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https://www.readbyqxmd.com/read/29710874/applicability-of-precision-medicine-approaches-to-managing-hypertension-in-rural-populations
#1
Jacqueline R Halladay, Kaitlin C Lenhart, Kimberly Robasky, Wendell Jones, Wayne F Homan, Doyle M Cummings, Crystal W Cené, Alan L Hinderliter, Cassandra L Miller, Katrina E Donahue, Beverly A Garcia, Thomas C Keyserling, Alice S Ammerman, Cam Patterson, Darren A DeWalt, Larry F Johnston, Monte S Willis, Jonathan C Schisler
As part of the Heart Healthy Lenoir Project, we developed a practice level intervention to improve blood pressure control. The goal of this study was: (i) to determine if single nucleotide polymorphisms (SNPs) that associate with blood pressure variation, identified in large studies, are applicable to blood pressure control in subjects from a rural population; (ii) to measure the association of these SNPs with subjects' responsiveness to the hypertension intervention; and (iii) to identify other SNPs that may help understand patient-specific responses to an intervention...
April 30, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29608345/meal-delivery-programs-reduce-the-use-of-costly-health-care-in-dually-eligible-medicare-and-medicaid-beneficiaries
#2
Seth A Berkowitz, Jean Terranova, Caterina Hill, Toyin Ajayi, Todd Linsky, Lori W Tishler, Darren A DeWalt
Delivering food to nutritionally vulnerable patients is important for addressing these patients' social determinants of health. However, it is not known whether food delivery programs can reduce the use of costly health services and decrease medical spending among these patients. We sought to determine whether home delivery of either medically tailored meals or nontailored food reduces the use of selected health care services and medical spending in a sample of adults dually eligible for Medicare and Medicaid...
April 2018: Health Affairs
https://www.readbyqxmd.com/read/29577574/the-effect-of-a-practice-based-multicomponent-intervention-that-includes-health-coaching-on-medication-adherence-and-blood-pressure-control-in-rural-primary-care
#3
Jia-Rong Wu, Doyle M Cummings, Quefeng Li, Alan Hinderliter, Hayden B Bosworth, Jimmy Tillman, Darren DeWalt
Low adherence to anti-hypertensive medications contributes to worse outcomes. The authors conducted a secondary data analysis to examine the effects of a health-coaching intervention on medication adherence and blood pressure (BP), and to explore whether changes in medication adherence over time were associated with changes in BP longitudinally in 477 patients with hypertension. Data regarding medication adherence and BP were collected at baseline, 6, 12, 18, and 24 months. The intervention resulted in increases in medication adherence (5...
March 25, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29432167/phylogenetic-classification-of-the-world-s-tropical-forests
#4
J W Ferry Slik, Janet Franklin, Víctor Arroyo-Rodríguez, Richard Field, Salomon Aguilar, Nikolay Aguirre, Jorge Ahumada, Shin-Ichiro Aiba, Luciana F Alves, Anitha K, Andres Avella, Francisco Mora, Gerardo A Aymard C, Selene Báez, Patricia Balvanera, Meredith L Bastian, Jean-François Bastin, Peter J Bellingham, Eduardo van den Berg, Polyanna da Conceição Bispo, Pascal Boeckx, Katrin Boehning-Gaese, Frans Bongers, Brad Boyle, Fabian Brambach, Francis Q Brearley, Sandra Brown, Shauna-Lee Chai, Robin L Chazdon, Shengbin Chen, Phourin Chhang, George Chuyong, Corneille Ewango, Indiana M Coronado, Jurgi Cristóbal-Azkarate, Heike Culmsee, Kipiro Damas, H S Dattaraja, Priya Davidar, Saara J DeWalt, Hazimah Din, Donald R Drake, Alvaro Duque, Giselda Durigan, Karl Eichhorn, Eduardo Schmidt Eler, Tsutomu Enoki, Andreas Ensslin, Adandé Belarmain Fandohan, Nina Farwig, Kenneth J Feeley, Markus Fischer, Olle