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https://www.readbyqxmd.com/read/28507460/validation-of-the-liver-mean-dose-in-terms-of-the-biological-effective-dose-for-the-prevention-of-radiation-induced-liver-damage
#1
Hiroshi Doi, Norihisa Masai, Kenji Uemoto, Osamu Suzuki, Hiroya Shiomi, Daisaku Tatsumi, Ryoong-Jin Oh
AIM: The purpose of this study was to determine the optimal mean liver biologically effective dose (BED) to prevent radiation-induced liver disease (RILD) in stereotactic body radiation therapy (SBRT). BACKGROUND: The actual mean doses appropriate for liver irradiation in modern radiotherapy techniques have not been adequately investigated, although SBRT is sometimes alternatively performed using fractionated regimens. MATERIALS AND METHODS: SBRT treatment plans for liver tumors in 50 patients were analyzed...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28490985/imaged-guided-liver-stereotactic-body-radiotherapy-using-vmat-and-real-time-adaptive-tumor-gating-concerns-about-technique-and-preliminary-clinical-results
#2
Carmen Llacer-Moscardo, Olivier Riou, David Azria, Ludovic Bedos, Norbert Ailleres, Francois Quenet, Philippe Rouanet, Marc Ychou, Pascal Fenoglietto
BACKGROUND: Motion management is a major challenge in abdominal SBRT. We present our study of SBRT for liver tumors using intrafraction motion review (IMR) allowing simultaneous KV information and MV delivery to synchronize the beam during gated RapidArc treatment. MATERIALS AND METHODS: Between May 2012 and March 2015, 41 patients were treated by liver SBRT using gated RapidArc technique in a Varian Novalis Truebeam STx linear accelerator. PTV was created by expanding 5 mm from the ITV...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28490979/dose-to-organ-at-risk-and-dose-prescription-in-liver-sbrt
#3
REVIEW
Rives Michel, Izar Françoise, Parent Laure, Modesto Anouchka, Portier Guillaume, Kirzin Sylvain
Stereotactic body radiation therapy (SBRT) is delivered in a curative intent to many primary and secondary tumors. Concerning liver metastasis, SBRT can be safely delivered using one to five fractions. An excellent local control is obtained with doses from 20 to 60 Gy. For primary hepatic tumors, results are also good, but the risk of hepatic toxicity related to liver pre-existent pathology must be taken into account. Radiation induced liver disease (RILD) is not frequent in its classical presentation, but modifications of liver enzymes are often observed...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28442242/dosimetric-analysis-of-liver-toxicity-after-liver-metastasis-stereotactic-body-radiation-therapy
#4
Aisling Barry, Andrew McPartlin, Patricia Lindsay, Lisa Wang, James Brierley, John Kim, Jolie Ringash, Rebecca Wong, Rob Dinniwell, Tim Craig, Laura A Dawson
PURPOSE: The aim of this study is to describe the incidence and type of liver toxicity seen following liver metastases stereotactic body radiation therapy (SBRT) and the corresponding clinical and dosimetric factors associated with toxicity. METHODS AND MATERIALS: Between 2002 and 2009, 81 evaluable patients with liver metastases were treated on 2 prospective studies assessing SBRT, with prescription doses based on the effective liver volume irradiated evaluated...
March 9, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28366501/analysis-of-repeated-proton-beam-therapy-for-patients-with-hepatocellular-carcinoma
#5
Yoshiko Oshiro, Masashi Mizumoto, Toshiyuki Okumura, Kuniaki Fukuda, Nobuyoshi Fukumitsu, Masato Abei, Hitoshi Ishikawa, Daichi Takizawa, Hideyuki Sakurai
PURPOSE: To evaluate the feasibility and efficacy of repeated proton beam therapy (PBT) and to analyze the dose-volume relationship. PATIENTS AND METHODS: A retrospective analysis was performed in 83 patients who received definitive repeated PBT. Proton beams were delivered with expiratory gating. The numbers of treatment courses were 2, 3, and 4 in 68, 12, and 3 patients, respectively. MIM software was used for dose analysis. RESULTS: The planned median total dose was 70...
