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Saravanan Alagesan, Silambarasi Nagasamy, Pradeep Elangovan, Haemanath Pandian, Ganesh Anantharaman
Carpometacarpal (CMC) joint dislocation is a rare injury that can be easily missed due to non-specific clinical signs and radiologic findings. We report a patient with an isolated and irreducible dorsal dislocation of the second CMC joint, which required an open reduction and K-wire transfixation. An extensor tendon was found to be interposed between the base and the trapezoid. K-wire removal was done after three weeks and following the removal of the wire, rehabilitation was started.
March 2024: Curēus
#22
JOURNAL ARTICLE
Christina M Knippler, Jamie L Arnst, Isaac E Robinson, Veronika Matsuk, Tala O Khatib, R Donald Harvey, Mala Shanmugam, Janna K Mouw, Haian Fu, Thota Ganesh, Adam I Marcus
Targeting cancer metabolism to limit cellular energy and metabolite production is an attractive therapeutic approach. Here, we developed analogs of the bisbiguanide, alexidine, to target lung cancer cell metabolism and assess a structure-activity relationship (SAR). The SAR led to the identification of two analogs, AX-4 and AX-7, that limit cell growth via G1/G0 cell-cycle arrest and are tolerated in vivo with favorable pharmacokinetics. Mechanistic evaluation revealed that AX-4 and AX-7 induce potent mitochondrial defects; mitochondrial cristae were deformed and the mitochondrial membrane potential was depolarized...
April 19, 2024: IScience
#23
JOURNAL ARTICLE
Ganesh Shunmugavel, Kannadhasan Suriyan, Jayachandran Arumugam
BACKGROUND: In this paper, we look at how to design and build a system to find tumors using 2 Convolutional Neural Network (CNN) models. With the help of digital image processing and deep Learning, we can make a system that automatically diagnoses and finds different diseases and abnormalities. The tumor detection system may include image enhancement, segmentation, data enhancement, feature extraction, and classification. These options are set up so that the CNN model can give the best results...
April 18, 2024: American Journal of Clinical Oncology
#24
JOURNAL ARTICLE
Yogesh A Jadhav, Ganesh K Rahane, Tanmay Goswami, Kusuma Jagadish, Kalyani Chordiya, Anurag Roy, Tushar Debnath, Sagar B Jathar, Rupesh Devan, Mousumi Upadhyay Kahaly, Sachin R Rondiya, Hirendra N Ghosh, Nelson Y Dzade
Considering the importance of physics and chemistry at material interfaces, we have explored the coupling of multinary chalcogenide semiconductor Cu2 NiSnS4 nanoparticles (CNTS NPs) for the first time with the noble metal (Au) to form Au-CNTS nano-heterostructures (NHSs). The Au-CNTS NHSs is synthesized by a simple facile hot injection method. Synergistic experimental and theoretical approaches are employed to characterize the structural, optical, and electrical properties of the Au-CNTS NHSs. The absorption spectra demonstrate enhanced and broadened optical absorption in the ultraviolet-visible-near-infrared (UV-Vis-NIR) region, which is corroborated by cyclic voltammetry (CV) readings...
April 17, 2024: ACS Applied Materials & Interfaces
#25
JOURNAL ARTICLE
Arokia Rajkumar Shancy Merlin, Vignesh Ravindran, Ganesh Jeevanandan, Rajalakshmanan Eswaramoorthy, Abirami Arthanari
Background The challenges associated with incorporating antimicrobial agents, such as the potential diminishment of the cement's physical properties, highlight the need for comprehensive evaluations. Balancing antimicrobial efficacy with the maintenance of structural integrity is a crucial aspect of material development. The acknowledgment of cytotoxic properties associated with tricalcium aluminate, a major constituent in conventional mineral trioxide aggregate (MTA), is critical in terms of long-term evaluation of treatment procedures...