Forshed, Queila Souza Garcia, Satish Chandra Garkoti, Thomas W Gillespie, Jean-Francois Gillet, Christelle Gonmadje, Iñigo Granzow-de la Cerda, Daniel M Griffith, James Grogan, Khalid Rehman Hakeem, David J Harris, Rhett D Harrison, Andy Hector, Andreas Hemp, Jürgen Homeier, M Shah Hussain, Guillermo Ibarra-Manríquez, I Faridah Hanum, Nobuo Imai, Patrick A Jansen, Carlos Alfredo Joly, Shijo Joseph, Kuswata Kartawinata, Elizabeth Kearsley, Daniel L Kelly, Michael Kessler, Timothy J Killeen, Robert M Kooyman, Yves Laumonier, Susan G Laurance, William F Laurance, Michael J Lawes, Susan G Letcher, Jeremy Lindsell, Jon Lovett, Jose Lozada, Xinghui Lu, Anne Mette Lykke, Khairil Bin Mahmud, Ni Putu Diana Mahayani, Asyraf Mansor, Andrew R Marshall, Emanuel H Martin, Darley Calderado Leal Matos, Jorge A Meave, Felipe P L Melo, Zhofre Huberto Aguirre Mendoza, Faizah Metali, Vincent P Medjibe, Jean Paul Metzger, Thiago Metzker, D Mohandass, Miguel A Munguía-Rosas, Rodrigo Muñoz, Eddy Nurtjahy, Eddie Lenza de Oliveira, Onrizal, Pia Parolin, Marc Parren, N Parthasarathy, Ekananda Paudel, Rolando Perez, Eduardo A Pérez-García, Ulf Pommer, Lourens Poorter, Lan Qie, Maria Teresa F Piedade, José Roberto Rodrigues Pinto, Axel Dalberg Poulsen, John R Poulsen, Jennifer S Powers, Rama Chandra Prasad, Jean-Philippe Puyravaud, Orlando Rangel, Jan Reitsma, Diogo S B Rocha, Samir Rolim, Francesco Rovero, Andes Rozak, Kalle Ruokolainen, Ervan Rutishauser, Gemma Rutten, Mohd Nizam Mohd Said, Felipe Z Saiter, Philippe Saner, Braulio Santos, João Roberto Dos Santos, Swapan Kumar Sarker, Christine B Schmitt, Jochen Schoengart, Mark Schulze, Douglas Sheil, Plinio Sist, Alexandre F Souza, Wilson Roberto Spironello, Tereza Sposito, Robert Steinmetz, Tariq Stevart, Marcio Seiji Suganuma, Rahayu Sukri, Aisha Sultana, Raman Sukumar, Terry Sunderland, Supriyadi, H S Suresh, Eizi Suzuki, Marcelo Tabarelli, Jianwei Tang, Ed V J Tanner, Natalia Targhetta, Ida Theilade, Duncan Thomas, Jonathan Timberlake, Márcio de Morisson Valeriano, Johan van Valkenburg, Tran Van Do, Hoang Van Sam, John H Vandermeer, Hans Verbeeck, Ole Reidar Vetaas, Victor Adekunle, Simone A Vieira, Campbell O Webb, Edward L Webb, Timothy Whitfeld, Serge Wich, John Williams, Susan Wiser, Florian Wittmann, Xiaobo Yang, C Yves Adou Yao, Sandra L Yap, Rakan A Zahawi, Rahmad Zakaria, Runguo Zang
Knowledge about the biogeographic affinities of the world's tropical forests helps to better understand regional differences in forest structure, diversity, composition, and dynamics. Such understanding will enable anticipation of region-specific responses to global environmental change. Modern phylogenies, in combination with broad coverage of species inventory data, now allow for global biogeographic analyses that take species evolutionary distance into account. Here we present a classification of the world's tropical forests based on their phylogenetic similarity...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29416396/updated-checklist-of-the-michigan-usa-caddisflies-with-regional-and-habitat-affinities
#5
David C Houghton, R Edward DeWalt, Angelica J Pytel, Constance M Brandin, Sarah E Rogers, David E Ruiter, Ethan Bright, Patrick L Hudson, Brian J Armitage
Based on examination of ~180,000 specimens from 695 collections of 443 localities collected from the 1930s to 2015 we report 295 species of caddisflies from Michigan. Of these, 41 are reported from the state for the first time. Another 18 species previously reported from Michigan are listed as doubtful. The 11 most abundant species collectively represented over half of all specimens collected. Conversely, 80 species were known from <10 specimens, and 27 species from a single specimen. The Michigan fauna is similar to those of Minnesota and Ohio, adjacent states with comparable recent collecting effort...
