keyword
MENU ▼
Read by QxMD icon Read
search

RILD

keyword
https://www.readbyqxmd.com/read/28886981/-lung-dose-constraints-for-normo-fractionated-radiotherapy-and-for-stereotactic-body-radiation-therapy
#1
REVIEW
E Blais, B Pichon, A Mampuya, M Antoine, P Lagarde, G Kantor, C Breton-Callu, C Lefebvre, M Gerard, A Aamarcha, M Ozsahin, J Bourhis, P Maingon, I Troussier, N Pourel
Radiation-induced lung disease (RILD) is common after radiation therapy and represents cornerstone toxicities after treatment of thoracic malignancies. From a review of literature, the objective of this article was to summarize clinical and non-clinical parameters associated with the risk of RILD in the settings of normo-fractionated radiotherapy and stereotactic body radiation therapy (SBRT). For the treatment of lung cancers with a normo-fractionated treatment, the mean lung dose (MLD) should be below 15-20Gy...
October 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28865518/radiation-induced-liver-toxicity
#2
REVIEW
Pablo Munoz-Schuffenegger, Sylvia Ng, Laura A Dawson
The advent of highly conformal radiation therapy (RT) has defined a new role for RT in the treatment of both primary and metastatic liver cancer. Despite major advances in how RT is delivered, radiation-induced liver disease (RILD) remains a concern. Classic RILD, characterized by anicteric ascites and hepatomegaly, is unlikely to occur if treating to doses of ≤30Gy in 2Gy per fraction in patients with baseline Child-Pugh A liver function. On the other hand, nonclassic RILD is a spectrum of liver toxicity, including a general decline in liver function and elevation of liver enzymes...
October 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/28844122/clinical-significance-of-radiation-induced-liver-disease-after-stereotactic-body-radiation-therapy-for-hepatocellular-carcinoma
#3
Baek Gyu Jun, Young Don Kim, Gab Jin Cheon, Eun Seog Kim, Eunjin Jwa, Sang Gyune Kim, Young Seok Kim, Boo Sung Kim, Soung Won Jeong, Jae Young Jang, Sae Hwan Lee, Hong Soo Kim
Background/Aims: The aim of this study was to investigate parameters that predict radiation-induced liver disease (RILD) following stereotactic body radiotherapy (SBRT) in patients with hepatocellular carcinoma (HCC) and to identify the clinical significance of RILD. Methods: We retrospectively reviewed the medical records of 117 HCC patients who were treated by SBRT from March 2011 to February 2015. RILD was defined as elevated liver transaminases more than five times the upper normal limit or a worsening of Child-Pugh (CP) score by 2 within 3 months after SBRT...
August 28, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28774597/nintedanib-reduces-radiation-induced-microscopic-lung-fibrosis-but-this-cannot-be-monitored-by-ct-imaging-a-preclinical-study-with-a-high-precision-image-guided-irradiator
#4
Dirk De Ruysscher, Patrick Vincent Granton, Natasja Gaby Lieuwes, Stefan van Hoof, Lutz Wollin, Birgit Weynand, Anne-Marie Dingemans, Frank Verhaegen, Ludwig Dubois
BACKGROUND: Nintedanib has anti-fibrotic and anti-inflammatory activity and is approved for the treatment of idiopathic pulmonary fibrosis. The aim of this study was to noninvasively assess the efficacy of nintedanib in a mouse model of partial lung irradiation to prevent radiation-induced lung damage (RILD). METHODS: 266 C57BL/6 adult male mice were irradiated with a single radiation dose (0, 4, 8, 12, 16 or 20Gy) using parallel-opposed fields targeting the upper right lung using a precision image-guided small animal irradiator sparing heart and spine based on micro-CT images...
September 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28729640/radiation-induced-liver-disease-current-understanding-and-future-perspectives
#5
REVIEW
Jieun Kim, Youngmi Jung
Although radiotherapy (RT) is used for the treatment of cancers, including liver cancer, radiation-induced liver disease (RILD) has emerged as a major limitation of RT. Radiation-induced toxicities in nontumorous liver tissues are associated with the development of numerous symptoms that may limit the course of therapy or have serious chronic side effects, including late fibrosis. Although the clinical characteristics of RILD patients have been relatively well described, the understanding of RILD pathogenesis has been hampered by a lack of reliable animal models for RILD...
