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Quinolone

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https://www.readbyqxmd.com/read/29457331/a-strain-of-streptomyces-sp-isolated-from-rhizospheric-soil-of-crataegus-oxycantha-producing-nalidixic-acid-a-synthetic-antibiotic
#1
Nidhi Arora, Sunil Kumar, N Satti, Asif Ali, Prasoon Gupta, Meenu Katoch
AIM: Exploration of microbes isolated from rhizospheric soil of Crataegus oxycantha for bioactive natural products. METHODS AND RESULTS: A strain of Streptomyces sp. (C-7) was isolated from rhizospheric soil of Crataegus oxycantha. The 16S rRNA gene sequence of strain C-7 displayed 99% sequence similarity with different Streptomyces species. The highest score was displayed for Streptomyces sp. strain Chy2-8 followed by Streptomyces violarus strain NBRC13104 and Streptomyces arenae strain ISP5293...
February 19, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29450774/removal-of-tetracyclines-sulfonamides-and-quinolones-by-industrial-scale-composting-and-anaerobic-digestion-processes
#2
Hang Liu, Chengjun Pu, Xiaolu Yu, Ying Sun, Junhao Chen
This study evaluated and compared the removal of antibiotics by industrial-scale composting and anaerobic digestion at different seasons. Twenty compounds belonged to three classes of widely used veterinary antibiotics (i.e., tetracyclines, sulfonamides, and quinolones) were investigated. Results show that of the three groups of antibiotics, tetracyclines were dominant in swine feces and poorly removed by anaerobic digestion with significant accumulation in biosolids, particularly in winter. Compared to that in winter, a much more effective removal (> 97%) by anaerobic digestion was observed for sulfonamides in summer...
February 15, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29446718/current-trends-and-future-directions-of-fluoroquinolones
#3
Hamada H H Mohammed, Gamal El-Din A A Abuo-Rahma, Samar H Abbas, El-Shimaa M N Abdelhafez
Fluoroquinolones represent an interesting synthetic class of antimicrobial agents with broad spectrum and potent activity. Since the discovery of nalidixic acid, the prototype of quinolones, several structural modifications to the quinolone nucleus have been carried out for improvement of potency, spectrum of activity, and to understand their structure activity relationship (SAR). The C-7 substituent was reported to have a major impact on the activity. Accordingly, Substitution at C-7 or its N-4-piperazinyl moiety was found to affect potency, bioavailability, and physicochemical properties...
February 14, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29445835/application-and-evaluation-of-a-high-resolution-mass-spectrometry-screening-method-for-veterinary-drug-residues-in-incurred-fish-and-imported-aquaculture-samples
#4
Sherri B Turnipseed, Joseph M Storey, I-Lin Wu, Charles M Gieseker, Nicholas R Hasbrouck, Tina C Crosby, Wendy C Andersen, Shanae Lanier, Christine R Casey, Robert Burger, Mark R Madson
The ability to detect chemical contaminants, including veterinary drug residues in animal products such as fish, is an important example of food safety analysis. In this paper, a liquid chromatography high-resolution mass spectrometry (LC-HRMS) screening method using a quadrupole-Orbitrap instrument was applied to the analysis of veterinary drug residues in incurred tissues from aquacultured channel catfish, rainbow trout, and Atlantic salmon and imported aquacultured products including European eel, yellow croaker, and tilapia...
February 14, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29442334/utilization-spending-and-price-trends-for-quinolones-in-the-us-medicaid-programs-25-years-experience-1991-2015
#5
Ziyad S Almalki, Xiaomeng Yue, Ying Xia, Patricia R Wigle, Jeff Jianfei Guo
BACKGROUND: Given that the quinolones is one of the antibacterial classes most frequently used to treat patients with bacterial infections in the United States, any change in prescribing patterns of quinolones will impact Medicaid medical expenditures. OBJECTIVES: This study was undertaken to examine trends in utilization, reimbursement, and prices of quinolone antibacterials for the US Medicaid population. METHODS: The publicly available Medicaid State Drug Utilization outpatient pharmacy files were used for this study...