2018: ZooKeys
https://www.readbyqxmd.com/read/29343209/mild-blast-injury-produces-acute-changes-in-basal-intracellular-calcium-levels-and-activity-patterns-in-mouse-hippocampal-neurons
#6
Kyle R Hansen, Gloria J DeWalt, Ali I Mohammed, Hua-An Tseng, Moona E Abdulkerim, Seth Bensussen, Venkatesh Saligrama, Bobak Nazer, William D Eldred, Xue Han
Mild traumatic brain injury (mTBI) represents a serious public health concern. While much is understood about long term changes in cell signaling and anatomical pathologies associated with mTBI, little is known about acute changes in neuronal function. Using large scale Ca2+ imaging in vivo, we characterized the intracellular Ca2+ dynamics in thousands of individual hippocampal neurons using a repetitive mild blast injury model where blasts were directed onto the cranium of unanesthetized mice on two consecutive days...
January 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29251294/comparison-of-legacy-fatigue-measures-with-the-promis-pediatric-fatigue-short-form
#7
Catherine F Macpherson, Jichuan Wang, Darren A DeWalt, Emily D Stern, Shana Jacobs, Pamela S Hinds
OBJECTIVES: To compare Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Fatigue Short Form measures and legacy patient-reported outcome fatigue measures to capture cancer-related fatigue change in pediatric patients with cancer. 
. SAMPLE &AMP; SETTING: 96 racially diverse children and adolescents with cancer. The study occurred in a 32-bed inpatient unit and three regional outpatient clinics.
. METHODS &AMP; VARIABLES: The Fatigue Scale-Child, Fatigue Scale-Adolescent, and the PROMIS Pediatric Fatigue Short Form measures were administered at three time points during chemotherapy...
January 1, 2018: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29135882/early-effects-of-medicare-s-bundled-payment-for-care-improvement-bpci-program-for-lumbar-fusion
#8
Timothy S Carey, Darren DeWalt
No abstract text is available yet for this article.
November 10, 2017: Spine
https://www.readbyqxmd.com/read/29133177/region-specific-alterations-in-astrocyte-and-microglia-morphology-following-exposure-to-blasts-in-the-mouse-hippocampus
#9
Gloria J DeWalt, Biraaj Mahajan, Andrea R Foster, Lauren D E Thompson, Andrew A Marttini, Eric V Schmidt, Sara Mansuri, Dwayne D'Souza, Shama B Patel, Madeline Tenenbaum, Karla I Brandao-Viruet, Dominique Thompson, Bryan Duong, Danica H Smith, Todd A Blute, William D Eldred
Traumatic brain injury (TBI) is a serious public health concern, especially injuries from repetitive insults. The main objective of this study was to immunocytochemically examine morphological alterations in astrocytes and microglia in the hippocampus 48h following a single blast versus multiple blasts in adult C57BL/6 mice. The effects of ketamine and xylazine (KX), two common anesthetic agents used in TBI research, were also evaluated due to the confounding effect of anesthetics on injury outcome. Results showed a significant increase in hypertrophic microglia that was limited to the outer molecular layer of the dentate gyrus, but only in the absence of KX...
January 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29107463/association-of-consistently-suboptimal-quality-of-life-with-consistently-poor-asthma-control-in-children-with-asthma
#10
Carrie R Howell, Lindsay A Thompson, Heather E Gross, Bryce B Reeve, Shih-Wen Huang, Darren A DeWalt, I-Chan Huang
No abstract text is available yet for this article.
