keyword
MENU ▼
Read by QxMD icon Read
search

Pignone

keyword
https://www.readbyqxmd.com/read/29710141/interventions-to-prevent-falls-in-community-dwelling-older-adults-us-preventive-services-task-force-recommendation-statement
#1
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Aaron B Caughey, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Martha Kubik, Seth Landefeld, Carol M Mangione, Michael Pignone, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Falls are the leading cause of injury-related morbidity and mortality among older adults in the United States. In 2014, 28.7% of community-dwelling adults 65 years or older reported falling, resulting in 29 million falls (37.5% of which needed medical treatment or restricted activity for a day or longer) and an estimated 33 000 deaths in 2015. Objective: To update the 2012 US Preventive Services Task Force (USPSTF) recommendation on the prevention of falls in community-dwelling older adults...
April 24, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29680485/-seclusion-and-mechanical-restraints-in-psychiatric-care-prescriptions-procedures-pharmacological-management-and-monitoring
#2
Chloé Tezenas du Montcel, Célia Kowal, Audrey Leherle, Soraya Kabbaj, Ariel Frajerman, Emmanuel Le Guen, Nora Hamdani, Franck Schürhoff, Marion Leboyer, Antoine Pelissolo, Baptiste Pignon
We will briefly summarize the French recommendations concerning the use of seclusion and mechanical restraint. Acute agitation and aggression or self-injurious activity during psychotic and manic episodes are the main indication of prescription of the coercive measures. Their prescriptions respect specific modalities that will be explained. Although they proved to be efficient, seclusion and restrain need to stay a last resort option, considering the risk of physical complications and psychological consequences...
April 18, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29650716/cardiovascular-genetic-risk-testing-for-targeting-statin-therapy-in-the-primary-prevention-of-atherosclerotic-cardiovascular-disease-a-cost-effectiveness-analysis
#3
Jamie Jarmul, Mark J Pletcher, Kristen Hassmiller Lich, Stephanie B Wheeler, Morris Weinberger, Christy L Avery, Daniel E Jonas, Stephanie Earnshaw, Michael Pignone
BACKGROUND: It is unclear whether testing for novel risk factors, such as a cardiovascular genetic risk score (cGRS), improves clinical decision making or health outcomes when used for targeting statin initiation in the primary prevention of atherosclerotic cardiovascular disease (ASCVD). Our objective was to estimate the cost-effectiveness of cGRS testing to inform clinical decision making about statin initiation in individuals with low-to-intermediate (2.5%-7.5%) 10-year predicted risk of ASCVD...
April 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29626745/influence-of-comorbid-alcohol-use-disorders-on-the-clinical-patterns-of-major-depressive-disorder-a-general-population-based-study
#4
Louise Carton, Baptiste Pignon, Alexandre Baguet, Imane Benradia, Jean-Luc Roelandt, Guillaume Vaiva, Pierre Thomas, Ali Amad, Philippe De Timary, Mickaël Naassila, Pierre A Geoffroy, Benjamin Rolland
BACKGROUND: To compare the symptom patterns of major depressive disorder (MDD) among subjects with MDD and 1) no alcohol use disorder (AUD), 2) alcohol abuse and 3) alcohol dependence, respectively. METHODS: In a general population survey of 38,694 French individuals, MDD and AUDs were assessed using the Mini International Neuropsychiatric Interview 5.0.0 (MINI). A total of 4339 subjects (11.2%) in the sample met the criteria for MDD. Among them, 413 (9.5%) AUD subjects were identified: 138 (3...
March 23, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29619580/prevalence-and-predictors-of-no-lifetime-utilization-of-mental-health-treatment-among-people-with-mental-disorders-in-france-findings-from-the-mental-health-in-general-population-mhgp-survey
#5
Hélène Font, Jean-Luc Roelandt, Hélène Behal, Pierre-Alexis Geoffroy, Baptiste Pignon, Ali Amad, Nicolas Simioni, Guillaume Vaiva, Pierre Thomas, Alain Duhamel, Imane Benradia, Benjamin Rolland
PURPOSE: No lifetime utilization of mental health treatment (NUMT) is an indicator of the treatment gap among people in need of treatment. Until now, the overall prevalence and predictors of NUMT have never been explored in France. METHODS: In a 39,617-respondent survey, participants were assessed for NUMT, i.e., no lifetime psychotherapy, psychopharmacotherapy, or psychiatric hospitalization. Mental disorders were investigated using the Mini International Neuropsychiatric Interview (MINI 5...
