isaline Renard, Azan Z Virji, Pierre Boulard, Eduardo X Rodriguez, Alexander J Allen, Sovitj Pou, Keith W Wegmann, Rolf W Winter, Aaron Nilsen, Jialing Mao, Douglas A Preston, Alexia A Belperron, Linda K Bockenstedt, David J Hinrichs, Michael K Riscoe, J Stone Doggett, Choukri Ben Mamoun
Human babesiosis is a tick-borne multisystem disease caused by Babesia species of the apicomplexan phylum. Most clinical cases and fatalities of babesiosis are caused by Babesia microti Current treatment for human babesiosis consists of two drug combinations, atovaquone + azithromycin or quinine + clindamycin. These treatments are associated with adverse side effects and a significant rate of drug failure. Here, we provide evidence for radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone (ELQ) prodrug and atovaquone...
June 27, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27118305/imipenem-cilastatin-induced-psychosis-a-case-report
#8
Jacob Ninan, Gemy Maria George
BACKGROUND: Elderly patients, in particular, have been reported to develop psychiatric side effects from antibiotics. Clarithromycin, quinolones, sulfamethoxazole-trimethoprim, isoniazid, penicillin, and cephalosporins have been reported to cause psychosis. This case report bridges a void in the medical literature with regards to the psychiatric adverse effects of imipenem-cilastatin. CASE PRESENTATION: A 64-year-old Hispanic man in septic shock due to urinary tract infection was initiated on imipenem-cilastatin and mechanically ventilated, following admission to hospital...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27086734/a-randomized-comparative-study-of-dual-therapy-doxycycline-rifampin-versus-triple-therapy-doxycycline-rifampin-levofloxacin-for-treating-acute-subacute-brucellosis
#9
Ahmad Hasanain, Reem Mahdy, Asmaa Mohamed, Mostafa Ali
AIM: The aim of this study was to compare both the efficacy and safety profile of the WHO-recommended, dual therapy (doxycycline-rifampin) to a quinolone-based, triple therapy (doxycycline-rifampin-levofloxacin) for treating acute/subacute brucellosis. PATIENTS AND METHODS: We studied 107 consecutive, naïve patients with acute/subacute brucellosis admitted to Assiut University Hospital. Patients were randomly allocated to receive the dual therapy of doxycycline-rifampin (group-A) or to receive the triple therapy of doxycycline-rifampin-levofloxacin (group-B)...
May 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/26930604/impaired-inactivation-of-l-type-ca2-current-as-a-potential-mechanism-for-variable-arrhythmogenic-liability-of-herg-k-channel-blocking-drugs
#10
Jae Gon Kim, Dong Jun Sung, Hyun-ji Kim, Sang Woong Park, Kyung Jong Won, Bokyung Kim, Ho Chul Shin, Ki-Suk Kim, Chae Hun Leem, Yin Hua Zhang, Hana Cho, Young Min Bae
The proarrhythmic effects of new drugs have been assessed by measuring rapidly activating delayed-rectifier K+ current (IKr) antagonist potency. However, recent data suggest that even drugs thought to be highly specific IKr blockers can be arrhythmogenic via a separate, time-dependent pathway such as late Na+ current augmentation. Here, we report a mechanism for a quinolone antibiotic, sparfloxacin-induced action potential duration (APD) prolongation that involves increase in late L-type Ca2+ current (ICaL) caused by a decrease in Ca2+-dependent inactivation (CDI)...
2016: PloS One
https://www.readbyqxmd.com/read/26865283/safety-concerns-surrounding-quinolone-use-in-children
#11
Karisma Patel, Jennifer L Goldman
Fluoroquinolones are highly effective antibiotics with many desirable pharmacokinetic and pharmacodynamic properties including high bioavailability, large volume of distribution, and a broad spectrum of antimicrobial activity. Despite their attractive profile as anti-infective agents, their use in children is limited, primarily due to safety concerns. In this review we highlight the pharmacological properties of fluoroquinolones and describe their current use in pediatrics. In addition, we provide a comprehensive assessment of the safety data associated with fluoroquinolone use in children...