May 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28339533/pneumocystis-pneumonia-versus-rituximab-induced-interstitial-lung-disease-in-lymphoma-patients-receiving-rituximab-containing-chemotherapy
#6
Se Yoon Park, Mi Young Kim, Won Jin Choi, Dok Hyun Yoon, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Cheolwon Suh, Jun Hee Woo, Sung-Han Kim
It is difficult to differentiate Pneumocystis pneumonia (PCP) from rituximab-induced interstitial lung disease (RILD) in lymphoma patients with diffuse pulmonary infiltrates who are receiving rituximab-containing chemotherapy. Using a clinical scoring system, we aim to differentiate PCP from RILD who are receiving rituximab-containing chemotherapy. We reviewed the medical records of lymphoma patients who had received rituximab-containing chemotherapy between 2012 and 2015 in a tertiary hospital. Among 613 lymphoma patients receiving rituximab-containing chemotherapy, 97 (16%) had diffuse pulmonary infiltrates...
June 1, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28291931/investigation-of-dosimetric-variations-of-liver-radiotherapy-using-deformable-registration-of-planning-ct-and-cone-beam-ct
#7
Pu Huang, Gang Yu, Jinhu Chen, Changsheng Ma, Shaohua Qin, Yong Yin, Yueqiang Liang, Hongsheng Li, Dengwang Li
Many patients with technically unresectable or medically inoperable hepatocellular carcinoma (HCC) had hepatic anatomy variations as a result of interfraction deformation during fractionated radiotherapy. We conducted this retrospective study to investigate interfractional normal liver dosimetric consequences via reconstructing weekly dose in HCC patients. Twenty-three patients with HCC received conventional fractionated three-dimensional conformal radiation therapy (3DCRT) were enrolled in this retrospective investigation...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28130353/gene-expression-profiles-among-murine-strains-segregate-with-distinct-differences-in-the-progression-of-radiation-induced-lung-disease
#8
Isabel L Jackson, Fitsum Baye, Chirayu P Goswami, Barry P Katz, Andrew Zodda, Radmila Pavlovic, Ganga Gurung, Don Winans, Zeljko Vujaskovic
Molecular mechanisms underlying development of acute pneumonitis and/or late fibrosis following thoracic irradiation remain poorly understood. Here, we hypothesize that heterogeneity in disease progression and phenotypic expression of radiation-induced lung disease (RILD) across murine strains presents an opportunity to better elucidate mechanisms driving tissue response toward pneumonitis and/or fibrosis. Distinct differences in disease progression were observed in age- and sex-matched CBA/J, C57L/J and C57BL/6J mice over 1 year after graded doses of whole-thorax lung irradiation (WTLI)...
April 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28123916/stereotactic-body-radiotherapy-for-inoperable-liver-tumors-results-of-a-single-institutional-experience
#9
Hussam Hijazi, Marie-Pierre Campeau, David Roberge, David Donath, Real Lapointe, Franck Vandenbroucke-Menu, Daniel Taussky, Karim Boudam, Gabriel Chan, Alexis Bujold, Guila Delouya
OBJECTIVES: Stereotactic body radiation therapy (SBRT) is an emerging treatment option for liver tumors unsuitable for ablation or surgery. We report our experience with SBRT in the treatment of liver tumors. MATERIALS AND METHODS: Patients with primary or secondary liver cancer were identified in our local SBRT database. Patients were included irrespective of prior liver-directed therapies. The primary endpoint of our review was in-field local control (LC). Secondary endpoints were progression-free survival (PFS), overall survival (OS), and toxicity...
December 20, 2016: Curēus
https://www.readbyqxmd.com/read/28086942/external-beam-radiotherapy-for-unresectable-hepatocellular-carcinoma-an-international-multicenter-phase-i-trial-sakk-77-07-and-sasl-26
#10
Evelyn Herrmann, Diana Naehrig, Manfred Sassowsky, Martin Bigler, Jeroen Buijsen, Ilja Ciernik, Daniel Zwahlen, Alessandra Franzetti Pellanda, Andreas Meister, Peter Brauchli, Simona Berardi, Erika Kuettel, Jean-François Dufour, Daniel M Aebersold
PURPOSE: To assess feasibility and safety of conventionally fractionated radiotherapy (cfRT) in patients with hepatocellular carcinoma (HCC). METHODS: Patients with histologically confirmed stage cT1-4, cN0-1 HCC and Child-Pugh Score (CPS) A or B disease were included in a phase I multicenter trial. Metastatic HCC were allowed if ≥90% of total tumor volume was located within the liver. Patients were enrolled onto five dose-escalation levels (54-70Gy in 2Gy fractions) based on a modified 3 + 3 design, with cohorts of five patients instead of three patients in dose levels 4 and 5...