April 4, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29597072/increased-prevalence-of-anxiety-disorders-in-third-generation-migrants-in-comparison-to-natives-and-to-first-generation-migrants
#6
Baptiste Pignon, Ali Amad, Antoine Pelissolo, Thomas Fovet, Pierre Thomas, Guillaume Vaiva, Jean-Luc Roelandt, Imane Benradia, Benjamin Rolland, Pierre A Geoffroy
INTRODUCTION: We sought to examine the prevalence of anxiety disorders associated with migration in the first-, second- and third-generation. METHODS: The French Mental Health in the General Population cross-sectional survey interviewed 38,694 individuals using the MINI. The prevalence of lifetime anxiety disorders, and comorbidities was compared between migrants and non-migrants and by generation. All analyses were adjusted for age, sex, and income and education levels...
March 20, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29568321/evaluation-of-treatment-effect-with-paired-failure-times-in-a-single-arm-phase-ii-trial-in-oncology
#7
Matthieu Texier, Federico Rotolo, Michel Ducreux, Olivier Bouché, Jean-Pierre Pignon, Stefan Michiels
In early phase clinical trials of cytotoxic drugs in oncology, the efficacy is typically evaluated based on the tumor shrinkage. However, this criterion is not always appropriate for more recent cytostatic agents, and alternative endpoints have been proposed. The growth modulation index (GMI), defined as the ratio between the times to progression in two successive treatment lines, has been proposed for a single-arm phase II trials. The treatment effect is evaluated by estimating the rate of patients having a GMI superior to a given threshold...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29544690/a-canine-adenovirus-type-2-vaccine-vector-confers-protection-against-foot-and-mouth-disease-in-guinea-pigs
#8
Annebel R De Vleeschauwer, Xiaocui Zhou, David J Lefebvre, Annabelle Garnier, Fleur Watier, Charly Pignon, Sandrine A Lacour, Stephan Zientara, Labib Bakkali-Kassimi, Kris De Clercq, Bernard Klonjkowski
Vaccination is a key element in the control of foot-and-mouth disease (FMD). The majority of the antigenic sites that induce protective immune responses are localized on the FMD virus (FMDV) capsid that is formed by four virus-encoded structural proteins, VP1 to VP4. In the present study, recombinant canine adenovirus type 2 (CAV2)-based FMD vaccines, Cav-P1/3C R° and Cav-VP1 R°, respectively expressing the structural P1 precursor protein along with the non-structural 3C protein or expressing the structural VP1 protein of the FMDV strain O/FRA/1/2001, were evaluated as novel vaccines against FMD...
April 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29532054/effect-of-a-digital-health-intervention-on-receipt-of-colorectal-cancer-screening-in-vulnerable-patients-a-randomized-controlled-trial
#9
David P Miller, Nancy Denizard-Thompson, Kathryn E Weaver, L Doug Case, Jennifer L Troyer, John G Spangler, Donna Lawler, Michael P Pignone
Background: Screening for colorectal cancer (CRC) reduces mortality, yet more than one third of age-eligible Americans are unscreened. Objective: To examine the effect of a digital health intervention, Mobile Patient Technology for Health-CRC (mPATH-CRC), on rates of CRC screening. Design: Randomized clinical trial. (ClinicalTrials.gov: NCT02088333). Setting: 6 community-based primary care practices. Participants: 450 patients (223 in the mPATH-CRC group and 227 in usual care) scheduled for a primary care visit and due for routine CRC screening...
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29470737/the-safety-of-iloprost-in-systemic-sclerosis-in-a-real-life-experience
#10
S Bellando-Randone, C Bruni, G Lepri, G Fiori, F Bartoli, M L Conforti, A Moggi-Pignone, S Guiducci, D Giuggioli, M Colaci, A Spinella, C Ferri, M Matucci-Cerinic
Iloprost (ILO) is employed intravenously for the treatment of severe Raynaud phenomenon (RP) and digital ulcers (DU) in systemic sclerosis (SSc). The aim of this study was to evaluate the safety and tolerability of the intravenous treatment with ILO in different phases of SSc. Eighty-one consecutive non-selected SSc patients, all on nifedipine, with moderate RP, treated with ILO infusion, were retrospectively evaluated. Patients were sub classified according to the edematous or fibrotic/atrophic cutaneous phase of the disease...