July 21, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28507460/validation-of-the-liver-mean-dose-in-terms-of-the-biological-effective-dose-for-the-prevention-of-radiation-induced-liver-damage
#6
Hiroshi Doi, Norihisa Masai, Kenji Uemoto, Osamu Suzuki, Hiroya Shiomi, Daisaku Tatsumi, Ryoong-Jin Oh
AIM: The purpose of this study was to determine the optimal mean liver biologically effective dose (BED) to prevent radiation-induced liver disease (RILD) in stereotactic body radiation therapy (SBRT). BACKGROUND: The actual mean doses appropriate for liver irradiation in modern radiotherapy techniques have not been adequately investigated, although SBRT is sometimes alternatively performed using fractionated regimens. MATERIALS AND METHODS: SBRT treatment plans for liver tumors in 50 patients were analyzed...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28490985/imaged-guided-liver-stereotactic-body-radiotherapy-using-vmat-and-real-time-adaptive-tumor-gating-concerns-about-technique-and-preliminary-clinical-results
#7
Carmen Llacer-Moscardo, Olivier Riou, David Azria, Ludovic Bedos, Norbert Ailleres, Francois Quenet, Philippe Rouanet, Marc Ychou, Pascal Fenoglietto
BACKGROUND: Motion management is a major challenge in abdominal SBRT. We present our study of SBRT for liver tumors using intrafraction motion review (IMR) allowing simultaneous KV information and MV delivery to synchronize the beam during gated RapidArc treatment. MATERIALS AND METHODS: Between May 2012 and March 2015, 41 patients were treated by liver SBRT using gated RapidArc technique in a Varian Novalis Truebeam STx linear accelerator. PTV was created by expanding 5 mm from the ITV...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28490979/dose-to-organ-at-risk-and-dose-prescription-in-liver-sbrt
#8
REVIEW
Rives Michel, Izar Françoise, Parent Laure, Modesto Anouchka, Portier Guillaume, Kirzin Sylvain
Stereotactic body radiation therapy (SBRT) is delivered in a curative intent to many primary and secondary tumors. Concerning liver metastasis, SBRT can be safely delivered using one to five fractions. An excellent local control is obtained with doses from 20 to 60 Gy. For primary hepatic tumors, results are also good, but the risk of hepatic toxicity related to liver pre-existent pathology must be taken into account. Radiation induced liver disease (RILD) is not frequent in its classical presentation, but modifications of liver enzymes are often observed...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28442242/dosimetric-analysis-of-liver-toxicity-after-liver-metastasis-stereotactic-body-radiation-therapy
#9
Aisling Barry, Andrew McPartlin, Patricia Lindsay, Lisa Wang, James Brierley, John Kim, Jolie Ringash, Rebecca Wong, Rob Dinniwell, Tim Craig, Laura A Dawson
PURPOSE: The aim of this study is to describe the incidence and type of liver toxicity seen following liver metastases stereotactic body radiation therapy (SBRT) and the corresponding clinical and dosimetric factors associated with toxicity. METHODS AND MATERIALS: Between 2002 and 2009, 81 evaluable patients with liver metastases were treated on 2 prospective studies assessing SBRT, with prescription doses based on the effective liver volume irradiated evaluated...
September 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28366501/analysis-of-repeated-proton-beam-therapy-for-patients-with-hepatocellular-carcinoma
#10
Yoshiko Oshiro, Masashi Mizumoto, Toshiyuki Okumura, Kuniaki Fukuda, Nobuyoshi Fukumitsu, Masato Abei, Hitoshi Ishikawa, Daichi Takizawa, Hideyuki Sakurai
PURPOSE: To evaluate the feasibility and efficacy of repeated proton beam therapy (PBT) and to analyze the dose-volume relationship. PATIENTS AND METHODS: A retrospective analysis was performed in 83 patients who received definitive repeated PBT. Proton beams were delivered with expiratory gating. The numbers of treatment courses were 2, 3, and 4 in 68, 12, and 3 patients, respectively. MIM software was used for dose analysis. RESULTS: The planned median total dose was 70...