March 2024: Curēus
#26
JOURNAL ARTICLE
Tahani Alrahbeni, Ahmed Mahal, Anas Alkhouri, Hadil Faris Alotaibi, Vineet Rajagopal, Ashish Behera, Khalid Al-Mugheed, Mahalaqua Nazli Khatib, Shilpa Gaidhane, Quazi Syed Zahiruddin, Muhammed Shabil, Ganesh Bushi, Sarvesh Rustagi, Neelima Kukreti, Prakasini Satapathy, Ranjan K Mohapatra, Arkadiusz Dziedzic, Bijaya Kumar Padhi
BACKGROUND: Migraine affects approximately 14-15% of the global population, contributing to nearly 5% of the world's health burden. When drug treatments prove ineffective for intractable migraines, highly specific surgical interventions emerge as potential solutions. We aimed to analyze surgical approaches for these refractory or intractable migraines through a systematic review and meta-analysis. METHODS: We conducted a literature search across databases such as PubMed, Scopus, Web of Science, and Embase, focusing on studies related to migraines and surgical outcomes...
April 15, 2024: International Journal of Surgery
#27
JOURNAL ARTICLE
J Paulo Lorenzo, Linda Molla, Elias Moris Amro, Ignacio L Ibarra, Sandra Ruf, Cedrik Neber, Christos Gkougkousis, Jana Ridani, Poorani Ganesh Subramani, Jonathan Boulais, Dewi Harjanto, Alin Vonica, Javier M Di Noia, Christoph Dieterich, Judith B Zaugg, F Nina Papavasiliou
The apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide (APOBEC) family is composed of nucleic acid editors with roles ranging from antibody diversification to RNA editing. APOBEC2, a member of this family with an evolutionarily conserved nucleic acid-binding cytidine deaminase domain, has neither an established substrate nor function. Using a cellular model of muscle differentiation where APOBEC2 is inducibly expressed, we confirmed that APOBEC2 does not have the attributed molecular functions of the APOBEC family, such as RNA editing, DNA demethylation, and DNA mutation...
April 23, 2024: Proceedings of the National Academy of Sciences of the United States of America
#28
JOURNAL ARTICLE
Atun Roy Choudhury, Neha Singh, Jitesh Lalwani, Mallikarjuna Goriparthi Rao, Bhanu Prakash Konyala, Chiradeep Nadella, Abhishek Nayakwadi, Sankar Ganesh Palani
Comprehensive and proper management of fecal sludge (FS) is an ongoing concern in many nations. Decentralized fecal sludge treatment plants (FSTPs) are effective in this regard; however, many have experienced strong public opposition based partly on suspicion of malodor. Fecal sludge and freshly generated fecal matter (FM) samples from various FSTPs were collected, characterized, and investigated for biomethane potential. The homogenized samples were anaerobically digested for 28 days. Digestion successfully reduced total suspended solids, biochemical oxygen demand, and threshold odor number values of 97,350-97,420 mg/l, 43,230-43,260 mg/l, and 130-150 for FM, to 49,500-49,650 mg/l, 23,760-23,850 mg/l, and 3338, respectively, for FS samples...
April 16, 2024: Environmental Science and Pollution Research International
#29
JOURNAL ARTICLE
N Vishnu Ganesh, B Rajesh, Qasem M Al-Mdallal, Hillary Muzara
This study examines the effects of magnetic-field-dependent (MFD) viscosity on the boundary layer flow of a non-Newtonian sodium alginate-based <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mi>F</mml:mi><mml:msub><mml:mrow><mml:mi>e</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub><mml:msub><mml:mrow><mml:mi>O</mml:mi></mml:mrow><mml:mrow><mml:mn>4</mml:mn></mml:mrow></mml:msub></mml:math> nanofluid over an impermeable stretching surface...
April 15, 2024: Heliyon
#30
JOURNAL ARTICLE
Kowsigan Magesan, Parthopratim D Majumder, Mamta Agarwal, Amala E George, Vinita Nair, Sudha K Ganesh, Jyotirmay Biswas
PURPOSE: To report the clinical pattern of surgically induced necrotizing scleritis (SINS) in a tertiary eye care center in Southern India. METHODS: Retrospective analysis of all SINS cases visiting the uveitis clinic of a tertiary eye institute between January 2009 and April 2019. RESULTS: In total, 15 patients with a median age of 65 (IQR:52-70) years were included in the study. Male (53%) predominance was noted, and SINS was unilateral (100%) in all cases...