May 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29417143/accuracy-of-predictions-of-patients-with-breast-cancer-of-future-well-being-after-immediate-breast-reconstruction
#11
Clara Nan-Hi Lee, Michael Patrick Pignone, Allison M Deal, Lillian Blizard, Caprice Hunt, Ruth Huh, Yuen-Jong Liu, Peter Anthony Ubel
Importance: Making a good decision about breast reconstruction requires predicting how one would feel after the procedure, but people tend to overestimate the impact of events on future well-being. Objective: To assess how well patients predict future well-being after mastectomy, with or without immediate reconstruction, with the following a priori hypotheses: Patients will overestimate the negative impact of mastectomy and positive impact of reconstruction, and prediction accuracy will be associated with decision satisfaction and decision regret...
April 18, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29339229/a-rare-case-of-candida-glabrata-spondylodiscitis-case-report-and-literature-review
#12
REVIEW
Manfredi Gagliano, Costanza Marchiani, Giulia Bandini, Paolo Bernardi, Nicolas Palagano, Elisa Cioni, Martina Finocchi, Silvia Bellando Randone, Alberto Moggi Pignone
BACKGROUND: Spondylodiscitis is an infection of the vertebral column, the incidence of which is increasing due to an increase in the susceptible population and improved ascertainment. This disease has been associated with a wide range of microorganisms. Fungal spondylodiscitis is uncommon (0.5-1.6%) and strongly associated with immunosuppression and diabetes (Gouliouris et al., 2010). A rare case of Candida glabrata spondylodiscitis in a non-neutropenic diabetic patient is reported herein, along with a review of the literature...
March 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29325548/a-pre-post-study-testing-a-lung-cancer-screening-decision-aid-in-primary-care
#13
Daniel S Reuland, Laura Cubillos, Alison T Brenner, Russell P Harris, Bailey Minish, Michael P Pignone
BACKGROUND: The United States Preventive Services Task Force (USPSTF) issued recommendations for older, heavy lifetime smokers to complete annual low-dose computed tomography (LDCT) scans of the chest as screening for lung cancer. The USPSTF recommends and the Centers for Medicare and Medicaid Services require shared decision making using a decision aid for lung cancer screening with annual LDCT. Little is known about how decision aids affect screening knowledge, preferences, and behavior...
January 12, 2018: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29232967/a-latent-class-analysis-of-psychotic-symptoms-in-the-general-population
#14
Baptiste Pignon, Hugo Peyre, Andrei Szöke, Pierre A Geoffroy, Benjamin Rolland, Renaud Jardri, Pierre Thomas, Guillaume Vaiva, Jean-Luc Roelandt, Imane Benradia, Hélène Behal, Franck Schürhoff, Ali Amad
OBJECTIVE: Individuals with psychotic symptoms may actually correspond to various subgroups, characterized by different patterns of psychotic symptoms as well as specific sociodemographic and clinical correlates. We aimed to identify groups of individuals from the general population with specific patterns of psychotic symptoms. METHODS: In a 38,694-subject survey, a latent class analysis was performed to identify subgroups based on the distribution of seven psychotic symptoms taken from the Mini International Neuropsychiatric Interview...