December 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28930462/correction-to-ph-dependent-inversion-of-hofmeister-trends-in-the-water-structure-of-the-electrical-double-layer
#11
Emma L DeWalt-Kerian, Sun Kim, Md Shafiul Azam, Hongbo Zeng, Qingxia Liu, Julianne M Gibbs
No abstract text is available yet for this article.
October 5, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28884421/assessing-responsiveness-over-time-of-the-promis-%C3%A2-pediatric-symptom-and-function-measures-in-cancer-nephrotic-syndrome-and-sickle-cell-disease
#12
Bryce B Reeve, Lloyd J Edwards, Byron C Jaeger, Pamela S Hinds, Carlton Dampier, Debbie S Gipson, David T Selewski, Jonathan P Troost, David Thissen, Vaughn Barry, Heather E Gross, Darren A DeWalt
PURPOSE: Previous studies provided evidence for the validity of the PROMIS Pediatric measures in cross-sectional studies. This study evaluated the ability of the PROMIS Pediatric measures to detect change over time in children and adolescents with cancer, nephrotic syndrome (NS), or sickle cell disease (SCD). METHODS: Participants (8-17 years) completed measures of fatigue, pain interference, anger, anxiety, depressive symptoms, mobility, upper extremity, and peer relationships at three or four time points (T1-T4)...
January 2018: Quality of Life Research
https://www.readbyqxmd.com/read/28865867/a-longitudinal-study-of-promis-pediatric-symptom-clusters-in-children-undergoing-chemotherapy
#13
Jichuan Wang, Shana Jacobs, Darren A Dewalt, Emily Stern, Heather Gross, Pamela S Hinds
CONTEXT: Children in treatment for cancer experience multiple, troubling, and interrelated symptoms. Analyzing the interrelatedness of symptoms and how that changes during treatment could yield clinically relevant patient profiles to guide patient care. OBJECTIVES: The aims were to identify pediatric profiles with respect to Patient-Reported Outcomes Measurement Information System® (PROMIS® ; U.S. Department of Health and Human Services, National Institutes of Health) symptom measures, changes in profile status throughout a chemotherapy cycle, and if a baseline single-item fatigue measure could significantly predict symptom profile status and its changes...
February 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28835233/responsiveness-of-the-promis%C3%A2-measures-to-changes-in-disease-status-among-pediatric-nephrotic-syndrome-patients-a-midwest-pediatric-nephrology-consortium-study
#14
David T Selewski, Jonathan P Troost, Danyelle Cummings, Susan F Massengill, Rasheed A Gbadegesin, Larry A Greenbaum, Ibrahim F Shatat, Yi Cai, Gaurav Kapur, Diane Hebert, Michael J Somers, Howard Trachtman, Priya Pais, Michael E Seifert, Jens Goebel, Christine B Sethna, John D Mahan, Heather E Gross, Emily Herreshoff, Yang Liu, Noelle E Carlozzi, Bryce B Reeve, Darren A DeWalt, Debbie S Gipson
BACKGROUND: Nephrotic syndrome represents a condition in pediatric nephrology typified by a relapsing and remitting course, proteinuria and the presence of edema. The PROMIS measures have previously been studied and validated in cross-sectional studies of children with nephrotic syndrome. This study was designed to longitudinally validate the PROMIS measures in pediatric nephrotic syndrome. METHODS: One hundred twenty seven children with nephrotic syndrome between the ages of 8 and 17 years participated in this prospective cohort study...
August 23, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28780328/impaired-patient-reported-outcomes-predict-poor-school-functioning-and-daytime-sleepiness-the-promis-pediatric-asthma-study
#15
Conor M Jones, Darren A DeWalt, I-Chan Huang
OBJECTIVE: Poor asthma control in children is related to impaired patient-reported outcomes (PROs; eg, fatigue, depressive symptoms, anxiety), but less well studied is the effect of PROs on children's school performance and sleep outcomes. In this study we investigated whether the consistency status of PROs over time affected school functioning and daytime sleepiness in children with asthma. METHODS: Of the 238 children with asthma enrolled in the Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Asthma Study, 169 children who provided survey data for all 4 time points were used in the analysis...
