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Radiation induced liver disease

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https://www.readbyqxmd.com/read/28089215/radiation-induced-liver-disease-secondary-to-adjuvant-therapy-for-extra-hepatic-cholangiocarcinoma
#1
Armando Peixoto, Pedro Pereira, Renato Bessa de Melo, Guilherme Macedo
No abstract text is available yet for this article.
December 21, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28086942/external-beam-radiotherapy-for-unresectable-hepatocellular-carcinoma-an-international-multicenter-phase-i-trial-sakk-77-07-and-sasl-26
#2
Evelyn Herrmann, Diana Naehrig, Manfred Sassowsky, Martin Bigler, Jeroen Buijsen, Ilja Ciernik, Daniel Zwahlen, Alessandra Franzetti Pellanda, Andreas Meister, Peter Brauchli, Simona Berardi, Erika Kuettel, Jean-François Dufour, Daniel M Aebersold
PURPOSE: To assess feasibility and safety of conventionally fractionated radiotherapy (cfRT) in patients with hepatocellular carcinoma (HCC). METHODS: Patients with histologically confirmed stage cT1-4, cN0-1 HCC and Child-Pugh Score (CPS) A or B disease were included in a phase I multicenter trial. Metastatic HCC were allowed if ≥90% of total tumor volume was located within the liver. Patients were enrolled onto five dose-escalation levels (54-70Gy in 2Gy fractions) based on a modified 3 + 3 design, with cohorts of five patients instead of three patients in dose levels 4 and 5...
January 13, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28071340/respiration-induced-intraorgan-deformation-of-the-liver
#3
Anna K Paulsson, Sue S Yom, Mekhail Anwar, Dilini Pinnaduwage, Atchar Sudhyadhom, Alexander R Gottschalk, Albert J Chang, Martina Descovich
Stereotactic body radiation therapy is a well-tolerated modality for the treatment of primary and metastatic liver lesions, and fiducials are often used as surrogates for tumor tracking during treatment. We evaluated respiratory-induced liver deformation by measuring the rigidity of the fiducial configuration during the breathing cycle. Seventeen patients, with 18 distinct treatment courses, were treated with stereotactic body radiosurgery using multiple fiducials. Liver deformation was empirically quantified by measuring the intrafiducial distances at different phases of respiration...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28069018/intraoperative-radiation-therapy-iort-in-pancreatic-cancer
#4
REVIEW
Robert Krempien, Falk Roeder
Despite the important improvements made in the fields of surgery, chemotherapy and radiation therapy, pancreatic cancer remains one of the most lethal malignancies. Improved outcomes with novel chemotherapy regimes led again to increased attention on the role of localized radiotherapy, since local tumor progression causes significant morbidity and mortality in patients. Even after resection local failure rates are as high as 50-80%. The immediate proximity to critical structures (bone marrow, spinal cord, kidneys, liver, and intestine) limits the dose of radiation that can be administered to the tumor bed with conventional external beam radiation therapy (EBRT)...
January 10, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28058710/stereotactic-ablative-radiotherapy-for-patients-with-unresectable-or-medically-inoperable-cholangiocarcinoma
#5
Ming-Yueh Liu, Cheng-Hsiang Lo, Chun-Shu Lin, Hsing-Lung Chao, Jen-Fu Yang, Kuen-Tze Lin, Chao-Yueh Fan, Yu-Fu Su, Wen-Yen Huang
PURPOSE: The role of stereotactic ablative radiotherapy (SABR) in patients with unresectable or medically inoperable cholangiocarcinoma remains unclear. We examined the efficacy and safety of SABR in this group of patients. METHODS: From January 2008 to December 2014, 15 patients with 17 lesions were included in this study. The lesions included 14 intrahepatic, 1 hilar, and 2 distal bile duct tumors. Three patients were classified as medically inoperable because of old age or multiple comorbidities...