May 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28339533/pneumocystis-pneumonia-versus-rituximab-induced-interstitial-lung-disease-in-lymphoma-patients-receiving-rituximab-containing-chemotherapy
#11
Se Yoon Park, Mi Young Kim, Won Jin Choi, Dok Hyun Yoon, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Cheolwon Suh, Jun Hee Woo, Sung-Han Kim
It is difficult to differentiate Pneumocystis pneumonia (PCP) from rituximab-induced interstitial lung disease (RILD) in lymphoma patients with diffuse pulmonary infiltrates who are receiving rituximab-containing chemotherapy. Using a clinical scoring system, we aim to differentiate PCP from RILD who are receiving rituximab-containing chemotherapy. We reviewed the medical records of lymphoma patients who had received rituximab-containing chemotherapy between 2012 and 2015 in a tertiary hospital. Among 613 lymphoma patients receiving rituximab-containing chemotherapy, 97 (16%) had diffuse pulmonary infiltrates...
June 1, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28291931/investigation-of-dosimetric-variations-of-liver-radiotherapy-using-deformable-registration-of-planning-ct-and-cone-beam-ct
#12
Pu Huang, Gang Yu, Jinhu Chen, Changsheng Ma, Shaohua Qin, Yong Yin, Yueqiang Liang, Hongsheng Li, Dengwang Li
Many patients with technically unresectable or medically inoperable hepatocellular carcinoma (HCC) had hepatic anatomy variations as a result of interfraction deformation during fractionated radiotherapy. We conducted this retrospective study to investigate interfractional normal liver dosimetric consequences via reconstructing weekly dose in HCC patients. Twenty-three patients with HCC received conventional fractionated three-dimensional conformal radiation therapy (3DCRT) were enrolled in this retrospective investigation...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28130353/gene-expression-profiles-among-murine-strains-segregate-with-distinct-differences-in-the-progression-of-radiation-induced-lung-disease
#13
Isabel L Jackson, Fitsum Baye, Chirayu P Goswami, Barry P Katz, Andrew Zodda, Radmila Pavlovic, Ganga Gurung, Don Winans, Zeljko Vujaskovic
Molecular mechanisms underlying development of acute pneumonitis and/or late fibrosis following thoracic irradiation remain poorly understood. Here, we hypothesize that heterogeneity in disease progression and phenotypic expression of radiation-induced lung disease (RILD) across murine strains presents an opportunity to better elucidate mechanisms driving tissue response toward pneumonitis and/or fibrosis. Distinct differences in disease progression were observed in age- and sex-matched CBA/J, C57L/J and C57BL/6J mice over 1 year after graded doses of whole-thorax lung irradiation (WTLI)...
April 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28123916/stereotactic-body-radiotherapy-for-inoperable-liver-tumors-results-of-a-single-institutional-experience
#14
Hussam Hijazi, Marie-Pierre Campeau, David Roberge, David Donath, Real Lapointe, Franck Vandenbroucke-Menu, Daniel Taussky, Karim Boudam, Gabriel Chan, Alexis Bujold, Guila Delouya
OBJECTIVES: Stereotactic body radiation therapy (SBRT) is an emerging treatment option for liver tumors unsuitable for ablation or surgery. We report our experience with SBRT in the treatment of liver tumors. MATERIALS AND METHODS: Patients with primary or secondary liver cancer were identified in our local SBRT database. Patients were included irrespective of prior liver-directed therapies. The primary endpoint of our review was in-field local control (LC). Secondary endpoints were progression-free survival (PFS), overall survival (OS), and toxicity...
December 20, 2016: Curēus
https://www.readbyqxmd.com/read/28086942/external-beam-radiotherapy-for-unresectable-hepatocellular-carcinoma-an-international-multicenter-phase-i-trial-sakk-77-07-and-sasl-26
#15
MULTICENTER STUDY
Evelyn Herrmann, Diana Naehrig, Manfred Sassowsky, Martin Bigler, Jeroen Buijsen, Ilja Ciernik, Daniel Zwahlen, Alessandra Franzetti Pellanda, Andreas Meister, Peter Brauchli, Simona Berardi, Erika Kuettel, Jean-François Dufour, Daniel M Aebersold
PURPOSE: To assess feasibility and safety of conventionally fractionated radiotherapy (cfRT) in patients with hepatocellular carcinoma (HCC). METHODS: Patients with histologically confirmed stage cT1-4, cN0-1 HCC and Child-Pugh Score (CPS) A or B disease were included in a phase I multicenter trial. Metastatic HCC were allowed if ≥90% of total tumor volume was located within the liver. Patients were enrolled onto five dose-escalation levels (54-70Gy in 2Gy fractions) based on a modified 3 + 3 design, with cohorts of five patients instead of three patients in dose levels 4 and 5...