November 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28697926/health-literacy-and-health-outcomes-in-very-old-patients-with-heart-failure
#16
Rocío León-González, Esther García-Esquinas, Emilio Paredes-Galán, Ana Isabel Ferrero-Martínez, José Luis González-Guerrero, Mercedes Hornillos-Calvo, Rocío Menéndez-Colino, Ivett Torres-Torres, María Concepción Galán, Marta Torrente-Carballido, Mayte Olcoz-Chiva, Carlos Rodríguez-Pascual, Fernando Rodríguez-Artalejo
INTRODUCTION AND OBJECTIVES: Health literacy (HL) has been associated with lower mortality in heart failure (HF). However, the results of previous studies may not be generalizable because the research was conducted in relatively young and highly-educated patients in United States settings. This study assessed the association of HL with disease knowledge, self-care, and all-cause mortality among very old patients, with a very low educational level. METHODS: This prospective study was performed in 556 patients (mean age, 85 years), with high comorbidity, admitted for HF to the geriatric acute-care unit of 6 hospitals in Spain...
March 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28576953/the-medication-optimization-value-proposition-aligning-teams-and-education-to-improve-care
#17
Jon C Easter, Darren A DeWalt
United States health care lags behind other countries in quality and cost. The present health care system is unsustainable, and there is now a quick movement toward value-based care. This article lays out essential care delivery elements, and makes the case for medication optimization to enable new value-based models. Success factors include enhancing team-based care and interdisciplinary education to achieve patient-centered care.
May 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28561571/ph-dependent-inversion-of-hofmeister-trends-in-the-water-structure-of-the-electrical-double-layer
#18
Emma L DeWalt-Kerian, Sun Kim, Md Shafiul Azam, Hongbo Zeng, Qingxia Liu, Julianne M Gibbs
Specific ion effects (SIEs) are known to influence the acid/base behavior of silica and the interfacial structure of water, yet evidence of the effect of pH on SIEs is lacking. Here broadband vibrational sum frequency generation (SFG) spectroscopy was used to study SIEs on the water structure at the electrical double layer (EDL) of silica as a function of pH and monovalent cation identity from pH 2-12 at 0.5 M salt concentration. SFG results indicate a direct Hofmeister series of cation adsorption at pH 8 (Li+ < Na+ < K+ < Cs+ ), with an inversion in this series occurring at pH > 10...
July 6, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28560719/visual-system-pathology-in-humans-and-animal-models-of-blast-injury
#19
REVIEW
Gloria J DeWalt, William D Eldred
Injury from blast exposure is becoming a more prevalent cause of death and disability worldwide. The devastating neurological impairments that result from blasts are significant and lifelong. Progress in the development of effective therapies to treat injury has been slowed by its heterogeneous pathology and the dearth of information regarding the cellular mechanisms involved. Within the last decade, a number of studies have documented visual dysfunction following injury. This brief review examines damage to the visual system in both humans and animal models of blast injury...
September 1, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28405344/successful-long-term-weight-loss-among-participants-with-diabetes-receiving-an-intervention-promoting-an-adapted-mediterranean-style-dietary-pattern-the-heart-healthy-lenoir-project
#20
Genevieve G R Embree, Carmen D Samuel-Hodge, Larry F Johnston, Beverly A Garcia, Ziya Gizlice, Kelly R Evenson, Darren A DeWalt, Alice S Ammerman, Thomas C Keyserling
OBJECTIVE: To examine weight change by diabetes status among participants receiving a Mediterranean-style diet, physical activity, and weight loss intervention adapted for delivery in the southeastern USA, where rates of cardiovascular disease (CVD) are disproportionately high. RESEARCH DESIGN AND METHODS: The intervention included: Phase I (months 1-6), an individually tailored intervention promoting a Mediterranean-style dietary pattern and increased walking; Phase II (months 7-12), option of a 16-week weight loss intervention for those with BMI≥25 kg/m2 offered as 16 weekly group sessions or 5 group sessions and 10 phone calls, or a lifestyle maintenance intervention; and Phase III (months 13-24), weight loss maintenance intervention for those losing ≥8 pounds with all others receiving a lifestyle maintenance intervention...
2017: BMJ Open Diabetes Research & Care
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