January 5, 2017: Tumori
https://www.readbyqxmd.com/read/28047582/su-g-206-16-investigation-of-dosimetric-consequence-via-cone-beam-ct-based-dose-reconstruction-in-hepatocellular-carcinoma-radiotherapy
#6
P Huang, H Li, J Chen, C Ma, Y Gang, S Qin, Y Yin, D Li
PURPOSE: Many patients with technically unresectable or medically inoperable hepatocellular carcinoma (HCC) had hepatic dosimetric variations as a result of inter-fraction anatomical deformation. This study was conducted to assess the hepatic dosimetric consequences via reconstructing weekly dose in HCC patients receiving three dimensional conformal radiation therapy. METHODS: Twenty-one HCC patients with 21 planning CT (pCT) scans and 63 weekly Cone-beam CT (CBCT) scans were enrolled in this investigation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047564/su-f-j-221-adjusted-dose-and-its-relation-to-radiation-induced-liver-disease-during-hepatocellular-carcinoma-radiotherapy
#7
P Huang, H Li, J Chen, C Ma, Y Gang, S Qin, Y Yin, D Li
PURPOSE: Many patients with hepatocellular carcinoma (HCC) had hepatic anatomy variations as a result of inter-fraction deformation during fractionated radiotherapy, which may result in difference from the planned dose. This study aimed to investigate the relationship between adjusted dose and radiation induced liver disease (RILD) in HCC patients receiving three dimensional conformal radiotherapy (3DCRT). METHODS: Twenty-three HCC patients received conventional fractionated 3DCRT were enrolled in this retrospective investigation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047463/su-f-t-103-analysis-of-hepatitis-b-virus-reactivation-after-conformal-radiotherapy-in-patients-with-hepatocellular-carcinoma-using-the-lyman-ntcp-model
#8
Z Li, W Huang, H Li, B Li
PURPOSE: The aim of this research was to investigate the feasibility of Lyman-Kutcher-Burman (LKB) normal tissue complication probability (NTCP) model in analyzing hepatitis B virus (HBV) reactivation in patients receiving conformal radiotherapy for patients with hepatocellular carcinoma (HCC). METHODS: Between June 2009 and June 2012, 108 HBV-related HCC patients (90 were specifically selected and 18 patients were excluded) treated with conformal RT at three centers were enrolled in this retrospective study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28004357/yttrium-90-radioembolization-for-colorectal-cancer-liver-metastases-a-prospective-cohort-study-on-circulating-angiogenic-factors-and-treatment-response
#9
C E N M Rosenbaum, A F van den Hoven, M N G J A Braat, M Koopman, M G E H Lam, B A Zonnenberg, H M Verkooijen, M A A J van den Bosch
BACKGROUND: Yttrium-90 radioembolization ((90)Y-RE) as a treatment for liver tumours induces radiation damage and hypoxia in liver tissue, which is also a trigger for systemic release of angiogenic factors, potentially stimulating tumour growth. We examined changes in circulating angiogenic factors following (90)Y-RE and investigated the association between response and angiogenic factors. In this prospective study, 42 patients with unresectable, chemorefractory metastatic colorectal cancer (CRCLM) were treated with (90)Y-RE...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27995093/new-perspectives-in-the-treatment-of-colorectal-metastases
#10
REVIEW
Dominique Elias, Luca Viganò, Franco Orsi, Marta Scorsetti, Tiziana Comito, Jan Lerut, Davide Cosola, Guido Torzilli
BACKGROUND: In recent years, the management of metastatic colorectal cancer has become more aggressive and more multidisciplinary. New treatment options have been proposed in addition to the standard approach of resection of liver metastases and chemotherapy. SUMMARY: Selected patients with synchronous limited peritoneal and liver disease (peritoneal cancer index <12 and <3 liver metastases) can be scheduled for aggressive treatment, including cytoreductive surgery, hyperthermic intraperitoneal chemotherapy, and liver resection...
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27931834/treatments-for-colorectal-liver-metastases-a-new-focus-on-a-familiar-concept
#11
REVIEW
M G Zampino, E Magni, P S Ravenda, C A Cella, G Bonomo, P Della Vigna, S Galdy, F Spada, G M Varano, G Mauri, N Fazio, F Orsi
A major challenge for the management of advanced-colorectal-cancer is the multidisciplinary approach required for the treatment of liver metastases. Reducing the burden of liver metastases with liver-directed therapy has an important impact on both survival and health-related quality of life. This paper debates the rationale and current liver-directed approaches for colorectal liver metastases based on the evidence of literature and new clinical trials. Surgery is the gold standard, when feasible, and it's the main treatment goal for patients with potentially-resectable disease as a means of prolonging progression-free survival...
December 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27926660/radioembolization-induced-liver-disease-a-systematic-review
#12
Manon N G J A Braat, Karel J van Erpecum, Bernard A Zonnenberg, Maurice A J van den Bosch, Marnix G E H Lam
Radioembolization (RE) is a relatively novel treatment modality for primary and secondary hepatic malignancies. Microspheres embedded with a β-emitting radioisotope are injected into the hepatic artery, resulting in microsphere deposition in the tumor arterioles and normal portal triads. Microsphere deposition in nontumorous parenchyma can result in radiation-induced liver injury, with lethal RE-induced liver disease (REILD) at the outer end of the spectrum. The primary aim of this study was to evaluate RE-related hepatotoxicity and present an overview of the currently applied definitions and clinically relevant characteristics of REILD...
February 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27855416/hedgehog-signaling-is-associated-with-liver-response-to-fractionated-irradiation-in-mice
#13
Jieun Kim, Sihyung Wang, Jeongeun Hyun, Cynthia D Guy, Youngmi Jung
BACKGROUND/AIMS: Radiation-induced liver disease (RILD) is a major obstacle in treating liver cancer; however, the mechanisms underlying RILD development remain unclear. Hedgehog (Hh) orchestrates liver response to injury. Herein, we investigated the liver response with Hh to fractionated irradiation (FI) using a small murine model for RILD. METHODS: Male mice exposed to liver-targeted FI with 6Gy in 5 consecutive weekly fractions were sacrificed at one day after weekly irradiation and 6 or 10 weeks post 5th FI for the acute and late response model, respectively...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27814485/ex-vivo-study-of-acoustic-radiation-force-impulse-imaging-elastography-for-evaluation-of-rat-liver-with-steatosis
#14
Yanrong Guo, Changfeng Dong, Haoming Lin, Xinyu Zhang, Huiying Wen, Yuanyuan Shen, Tianfu Wang, Siping Chen, Yingxia Liu, Xin Chen
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in developed countries. Accurate, noninvasive tests for diagnosing NAFLD are urgently needed. The goals of this study were to evaluate the utility of acoustic radiation force impulse (ARFI) elastography for determining the severity grade of steatosis in rat livers, and to investigate the changes in various histologic and biochemical characteristics. Steatosis was induced in the livers of 57 rats by gavage feeding of a high fat emulsion; 12 rats received a standard diet only and served as controls...