December 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29191602/lkb1-stk11-mutations-in-non-small-cell-lung-cancer-patients-descriptive-analysis-and-prognostic-value
#15
Francesco Facchinetti, Maria Virginia Bluthgen, Gabrielle Tergemina-Clain, Laura Faivre, Jean-Pierre Pignon, David Planchard, Jordi Remon, Jean-Charles Soria, Ludovic Lacroix, Benjamin Besse
BACKGROUND: LKB1/STK11 (STK11) is among the most inactivated tumor-suppressor genes in non-small cell lung cancer (NSCLC). While evidence concerning the biologic role of STK11 is accumulating, its prognostic significance in advanced NSCLC has not been envisaged yet. MATERIALS AND METHODS: This retrospective analysis included consecutive NSCLC patients with available STK11 information who underwent a platinum-based chemotherapy. STK11 mutational status was correlated to clinico-pathological and mutational features...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29191581/prognostic-value-of-hla-a2-status-in-advanced-non-small-cell-lung-cancer-patients
#16
Laura Mezquita, Melinda Charrier, Laura Faivre, Louise Dupraz, Béranger Lueza, Jordi Remon, David Planchard, Maria Virginia Bluthgen, Francesco Facchinetti, Arslane Rahal, Valentina Polo, Anas Gazzah, Caroline Caramella, Julien Adam, Jean Pierre Pignon, Jean-Charles Soria, Nathalie Chaput, Benjamin Besse
INTRODUCTION: The class I human leucocyte antigen (HLA) molecules play a critical role as an escape mechanism of antitumoral immunity. HLA-A2 status has been evaluated as a prognostic factor in lung cancer, mostly in localized disease and with inconsistent findings. We evaluated the role of HLA-A2 status as a prognostic factor in a large and homogeneus cohort of advanced NSCLC patients. METHODS: Advanced NSCLC patients eligible for platinum-based chemotherapy were consecutively included in a single center between October 2009 and July 2015 in the prospective MSN study (NCT02105168)...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29137759/ultrasonic-assisted-production-of-starch-nanoparticles-structural-characterization-and-mechanism-of-disintegration
#17
Sami Boufi, Sihem Bel Haaj, Albert Magnin, Frédéric Pignon, Marianne Impéror-Clerc, Gérard Mortha
In this paper, the disintegration of starch (waxy and standard starch) granules into nanosized particles under the sole effect of high power ultrasonication treatment in water/isopropanol is investigated, by using wide methods of analysis. The present work aims at a fully characterization of the starch nanoparticles produced by ultrasonication, in terms of size, morphology and structural properties, and the proposition of a possible mechanism explaining the top-down generation of starch nanoparticles (SNPs) via high intensity ultrasonication...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29110139/the-place-of-antipsychotics-in-the-therapy-of-anxiety-disorders-and-obsessive-compulsive-disorders
#18
REVIEW
Baptiste Pignon, Chloé Tezenas du Montcel, Louise Carton, Antoine Pelissolo
PURPOSE OF REVIEW: The purpose of this review was to assess and present the findings up to this date on the efficacy of antipsychotics in the treatment of generalized anxiety disorders (GAD), social anxiety disorders (SAD), panic disorders (PD), and obsessive-compulsive disorders (OCD), mostly based on published randomized controlled trials (RCTs) or on open-label studies when RCT were lacking. RECENT FINDINGS: Quetiapine could be recommended in patients with GAD...
November 7, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29103041/association-of-the-new-variant-tyr424asp-at-tbk1-gene-with-amyotrophic-lateral-sclerosis-and-cognitive-decline
#19
Irene Piaceri, Valentina Bessi, Sabrina Matà, Cristina Polito, Andrea Tedde, Valentina Berti, Silvia Bagnoli, Arianna Braccia, Monica Del Mastio, Alberto Moggi Pignone, Alberto Pupi, Sandro Sorbi, Benedetta Nacmias
A new risk gene associated with amyotrophic lateral sclerosis (ALS) has recently been identified: the Tank-binding kinase 1 (TBK1) gene. Up to now, 90 TBK1 variants have been described in ALS patients with or without frontotemporal dementia (FTD), thus making TBK1 the third or fourth most frequent genetic cause of ALS and FTD. A point mutation analysis in a cohort of 69 Italian ALS patients was performed in order to analyze the frequency of TBK1 mutations and the correlation with clinical phenotypes. The analysis identified the novel variant p...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29100700/prognostic-impact-of-hpv-associated-p16-expression-and-smoking-status-on-outcomes-following-radiotherapy-for-oropharyngeal-cancer-the-march-hpv-project
#20
Pernille Lassen, Benjamin Lacas, Jean-Pierre Pignon, Andy Trotti, Bjorn Zackrisson, Qiang Zhang, Jens Overgaard, Pierre Blanchard
BACKGROUND AND PURPOSE: Evaluate the prognostic and predictive impact of HPV-associated p16-expression and assess the combined prognostic impact of p16 and smoking on altered fractionated radiotherapy (AFRT) for oropharyngeal cancer (OPC) within the frames of the update of the Meta-Analysis of Radiotherapy in Carcinomas of Head and neck (MARCH). MATERIALS AND METHODS: Patients with OPC, known tumor p16-status and smoking history were identified from the MARCH update, resulting in a dataset of 815 patients from four randomized trials (RTOG9003, DAHANCA6&7, RTOG0129, ARTSCAN)...
January 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
keyword
keyword
104099
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"