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Radiation induced liver disease

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https://www.readbyqxmd.com/read/27855416/hedgehog-signaling-is-associated-with-liver-response-to-fractionated-irradiation-in-mice
#1
Jieun Kim, Sihyung Wang, Jeongeun Hyun, Cynthia D Guy, Youngmi Jung
BACKGROUND/AIMS: Radiation-induced liver disease (RILD) is a major obstacle in treating liver cancer; however, the mechanisms underlying RILD development remain unclear. Hedgehog (Hh) orchestrates liver response to injury. Herein, we investigated the liver response with Hh to fractionated irradiation (FI) using a small murine model for RILD. METHODS: Male mice exposed to liver-targeted FI with 6Gy in 5 consecutive weekly fractions were sacrificed at one day after weekly irradiation and 6 or 10 weeks post 5th FI for the acute and late response model, respectively...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27814485/ex-vivo-study-of-acoustic-radiation-force-impulse-imaging-elastography-for-evaluation-of-rat-liver-with-steatosis
#2
Yanrong Guo, Changfeng Dong, Haoming Lin, Xinyu Zhang, Huiying Wen, Yuanyuan Shen, Tianfu Wang, Siping Chen, Yingxia Liu, Xin Chen
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in developed countries. Accurate, noninvasive tests for diagnosing NAFLD are urgently needed. The goals of this study were to evaluate the utility of acoustic radiation force impulse (ARFI) elastography for determining the severity grade of steatosis in rat livers, and to investigate the changes in various histologic and biochemical characteristics. Steatosis was induced in the livers of 57 rats by gavage feeding of a high fat emulsion; 12 rats received a standard diet only and served as controls...
February 2017: Ultrasonics
https://www.readbyqxmd.com/read/27795503/role-of-inflammatory-macrophages-and-ccr9-ccl25-chemokine-axis-in-the-pathogenesis-of-liver-injury-as-a-therapeutic-target
#3
Nobuhiro Nakamoto
  It is widely known that a variety of immune cells in the liver contribute to the pathogenesis of liver diseases. Recently, roles of chemokines/chemokines receptors axes regarding the migration of immune competent cells to the inflamed liver have been reported as possible therapeutic targets. We here showed that CCR9(+) CD11b(+) macrophages play an important role during the course of Concanavalin A-induced murine acute liver injury as well as human acute hepatitis via the production of inflammatory cytokines and the Th1 induction...
2016: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/27765860/microarray-studies-on-211at-administration-in-balb-c-nude-mice-indicate-systemic-effects-on-transcriptional-regulation-in-non-thyroid-tissues
#4
Britta Langen, Nils Rudqvist, Khalil Helou, Eva B Forssell-Aronsson
INTRODUCTION: Targeted α-therapy is a promising treatment option for various types of malignant tumors. Radiolabeled cancer-seeking agents, however, undergo degradation resulting in a certain percentage of free radionuclide in the body. The radiohalogen (211)At accumulates in various tissues with specifically high uptake in the thyroid. When normal thyroid function is disturbed due to ionizing radiation (IR) exposure, deleterious effects can occur in tissues that depend on thyroid hormone (TH) regulation for normal physiological function...
October 20, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27699275/synergy-of-radiotherapy-and-pd-1-blockade-in-kras-mutant-lung-cancer
#5
Grit S Herter-Sprie, Shohei Koyama, Houari Korideck, Josephine Hai, Jiehui Deng, Yvonne Y Li, Kevin A Buczkowski, Aaron K Grant, Soumya Ullas, Kevin Rhee, Jillian D Cavanaugh, Neermala Poudel Neupane, Camilla L Christensen, Jan M Herter, G Mike Makrigiorgos, F Stephen Hodi, Gordon J Freeman, Glenn Dranoff, Peter S Hammerman, Alec C Kimmelman, Kwok-Kin Wong
Radiation therapy (RT), a critical modality in the treatment of lung cancer, induces direct tumor cell death and augments tumor-specific immunity. However, despite initial tumor control, most patients suffer from locoregional relapse and/or metastatic disease following RT. The use of immunotherapy in non-small-cell lung cancer (NSCLC) could potentially change this outcome by enhancing the effects of RT. Here, we report significant (up to 70% volume reduction of the target lesion) and durable (up to 12 weeks) tumor regressions in conditional Kras-driven genetically engineered mouse models (GEMMs) of NSCLC treated with radiotherapy and a programmed cell death 1 antibody (αPD-1)...