February 2017: Ultrasonics
https://www.readbyqxmd.com/read/27795503/role-of-inflammatory-macrophages-and-ccr9-ccl25-chemokine-axis-in-the-pathogenesis-of-liver-injury-as-a-therapeutic-target
#15
Nobuhiro Nakamoto
  It is widely known that a variety of immune cells in the liver contribute to the pathogenesis of liver diseases. Recently, roles of chemokines/chemokines receptors axes regarding the migration of immune competent cells to the inflamed liver have been reported as possible therapeutic targets. We here showed that CCR9(+) CD11b(+) macrophages play an important role during the course of Concanavalin A-induced murine acute liver injury as well as human acute hepatitis via the production of inflammatory cytokines and the Th1 induction...
2016: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/27765860/microarray-studies-on-211at-administration-in-balb-c-nude-mice-indicate-systemic-effects-on-transcriptional-regulation-in-non-thyroid-tissues
#16
Britta Langen, Nils Rudqvist, Khalil Helou, Eva B Forssell-Aronsson
INTRODUCTION: Targeted α-therapy is a promising treatment option for various types of malignant tumors. Radiolabeled cancer-seeking agents, however, undergo degradation resulting in a certain percentage of free radionuclide in the body. The radiohalogen (211)At accumulates in various tissues with specifically high uptake in the thyroid. When normal thyroid function is disturbed due to ionizing radiation (IR) exposure, deleterious effects can occur in tissues that depend on thyroid hormone (TH) regulation for normal physiological function...
October 20, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27699275/synergy-of-radiotherapy-and-pd-1-blockade-in-kras-mutant-lung-cancer
#17
Grit S Herter-Sprie, Shohei Koyama, Houari Korideck, Josephine Hai, Jiehui Deng, Yvonne Y Li, Kevin A Buczkowski, Aaron K Grant, Soumya Ullas, Kevin Rhee, Jillian D Cavanaugh, Neermala Poudel Neupane, Camilla L Christensen, Jan M Herter, G Mike Makrigiorgos, F Stephen Hodi, Gordon J Freeman, Glenn Dranoff, Peter S Hammerman, Alec C Kimmelman, Kwok-Kin Wong
Radiation therapy (RT), a critical modality in the treatment of lung cancer, induces direct tumor cell death and augments tumor-specific immunity. However, despite initial tumor control, most patients suffer from locoregional relapse and/or metastatic disease following RT. The use of immunotherapy in non-small-cell lung cancer (NSCLC) could potentially change this outcome by enhancing the effects of RT. Here, we report significant (up to 70% volume reduction of the target lesion) and durable (up to 12 weeks) tumor regressions in conditional Kras-driven genetically engineered mouse models (GEMMs) of NSCLC treated with radiotherapy and a programmed cell death 1 antibody (αPD-1)...
June 16, 2016: JCI Insight
https://www.readbyqxmd.com/read/27675202/adjusted-dose-and-the-relation-to-radiation-induced-liver-disease-during-liver-3-dimensional-conformal-radiation-therapy
#18
P Huang, D Li, D S Kapp, H Li, J Chen, C Ma, G Yu, S Qin, Y Yin, Y Yang, L Xing
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675062/a-mice-radiation-induced-liver-disease-model-for-stereotactic-body-radiation-therapy-validated-in-patients-with-hepatocellular-carcinoma
#19
Z F Wu, J Y Zhang, X Y Shen, L Y Zhou, Y B Gao, Y Hu, Z C Zeng
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27626826/long-term-effects-of-radiation-exposure-and-metabolic-status-on-telomere-length-of-peripheral-blood-t-cells-in-atomic-bomb-survivors
#20
Kengo Yoshida, Munechika Misumi, Yoshiko Kubo, Mika Yamaoka, Seishi Kyoizumi, Waka Ohishi, Tomonori Hayashi, Yoichiro Kusunoki
In a series of studies of atomic bomb survivors, radiation-dose-dependent alterations in peripheral T-cell populations have been reported. For example, reduced size in naïve T-cell pools and impaired proliferation ability of T cells were observed. Because these alterations are also generally observed with human aging, we hypothesized that radiation exposure may accelerate the aging process of the T-cell immune system. To further test this hypothesis, we conducted cross-sectional analyses of telomere length, a hallmark of cellular aging, of naïve and memory CD4 T cells and total CD8 T cells in the peripheral blood of 620 atomic bomb survivors as it relates to age and radiation dose, using fluorescence in situ hybridization with flow cytometry...
September 14, 2016: Radiation Research
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