January 13, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28047582/su-g-206-16-investigation-of-dosimetric-consequence-via-cone-beam-ct-based-dose-reconstruction-in-hepatocellular-carcinoma-radiotherapy
#11
P Huang, H Li, J Chen, C Ma, Y Gang, S Qin, Y Yin, D Li
PURPOSE: Many patients with technically unresectable or medically inoperable hepatocellular carcinoma (HCC) had hepatic dosimetric variations as a result of inter-fraction anatomical deformation. This study was conducted to assess the hepatic dosimetric consequences via reconstructing weekly dose in HCC patients receiving three dimensional conformal radiation therapy. METHODS: Twenty-one HCC patients with 21 planning CT (pCT) scans and 63 weekly Cone-beam CT (CBCT) scans were enrolled in this investigation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047564/su-f-j-221-adjusted-dose-and-its-relation-to-radiation-induced-liver-disease-during-hepatocellular-carcinoma-radiotherapy
#12
P Huang, H Li, J Chen, C Ma, Y Gang, S Qin, Y Yin, D Li
PURPOSE: Many patients with hepatocellular carcinoma (HCC) had hepatic anatomy variations as a result of inter-fraction deformation during fractionated radiotherapy, which may result in difference from the planned dose. This study aimed to investigate the relationship between adjusted dose and radiation induced liver disease (RILD) in HCC patients receiving three dimensional conformal radiotherapy (3DCRT). METHODS: Twenty-three HCC patients received conventional fractionated 3DCRT were enrolled in this retrospective investigation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047463/su-f-t-103-analysis-of-hepatitis-b-virus-reactivation-after-conformal-radiotherapy-in-patients-with-hepatocellular-carcinoma-using-the-lyman-ntcp-model
#13
Z Li, W Huang, H Li, B Li
PURPOSE: The aim of this research was to investigate the feasibility of Lyman-Kutcher-Burman (LKB) normal tissue complication probability (NTCP) model in analyzing hepatitis B virus (HBV) reactivation in patients receiving conformal radiotherapy for patients with hepatocellular carcinoma (HCC). METHODS: Between June 2009 and June 2012, 108 HBV-related HCC patients (90 were specifically selected and 18 patients were excluded) treated with conformal RT at three centers were enrolled in this retrospective study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27855416/hedgehog-signaling-is-associated-with-liver-response-to-fractionated-irradiation-in-mice
#14
Jieun Kim, Sihyung Wang, Jeongeun Hyun, Cynthia D Guy, Youngmi Jung
BACKGROUND/AIMS: Radiation-induced liver disease (RILD) is a major obstacle in treating liver cancer; however, the mechanisms underlying RILD development remain unclear. Hedgehog (Hh) orchestrates liver response to injury. Herein, we investigated the liver response with Hh to fractionated irradiation (FI) using a small murine model for RILD. METHODS: Male mice exposed to liver-targeted FI with 6Gy in 5 consecutive weekly fractions were sacrificed at one day after weekly irradiation and 6 or 10 weeks post 5th FI for the acute and late response model, respectively...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27733321/human-hepatocytes-loaded-in-3d-bioprinting-generate-mini-liver
#15
Cheng Zhong, Hai-Yang Xie, Lin Zhou, Xiao Xu, Shu-Sen Zheng
BACKGROUND: Because of an increasing discrepancy between the number of potential liver graft recipients and the number of organs available, scientists are trying to create artificial liver to mimic normal liver function and therefore, to support the patient's liver when in dysfunction. 3D printing technique meets this purpose. The present study was to test the feasibility of 3D hydrogel scaffolds for liver engineering. METHODS: We fabricated 3D hydrogel scaffolds with a bioprinter...