June 16, 2016: JCI Insight
https://www.readbyqxmd.com/read/27675202/adjusted-dose-and-the-relation-to-radiation-induced-liver-disease-during-liver-3-dimensional-conformal-radiation-therapy
#6
P Huang, D Li, D S Kapp, H Li, J Chen, C Ma, G Yu, S Qin, Y Yin, Y Yang, L Xing
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675062/a-mice-radiation-induced-liver-disease-model-for-stereotactic-body-radiation-therapy-validated-in-patients-with-hepatocellular-carcinoma
#7
Z F Wu, J Y Zhang, X Y Shen, L Y Zhou, Y B Gao, Y Hu, Z C Zeng
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27626826/long-term-effects-of-radiation-exposure-and-metabolic-status-on-telomere-length-of-peripheral-blood-t-cells-in-atomic-bomb-survivors
#8
Kengo Yoshida, Munechika Misumi, Yoshiko Kubo, Mika Yamaoka, Seishi Kyoizumi, Waka Ohishi, Tomonori Hayashi, Yoichiro Kusunoki
In a series of studies of atomic bomb survivors, radiation-dose-dependent alterations in peripheral T-cell populations have been reported. For example, reduced size in naïve T-cell pools and impaired proliferation ability of T cells were observed. Because these alterations are also generally observed with human aging, we hypothesized that radiation exposure may accelerate the aging process of the T-cell immune system. To further test this hypothesis, we conducted cross-sectional analyses of telomere length, a hallmark of cellular aging, of naïve and memory CD4 T cells and total CD8 T cells in the peripheral blood of 620 atomic bomb survivors as it relates to age and radiation dose, using fluorescence in situ hybridization with flow cytometry...
September 14, 2016: Radiation Research
https://www.readbyqxmd.com/read/27625896/focal-hepatic-fluorodeoxyglucose-uptake-mimics-liver-metastasis-following-external-beam-radiation-for-gastroesophageal-cancers-a-case-and-review-of-the-literature
#9
Randy Wei, Avinash Chaurasia, Suhong Yu, Chandana Lall, Samuel J Klempner
Patients with locally advanced gastroesophageal cancers frequently undergo concurrent chemotherapy and radiation (CRT). 18-fluorodeoxyglucose-positron emission tomography ((18)FDG-PET) in combination with computed tomography is used for disease staging and assessing response to therapy. (18)FDG-PET interpretation is subject to confounding influences including infectious/inflammatory conditions, serum glucose, and concurrent medications. Radiotherapy induces tissue damage, which may be associated with FDG-avidity; however, few reports have described the focal areas of hepatic uptake following concurrent chemoradiation (CRT)...
2016: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/27614200/using-a-self-organizing-map-to-analyse-liver-damage-in-mice-caused-by-radon-x-ray-or-alcohol-treatments
#10
Norie Kanzaki, Takahiro Kataoka, Reo Etani, Kaori Sasaoka, Akihiro Kanagawa, Kiyonori Yamaoka
In our previous studies, we found that low-dose radiation inhibits oxidative stress-induced diseases due to increased antioxidants. Although these effects of low-dose radiation were demonstrated, further research was needed to clarify the effects. However, the analysis of oxidative stress is challenging, especially that of low levels of oxidative stress, because antioxidative substances are intricately involved. Thus, we proposed an approach for analysing oxidative liver damage via use of a self-organizing map (SOM)-a novel and comprehensive technique for evaluating hepatic and antioxidative function...
September 10, 2016: Journal of Radiation Research
https://www.readbyqxmd.com/read/27566894/stereotactic-body-radiotherapy-for-primary-hepatic-malignancies-report-of-a-phase-i-ii-institutional-study
#11
Ashley A Weiner, Jeffrey Olsen, Daniel Ma, Pawel Dyk, Todd DeWees, Robert J Myerson, Parag Parikh
BACKGROUND AND PURPOSE: To report outcomes and toxicities of a single-institution phase I/II study of stereotactic body radiotherapy (SBRT) in the treatment of unresectable hepatocellular cancer (HCC) and intrahepatic cholangiocarcinoma (IHC). MATERIALS AND METHODS: Patients with Child-Pugh score less than 8 were eligible. A total of 32 lesions in 26 patients were treated with SBRT. Kaplan-Meier survival analysis was performed. Toxicities were graded by CTCAEv4 criteria and response was scored by EASL guidelines...
