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https://www.readbyqxmd.com/read/28922058/evolution-of-regions-containing-antibiotic-resistance-genes-in-fii-2-fib-1-colv-colla-virulence-plasmids
#1
Robert A Moran, Ruth M Hall
Three ColV virulence plasmids carrying antibiotic resistance genes were assembled from draft genome sequences of commensal ST95, ST131, and ST2705 Escherichia coli isolates from healthy Australians. Plasmids pCERC4, pCERC5, and pCERC9 include almost identical backbones containing FII-2 and FIB-1 replicons and the conserved ColV virulence region with an additional ColIa determinant. Only pCERC5 includes a complete, uninterrupted F-like transfer region and was able to conjugate. pCERC5 and pCERC9 contain Tn1721, carrying the tet(A) tetracycline resistance determinant in the same location, with Tn2 (blaTEM; ampicillin resistance) interrupting the Tn1721 in pCERC5...
September 18, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28906010/serial-changes-in-liver-stiffness-and-controlled-attenuation-parameter-following-direct-acting-antiviral-therapy-against-hepatitis-c-virus-genotype-1b
#2
Nobuhiko Ogasawara, Masahiro Kobayashi, Norio Akuta, Yoko Kominami, Shunichiro Fujiyama, Yusuke Kawamura, Hitomi Sezaki, Tetsuya Hosaka, Fumitaka Suzuki, Satoshi Saitoh, Yoshiyuki Suzuki, Yasuji Arase, Kenji Ikeda, Mariko Kobayashi, Hiromitsu Kumada
Little information is available on the impact of direct-acting antiviral (DAA) therapy on changes in liver fibrosis and steatosis. Liver stiffness (LS) and controlled attenuation parameter (CAP) values were evaluated using transient elastography. The study subjects were 214 elderly patients infected with HCV genotype 1b who received 24-week daclatasvir and asunaprevir dual therapy. All patients of this retrospective study had no hepatocellular carcinoma before and during DAA therapy. LS and CAP were assessed before treatment (baseline), at end of treatment (EOT), and at 24, 48, 72 weeks (W) after EOT...
September 14, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28890481/free-testosterone-concentration-is-inversely-associated-with-markers-of-liver-fibrosis-in-men-with-type-2-diabetes-mellitus
#3
Shozo Miyauchi, Teruki Miyake, Masumi Miyazaki, Toru Eguchi, Tetsuji Niiya, Shin Yamamoto, Hidenori Senba, Shinya Furukawa, Bunzo Matsuura, Yoichi Hiasa
The association between serum testosterone level and liver fibrosis in patients with non-alcoholic fatty liver disease is unclear. To clarify this association, we investigated the relationship between serum free testosterone concentration and markers of liver fibrosis in men with type 2 diabetes mellitus but no obvious features of alcohol consumption. This retrospective observational cross-sectional study enrolled 248 men with type 2 diabetes mellitus. The FIB-4 index was measured as a marker of liver fibrosis, and multiple linear regression analysis was performed to examine its association with serum free testosterone concentration...
September 9, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28875860/scaffold-hopping-strategy-for-the-design-synthesis-and-biological-activity-evaluation-of-novel-hexacyclic-scutellarein-derivatives-with-a-1-3-oxazine-ring-fused-at-a-ring
#4
Yue Zhong, Yu-Ting Lu, Ying Sun, Nian-Guang Li, Ting Gu, Wen-Yu Wu, Shao-Peng Yu, Zhi-Hao Shi
BACKGROUND: Discovery of novel agents with anticoagulant and antioxidant activity is very important to treat cerebrovascular disease. Lead compound LR3d discovered in our laboratory exhibited stronger anticoagulant ability and good antioxidant activity, compared with scutellarein (2), which is the major in vivo active metabolite of the natural product scutellarin (1). OBJECTIVE: Design and synthesis novel scutellarein derivatives with improved anticoagulant and antioxidant activity...
September 6, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28853728/fibrosis-4-index-helps-identify-hbv-carriers-with-the-lowest-risk-of-hepatocellular-carcinoma
#5
Tai-Chung Tseng, Chun-Jen Liu, Tung-Hung Su, Wan-Ting Yang, Chi-Ling Chen, Hung-Chih Yang, Chia-Chi Wang, Stephanie Fang-Tzu Kuo, Chen-Hua Liu, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao
OBJECTIVES: Several viral and host risk factors have been used to predict risks of hepatocellular carcinoma (HCC) in patients with chronic infection of hepatitis B virus (HBV). However, little is known whether fibrosis-4 (FIB-4) index, a liver fibrosis biomarker, helps identify non-cirrhotic patients with the lowest HCC risk. METHODS: A total of 2075 treatment-naive Taiwanese patients with chronic HBV infection were followed for an average period of 16.02 years...
