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https://www.readbyqxmd.com/read/29149672/the-application-of-bacteriophages-as-novel-indicators-of-viral-pathogens-in-wastewater-treatment-systems
#1
Edgard Dias, James Ebdon, Huw Taylor
Many wastewater treatment technologies have been shown to remove bacterial pathogens more effectively than viral pathogens and, in aquatic environments, levels of traditional faecal indicator bacteria (FIB) do not appear to correlate consistently with levels of human viral pathogens. There is, therefore, a need for novel viral indicators of faecal pollution and surrogates of viral pathogens, especially given the increasing importance of indirect and direct wastewater reuse. Potential candidates include bacteriophages (phages) and the study described here sought to elucidate the relationship between three groups of phages (somatic coliphages (SOMPH), F-RNA coliphages (F-RNAPH) and human-specific phages infecting B...
November 9, 2017: Water Research
https://www.readbyqxmd.com/read/29147645/real-world-cure-rates-for-hepatitis-c-virus-treatments-that-include-simeprevir-and-or-sofosbuvir-are-comparable-to-clinical-trial-results
#2
Kian Bichoupan, Neeta Tandon, James F Crismale, Joshua Hartman, David Del Bello, Neal Patel, Sweta Chekuri, Alyson Harty, Michel Ng, Keith M Sigel, Meena B Bansal, Priya Grewal, Charissa Y Chang, Jennifer Leong, Gene Y Im, Lawrence U Liu, Joseph A Odin, Nancy Bach, Scott L Friedman, Thomas D Schiano, Ponni V Perumalswami, Douglas T Dieterich, Andrea D Branch
AIM: To assess the real-world effectiveness and cost of simeprevir (SMV), and/or sofosbuvir (SOF)-based therapy for chronic hepatitis C virus (HCV) infection. METHODS: The real-world performance of patients treated with SMV/SOF ± ribavirin (RBV), SOF/RBV, and SOF/RBV with pegylated-interferon (PEG) were analyzed in a consecutive series of 508 patients with chronic HCV infection treated at a single academic medical center. Patients with genotypes 1 through 4 were included...
November 12, 2017: World Journal of Virology
https://www.readbyqxmd.com/read/29142422/chemotaxonomic-diversity-of-three-ficus-species-their-discrimination-using-chemometric-analysis-and-their-role-in-combating-oxidative-stress
#3
Nawal Al-Musayeib, Sherif S Ebada, Haidy A Gad, Fadia S Youssef, Mohamed Lotfy Ashour
Background: Genus Ficus (Moraceae) constitutes more than 850 species and about 2000 varieties and it acts as a golden mine that could afford effective and safe remedies combating many health disorders. Objectives: Discrimination of Ficus cordata, Ficus ingens, and Ficus palmata using chemometric analysis and assessment of their role in combating oxidative stress. Materials and Methods: Phytochemical profiling of the methanol extracts of the three Ficus species and their successive fractions was performed using high-performance liquid chromatography/electrospray ionization mass spectrometry...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29139273/-comparative-study-on-promoting-blood-effects-of-danshen-honghua-herb-pair-with-different-preparations-based-on-chemometrics-and-multi-attribute-comprehensive-index-methods
#4
Cheng Qu, Yu-Ping Tang, Xu-Qin Shi, Gui-Sheng Zhou, Er-Xin Shang, Li-Li Shang, Jian-Ming Guo, Pei Liu, Jing Zhao, Bu-Chang Zhao, Jin-Ao Duan
To evaluate the promoting blood circulation and removing blood stasis effects of Danshen-Honghua(DH) herb pair with different preparations (alcohol, 50% alcohol and water) on blood rheology and coagulation functions in acute blood stasis rats, and optimize the best preparation method of DH based on principal component analysis(PCA), hierarchical cluster heatmap analysis and multi-attribute comprehensive index methods. Ice water bath and subcutaneous injection of adrenaline were both used to establish the acute blood stasis rat model...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29128062/diagnosis-and-evaluation-of-nonalcoholic-fatty-liver-disease-nonalcoholic-steatohepatitis-including-noninvasive-biomarkers-and-transient-elastography
#5
REVIEW
Eugenia Tsai, Tai-Ping Lee
The incidence and prevalence of nonalcoholic fatty liver disease (NAFLD) are increasing and identification of people at risk of disease progression is extremely important. The current gold standard for diagnosing NAFLD/nonalcoholic steatohepatitis (NASH) is by liver biopsy, but it has several limitations. Noninvasive tests via biomarkers and transient elastography to assess NAFLD/NASH are being used in clinical practice. The most validated diagnostic panels include the NAFLD fibrosis score, FIB-4 (Fibrosis-4), and FibroMeter...