September 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/26847964/levofloxacin-bismuth-amoxicillin-and-esomeprazole-as-second-line-helicobacter-pylori-therapy-after-failure-of-non-bismuth-quadruple-therapy
#12
Zhiqiang Song, Liya Zhou, Jianzhong Zhang, Lihua He, Peng Bai, Yan Xue
BACKGROUND: The best rescue therapy for Helicobacter pylori (H. pylori) infection following failure of non-bismuth quadruple therapy (NBQT) remains unanswered. AIMS: To determine the efficacy, safety and compliance of levofloxacin, bismuth, amoxicillin and esomeprazole (LBAE) regimen following failure of NBQT. METHODS: 132 patients with H. pylori infection refractory to first-line NBQT received LBAE regimen (levofloxacin 500mg once/day, bismuth potassium citrate 220mg twice/day, amoxicillin 1000mg twice/day and esomeprazole 20mg twice/day for 14 days)...
May 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/26646050/gastrointestinal-disorders-and-medical-depression
#13
COMMENT
Michael K Popkin
No abstract text is available yet for this article.
November 2015: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/26580313/antibiotic-exposure-and-the-risk-for-depression-anxiety-or-psychosis-a-nested-case-control-study
#14
Ido Lurie, Yu-Xiao Yang, Kevin Haynes, Ronac Mamtani, Ben Boursi
OBJECTIVE: Changes in the microbiota (dysbiosis) were suggested to increase the risk of several psychiatric conditions through neurologic, metabolic, and immunologic pathways. Our aim was to assess whether exposure to specific antibiotic groups increases the risk for depression, anxiety, or psychosis. METHOD: We conducted 3 nested case-control studies during the years 1995-2013 using a large population-based medical record database from the United Kingdom. The study included 202,974 patients with depression, 14,570 with anxiety, and 2,690 with psychosis and 803,961, 57,862, and 10,644 matched controls, respectively...
November 2015: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/26490945/long-acting-beta2-agonist-in-addition-to-tiotropium-versus-either-tiotropium-or-long-acting-beta2-agonist-alone-for-chronic-obstructive-pulmonary-disease
#15
REVIEW
Hugo A Farne, Christopher J Cates
BACKGROUND: Long-acting bronchodilators, comprising long-acting beta2-agonists (LABA) and long-acting anti-muscarinic agents (LAMA, principally tiotropium), are commonly used for managing persistent symptoms of chronic obstructive pulmonary disease (COPD). Combining these treatments, which have different mechanisms of action, may be more effective than the individual components. However, the benefits and risks of combining tiotropium and LABAs for the treatment of COPD are unclear. OBJECTIVES: To compare the relative effects on markers of quality of life, exacerbations, symptoms, lung function and serious adverse events in people with COPD randomised to LABA plus tiotropium versus tiotropium alone; or LABA plus tiotropium versus LABA alone...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26446517/factors-associated-with-potentially-harmful-antibiotic-prescription-during-pregnancy-a-population-based-study
#16
Yichen Lee, Chuchieh Chen, Dachen Chu, Mingchung Ko
RATIONALE, AIMS AND OBJECTIVES: Inappropriate antibiotic prescriptions during pregnancy may adversely affect the fetus. There were few studies on factors associated with antibiotic prescriptions potentially harmful to the fetus. METHODS: This was a population-based cross-sectional study using data from National Health Insurance Research Database. We calculated the frequency of antibiotic prescription according to the status of pregnancy, type of infections, characteristics of patients, doctors and medical institutions...
