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https://www.readbyqxmd.com/read/29928943/co-occurrence-of-biofilm-formation-and-quinolone-resistance-in-salmonella-enterica-serotype-typhimurium-carrying-an-inchi2-type-oqxab-positive-plasmid
#1
Hongping Shi, Xueyan Zhou, Wencheng Zou, Yongxiang Wang, Changwei Lei, Rong Xiang, Long Zhou, Bihui Liu, Anyun Zhang, Hongning Wang
The objective of this study was to investigate the co-occurrence of biofilms and quinolone resistance in Salmonella enterica serotype Typhimurium mediated by IncHI2-type oqxAB-positive plasmids. Among the 40 Salmonella strains, we found that 27 isolates formed biofilms and displayed identical multidrug-resistance profiles to ciprofloxacin, doxycycline, sulfamethoxazole-trimethoprim, ampicillin and streptomycin, based on biofilm formation assays and antimicrobial susceptibility testing. In particular, a single S...
June 18, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29926967/antileishmanial-activity-structure-activity-relationship-of-series-of-2-trifluoromethyl-benzo-b-1-8-naphthyridin-4-1h-ones
#2
Angel H Romero, Simon E López, Noris Rodríguez, Henry Oviedo
Trifluoromethyl-substituted quinolones and their analogues have emerged as an interesting platform in the last 6 years to design antiparasite agents. Many of their derivatives have been demonstrated to display excellent efficacy against flagellate parasites such as Plasmodium spp. In order to identify new analogues of trifluoromethyl-substituted quinolones to treat the American cutaneous leishmaniasis, we evaluated the antiproliferative activity of a series of 2-(trifluoromethyl)benzo[b]-[1,8]naphthyridin-4(1H)-ones on the Leishmania braziliensis and Leishmania mexicana parasites...
June 21, 2018: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29924770/potential-drug-drug-interactions-with-antimicrobials-in-hospitalized-patients-a-multicenter-point-prevalence-study
#3
Ferit Kuscu, Aslihan Ulu, Ayse S Inal, Bedia M Suntur, Hande Aydemir, Serdar Gul, Kenan Ecemis, Suheyla Komur, Behice Kurtaran, Ozlem Ozkan Kuscu, Yesim Tasova
BACKGROUND Improper use of antimicrobials can cause adverse drug events and high costs. The purpose of this study was to investigate the frequency and potential drug-drug interactions associated with antimicrobials among hospitalized patients. MATERIAL AND METHODS This study was conducted on the same day in 5 different hospitals in Turkey. We included patients aged ³18 years who received at least 1 antimicrobial drug and at least 1 of any other drug. The Micromedex® online drug reference system was used to control and describe the interactions...
June 20, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29924052/molecular-epidemiology-and-antimicrobial-susceptibility-of-human-clostridium-difficile-isolates-from-a-single-institution-in-northern-china
#4
Baoya Wang, Zhi Lv, Pingping Zhang, Jianrong Su
Because the epidemiology of Clostridium difficile infection (CDI) is region-specific, the present study was undertaken to examine the epidemiology of C difficile outbreaks in Beijing, China.Eighty nonduplicate isolates were collected from March, 2016 to December, 2016. The molecular type and phylogenetic analysis were evaluated by multilocus sequence typing (MLST). The minimum inhibitory concentrations (MICs) for 11 antibiotics and the resistance mechanisms were investigated.Sixty-five toxigenic strains (81...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29921060/-analysis-of-drug-sensitivity-of-staphylococcus-aureus-in-patients-with-chronic-sinusitis
#5
Y Liu, L Fan, Y Q Tang, Z Y Zhang
Objective: To investigate the prevalence and drug sensitivity of nasal Staphylococcus aureus infection in patients with chronic sinusitis and healthy controls. Method: Bacterial culture and drug sensitivity test were performed in 71 patients with CRS (experimental group) and 103 healthy controls (control group). The infection rate of Staphylococcus aureus and the sensitivity of the drug were analyzed based on these results. Result: Twenty-nine Staphylococcus aureus strains were isolated from 71 cases of patients in the experimental group, and the positive rate was 40...