February 2018: Clinics in Liver Disease
https://www.readbyqxmd.com/read/29120866/surface-effects-on-exciton-diffusion-in-non-polar-zno-znmgo-heterostructures
#6
G Sakr, C Sartel, V Sallet, A Lusson, G Patriarche, P Galtier, J Barjon
The diffusion of excitons injected in ZnO/Zn0.92Mg0.08O quantum well heterostructures grown by metal-organic-vapor-phase-epitaxy on non-polar ZnO substrates is investigated at room temperature. Cathodoluminescence linescans in a field-emission-gun scanning-electron-microscope are performed across cleaved cross-sections. A 55 nm diffusion length is assessed for excitons in bulk ZnMgO. When prepared as small angle bevels using focused ion beam (FIB), the effective diffusion length of excitons is shown to decrease down to 8 nm in the thinner part of the slab...
November 9, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29116099/sensing-performances-of-pure-and-hybridized-carbon-nanotubes-zno-nanowire-networks-a-detailed-study
#7
Oleg Lupan, Fabian Schütt, Vasile Postica, Daria Smazna, Yogendra Kumar Mishra, Rainer Adelung
In this work, the influence of carbon nanotube (CNT) hybridization on ultraviolet (UV) and gas sensing properties of individual and networked ZnO nanowires (NWs) is investigated in detail. The CNT concentration was varied to achieve optimal conditions for the hybrid with improved sensing properties. In case of CNT decorated ZnO nanonetworks, the influence of relative humidity (RH) and applied bias voltage on the UV sensing properties was thoroughly studied. By rising the CNT content to about 2.0 wt% (with respect to the entire ZnO network) the UV sensing response is considerably increased from 150 to 7300 (about 50 times)...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29115339/electro-oxidation-of-a-cobalt-based-steel-in-lioh-a-non-noble-metal-based-electro-catalyst-suitable-for-durable-water-splitting-in-an-acidic-milieu
#8
Helmut Schäfer, Karsten Küpper, Klaus Müller-Buschbaum, Diemo Daum, Martin Steinhart, Joachim Wollschläger, Ulrich Krupp, Mercedes Schmidt, Weijia Han, Johannes Stangl
The use of proton exchange membrane (PEM) electrolyzers is the method of choice for the conversion of solar energy when frequently occurring changes of the current load are an issue. However, this technique requires electrolytes with low pH. All oxygen evolving electrodes working durably and actively in acids contain IrOx. Due to their scarcity and high acquisition costs, noble elements like Pt, Ru and Ir need to be replaced by earth abundant elements. We have evaluated a cobalt containing steel for use as an oxygen-forming electrode in H2SO4...
November 8, 2017: Nanoscale
https://www.readbyqxmd.com/read/29097288/trend-over-time-in-hepatic-fibrosis-score-in-a-cohort-of-type-2-diabetes-patients
#9
Carlo Bruno Giorda, Gabriele Forlani, Roberta Manti, Arianna Mazzotti, Salvatore De Cosmo, Maria Chiara Rossi, Antonio Nicolucci, Paolo Di Bartolo, Antonio Ceriello, Pietro Guida, Barbara Tartaglino, Giuseppina Russo
AIMS: The prevalence and progression of hepatic fibrosis and its correlated factors in type 2 diabetes (T2DM) are poorly known. We aimed to define the percentage of T2DM patients who progress to fibrosis and the factors associated with disease progression. METHODS: Data from the electronic health records of 1527 patients with diagnosed T2DM and nonalcoholic fatty liver disease (NAFLD), as diagnosed by the Fatty Liver Index, were extracted from the AMD Annals database, which collects data from the Italian network of diabetes clinics...
October 30, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29096394/si-amorphization-by-focused-ion-beam-milling-point-defect-model-with-dynamic-bca-simulation-and-experimental-validation
#10
J Huang, M Loeffler, U Muehle, W Moeller, J J L Mulders, L F Tz Kwakman, W F Van Dorp, E Zschech
A Ga focused ion beam (FIB) is often used in transmission electron microscopy (TEM) analysis sample preparation. In case of a crystalline Si sample, an amorphous near-surface layer is formed by the FIB process. In order to optimize the FIB recipe by minimizing the amorphization, it is important to predict the amorphous layer thickness from simulation. Molecular Dynamics (MD) simulation has been used to describe the amorphization, however, it is limited by computational power for a realistic FIB process simulation...