August 23, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27566310/stereotactic-ablative-radiotherapy-in-the-treatment-of-hepatocellular-carcinoma-3%C3%A2-cm
#12
Alessia Guarneri, Pierfrancesco Franco, Elisabetta Trino, Daniela Campion, Riccardo Faletti, Stefano Mirabella, Silvia Gaia, Riccardo Ragona, Margherita Diotallevi, Giorgio Saracco, Mauro Salizzoni, Umberto Ricardi, Patrizia Carucci
Stereotactic ablative radiotherapy (SABR) is a safe treatment approach for hepatocellular carcinoma (HCC) with comparable results to other local therapies. For lesions larger than 3 cm, no definitive standard treatment is present and several options are available. We retrospectively review local control (LC) and survival results of SABR in patients with HCC lesions >3 cm. Between 2012 and 2015, we treated 29 patients (39 lesions) having histological or radiological diagnosis of HCC and at least one lesion sized >3 cm...
October 2016: Medical Oncology
https://www.readbyqxmd.com/read/27541825/metabolic-profile-as-a-potential-modifier-of-long-term-radiation-effects-on-peripheral-lymphocyte-subsets-in-atomic-bomb-survivors
#13
Kengo Yoshida, Eiji Nakashima, Seishi Kyoizumi, Masayuki Hakoda, Tomonori Hayashi, Ayumi Hida, Waka Ohishi, Yoichiro Kusunoki
Immune system impairments reflected by the composition and function of circulating lymphocytes are still observed in atomic bomb survivors, and metabolic abnormalities including altered blood triglyceride and cholesterol levels have also been detected in such survivors. Based on closely related features of immune and metabolic profiles of individuals, we investigated the hypothesis that long-term effects of radiation exposure on lymphocyte subsets might be modified by metabolic profiles in 3,113 atomic bomb survivors who participated in health examinations at the Radiation Effect Research Foundation, Hiroshima and Nagasaki, in 2000-2002...
September 2016: Radiation Research
https://www.readbyqxmd.com/read/27499926/rapid-and-reliable-diagnosis-of-wilson-disease-using-x-ray-fluorescence
#14
Slávka Kaščáková, Cameron M Kewish, Stéphan Rouzière, Françoise Schmitt, Rodolphe Sobesky, Joël Poupon, Christophe Sandt, Bruno Francou, Andrea Somogyi, Didier Samuel, Emmanuel Jacquemin, Anne Dubart-Kupperschmitt, Tuan Huy Nguyen, Dominique Bazin, Jean-Charles Duclos-Vallée, Catherine Guettier, François Le Naour
Wilson's disease (WD) is a rare autosomal recessive disease due to mutations of the gene encoding the copper-transporter ATP7B. The diagnosis is hampered by the variability of symptoms induced by copper accumulation, the inconstancy of the pathognomonic signs and the absence of a reliable diagnostic test. We investigated the diagnostic potential of X-ray fluorescence (XRF) that allows quantitative analysis of multiple elements. Studies were performed on animal models using Wistar rats (n = 10) and Long Evans Cinnamon (LEC) rats (n = 11), and on human samples including normal livers (n = 10), alcohol cirrhosis (n = 8), haemochromatosis (n = 10), cholestasis (n = 6) and WD (n = 22)...
July 2016: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/27495217/diagnostic-hepatic-hemodynamic-techniques-safety-and-radiation-exposure
#15
Andrej Hari, Hari Kumar Nair, Andrea De Gottardi, Iris Baumgartner, Jean-François Dufour, Annalisa Berzigotti
BACKGROUND & AIMS: Hepatic venous pressure gradient (HVPG) and transjugular liver biopsy (TJLB) are increasingly used in the management of patients with liver disease. We aimed to describe the safety profile of these procedures, providing data on the intra- and peri-procedure complications, radiation exposure, and amount of iodinated contrast material used. METHODS: In 106 consecutive patients undergoing HVPG and TJLB data on fluoroscopy time (FT), absorbed radiation dose, equivalent effective dose (mSv), and volume of iodinated contrast material (ICM) were prospectively collected and reviewed, together with clinical and laboratory data...