January 13, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28047582/su-g-206-16-investigation-of-dosimetric-consequence-via-cone-beam-ct-based-dose-reconstruction-in-hepatocellular-carcinoma-radiotherapy
#16
P Huang, H Li, J Chen, C Ma, Y Gang, S Qin, Y Yin, D Li
PURPOSE: Many patients with technically unresectable or medically inoperable hepatocellular carcinoma (HCC) had hepatic dosimetric variations as a result of inter-fraction anatomical deformation. This study was conducted to assess the hepatic dosimetric consequences via reconstructing weekly dose in HCC patients receiving three dimensional conformal radiation therapy. METHODS: Twenty-one HCC patients with 21 planning CT (pCT) scans and 63 weekly Cone-beam CT (CBCT) scans were enrolled in this investigation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047564/su-f-j-221-adjusted-dose-and-its-relation-to-radiation-induced-liver-disease-during-hepatocellular-carcinoma-radiotherapy
#17
P Huang, H Li, J Chen, C Ma, Y Gang, S Qin, Y Yin, D Li
PURPOSE: Many patients with hepatocellular carcinoma (HCC) had hepatic anatomy variations as a result of inter-fraction deformation during fractionated radiotherapy, which may result in difference from the planned dose. This study aimed to investigate the relationship between adjusted dose and radiation induced liver disease (RILD) in HCC patients receiving three dimensional conformal radiotherapy (3DCRT). METHODS: Twenty-three HCC patients received conventional fractionated 3DCRT were enrolled in this retrospective investigation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047463/su-f-t-103-analysis-of-hepatitis-b-virus-reactivation-after-conformal-radiotherapy-in-patients-with-hepatocellular-carcinoma-using-the-lyman-ntcp-model
#18
Z Li, W Huang, H Li, B Li
PURPOSE: The aim of this research was to investigate the feasibility of Lyman-Kutcher-Burman (LKB) normal tissue complication probability (NTCP) model in analyzing hepatitis B virus (HBV) reactivation in patients receiving conformal radiotherapy for patients with hepatocellular carcinoma (HCC). METHODS: Between June 2009 and June 2012, 108 HBV-related HCC patients (90 were specifically selected and 18 patients were excluded) treated with conformal RT at three centers were enrolled in this retrospective study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27855416/hedgehog-signaling-is-associated-with-liver-response-to-fractionated-irradiation-in-mice
#19
Jieun Kim, Sihyung Wang, Jeongeun Hyun, Cynthia D Guy, Youngmi Jung
BACKGROUND/AIMS: Radiation-induced liver disease (RILD) is a major obstacle in treating liver cancer; however, the mechanisms underlying RILD development remain unclear. Hedgehog (Hh) orchestrates liver response to injury. Herein, we investigated the liver response with Hh to fractionated irradiation (FI) using a small murine model for RILD. METHODS: Male mice exposed to liver-targeted FI with 6Gy in 5 consecutive weekly fractions were sacrificed at one day after weekly irradiation and 6 or 10 weeks post 5th FI for the acute and late response model, respectively...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27733321/human-hepatocytes-loaded-in-3d-bioprinting-generate-mini-liver
#20
Cheng Zhong, Hai-Yang Xie, Lin Zhou, Xiao Xu, Shu-Sen Zheng
BACKGROUND: Because of an increasing discrepancy between the number of potential liver graft recipients and the number of organs available, scientists are trying to create artificial liver to mimic normal liver function and therefore, to support the patient's liver when in dysfunction. 3D printing technique meets this purpose. The present study was to test the feasibility of 3D hydrogel scaffolds for liver engineering. METHODS: We fabricated 3D hydrogel scaffolds with a bioprinter...
October 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
keyword
keyword
104109
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"