October 25, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/29094442/prevalence-and-severity-of-non-alcoholic-fatty-liver-disease-are-underestimated-in-clinical-practice-impact-of-a-dedicated-screening-approach-at-a-large-university-teaching-hospital
#11
T Marjot, E Sbardella, A Moolla, J Hazlehurst, G D Tan, M Ainsworth, J F L Cobbold, J W Tomlinson
AIMS: To define the attitudes and current clinical practice of diabetes specialists with regard to non-alcoholic fatty liver disease and, based on the results, implement an evidenced-based pathway for non-alcoholic fatty liver disease assessment. METHODS: An online survey was disseminated to diabetes specialists. Based on findings from this survey, we sought a local solution by launching an awareness campaign and implementing a screening algorithm across all diabetes clinics at a secondary/tertiary referral centre...
November 2, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29091092/three-dimensional-morphometry-of-collagen-fibrils-in-membranous-bone
#12
Mana Hashimoto, Noriyuki Nagaoka, Kaori Tabata, Tomoyo Tanaka, Ryuta Osumi, Naoya Odagaki, Toru Hara, Hiroshi Kamioka
The collagen network acts as a scaffold for calcification and its three-dimensional structure influences bone strength. It is therefore important to observe the collagen network in detail and three-dimensionally. In this study, we observed the collagen network of chick embryonic calvariae in membranous bone three-dimensionally using orthogonally arranged FIB-SEM. A 25 × 25 μm area of chick embryonic calvaria was observed at a high resolution (25 nm per pixel). The inside of the bone (i.e. the primary calcified tissue), the bone cells (i...
November 13, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29083080/underappreciation-of-non-alcoholic-fatty-liver-disease-by-primary-care-clinicians-limited-awareness-of-surrogate-markers-of-fibrosis
#13
Preya J Patel, Xuan Banh, Leigh U Horsfall, Kelly L Hayward, Fabrina Hossain, Tracey Johnson, Katherine A Stuart, Nigel N Brown, Nivene Saad, Andrew Clouston, Katharine M Irvine, Anthony W Russell, Patricia C Valery, Suzanne Williams, Elizabeth E Powell
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a common cause of incidental liver test abnormalities. General practitioners have a key role in identifying people with NAFLD at risk of significant liver disease. Recent specialist guidelines emphasize the use of fibrosis algorithms or serum biomarkers rather than routine liver tests, to assess advanced fibrosis. This study evaluated primary care clinicians' current approach to diagnosis, management and referral of NAFLD. METHODS: A cross-sectional survey of primary care clinicians was undertaken through a structured questionnaire about NAFLD...
October 30, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29078105/quantitative-haadf-stem-of-sige-in-presence-of-amorphous-surface-layers-from-fib-preparation
#14
Tim Grieb, Moritz Tewes, Marco Schowalter, Knut Müller-Caspary, Florian F Krause, Thorsten Mehrtens, Jean-Michel Hartmann, Andreas Rosenauer
The chemical composition of four Si1-xGex layers grown on silicon was determined from quantitative scanning transmission electron microscopy (STEM). The chemical analysis was performed by a comparison of the high-angle annular dark field (HAADF) intensity with multislice simulations. It could be shown that amorphous surface layers originating from the preparation process by focused-ion beam (FIB) at 30 kV have a strong influence on the quantification: the local specimen thickness is overestimated by approximately a factor of two, and the germanium concentration is substantially underestimated...
October 13, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/29077674/macrophage-activation-and-the-tumor-necrosis-factor-cascade-in-hepatitis-c-disease-progression-among-hiv-infected-women-participating-in-the-women-s-interagency-hiv-study
#15
Audrey L French, Jonathan W Martin, Charlesnika T Evans, Marion Peters, Seble G Kessaye, Marek Nowicki, Mark Kuniholm, Elizabeth Golub, Michael Augenbraun, Seema N Desai
BACKGROUND: HIV/hepatitis C-coinfected persons experience more rapid liver disease progression than hepatitis C virus (HCV) monoinfected persons, even in the setting of potent antiretroviral therapy. METHODS: We sought to articulate the role of macrophage activation and inflammation in liver disease progression by measuring serial soluble markers in HIV/HCV-coinfected women. We compared markers measured during retrospectively defined periods of rapid liver disease progression to periods where little or no liver disease progression occurred...
