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https://www.readbyqxmd.com/read/28923210/angiogenesis-inhibition-in-the-second-line-treatment-of-metastatic-colorectal-cancer-a-definite-conclusion
#1
EDITORIAL
M Ducreux, P Österlund, J P Pignon
No abstract text is available yet for this article.
April 2017: Seminars in Oncology
https://www.readbyqxmd.com/read/28885238/improving-the-implementation-of-lung-cancer-screening-guidelines-at-an-academic-primary-care-practice
#2
Alison T Brenner, Laura Cubillos, Katherine Birchard, Caleb Doyle-Burr, John Eick, Louise Henderson, Laura Jones, Michael Massaro, Bailey Minish, Paul Molina, Michael Pignone, Shana Ratner, Maria Patricia Rivera, Daniel S Reuland
Expert groups recommend annual chest computed tomography for lung cancer screening (LCS) in high-risk patients. Lung cancer screening in primary care is a complex process that includes identification of the at-risk population, comorbidity assessment, and shared decision making. We identified three key processes required for high-quality screening implementation in our academic primary care practice: (1) systematic collection of lifetime cumulative smoking history to identify potentially eligible patients; (2) visit-based clinical reminders and order sets embedded in the electronic health record (EHR); and (3) tools to facilitate shared decision making and appropriate test ordering...
September 1, 2017: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/28873142/using-outreach-to-improve-colorectal-cancer-screening
#3
EDITORIAL
Michael Pignone, David P Miller
No abstract text is available yet for this article.
September 5, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28835308/research-letter-auto-activation-deficit-in-schizophrenia-a-case-report
#4
A Leroy, G Petyt, B Pignon, G Vaiva, R Jardri, A Amad
No abstract text is available yet for this article.
August 24, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28770301/genome-wide-association-mapping-reveals-a-rich-genetic-architecture-of-stripe-rust-resistance-loci-in-emmer-wheat-triticum-turgidum-ssp-dicoccum
#5
Weizhen Liu, Marco Maccaferri, Xianming Chen, Gaetano Laghetti, Domenico Pignone, Michael Pumphrey, Roberto Tuberosa
SNP-based genome scanning in worldwide domesticated emmer germplasm showed high genetic diversity, rapid linkage disequilibrium decay and 51 loci for stripe rust resistance, a large proportion of which were novel. Cultivated emmer wheat (Triticum turgidum ssp. dicoccum), one of the oldest domesticated crops in the world, is a potentially rich reservoir of variation for improvement of resistance/tolerance to biotic and abiotic stresses in wheat. Resistance to stripe rust (Puccinia striiformis f. sp. tritici) in emmer wheat has been under-investigated...
August 2, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28757375/role-of-radiotherapy-fractionation-in-head-and-neck-cancers-march-an-updated-meta-analysis
#6
Benjamin Lacas, Jean Bourhis, Jens Overgaard, Qiang Zhang, Vincent Grégoire, Matthew Nankivell, Björn Zackrisson, Zbigniew Szutkowski, Rafał Suwiński, Michael Poulsen, Brian O'Sullivan, Renzo Corvò, Sarbani Ghosh Laskar, Carlo Fallai, Hideya Yamazaki, Werner Dobrowsky, Kwan Ho Cho, Adam S Garden, Johannes A Langendijk, Celia Maria Pais Viegas, John Hay, Mohamed Lotayef, Mahesh K B Parmar, Anne Aupérin, Carla van Herpen, Philippe Maingon, Andy M Trotti, Cai Grau, Jean-Pierre Pignon, Pierre Blanchard
BACKGROUND: The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of altered fractionation within the context of concomitant chemotherapy with the inclusion of new trials...
September 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28699661/very-early-hallucinatory-experiences-a-school-based-study
#7
Baptiste Pignon, Pierre A Geoffroy, Axelle Gharib, Pierre Thomas, Dan Moutot, William Brabant, Brigitte Weens, Marie-Pierre Dupond, Annick Caron, Bruno Falissard, François Medjkane, Renaud Jardri
BACKGROUND: The prevalence and clinical significance of hallucinatory experiences among children below 7 years of age remain unknown. We aimed to determine the independent influences of sensory deficits, the presence of an imaginary companion and metacognition on hallucinatory experiences. We assumed that hallucinatory experiences were associated with (a) sensory deficits, (b) the presence of an imaginary companion (IC) and (c) metacognition defaults (i.e. first- and second-order theory of mind default)...
July 12, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28692733/shared-decision-making-the-importance-of-diagnosing-preferences
#8
Glyn Elwyn, Nan Cochran, Michael Pignone
No abstract text is available yet for this article.
September 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28689754/sociodemographic-and-clinical-correlates-of-psychotic-symptoms-in-the-general-population-findings-from-the-mhgp-survey
#9
Baptiste Pignon, Franck Schürhoff, Andrei Szöke, Pierre A Geoffroy, Renaud Jardri, Jean-Luc Roelandt, Benjamin Rolland, Pierre Thomas, Guillaume Vaiva, Ali Amad
BACKGROUND: We aimed to explore the sociodemographic and psychiatric correlates of psychotic symptoms in a large general population sample. METHODS: The French Mental Health in the General Population cross-sectional survey interviewed 38,694 individuals using the Mini International Neuropsychiatric Interview. We looked for associations between the presence of lifetime psychotic symptoms, sociodemographic characteristics (including migrant status over three generations) and clinical characteristics...