August 29, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28853552/nanoscale-chemical-characterization-of-solid-state-microbattery-stacks-by-means-of-auger-spectroscopy-and-ion-milling-cross-section-preparation
#6
A Uhart, J B Ledeuil, B Pecquenard, F Le Cras, M Proust, H Martinez
The current sustained demand for "smart" and connected devices has created a need for more miniaturized power sources, hence for microbatteries. Lithium-ion or "lithium-free" all-solid-state thin-film batteries are adapted solutions to this issue. The capability to carry out spatially resolved chemical analysis is fundamental for the understanding of the operation in an all-solid-state microbattery. Classically cumbersome and not straightforward techniques as TEM/STEM/EELS and FIB preparation methods could be used to address this issue...
September 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28841822/diminished-accuracy-of-biomarkers-of-fibrosis-in-low-replicative-chronic-hepatitis-b
#7
Faisal M Sanai, Taha Farah, Khalid Albeladi, Faisal Batwa, Yaser Dahlan, Mohammed A Babatin, Hamad Al-Ashgar, Hadeel AlMana, Khaled S Alsaad, Khalid AlSwat, Abdulrahman Aljumah, Ibrahim H AlTraif, Bahaa E Kailani, Khalid I Bzeizi
BACKGROUND: We evaluated the diagnostic accuracy of aspartate aminotransferase (AST)-to-platelet ratio index (APRI), fibrosis-4 index (FIB-4), AST/alanine aminotransferase (ALT) ratio (AAR), and age-platelet index (API) for significant fibrosis (Metavir F2-4) in low-replicative (HBV DNA <20,000 IU/mL) chronic hepatitis B virus (HBV) patients. METHODS: The sensitivity, specificity, and area under the receiver-operating characteristic curve (AUROC) of HBeAg-negative, low-replicative (n = 213) and high-replicative (HBV DNA ≥20,000 IU/mL, n = 153) patients was assessed...
August 25, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28839987/effect-of-huisheng-oral-solution-on-coagulation-function-in-perioperative-period-in-patients-with-primary-lung-cancer
#8
Xiaoguang Yang, Helin Zhang, Fanyi Kong, Guochen Wang, Qianyu Gu, Zheng Zhao, Tiezhi Li, Mingming Ren, Zuosheng Li, Yang Guo
BACKGROUND: The incidence of venous thromboembolism (VTE) is about 4-10% in lung cancer patients. Huisheng oral solution (HSOS) has been previously demonstrated to inhibit carageenan induced acute thrombosis in rats, reduce the incidence of thrombosis in the lungs and mesentery of tumor-bearing mice and inhibit tumor cell metastasis. The purpose of this study was to assess the anticoagulant effect of HSOS in lung cancer patients in the perioperative period. METHODS: This study was a multicenter, randomized, single-blind, blank-controlled clinical trial...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28831062/visualization-of-the-internal-structure-of-didymosphenia-geminata-frustules-using-nano-x-ray-tomography
#9
Izabela Zgłobicka, Qiong Li, Jürgen Gluch, Magdalena Płocińska, Teresa Noga, Romuald Dobosz, Robert Szoszkiewicz, Andrzej Witkowski, Ehrenfried Zschech, Krzysztof J Kurzydłowski
For the first time, the three-dimensional (3D) internal structure of naturally produced Didymosphenia geminata frustules were nondestructively visualized at sub-100 nm resolution. The well-optimized hierarchical structures of these natural organisms provide insight that is needed to design novel, environmentally friendly functional materials. Diatoms, which are widely distributed in freshwater, seawater and wet soils, are well known for their intricate, siliceous cell walls called 'frustules'. Each type of diatom has a specific morphology with various pores, ribs, minute spines, marginal ridges and elevations...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807799/the-influence-of-yttrium-segregation-dependent-phase-partitioning-and-residual-stresses-on-the-aging-and-fracture-behaviour-of-3y-tzp-ceramics
#10
Dušan Bučevac, Tomaž Kosmač, Andraž Kocjan
The yttrium-segregation-dependent phase partitioning and residual stress development that influence both the aging and the fracture behaviour in 3Y-TZP bioceramics were studied by sintering alumina-free 3Y-TZP, varying the sintering temperature and the time, to yield ceramics with identical grain size distributions, but with different phase compositions. The structure and stability of the resulting tetragonal phases, in the form of transformable, yttria-lean t-ZrO2 (YLZ) and non-transformable, yttria-rich t"-ZrO2 and/or t'-ZrO2 (YRZ), were studied by X-ray diffraction (XRD) and focused ion beam scanning electron microscopy (FIB-SEM)...