August 6, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27485285/identifying-urinary-and-serum-exosome-biomarkers-for-radiation-exposure-using-a-data-dependent-acquisition-and-swath-ms-combined-workflow
#16
Shilpa Kulkarni, Antonius Koller, Kartik M Mani, Ruofeng Wen, Alan Alfieri, Subhrajit Saha, Jian Wang, Purvi Patel, Nuno Bandeira, Chandan Guha, Emily I Chen
PURPOSE: Early and accurate assessment of radiation injury by radiation-responsive biomarkers is critical for triage and early intervention. Biofluids such as urine and serum are convenient for such analysis. Recent research has also suggested that exosomes are a reliable source of biomarkers in disease progression. In the present study, we analyzed total urine proteome and exosomes isolated from urine or serum for potential biomarkers of acute and persistent radiation injury in mice exposed to lethal whole body irradiation (WBI)...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27479949/recurrence-of-epithelioid-hemangioendothelioma-during-pregnancy-case-report-and-systematic-review
#17
REVIEW
Michael Mcculloch, Michael Russin, Arian Nachat
INTRODUCTION: Epithelioid hemangioendothelioma (EHE) is a family of blood vessel tumors originating in blood vessels, bone, brain, kidney, liver, and lung. EHE is more common in women, and chemotherapy, radiation, and surgery have brought few successes. CASE PRESENTATION: We present a case of a 28-year-old woman whose EHE recurred during pregnancy, suggesting hormonal involvement. We conducted a systematic review to provide analysis and interpretation of the potential significance of her disease recurring, with fatal outcome, during pregnancy...
2016: Permanente Journal
https://www.readbyqxmd.com/read/27478545/therapeutic-effects-of-dihydroartemisinin-and-transferrin-against-glioblastoma
#18
Suk Hee Kim, Seong Hee Kang, Bo Sun Kang
BACKGROUND/OBJECTIVES: Artemisinin, a natural product isolated from Gaeddongssuk (artemisia annua L.) and its main active derivative, dihydroartemisinin (DHA), have long been used as antimalarial drugs. Recent studies reported that artemisinin is efficacious for curing diseases, including cancers, and for improving the immune system. Many researchers have shown the therapeutic effects of artemisinin on tumors such as breast cancer, liver cancer and kidney cancer, but there is still insufficient data regarding glioblastoma (GBM)...
August 2016: Nutrition Research and Practice
https://www.readbyqxmd.com/read/27435327/targeting-hepatic-fibrosis-in-autoimmune-hepatitis
#19
Aldo J Montano-Loza, Ragesh B Thandassery, Albert J Czaja
Hepatic fibrosis develops or progresses in 25 % of patients with autoimmune hepatitis despite corticosteroid therapy. Current management regimens lack reliable noninvasive methods to assess changes in hepatic fibrosis and interventions that disrupt fibrotic pathways. The goals of this review are to indicate promising noninvasive methods to monitor hepatic fibrosis in autoimmune hepatitis and identify anti-fibrotic interventions that warrant evaluation. Laboratory methods can differentiate cirrhosis from non-cirrhosis, but their accuracy in distinguishing changes in histological stage is uncertain...
November 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27431384/activation-of-the-jnk-c-jun-pathway-in-response-to-irradiation-facilitates-fas-ligand-secretion-in-hepatoma-cells-and-increases-hepatocyte-injury
#20
Yinying Dong, Xiaoyun Shen, Mingyan He, Zhifeng Wu, Qiongdan Zheng, Yaohui Wang, Yuhan Chen, Sifan Wu, Jiefeng Cui, Zhaochong Zeng
BACKGROUND: It is well established that some irradiated liver non-parenchymal cells secrete pro-inflammatory cytokines to facilitate the development of radiation-induced liver disease. However, little is known on whether the irradiated hepatoma cells-mediated non-irradiated hepatocyte injury occurs in HCC patients. Here, we elucidated the roles of the irradiated hepatoma cells in driving non-irradiated hepatocyte injury and its underlying mechanism. METHODS: SMMC7721 cells were cultured and divided into irradiated (4-Gy X-ray, R) and non-irradiated (NR) groups...
2016: Journal of Experimental & Clinical Cancer Research: CR
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