June 5, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29916344/antimicrobial-resistance-in-pasteurellaceae-of-veterinary-origin
#6
Geovana B Michael, Janine T Bossé, Stefan Schwarz
Members of the highly heterogeneous family Pasteurellaceae cause a wide variety of diseases in humans and animals. Antimicrobial agents are the most powerful tools to control such infections. However, the acquisition of resistance genes, as well as the development of resistance-mediating mutations, significantly reduces the efficacy of the antimicrobial agents. This article gives a brief description of the role of selected members of the family Pasteurellaceae in animal infections and of the most recent data on the susceptibility status of such members...
May 2018: Microbiology Spectrum
https://www.readbyqxmd.com/read/29914953/genes-and-proteins-involved-in-qnrs1-induction
#7
Rubén Monárrez, Yin Wang, Yingmei Fu, Chun-Hsing Liao, Ryo Okumura, Molly R Braun, George A Jacoby, David C Hooper
Expression of the quinolone resistance gene qnrS1 is increased by quinolones, but, unlike induction of some other qnr genes, the bacterial SOS system is not involved and no lexA box is found upstream. Nonetheless, at least 205-bp of upstream sequence is required for induction to take place. An upstream sequence bound to beads trapped potential binding proteins from cell extracts that were identified by mass spectrometry as Dps, Fis, Ihf, Lrp, CysB, and YjhU. To further elucidate their role a reporter plasmid linking the qnrS1 upstream sequence to lacZ was introduced into cells of the Keio collection with single gene deletions and screened for lacZ expression...
June 18, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29913564/antibiotics-in-water-and-sediments-of-rivers-and-coastal-area-of-zhuhai-city-pearl-river-estuary-south-china
#8
Si Li, Wanzi Shi, Huimin Li, Nan Xu, Ruijie Zhang, Xuejiao Chen, Weiling Sun, Donghui Wen, Shanliang He, Jianguo Pan, Zhidong He, Yingying Fan
The occurrence, spatiotemporal distribution and ecological risks of 27 antibiotics in water and sediments from rivers and coastal area of Zhuhai, Pearl River estuary, south China were investigated. Higher concentrations of antibiotics were found in river water in dry season than those in wet season (p < 0.01), especially for quinolones (QNs) (6.36-463 ng/L) and aminoglycosides (AGs) (94.9-458 ng/L). In coastal water samples, the concentrations of antibiotics were up to 419 ng/L and 357 ng/L in dry season and wet season, respectively...
September 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29913103/inhibitory-effect-of-mixture-herbs-spices-on-formation-of-heterocyclic-amines-and-mutagenic-activity-of-grilled-beef
#9
Shabnam Sepahpour, Jinap Selamat, Alfi Khatib, Mohd Yazid Abdul Manap, Ahmad Faizal Abdull Razis
Natural antioxidants in spices and herbs have attracted considerable attention as potential inhibitors against the formation of mutagenic heterocyclic amines (HCAs) in heat processed meat. In this study, the inhibitory activity of four spices/herbs and their mixtures on HCAs formation in grilled beef were examined. A simplex centroid mixture design with four components comprising turmeric, curry leaf, torch ginger and lemon grass in 19 different proportions were applied on beef samples before grilling at 240 ºC for 10 min...
June 18, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29912980/prevalence-of-antibiotic-resistance-in-commensal-escherichia-coli-among-the-children-in-rural-hill-communities-of-northeast-india
#10
Ashish Kumar Singh, Saurav Das, Samer Singh, Varsha Rani Gajamer, Nilu Pradhan, Yangchen Doma Lepcha, Hare Krishna Tiwari
Commensal bacteria are the representative of the reservoir of antibiotic resistance genes present in a community. The usage of antibiotics along with the demographic factors is generally associated with an increase in antibiotics resistance in pathogens. Northeast (NE) India is untapped with regard to antibiotic resistance prevalence and spread. In the current study, the prevalence of antibiotic-resistant commensal Escherichia coli in pre-school and school-going children (n = 550, 1-14 years old) from the rural areas of the state of Sikkim-an NE Indian state, with respect to associated demographic factors was investigated...