August 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28797948/a-scanning-probe-mounted-on-a-field-effect-transistor-characterization-of-ion-damage-in-si
#11
Kumjae Shin, Hoontaek Lee, Min Sung, Sang Hoon Lee, Hyunjung Shin, Wonkyu Moon
We have examined the capabilities of a Tip-On-Gate of Field-Effect Transistor (ToGoFET) probe for characterization of FIB-induced damage in Si surface. A ToGoFET probe is the SPM probe which the Field Effect Transistor(FET) is embedded at the end of a cantilever and a Pt tip was mounted at the gate of FET. The ToGoFET probe can detect the surface electrical properties by measuring source-drain current directly modulated by the charge on the tip. In this study, a Si specimen whose surface was processed with Ga+ ion beam was prepared...
July 24, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28772763/a-comparison-of-microscale-techniques-for-determining-fracture-toughness-of-limn%C3%A2-o%C3%A2-particles
#12
Muhammad Zeeshan Mughal, Hugues-Yanis Amanieu, Riccardo Moscatelli, Marco Sebastiani
Accurate estimation of fracture behavior of commercial LiMn₂O₄ particles is of great importance to predict the performance and lifetime of a battery. The present study compares two different microscale techniques to quantify the fracture toughness of LiMn₂O₄ particles embedded in an epoxy matrix. The first technique uses focused ion beam (FIB) milled micro pillars that are subsequently tested using the nanoindentation technique. The pillar geometry, critical load at pillar failure, and cohesive FEM simulations are then used to compute the fracture toughness...
April 12, 2017: Materials
https://www.readbyqxmd.com/read/28768482/comparative-genomic-analysis-and-characterization-of-incompatibility-group-fib-plasmid-encoded-virulence-factors-of-salmonella-enterica-isolated-from-food-sources
#13
Bijay K Khajanchi, Nur A Hasan, Seon Young Choi, Jing Han, Shaohua Zhao, Rita R Colwell, Carl E Cerniglia, Steven L Foley
BACKGROUND: The degree to which the chromosomal mediated iron acquisition system contributes to virulence of many bacterial pathogens is well defined. However, the functional roles of plasmid encoded iron acquisition systems, specifically Sit and aerobactin, have yet to be determined for Salmonella spp. In a recent study, Salmonella enterica strains isolated from different food sources were sequenced on the Illumina MiSeq platform and found to harbor the incompatibility group (Inc) FIB plasmid...
August 2, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28765691/fibrinogen-deficiency-suppresses-the-development-of-early-and-delayed-radiation-enteropathy
#14
Junru Wang, Rupak Pathak, Sarita Garg, Martin Hauer-Jensen
AIM: To determine the mechanistic role of fibrinogen, a key regulator of inflammation and fibrosis, in early and delayed radiation enteropathy. METHODS: Fibrinogen wild-type (Fib(+/+)), fibrinogen heterozygous (Fib(+/-)), and fibrinogen knockout (Fib(-/-)) mice were exposed to localized intestinal irradiation and assessed for early and delayed structural changes in the intestinal tissue. A 5-cm segment of ileum of mice was exteriorized and exposed to 18.5 Gy of x-irradiation...
July 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28759595/hbv-infection-in-untreated-hiv-infected-adults-in-maputo-mozambique
#15
Lúcia Mabalane Chambal, Eduardo Samo Gudo, Awa Carimo, Rita Corte Real, Nédio Mabunda, Cremildo Maueia, Adolfo Vubil, Ana Flora Zicai, Nilesh Bhatt, Francisco Antunes
BACKGROUND: HIV/ HBV coinfected patients are at high risk of developing chronic HBV infection, liver cirrhosis and hepatocellular carcinoma. In Mozambique, where HIV prevalence is one of the highest in the world, HIV-infected patients are scarcely characterized in terms of HBV coinfection and 3TC-resistance mutations profile. METHODS: To characterize ART-naïve HIV-infected adults, with and without HBV coinfection, a cross-sectional study was conducted between May and November 2012 in two health centers from Maputo city, Mozambique...