April 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/26234174/vosaroxin-plus-cytarabine-versus-placebo-plus-cytarabine-in-patients-with-first-relapsed-or-refractory-acute-myeloid-leukaemia-valor-a-randomised-controlled-double-blind-multinational-phase-3-study
#17
RANDOMIZED CONTROLLED TRIAL
Farhad Ravandi, Ellen K Ritchie, Hamid Sayar, Jeffrey E Lancet, Michael D Craig, Norbert Vey, Stephen A Strickland, Gary J Schiller, Elias Jabbour, Harry P Erba, Arnaud Pigneux, Heinz-August Horst, Christian Recher, Virginia M Klimek, Jorge Cortes, Gail J Roboz, Olatoyosi Odenike, Xavier Thomas, Violaine Havelange, Johan Maertens, Hans-Günter Derigs, Michael Heuser, Lloyd Damon, Bayard L Powell, Gianluca Gaidano, Angelo-Michele Carella, Andrew Wei, Donna Hogge, Adam R Craig, Judith A Fox, Renee Ward, Jennifer A Smith, Gary Acton, Cyrus Mehta, Robert K Stuart, Hagop M Kantarjian
BACKGROUND: Safe and effective treatments are urgently needed for patients with relapsed or refractory acute myeloid leukaemia. We investigated the efficacy and safety of vosaroxin, a first-in-class anticancer quinolone derivative, plus cytarabine in patients with relapsed or refractory acute myeloid leukaemia. METHODS: This phase 3, double-blind, placebo-controlled trial was undertaken at 101 international sites. Eligible patients with acute myeloid leukaemia were aged 18 years of age or older and had refractory disease or were in first relapse after one or two cycles of previous induction chemotherapy, including at least one cycle of anthracycline (or anthracenedione) plus cytarabine...
September 2015: Lancet Oncology
https://www.readbyqxmd.com/read/26181194/evaluation-of-potential-pharmacokinetic-drug-drug-interaction-between-armodafinil-and-aripiprazole-in-healthy-adults
#18
M Darwish, M Bond, R Yang, E T Hellriegel, P Robertson
INTRODUCTION: Armodafinil, a moderate inducer of cytochrome P450 (CYP) 3A4, has been studied as adjunctive therapy to maintenance medications for major depressive episodes associated with bipolar I disorder. We evaluated the effect of daily dosing with armodafinil on the pharmacokinetics and safety of the CYP3A4 substrate aripiprazole, an atypical antipsychotic used to treat bipolar I disorder. METHODS: Healthy adults received 15 mg aripiprazole alone and after armodafinil (250 mg/day) pretreatment...
July 2015: Pharmacopsychiatry
https://www.readbyqxmd.com/read/26082625/lantern-a-randomized-study-of-qva149-versus-salmeterol-fluticasone-combination-in-patients-with-copd
#19
RANDOMIZED CONTROLLED TRIAL
Nanshan Zhong, Changzheng Wang, Xiangdong Zhou, Nuofu Zhang, Michael Humphries, Linda Wang, Chau Thach, Francesco Patalano, Donald Banerji
BACKGROUND: The current Global initiative for chronic Obstructive Lung Disease (GOLD) treatment strategy recommends the use of one or more bronchodilators according to the patient's airflow limitation, their history of exacerbations, and symptoms. The LANTERN study evaluated the effect of the long-acting β2-agonist (LABA)/long-acting muscarinic antagonist (LAMA) dual bronchodilator, QVA149 (indacaterol/glycopyrronium), as compared with the LABA/inhaled corticosteroid, salmeterol/fluticasone (SFC), in patients with moderate-to-severe COPD with a history of ≤1 exacerbation in the previous year...
2015: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/26070805/impact-of-a-clinical-guideline-for-prescribing-antibiotics-to-inpatients-reporting-penicillin-or-cephalosporin-allergy
#20
Kimberly G Blumenthal, Erica S Shenoy, Christy A Varughese, Shelley Hurwitz, David C Hooper, Aleena Banerji
BACKGROUND: Self-reported penicillin allergy infrequently reflects an inability to tolerate penicillins. Inpatients reporting penicillin allergy receive alternative antibiotics that might be broader spectrum, more toxic, or less effective. OBJECTIVE: To develop and assess a clinical guideline for the general inpatient provider that directs taking a history and prescribing antibiotics for patients with penicillin or cephalosporin allergy. METHODS: A guideline was implemented to assist providers with assessing allergy history and prescribing antibiotics for patients with reported penicillin or cephalosporin allergy...
October 2015: Annals of Allergy, Asthma & Immunology
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