2018: PloS One
https://www.readbyqxmd.com/read/29912252/-qnr-genes-in-enterobacteriaceae-isolated-from-at-a-hospital-in-venezuela
#11
José García, Dianny Martínez, Luisa Caña, Diorelis González, Lucy Rodríguez, Hectorina Rodulfo, Marcos De Donato, Militza Guzmán
BACKGROUND: Enterobacteria resistant to quinolones is increasing worldwide, including Venezuela. The mechanism for this resistance could be due to genes included in the chromosome or in transmissible plasmids. AIM: To evaluate the resistance to quinolones, coded by qnr genes present in enterobacteria species, isolated in the University Hospital of Cumana, Venezuela. METHODS: Antimicrobial susceptibility tests to quinolones, beta-lactams and aminoglycosides were carried out to all the isolates...
April 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29911761/antibiotic-exposure-in-the-community-and-resistance-patterns-of-escherichia-coli-community-acquired-bloodstream-infection
#12
Bat-Sheva Gottesman, Pnina Shitrit, Michal Katzir, Michal Chowers
BACKGROUND: Increasing antibiotic resistance in the community results in greater use of empiric broad spectrum antibiotics for patients at hospital admission. As a measure of antibiotic stewardship it is important to identify a patient population that can receive narrow spectrum antibiotics. OBJECTIVES: To evaluate resistance patterns of Escherichia coli bloodstream infection (BSI) from strictly community-acquired infection and the impact of recent antibiotic use on this resistance...
June 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29909794/comparative-efficacies-of-topical-antiseptic-eardrops-against-biofilms-from-methicillin-resistant-staphylococcus-aureus-and-quinolone-resistant-pseudomonas-aeruginosa
#13
C K Youn, Y Jun, E-R Jo, S-J Jang, H Song, S I Cho
OBJECTIVE: The present study aimed to compare the anti-biofilm activities of four commonly available antiseptic eardrops against biofilms from methicillin-resistant Staphylococcus aureus and quinolone-resistant Pseudomonas aeruginosa in vitro. METHODS: The anti-biofilm activities of 50 per cent Burow's solution, vinegar with water (1:1), 2 per cent acetic acid solution, and 4 per cent boric acid solution were evaluated using biofilm assays. Additionally, the anti-biofilm activities of the four antiseptic solutions against tympanostomy tube biofilms were compared using a scanning electron microscope...
June 18, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29909525/detection-of-different-%C3%AE-lactamases-encoding-genes-including-bla-ndm-and-plasmid-mediated-quinolone-resistance-genes-in-different-water-sources-from-brazil
#14
Danilo Garcia Sanchez, Fernanda Maciel de Melo, Eduardo Angelino Savazzi, Eliana Guedes Stehling
Bacterial resistance occurs by spontaneous mutations or horizontal gene transfer mediated by mobile genetic elements, which represents a great concern. Resistance to β-lactam antibiotics is mainly due to the production of β-lactamases, and an important mechanism of fluoroquinolone resistance is the acquisition plasmid determinants. The aim of this study was to verify the presence of β-lactamase-encoding genes and plasmid-mediated quinolone resistance genes in different water samples obtained from São Paulo state, Brazil...