July 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28688693/very-accelerated-radiotherapy-or-concurrent-chemoradiotherapy-for-n3-head-and-neck-squamous-cell-carcinoma-pooled-analysis-of-two-gortec-randomized-trials
#10
Yungan Tao, Anne Aupérin, Pierre Graff, Michel Lapeyre, Vincent Grégoire, Philippe Maingon, Lionel Geoffrois, Pierre Verrelle, Gilles Calais, Bernard Gery, Laurent Martin, Marc Alfonsi, Patrick Deprez, Etienne Bardet, Thierry Pignon, Michel Rives, Christian Sire, Jean Bourhis
OBJECTIVE: To analyze the outcome of N3 patients treated with very accelerated radiotherapy (VART) or different schedules of concurrent chemoradiotherapy (CRT) within two phase III trials. PATIENTS AND METHODS: Data of 179 patients with N3 HNSCC from two GORTEC randomized trials (96-01 and 99-02) were pooled. Patients received either VART: 64.8Gy/3.5weeks or one of the 3 following CRT regimens: Conventional CRT: 70Gy/7weeks+3 cycles carboplatin-5FU; Moderately accelerated CRT: 70Gy/6weeks+2 cycles carboplatin-5FU; Strongly intensified CRT: 64Gy/5weeks+cisplatin (days 2, 16, 30) and 5 FU (days 1-5, 29-33) followed by 2 cycles adjuvant cisplatin-5FU...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28649273/high-burden-of-malaria-and-anemia-among-tribal-pregnant-women-in-a-chronic-conflict-corridor-in-india
#11
Gustavo Corrêa, Mrinalini Das, Rama Kovelamudi, Nagendra Jaladi, Charlotte Pignon, Kalyan Vysyaraju, Usha Yedla, Vijya Laxmi, Pavani Vemula, Vijaya Gowthami, Hemant Sharma, Daniel Remartinez, Stobdan Kalon, Kirrily de Polnay, Martin De Smet, Petros Isaakidis
BACKGROUND: With more than 200 million cases a year, malaria is an important global health concern, especially among pregnant women. The forested tribal areas of Andhra Pradesh, Telangana and Chhattisgarh in India are affected by malaria and by an on-going chronic conflict which seriously limits access to health care. The burden of malaria and anemia among pregnant women in these areas is unknown; moreover there are no specific recommendations for pregnant women in the Indian national malaria policy...
2017: Conflict and Health
https://www.readbyqxmd.com/read/28603176/autologous-bone-marrow-mononuclear-cell-implantation-and-its-impact-on-the-outcome-of-patients-with-critical-limb-ischemia%C3%A3-results-of-a-randomized-double-blind-placebo-controlled-trial
#12
Bernard Pignon, Marie-Antoinette Sevestre, Lukshe Kanagaratnam, Gilles Pernod, Dominique Stephan, Joseph Emmerich, Claude Clement, Gabrielle Sarlon, Carine Boulon, Claire Tournois, Philippe Nguyen
BACKGROUND: Cell therapy is a therapeutic option for patients presenting with nonrevascularizable critical limb ischemia (CLI). However there is a lack of firm evidence on its efficacy because of the paucity of randomized controlled trials.Methods and Results:The BALI trial was a multicenter, randomized, controlled, double-blind clinical trial that included 38 patients. For all of them, 500 mL of bone marrow were collected for preparation of a BM-MNC product that was implanted in patients assigned to active treatment...
June 10, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28577631/update-on-key-clinical-preventive-services-for-adults
#13
EDITORIAL
Michael P Pignone, Kirsten Bibbins-Domingo
No abstract text is available yet for this article.
July 2017: Medical Clinics of North America
https://www.readbyqxmd.com/read/28577628/screening-adults-for-depression-in-primary-care
#14
REVIEW
Sarah Smithson, Michael P Pignone
The burden of depression in the United States is substantial. Evidence supports the benefits of screening for depression in all adults, including older patients and pregnant and postpartum women, when coupled with appropriate resources for management of disease. Developing, implementing, and sustaining a high-fidelity screening process is an important first step for improving the care of patients with depression in primary care. Initial treatment for depression should include psychotherapy, pharmacotherapy, or a combination of both...
July 2017: Medical Clinics of North America
https://www.readbyqxmd.com/read/28524888/reducing-unplanned-admissions-focusing-on-hospital-admissions-and-emergency-department-visits-for-patients-with-head-and-neck-cancer-during-radiation-therapy%C3%A2
#15
Lauren Terzo, Mary Fleming, Alekhya Yechoor, Jayne Camporeale, Miriam Troxler, Elaine Roth, Xianming Tan, Michael Pignone, Lawrence Marks, Bhishamjit S Chera
BACKGROUND: Head and neck cancer (HNC) treatments cause severe toxicities, leading to high rates of emergency department (ED) visits and unplanned hospital admissions (UHAs). 