2017: PloS One
https://www.readbyqxmd.com/read/28753012/identification-of-urinary-food-intake-biomarkers-for-milk-cheese-and-soy-based-drink-by-untargeted-gc-ms-and-nmr-in-healthy-humans
#16
Linda H Münger, Alessia Trimigno, Gianfranco Picone, Carola Freiburghaus, Grégory Pimentel, Kathryn J Burton, François P Pralong, Nathalie Vionnet, Francesco Capozzi, René Badertscher, Guy Vergères
The measurement of food intake biomarkers (FIBs) in biofluids represents an objective tool for dietary assessment. FIBs of milk and cheese still need more investigation due to the absence of candidate markers. Thus, an acute intervention study has been performed to sensitively and specifically identify candidate FIBs. Eleven healthy male and female volunteers participated in the randomized, controlled crossover study that tested a single intake of milk and cheese as test products, and soy-based drink as a control...
August 10, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28752524/serial-combination-of-non-invasive-tools-improves-the-diagnostic-accuracy-of-severe-liver-fibrosis-in-patients-with-nafld
#17
S Petta, V W-S Wong, C Cammà, J-B Hiriart, G L-H Wong, J Vergniol, A W-H Chan, V Di Marco, W Merrouche, H L-Y Chan, F Marra, B Le-Bail, U Arena, A Craxì, V de Ledinghen
BACKGROUND: The accuracy of available non-invasive tools for staging severe fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) is still limited. AIM: To assess the diagnostic performance of paired or serial combination of non-invasive tools in NAFLD patients. METHODS: We analysed data from 741 patients with a histological diagnosis of NAFLD. The GGT/PLT, APRI, AST/ALT, BARD, FIB-4, and NAFLD Fibrosis Score (NFS) scores were calculated according to published algorithms...
July 27, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28745782/effects-of-heparin-catheter-sealing-solution-for-implantable-venous-access-ports-on-d-dimer-levels-in-older-cancer-patients
#18
X-M Gao, R He, J-F Guan, L Tian
OBJECTIVE: To investigate the effects of different concentrations of heparin catheter-sealing solution for implantable venous access ports (VAPs) on D-dimers (D-D) in older cancer patients. PATIENTS AND METHODS: A total of 208 older cancer patients who received intravenous chemotherapy for the first time were randomly divided into four groups: the normal saline group, the low concentration heparin group (25 U/ml), the medium concentration heparin group (50 U/ml), and the high concentration heparin group (75 U/ml), with 52 patients in each group...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28735336/acoustic-radiation-force-impulse-arfi-elastography-and-serological-markers-in-assessment-of-liver-fibrosis-and-free-portal-pressure-in-patients-with-hepatitis-b
#19
Jun Li, Jie Yu, Xin-Yu Peng, Ting-Ting Du, Jia-Jia Wang, Jin Tong, Gui-Lin Lu, Xiang-Wei Wu
BACKGROUND The aim of this study was to investigate the feasibility of using acoustic radiation force impulse (ARFI) elastography, AST-to-platelet ratio index (APRI), and FIB-4 in assessing liver fibrosis and free portal pressure in patients with hepatitis B. MATERIAL AND METHODS We enrolled 126 patients with hepatitis B who underwent liver surgery at the General Surgery Department of the First Affiliated Hospital of Shihezi University Medical School from February 2013 to August 2015. Preoperatively, shear wave velocity (SWV) of the liver was measured with the Siemens S2000 ultrasound system to reflect liver stiffness...
July 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28708426/phenotypic-characteristics-and-genetic-diversity-of-salmonella-enterica-serotype-derby-isolated-from-human-patients-and-foods-of-animal-origin
#20
Chenggang Xu, Xingxing Ren, Zhou Feng, Ying Fu, Yanfen Hong, Zujie Shen, Lina Zhang, Ming Liao, Xuebin Xu, Jianmin Zhang
Salmonella enterica serotype Derby is among the three most common serotypes of nontyphoidal Salmonella isolated from patients with diarrhea in China. In this study, 133 Salmonella Derby isolates from human patients (n = 74) and foods of animal origin (n = 59) in Shanghai, China, between September 2013 and December 2014, were selected to study its phenotypic characteristics and genetic diversity. The isolates were subjected to antimicrobial susceptibility testing, plasmid replicon typing, virulence profile determination, and molecular subtyping by pulsed-field gel electrophoresis (PFGE)...
July 14, 2017: Foodborne Pathogens and Disease
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