Hannah Felchle, Valentina Brunner, Tanja Groll, Caroline N Walther, Sophie M Nefzger, Antonio E Zaurito, Miguel G Silva, Julia Gissibl, Geoffrey J Topping, Laura Lansink Rotgerink, Dieter Saur, Katja Steiger, Stephanie E Combs, Markus Tschurtschenthaler, Julius C Fischer
PURPOSE: Preoperative (neoadjuvant) radiation therapy (RT) is an essential part of multimodal rectal cancer therapy. Recently, total neoadjuvant therapy (TNT) which combines simultaneous radio-chemotherapy with additional courses of chemotherapy (CTx) has emerged as an effective approach. TNT achieves a pathological complete remission in approximately 30% of resected patients, opening avenues for treatment strategies that avoid radical organ resection. Furthermore, recent studies have demonstrated that anti-PD-1 immunotherapy (IT) can induce clinical complete responses in patients with specific genetic alterations...
October 22, 2023: International Journal of Radiation Oncology, Biology, Physics