June 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29441201/leech-management-before-application-on-patient-a-nationwide-survey-of-practices-in-french-university-hospitals
#6
Delphine Grau, Raphaël Masson, Maxime Villiet, Brigitte Lamy
Background: Leech therapy in plastic/reconstructive microsurgery significantly improves a successful outcome of flap salvage but the drawback is a risk of severe infection that results in a drop of the salvage rates from 70-80% to below 30%. We report the results of a national survey conducted in all the French university hospitals to assess the current extent of use of leech for medical practices in the hospital and to investigate maintenance, delivery practices and prevention of the risk of infection...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29435265/prevalence-and-molecular-characterization-of-oqxab-in-clinical-escherichia-coli-isolates-from-companion-animals-and-humans-in-henan-province-china
#7
Baoguang Liu, Hua Wu, Yajun Zhai, Zhipei He, Huarun Sun, Tian Cai, Dandan He, Jianhua Liu, Shanmei Wang, Yushan Pan, Li Yuan, Gongzheng Hu
Background: The plasmid-encoded multidrug efflux pump oqxAB confers bacterial resistance primarily to olaquindox, quinolones, and chloramphenicol. The aims of this study were to investigate the prevalence of oqxAB among Escherichia coli isolates from dogs, cats, and humans in Henan, China and the susceptibilities of E. coli isolates to common antibiotics. Methods: From 2012 to 2014, a total of 600 samples which included 400 rectal samples and 200 clinical human specimens were tested for the presence of E...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29434398/a-highly-promiscuous-integron-plasmids-extended-spectrum-beta-lactamases-and-efflux-pumps-as-factors-governing-multidrug-resistance-in-a-highly-drug-resistant-vibrio-fluvialis-isolate-bd146-from-kolkata-india
#8
Neha Rajpara, Mrinalini Nair, Ashima Kushwaha Bhardwaj
In an earlier study from this laboratory, Vibrio fluvialis BD146, a clinical isolate from Kolkata, India, 2002, was found to be resistant to all the fourteen antibiotics tested. It harboured a high copy number plasmid pBD146 and a low copy number plasmid. In the present study, a more detailed analysis was carried out to unravel different resistance mechanisms in this isolate. Sequencing showed that variable region of class 1 integron located on low copy number plasmid harbored arr3-cmlA-blaOXA10-aadA1 gene cassettes...
March 2018: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29432492/molecular-epidemiology-of-fluoroquinolone-resistant-salmonella-in-africa-a-systematic-review-and-meta-analysis
#9
Getachew Tadesse, Tesfaye S Tessema, Getenet Beyene, Abraham Aseffa
BACKGROUND: Wide-ranging evidence on the occurrence of fluoroquinolone (FQ) resistance genetic determinants in African Salmonella strains is not available. The main objectives of this study were to assess the heterogeneity, estimate pooled proportions and describe the preponderance of FQ-resistance determinants in typhoidal and non-typhoidal Salmonella (NTS) isolates of Africa. METHODS: Genetic and phenotypic data on 6103 Salmonella isolates were considered. Meta- and frequency analyses were performed depending on the number of studies by category, number of isolates and risks of bias...
2018: PloS One
https://www.readbyqxmd.com/read/29431590/antimicrobial-prescribing-in-post-graduate-training-practices-a-cross-sectional-study-of-prescribing-data-in-general-practices-in-england
#10
Sanjiv Ahluwalia, Mohamed Sadak, Mark Ashworth
Introduction Seventy-five percent of all antimicrobials are prescribed in primary care. There is a growing concern about inappropriate oral antimicrobial prescribing. Interventions to enhance antimicrobial stewardship are actively promoted through educational and other means. GP training practice status has been shown to influence patient care. This study seeks to study the influence of GP training practice status on antimicrobial prescribing. Methods A cross-sectional analysis of practice antimicrobial prescribing data was conducted for the year 2015-2016 comparing training and non-training practices across England...