October 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/27567554/imaging-after-radiation-therapy-of-thoracic-tumors
#16
B Ghaye, M Wanet, M El Hajjam
Radiation-induced lung disease (RILD) is frequent after therapeutic irradiation of thoracic malignancies. Many technique-, treatment-, tumor- and patient-related factors influence the degree of injury sustained by the lung after irradiation. Based on the time interval after the completion of the treatment RILD presents as early and late features characterized by inflammatory and fibrotic changes, respectively. They are usually confined to the radiation port. Though the typical pattern of RILD is easily recognized after conventional two-dimensional radiation therapy (RT), RILD may present with atypical patterns after more recent types of three- or four-dimensional RT treatment...
October 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27566894/stereotactic-body-radiotherapy-for-primary-hepatic-malignancies-report-of-a-phase-i-ii-institutional-study
#17
Ashley A Weiner, Jeffrey Olsen, Daniel Ma, Pawel Dyk, Todd DeWees, Robert J Myerson, Parag Parikh
BACKGROUND AND PURPOSE: To report outcomes and toxicities of a single-institution phase I/II study of stereotactic body radiotherapy (SBRT) in the treatment of unresectable hepatocellular cancer (HCC) and intrahepatic cholangiocarcinoma (IHC). MATERIALS AND METHODS: Patients with Child-Pugh score less than 8 were eligible. A total of 32 lesions in 26 patients were treated with SBRT. Kaplan-Meier survival analysis was performed. Toxicities were graded by CTCAEv4 criteria and response was scored by EASL guidelines...
October 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27511851/a-voxel-based-approach-to-explore-local-dose-differences-associated-with-radiation-induced-lung-damage
#18
Giuseppe Palma, Serena Monti, Vittoria D'Avino, Manuel Conson, Raffaele Liuzzi, Maria Cristina Pressello, Vittorio Donato, Joseph O Deasy, Mario Quarantelli, Roberto Pacelli, Laura Cella
PURPOSE: To apply a voxel-based (VB) approach aimed at exploring local dose differences associated with late radiation-induced lung damage (RILD). METHODS AND MATERIALS: An interinstitutional database of 98 patients who were Hodgkin lymphoma (HL) survivors treated with postchemotherapy supradiaphragmatic radiation therapy was analyzed in the study. Eighteen patients experienced late RILD, classified according to the Radiation Therapy Oncology Group scoring system...
September 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27447803/stereotactic-ablative-radiation-therapy-prior-to-liver-transplantation-in-hepatocellular-carcinoma
#19
Alessia Guarneri, Pierfrancesco Franco, Renato Romagnoli, Elisabetta Trino, Stefano Mirabella, Luca Molinaro, Giorgia Rizza, Andrea Riccardo Filippi, Patrizia Carucci, Mauro Salizzoni, Umberto Ricardi
OBJECTIVE: Stereotactic ablative radiotherapy (SABR) is a safe treatment approach for hepatocellular carcinoma (HCC) with comparable effectiveness to other local therapies. Only scant information is available concerning the role of SABR prior to liver transplantation (LT) for HCC. We present a consecutive case series investigating the role of SABR as a bridge or downstaging option in HCC patients subsequently submitted to LT. MATERIALS AND METHODS: Between September 2012 and May 2014, 8 patients for a total of 13 lesions underwent SABR prior to LT...
November 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27370150/a-mouse-radiation-induced-liver-disease-model-for-stereotactic-body-radiation-therapy-validated-in-patients-with-hepatocellular-carcinoma
#20
Zhi-Feng Wu, Jian-Ying Zhang, Xiao-Yun Shen, Le-Yuan Zhou, Ya-Bo Gao, Yong Hu, Zhao-Chong Zeng
PURPOSE: Lower radiation tolerance of the whole liver hinders dose escalations of stereotactic body radiation therapy (SBRT) in hepatocellular carcinoma (HCC) treatment. This study was conducted to define the exact doses that result in radiation-induced liver disease (RILD) as well as to determine dose constraints for the critical organs at risk (OARs) in mice; these parameters are still undefined in HCC SBRT. METHODS: This study consisted of two phases. In the primary phase, mice treated with helical tomotherapy-based SBRT were stratified according to escalating radiation doses to the livers...
July 2016: Medical Physics
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