June 16, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29904445/malignant-ventricular-arrhythmias-resulting-from-drug-induced-qtc-prolongation-a-retrospective-study
#15
Renato De Vecchis, Carmelina Ariano, Giuseppina Di Biase, Michel Noutsias
Background: Several drug classes (antiarrhythmics, antimicrobials, antidepressants, phenothiazines, opiates, prokinetics of digestive tract, etc.) have been related to ventricular hyperkinetic arrhythmias such as torsade de pointes (TdP). TdPs are usually heralded by an abnormal prolongation of heart rate-corrected QT interval on the electrocardiogram, so-called drug-induced long heart rate-corrected QT (diLQTc). We don't know to what extent the drug-induced QTc prolongation is able to predict malignant arrhythmias...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29903172/-antimicrobial-resistance-analysis-and-mechanism-of-salmonella-recovered-from-retail-chicken-carcasses-in-beijing-in-summer-2013
#16
Yujie Hu, Yingying He, Yao Bai, Fengqin Li, Jin Xu
OBJECTIVE: Research were carried out to determine the antimicrobial resistance and mechanism of Salmonella isolates recovered from retail chicken carcasses in Beijing in summer, 2013. METHODS: Broth microdilution method were used for antimicrobial susceptibility testing to obtain the minimal inhibitory concentration( MICs)against 11 antimicrobial compounds which belongs to 8 categories and 166 Salmonella strains isolated from 33 retail chicken carcasses in Beijing in summer, 2013 were tested...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29898575/vibrio-vulnificus-infection-a-persistent-threat-to-public-health
#17
Na Ra Yun, Dong-Min Kim
Vibrio vulnificus is a gram-negative bacterium that can cause serious, potentially fatal infections. V. vulnificus causes three distinct syndromes: an overwhelming primary septicemia caused by consuming contaminated seafood, wound infections acquired when an open wound is exposed to contaminated warm seawater, and gastrointestinal tract-limited infections. Case-fatality rates are higher than 50% for primary septicemia, and death typically occurs within 72 hours of hospitalization. Risk factors for V. vulnificus infection include chronic liver disease, alcoholism, and hematological disorders...
June 15, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29897796/antimicrobial-resistance-and-treatment-an-unmet-clinical-safety-need
#18
Matteo Bassetti, Alessandro Russo, Alessia Carnelutti, Alessandro La Rosa, Elda Righi
Introduction Infections due to multidrug-resistant (MDR) bacteria are burdened by high mortality rates. The development of new compounds to face the global threat of resistance is urgently needed. Combination regimens including "old" high-dose antimicrobials are currently limited by the risk of toxicity, resistance selection, and reduced efficacy. Following the Infectious Diseases Society of America call to develop 10 new antibacterials by 2020, new molecules are currently under development or have become available for use in clinical practice...
June 13, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29897533/comparative-genetic-characterization-of-third-generation-cephalosporin-resistant-escherichia-coli-from-chicken-meat-produced-by-integrated-broiler-operations-in-south-korea
#19
Kwang Won Seo, Yeong Bin Kim, Hye Young Jeon, Suk-Kyung Lim, Young Ju Lee
Vertical integration of the broiler industry allows producers to combine different biosecurity and sanitation practices, housing technologies, and feeding regimens to improve food safety. The objectives of this study were to determine the antimicrobial resistance pattern of β-lactamase-producing E. coli and to compare the characteristics of E. coli recovered from 7 different integrated broiler operations in South Korea. Among 200 chicken meat samples, 101 were observed to be positive for E. coli. However, the prevalence varied from 37...
April 20, 2018: Poultry Science
https://www.readbyqxmd.com/read/29896100/recent-initiatives-in-the-republic-of-srpska-to-enhance-appropriate-use-of-antibiotics-in-ambulatory-care-their-influence-and-implications
#20
Ljubica Bojanić, Vanda Marković-Peković, Ranko Škrbić, Nataša Stojaković, Mirjana Ðermanović, Janja Bojanić, Jurij Fürst, Amanj B Kurdi, Brian Godman
Introduction: There are increasing concerns world-wide with growing rates of antibiotic resistance necessitating urgent action. There have been a number of initiatives in the Republic of Srpska in recent years to address this and improve rational antibiotic prescribing and dispensing despite limited resources to fund multiple initiatives. Objective: Analyse antibiotic utilization patterns in the Republic of Srpska following these multiple initiatives as a basis for developing future programmes in the Republic if needed...
2018: Frontiers in Pharmacology
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