April 16, 2024: Indian Journal of Ophthalmology
#31
JOURNAL ARTICLE
Jinxia Liu, Jane MacNaughtan, Annarein J C Kerbert, Theo Portlock, Javier Martínez Gonzalez, Yi Jin, Frederick Clasen, Abeba Habtesion, Huoyan Ji, Qin Jin, Alexandra Phillips, Francesco De Chiara, Ganesh Ingavle, Cesar Jimenez, Giacomo Zaccherini, Katherine Husi, Miguel Angel Rodriguez Gandia, Paul Cordero, Junpei Soeda, Lynda McConaghy, Jude Oben, Karen Church, Jia V Li, Haifeng Wu, Aarti Jalan, Pere Gines, Elsa Solà, Simon Eaton, Carrie Morgan, Michal Kowalski, Daniel Green, Amir Gander, Lindsey A Edwards, I Jane Cox, Helena Cortez-Pinto, Thomas Avery, Reiner Wiest, Francois Durand, Paolo Caraceni, Roberto Elosua, Joan Vila, Marco Pavesi, Vicente Arroyo, Nathan Davies, Rajeshwar P Mookerjee, Victor Vargas, Susan Sandeman, Gautam Mehta, Saeed Shoaie, Julian Marchesi, Agustín Albillos, Fausto Andreola, Rajiv Jalan
OBJECTIVE: Targeting bacterial translocation in cirrhosis is limited to antibiotics with risk of antimicrobial resistance. This study explored the therapeutic potential of a non-absorbable, gut-restricted, engineered carbon bead adsorbent, Yaq-001 in models of cirrhosis and acute-on-chronic liver failure (ACLF) and, its safety and tolerability in a clinical trial in cirrhosis. DESIGN: Performance of Yaq-001 was evaluated in vitro . Two-rat models of cirrhosis and ACLF, (4 weeks, bile duct ligation with or without lipopolysaccharide), receiving Yaq-001 for 2 weeks; and two-mouse models of cirrhosis (6-week and 12-week carbon tetrachloride (CCl4)) receiving Yaq-001 for 6 weeks were studied...
April 15, 2024: Gut
#32
JOURNAL ARTICLE
Velmurugan Ajithkumar, ArunKumar Malaisamy, Appaiyan Philomina, Nagamalai Sakthi Vignesh, Elamathi Vimali, Drishanu Dey, Innasi Muthu Ganesh Moorthy, Balasubramaniem Ashokkumar, Perumal Varalakshmi
Microalgae, owing to their efficacy and eco-friendliness have emerged as a promising solution for mitigating Bisphenol A (BPA), a hazardous environmental pollutant. This study mainly investigated the BPA degradation by Coelastrella sp. M60 at various concentrations (10 to 50 mg/L) using GC-MS analysis. Further, the metabolic profiling of Coelastrella sp. M60 was performed via the MetaboAnalyst and results revealed that BPA exposure modulated the metabolites profile with the presence of intermediates like 4-hydroxybenzoic acid and benzene...
April 13, 2024: Bioresource Technology
#33
Thaddeus H Gugu, Christopher O Eze, Franklin C Kenechukwu, Muhammd A Khumaini Mudhar Bintang, Sanjay B Patil, Ganesh D Basarkar, Anthony A Attama, Emmanuel C Ibezim, Chandrashekhar D Upasani, Teerapol Srichana
[This retracts the article DOI: 10.1016/j.heliyon.2023.e16963.].
March 30, 2024: Heliyon
#34
JOURNAL ARTICLE
Samrat Ray, Catherine Parmentier, Masataka Kawamura, Sujani Ganesh, Emmanuel Nogueira, Francisco Calderon Novoa, Christian Hobeika, Tunpang Chu, Sangeetha N Kalimuthu, Markus Selzner, Trevor W Reichman
BACKGROUND: Pancreas transplant volumes are limited because of poor utilization of "extended criteria grafts." Prolonged cold ischemia is a risk factor associated with poor allograft survival. We aimed to establish the feasibility of transplantation using grafts subjected to prolonged cold ischemia and determine whether these grafts could be optimized using normothermic ex vivo perfusion (NEVP) in a porcine model. METHODS: The study population consisted of 35 to 40 kg male Yorkshire pigs in an allotransplantation model with a 3-d survival plan for recipients...