December 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29069254/accuracy-of-transient-elastography-fibroscan%C3%A2-acoustic-radiation-force-impulse-arfi-imaging-the-enhanced-liver-fibrosis-elf-test-apri-and-the-fib-4-index-compared-with-liver-biopsy-in-patients-with-chronic-hepatitis-c
#16
Taisa Grotta Ragazzo, Denise Paranagua-Vezozzo, Fabiana Roberto Lima, Daniel Ferraz de Campos Mazo, Mário Guimarães Pessoa, Claudia Pinto Oliveira, Venancio Avancini Ferreira Alves, Flair José Carrilho
OBJECTIVES: Although liver biopsy is the gold standard for determining the degree of liver fibrosis, issues regarding its invasiveness and the small amount of liver tissue evaluated can limit its applicability and interpretation in clinical practice. Non-invasive evaluation methods for liver fibrosis can address some of these limitations. The aim of this study was to evaluate the accuracy of transient elastography-FibroScan®, acoustic radiation force impulse (ARFI), enhanced liver fibrosis (ELF), the aspartate aminotransferase-to-platelet ratio index (APRI), and the FIB-4 index compared with liver biopsy in hepatitis C...
October 2017: Clinics
https://www.readbyqxmd.com/read/29068669/electrophilic-nucleophilic-dualism-of-nickel-ii-toward-ni%C3%A2-%C3%A2-%C3%A2-i-noncovalent-interactions-semicoordination-of-iodine-centers-via-electron-belt-and-halogen-bonding-via-%C3%AF-hole
#17
Zarina M Bikbaeva, Daniil M Ivanov, Alexander S Novikov, Ivan V Ananyev, Nadezhda A Bokach, Vadim Yu Kukushkin
The nitrosoguanidinate complex [Ni{NH═C(NMe2)NN(O)}2] (1) was cocrystallized with I2 and sym-trifluorotriiodobenzene (FIB) to give associates 1·2I2 and 1·2FIB. Structures of these solid species were studied by XRD followed by topological analysis of the electron density distribution within the framework of Bader's approach (QTAIM) at the M06/DZP-DKH level of theory and Hirshfeld surface analysis. Our results along with inspection of XRD (CCDC) data, accompanied by the theoretical calculations, allowed the identification of three types of Ni···I contacts...
November 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29066405/effects-of-danhong-injection-on-platelet-aggregation-in-hyperlipidemia-rats
#18
Hongjing Fan, Min Li, Li Yu, Weifeng Jin, Jiehong Yang, Yuyan Zhang, Haitong Wan
ETHNOPHARMACOLOGICAL RELEVANCE: Danhong Injection (DHI), a Chinese medical product extracted from Radix et Rhizoma Salviae Miltiorrhizae (Salvia miltiorrhiza Bge., Labiatae, Danshen in Chinese) and Flos Carthami (Carthamus tinctorius L., Compositae, Honghua in Chinese), has been reported to have effects on inflammatory, anti-fibrinolytic properties, antithrombotic and decrease blood-lipid. It is extensively used for the clinical treatment of cardiovascular disease. This study aimed to investigate the effects of DHI on blood-lipid levels and platelet aggregation rate in hyperlipidemia rats...
October 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29064821/senescence-associated-ultrastructural-features-of-long-term-cultures-of-induced-pluripotent-stem-cells-ipscs
#19
Fiorella Colasuonno, Rossella Borghi, Alessia Niceforo, Maurizio Muzzi, Enrico Bertini, Andrea Di Giulio, Sandra Moreno, Claudia Compagnucci
Induced pluripotent stem cells (iPSCs) hold great promise for developing personalized regenerative medicine, however characterization of their biological features is still incomplete. Moreover, changes occurring in long-term cultured iPSCs have been reported, suggesting these as a model of cellular aging. For this reason, we addressed the ultrastructural characterization of iPSCs, with a focus on possible time-dependent changes, involving specific cell compartments. To this aim, we comparatively analysed cultures at different timepoints, by an innovative electron microscopic technology (FIB/SEM)...
October 23, 2017: Aging
https://www.readbyqxmd.com/read/29062242/impact-of-hepatitis-c-virus-genotype-4-eradication-following-direct-acting-antivirals-on-liver-stiffness-measurement
#20
Mohammed Tag-Adeen, Ahlam Mohamed Sabra, Yuko Akazawa, Ken Ohnita, Kazuhiko Nakao
BACKGROUND: Liver fibrosis is the most important prognostic factor in chronic hepatitis C virus (HCV) patients, and Egypt shows the highest worldwide HCV prevalence with genotype-4 pre-dominance. The aim of this study was to investigate the degree of liver stiffness measurement (LSM) improvement after successful HCV eradication. PATIENTS AND METHODS: The study included 84 chronic HCV Egyptian patients, and was conducted at Qena University Hospital from November 1, 2015 till October 31, 2016...
2017: Hepatic Medicine: Evidence and Research
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