. OBJECTIVES: The study aimed to evaluate a quality improvement project to reduce ED visits and UHAs.
. METHODS: A weekly nurse/nurse practitioner-led symptom management clinic was created for patients with HNC receiving radiation therapy deemed at high risk for an ED visit or UHA...
June 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28517239/the-dose-effect-relationship-of-baclofen-in-alcohol-dependence-a-1-year-cohort-study
#16
Baptiste Pignon, Julien Labreuche, Marine Auffret, Sophie Gautier, Sylvie Deheul, Nicolas Simioni, Olivier Cottencin, Régis Bordet, Alain Duhamel, Benjamin Rolland
OBJECTIVE: Our aim is to study the relationship between dose of baclofen and effectiveness in alcohol dependence. METHODS: Two hundred two patients with alcohol dependence, who received baclofen treatment for drinking reduction, were followed up for 1 year. For each patient-month of treatment, the maximum daily dose of baclofen (DDB) and average weekly alcohol consumption (AWAC) were calculated. We defined a favorable drinking outcome as an AWAC under 200 g/w for at least 2 consecutive months...
May 18, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28505217/effect-of-combined-patient-decision-aid-and-patient-navigation-vs-usual-care-for-colorectal-cancer-screening-in-a-vulnerable-patient-population-a-randomized-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Daniel S Reuland, Alison T Brenner, Richard Hoffman, Andrew McWilliams, Robert L Rhyne, Christina Getrich, Hazel Tapp, Mark A Weaver, Danelle Callan, Laura Cubillos, Brisa Urquieta de Hernandez, Michael P Pignone
Importance: Colorectal cancer (CRC) screening is underused, especially among vulnerable populations. Decision aids and patient navigation are potentially complementary interventions for improving CRC screening rates, but their combined effect on screening completion is unknown. Objective: To determine the combined effect of a CRC screening decision aid and patient navigation compared with usual care on CRC screening completion. Design, Setting, and Participants: In this randomized clinical trial, data were collected from January 2014 to March 2016 at 2 community health center practices, 1 in North Carolina and 1 in New Mexico, serving vulnerable populations...
July 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28470666/alcohol-use-disorders-and-immigration-up-to-the-third-generation-in-france-findings-from-a-39-617-subject-survey-in-the-general-population
#18
Benjamin Rolland, Pierre-Alexis Geoffroy, Baptiste Pignon, Imane Benradia, Hélène Font, Jean-Luc Roelandt, Ali Amad
BACKGROUND: In the United States, first-generation immigrants (FGIs) show lower prevalence rates of alcohol use disorders (AUDs) than the native population, although they experience more psychosocial risk factors. This epidemiological phenomenon is called an "immigrant paradox." No previous study has investigated whether immigrants also exhibit a reduced risk of AUDs in Europe. In a study of the general population in France, we have assessed the adjusted risk of AUDs between nonimmigrants and FGIs, second-generation immigrants (SGIs), and third-generation immigrants (TGIs)...
May 2, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28469077/p63-ureteric-bud-tip-cells-are-progenitors-of-intercalated-cells
#19
Samir S El-Dahr, Yuwen Li, Jiao Liu, Elleny Gutierrez, Kathleen S Hering-Smith, Sabina Signoretti, Jean-Christophe Pignon, Satrajit Sinha, Zubaida Saifudeen
During renal branching morphogenesis, ureteric bud tip cells (UBTC) serve as the progenitor epithelium for all cell types of the collecting duct. While the transcriptional circuitry of ureteric bud (UB) branching has been intensively studied, the transcriptional control of UBTC differentiation has been difficult to ascertain. This is partly due to limited knowledge of UBTC-specific transcription factors that mark the progenitor state. Here, we identify the transcription factor p63 (also known as TP63), a master regulator of basal stem cells in stratified epithelia, as a specific marker of mouse and human UBTC...
May 4, 2017: JCI Insight
https://www.readbyqxmd.com/read/28467530/quality-of-patient-decisions-about-breast-reconstruction-after-mastectomy
#20
Clara Nan-Hi Lee, Allison M Deal, Ruth Huh, Peter Anthony Ubel, Yuen-Jong Liu, Lillian Blizard, Caprice Hunt, Michael Patrick Pignone
Importance: Breast reconstruction has the potential to improve a person's body image and quality of life but has important risks. Variations in who undergoes breast reconstruction have led to questions about the quality of patient decisions. Objective: To assess the quality of patient decisions about breast reconstruction. Design, Setting, and Participants: A prospective, cross-sectional survey study was conducted from June 27, 2012, to February 28, 2014, at a single, academic, multidisciplinary oncology clinic among women planning to undergo mastectomy for stage I to III invasive ductal or lobular breast cancer, ductal carcinoma in situ, or prophylaxis...
August 1, 2017: JAMA Surgery
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