May 2024: Transplantation Direct
#35
JOURNAL ARTICLE
Sangam Rai, Ganesh Dangal, Aruna Karki, Peru Pradhan, Ranjana Shrestha, Kabin Bhattachan, Sunita Maharajan, Srijana Bhandari, Amog Basnyat
Endometrioma is the localization of endometriosis in ovary which often develops as cyst. The condition can be complicated with infection, torsion and rupture leading to significant hemoperitoneum and ascites. We present here a 28-year female P2 L1 presented with the features of acute abdomen and severe anemia referred from other hospital where pain management was done. She had raised Ca-125 level, negative Urine Beta HCG and USG findings of left endometrioma with degenerating subserosal fibroid. The improvement of her general condition with analgesics was misleading however a static hematocrit level despite blood transfusion raised suspicion of ongoing pathology leading to blood loss and diagnostic paracentesis confirmed the hemoperitoneum while awaiting of CT report...
March 31, 2024: Journal of Nepal Health Research Council
#36
JOURNAL ARTICLE
Ganesh Dangal, Ojash Dangal
N/A.
March 31, 2024: Journal of Nepal Health Research Council
#37
JOURNAL ARTICLE
Srijana Bhandari, Ganesh Dangal, Aruna Karki, Hema Pradhan, Ranjana Shrestha, Kabin Bhattachan, Kenusha Devi Tiwari, Sonu Bharati, Sunita Maharjan
Mayer-Rokitansky-Kuster-Hauser syndrome also known as mullerian agenesis is a rare congenital condition in which there is absence of uterus along with upper vagina. Patient usually presents with primary amenorrhea with or without cyclical lower abdominal pain but have normal secondary sexual characters. Modified McIndoe Vaginoplasty with amnion graft is the commonest surgery performed worldwide. A 23 year old girl with normal secondary sexual characters presented with primary amenorrhea with cyclical lower abdominal pain; on examination blind vagina was present...
March 22, 2024: Journal of Nepal Health Research Council
#38
REVIEW
Kanagavalli Ramasubbu, Ganesh Venkatraman, Ganasambanthan Ramanathan, Sivaraman Dhanasekar, V Devi Rajeswari
Neural tissue engineering is a sub-field of tissue engineering that develops neural tissue. Damaged central and peripheral nervous tissue can be fabricated with a suitable scaffold printed with biomaterials. These scaffolds promote cell growth, development, and migration, yet they vary according to the biomaterial and scaffold printing technique, which determine the physical and biochemical properties. The physical and biochemical properties of scaffolds stimulate diverse signalling pathways, such as Wnt, NOTCH, Hedgehog, and ion channels- mediated pathways to promote neuron migration, elongation and migration...
April 13, 2024: Life Sciences
#39
REVIEW
Rajesh Nachiappa Ganesh, Gabriela Garcia, Luan Truong
The monocyte-macrophage lineage of inflammatory cells is characterized by significant morphologic and functional plasticity. Macrophages have broad M1 and M2 phenotype subgroups with distinctive functions and dual reno-toxic and reno-protective effects. Macrophages are a major contributor to injury in immune-complex-mediated, as well as pauci-immune, glomerulonephritis. Macrophages are also implicated in tubulointerstitial and vascular disease, though there have not been many human studies. Patrolling monocytes in the intravascular compartment have been reported in auto-immune injury in the renal parenchyma, manifesting as acute kidney injury...
March 28, 2024: International Journal of Molecular Sciences
#40
JOURNAL ARTICLE
Palanichamy Sundaram, Anbalagan Sathishkumar, Jie Liu, Rajendran Prabakaran, Poongavanam Ganesh Kumar, Pandian Pragathi, Sung Chul Kim
In building cooling, the demand for cooling surges during specific times, stressing air-conditioner operation, and additional cooling is often wasted during low-demand periods. Water-phase change material (W-PCM)-based thermal energy storage (TES) allows for load shifting and effective management of peak demand by storing cooling energy when the demand is low. This stored energy can be deployed during peak hours, decreasing energy usage and associated CO2 emissions. However, the use of W-PCMs was hindered by phase separation, slow energy transfer, and high supercooling degree (SCD)...
April 12, 2024: Environmental Science and Pollution Research International
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