February 12, 2018: Education for Primary Care
https://www.readbyqxmd.com/read/29431570/levofloxacin-loaded-nanoparticles-decrease-emergence-of-fluoroquinolone-resistance-in-escherichia-coli
#11
Safy Hadiya, Xiaoqiang Liu, Wegdan Abd El-Hammed, Mahmoud Elsabahy, Sherine A Aly
Antimicrobial resistance is a major global health problem that is developed upon exposure of bacteria to antimicrobial agents, and, thus, reducing or eliminating the ability of the currently available antibacterial drugs to eradicate bacterial infections. The aim of the current study was to encapsulate levofloxacin (third generation fluoroquinolones) into chitosan (CS) nanoparticles, to evaluate the antibacterial potency of the nanosized drug, and to characterize the major genetic mutations associated with the exposure of bacteria to the levofloxacin-loaded nanoparticle versus free levofloxacin...
February 12, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29429416/microbiology-and-antimicrobial-susceptibility-of-otitis-externa-a-changing-pattern-of-antimicrobial-resistance
#12
E Heward, M Cullen, J Hobson
OBJECTIVE: Otitis externa is a common presentation to secondary care otolaryngology clinics. Despite this, few studies have investigated the microbiology and antimicrobial resistance of otitis externa. This study aimed to examine these issues. METHODS: Analysis identified 302 swabs taken from 217 patients (100 male, 117 female), between 1 January 2015 and 30 March 2016, at our rapid access otolaryngology clinic. RESULTS: In total, 315 organisms were isolated; the most frequent was Pseudomonas aeruginosa (31...
February 12, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29428755/salmonella-enterica-and-extended-spectrum-cephalosporin-resistant-escherichia-coli-recovered-from-holstein-dairy-calves-from-8-farms-in-new-brunswick-canada
#13
Babafela Awosile, J McClure, Javier Sanchez, Juan Carlos Rodriguez-Lecompte, Greg Keefe, Luke C Heider
This study was carried out to determine the frequency of fecal carriage, antimicrobial susceptibility, and resistance genes in Salmonella enterica and Escherichia coli with reduced susceptibility to extended-spectrum cephalosporins (ESC) isolated from 488 dairy calves from 8 farms in New Brunswick, Canada. Both S. enterica and E. coli with reduced susceptibility to ESC were isolated using selective culture. Minimum inhibitory concentrations to a panel of antimicrobial drugs were determined for randomly selected E...
February 7, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29427764/identification-and-characterization-of-plasmid-mediated-quinolone-resistance-determinants-in-enterobacteriaceae-isolated-from-healthy-poultry-in-brazil
#14
Joseane Cristina Ferreira, Rafael Antonio Casarin Penha Filho, Ana Paula Yorika Kuaye, Leonardo Neves Andrade, Angelo Berchieri Junior, Ana Lúcia Costa Darini
The expression of plasmid-mediated quinolone resistance (PMQR) genes confers low-level quinolone and fluoroquinolones resistance alone. However, the association to chromosomal resistance mechanisms determines an expressively higher resistance in Enterobacteriaceae. These mechanisms are horizontally disseminated within plasmids and have contributed to the emergence of bacteria with reduced susceptibility or resistant to therapies worldwide. The epidemiological characterization of PMQR dissemination is highly relevant in the scientific and medical context, to investigate the dissemination within enterobacteria, from different populations, including humans and food-producing animals...
February 7, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29426547/upconversion-particle-fe3o4-molecularly-imprinted-polymer-with-controllable-shell-thickness-as-high-performance-fluorescent-probe-for-sensing-quinolones
#15
Yiwei Tang, Huan Liu, Jingwen Gao, Xiuying Liu, Xue Gao, Xiaonan Lu, Guozhen Fang, Junping Wang, Jianrong Li
Localized photo-polymerization was ingeniously applied to prepare a multifunctional molecularly imprinted polymer (MIP) fluorescent probe using the "layer-by-layer" assembly of MIP and Fe3O4 nanoparticles on NaYF4: Yb3+, Er3+ upconversion particles (MUCPs@MIP). Enrofloxacin was used as the template and chosen as the target molecular during the investigation of the adsorption property. This ternary probe has magnetic and broad-spectrum molecular recognition capability, fast response, and upconversion fluorescence...
May 1, 2018: Talanta
https://www.readbyqxmd.com/read/29424545/copper-catalyzed-aza-michael-addition-of-2-aminobenzoate-to-%C3%AE-substituted-%C3%AE-%C3%AE-unsaturated-ketones-one-pot-synthesis-of-3-carbonyl-2-substituted-quinolin-4-1h-ones
#16
Seongil Kang, Subin Park, Kyung-Su Kim, Changsik Song, Yunmi Lee
We present a new and straightforward one-pot process for the synthesis of 3-carbonyl-4-quinolone derivatives through highly efficient Cu-catalyzed aza-Michael addition of 2-aminobenzoates to β-substituted α,β-unsaturated ketones/cyclization/mild oxidation reactions. A broad range of new versatile 3-carbonyl-quinolin-4(1H)-ones is prepared from readily available chemicals under mild reaction conditions with short reaction times, producing good to excellent yields (up to 99%).
February 9, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29422194/ultrahigh-selective-adsorption-of-zwitterionic-ppcps-both-in-the-absence-and-presence-of-humic-acid-performance-and-mechanism
#17
Jing Jin, Tianyu Feng, Rui Gao, Yan Ma, Wei Wang, Qing Zhou, Aimin Li
Since zwitterionic PPCPs could be combined with humic acid (HA) leading to certain contaminants residue in aqueous solution, adsorbents with much stronger binding with zwitterionic PPCPs were needed to avoid this phenomenon. Through comparison of serial magnetic carboxyl modified hypercrosslinked resins including MA10, MA30, MA40 and MA70, MA50 was found to exhibit ultrahigh selective adsorption of zwitterionic PPCPs including tetracycline and quinolone antibiotics due to the remarkable synergistic effects generated from cation exchange interaction and non-ion exchange interaction...
April 15, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29421362/increased-exposure-to-extended-spectrum-%C3%AE-lactamase-producing-multidrug-resistant-enterobacteriaceae-through-the-consumption-of-chicken-and-sushi-products
#18
Ana Isabel Vitas, Dixita Naik, Lara Pérez-Etayo, David González
The aim of this study was to determine the occurrence and patterns of resistance of extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae in food products purchased in Navarra, northern Spain. A total of 174 samples of fish and chicken were analyzed from September 2015 to September 2016, including raw and ready-to-eat products: trout (n = 25), salmon (n = 28), panga (n = 13), chicken nuggets and chicken scalopes (n = 32), sushi (n = 31) and sliced cooked poultry (n = 45)...
February 1, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29420133/distribution-of-antimicrobial-resistance-genes-and-class-1-integron-gene-cassette-arrays-in-motile-aeromonas-spp-isolated-from-goldfish-carassius-auratus
#19
Sabrina Hossain, Benthotage Chamara Jayasankha De Silva, Sudu Hakuruge Madusha Pramud Wimalasena, Hansani Nilupama Kumari Senarath Pathirana, Pasan Sepala Dahanayake, Gang-Joon Heo
Aeromonas spp. are opportunistic pathogens related to multiple infectious diseases in ornamental fishes. In the present study, the antimicrobial susceptibility, resistance genes, and integrons of 65 goldfish-borne Aeromonas spp. were evaluated. The isolates were identified as A. hydrophila (n = 30), A. veronii (n = 32), and A. punctata (n = 3) by gyrB sequencing. The antimicrobial susceptibility testing of the isolates designated that most of the isolates were resistant to amoxicillin (100.00%), nalidixic acid (100...
February 8, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29415186/microbial-spectrum-of-intra-abdominal-abscesses-in-perforating-crohn-s-disease-results-from-a-prospective-german-registry
#20
P A Reuken, W Kruis, C Maaser, N Teich, J Büning, J C Preiß, R Schmelz, T Bruns, S Fichtner-Feigl, A Stallmach
Background: Intra-abdominal abscesses (IAA) are common life threatening complications in patients with Crohn's disease (CD). In addition to interventional drainage and surgical therapy, empirical antibiotic therapy represents a corner stone of treatment but contemporary data on microbial spectra and antimicrobial resistance are scarce. Methods: We recruited 105 patients with CD and IAA from 9 German centers for a prospective registry in order to characterize the microbiological spectrum, resistance profiles, antibiotic therapy and outcome...
February 5, 2018: Journal of Crohn's & Colitis
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