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Intestinal ischemia

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https://www.readbyqxmd.com/read/28740960/prognostic-factors-in-patients-with-acute-mesenteric-ischemia
#1
Doğan Yıldırım, Adnan Hut, Cihad Tatar, Turgut Dönmez, Muzaffer Akıncı, Mehmet Toptaş
OBJECTIVE: Acute mesenteric ischemia, one of the causes of acute abdominal pain due to occlusion of the superior mesenteric artery, has a fatal course as a result of intestinal necrosis. There is no specific laboratory test to diagnose acute mesenteric ischemia. The basis of treatment in cases of acute mesenteric ischemia is composed of early diagnosis, resection of intestinal sections with infarction, regulation of intestinal blood flow, second look laparotomy when required, and intensive care support...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28738006/effect-of-lidocaine-on-inflammation-in-equine-jejunum-subjected-to-manipulation-only-and-remote-to-intestinal-segments-subjected-to-ischemia
#2
Anje G Bauck, Astrid Grosche, Alison J Morton, A Sarah Graham, Thomas W Vickroy, David E Freeman
OBJECTIVE To examine effects of continuous rate infusion of lidocaine on transmural neutrophil infiltration in equine intestine subjected to manipulation only and remote to ischemic intestine. ANIMALS 14 healthy horses. PROCEDURES Ventral midline celiotomy was performed (time 0). Mild ischemia was induced in segments of jejunum and large colon. A 1-m segment of jejunum was manipulated by massaging the jejunal wall 10 times. Horses received lidocaine (n = 7) or saline (0.9% NaCl) solution (7) throughout anesthesia...
August 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28735976/predictive-value-of-procalcitonin-for-intestinal-ischemia-and-or-necrosis-in-pediatric-patients-with-adhesive-small-bowel-obstruction-asbo
#3
Eduardo Bracho-Blanchet, Alfredo Dominguez-Muñoz, Emilio Fernandez-Portilla, Cristian Zalles-Vidal, Roberto Davila-Perez
PURPOSE: Evaluate serum procalcitonin (PCT) level as a predictor of intestinal ischemia or necrosis (IN) in patients with postoperative adhesive small bowel obstruction (ASBO). METHODS: Prospective cohort of consecutive patients with ASBO. Patients previously treated with antibiotics or septic were excluded. PCT was measured at the diagnosis of ASBO and every 24 h afterwards. MAIN OUTCOME: intestinal ischemia or necrosis (IN). RESULTS: Fifty-nine patients were included, 12 of whom were excluded; 47 patients remained in the study; male-to-female ratio = 1...
July 13, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28733146/resveratrol-efficiently-improves-pulmonary-function-via-stabilizing-mast-cells-in-a-rat-intestinal-injury-model
#4
Xiaolei Huang, Weicheng Zhao, Dan Hu, Xue Han, Hanbin Wang, Jianyu Yang, Yang Xu, Yuantao Li, Weifeng Yao, Chaojin Chen
BACKGROUND: Intestinal ischemia/reperfusion (IIR) leads to acute lung injury (ALI) distally by aggravating pulmonary oxidative stress. Resveratrol is effective in attenuating ALI through its antioxidant capacity. This study aimed to determine the effects of resveratrol on IIR-induced ALI and to explore the role of mast cells (MCs) activation in a rat model of IIR. METHODS: Adult Sprague-Dawley rats were subjected to IIR by occluding the superior mesenteric artery for 60min followed by 4-hour reperfusion...
July 18, 2017: Life Sciences
https://www.readbyqxmd.com/read/28726782/pkc%C3%AE-phosphorylates-traf2-to-protect-against-intestinal-ischemia-reperfusion-induced-injury
#5
Wei Zhou, Jihong Yao, Guangzhi Wang, Zhao Chen, Zhenlu Li, Dongcheng Feng, Yang Li, Wasim Qasim, Wenzhi Tan, Shili Ning, Xiaofeng Tian
Intestinal ischemia-reperfusion (I/R) is a common clinical problem that occurs during various clinical pathological processes. Excessive apoptosis has an indispensable role in intestinal I/R injury. Tumor necrosis factor receptor-associated factor 2 (TRAF2) and PKCζ have an essential role in apoptosis. Here, we aimed to investigate the effects of PKCζ and TRAF2 and to explore the correlation between PKCζ and TRAF2 in intestinal I/R injury. Mice were subjected to intestinal I/R injury in vivo. In vitro experiments were conducted by treating Caco-2 cells with hypoxia/reoxygenation (H/R) stimulation to simulate intestinal I/R...
July 20, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28724276/fatal-small-intestinal-ischemia-due-to-methamphetamine-intoxication-report-of-a-case-with-autopsy-results
#6
Hamid Attaran
Methamphetamine is one of the most common abused drugs, so its various effects on different body organs should be familiar to all physicians. Regarding its gastrointestinal sequels, there are few reports of ischemic colitis induced by its vasoconstrictive effects. This is the first report of isolated small intestinal infarction resulting in death following methamphetamine toxicity. A 40-year-old woman with a past history of medical treatment for obesity referred to hospital with severe chest and back pain, perspiration, nausea, agitation, high blood pressure, bradycardia and subsequent lethargy and vasomotor instability...
May 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28713893/interleukin%C3%A2-6-rna-knockdown-ameliorates-acute-lung-injury-induced-by-intestinal-ischemia-reperfusion-in-rats-by-upregulating-interleukin%C3%A2-10-expression
#7
Bing Yuan, Liu-Lin Xiong, Mu-Dong Wen, Piao Zhang, Hong-Yu Ma, Ting-Hua Wang, Yun-Hui Zhang
Acute lung injury (ALI) is a common complication following intestinal ischemia/reperfusion (II/R) injury and contributes to the associated high mortality rate. However, the underlying mechanism is poorly understood and treatments are limited. RNA interference (RNAi) has been demonstrated to provide a promising disease treatment strategy both in vitro and in vivo. Therefore, the present study aimed to test whether blocking the proinflammatory cytokine IL‑6 by RNAi may protect the lungs from remote organ injury following II/R, and to investigate the potential underlying mechanisms...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28710988/intestinal-fatty-acid-binding-protein-level-as-a-predictor-of-28-day-mortality-and-bowel-ischemia-in-patients-with-septic-shock-a-preliminary-study
#8
Motohiro Sekino, Hiroyuki Funaoka, Shuntaro Sato, Kyoko Okada, Haruka Inoue, Rintaro Yano, Sojiro Matsumoto, Taiga Ichinomiya, Ushio Higashijima, Shuhei Matsumoto, Tetsuya Hara
PURPOSE: We sought to evaluate the levels of intestinal fatty acid-binding protein (I-FABP), a biomarker of enterocyte injury, as a predictor of 28-day mortality and bowel ischemia in septic shock patients. MATERIAL AND METHODS: In this preliminary prospective observational study, 57 adult septic shock patients under mechanical ventilation were enrolled. Serum I-FABP levels and prognostic biomarkers were recorded upon intensive care unit (ICU) admission. RESULTS: The overall 28-day mortality rate of participants was 23% (13/57)...
July 6, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28709648/deficiency-in-cold-inducible-rna-binding-protein-attenuates-acute-respiratory-distress-syndrome-induced-by-intestinal-ischemia-reperfusion
#9
Cindy Cen, Joseph McGinn, Monowar Aziz, Weng-Lang Yang, Joaquin Cagliani, Jeffrey M Nicastro, Gene F Coppa, Ping Wang
BACKGROUND: Intestinal ischemia-reperfusion can occur in shock and mesenteric occlusive diseases, causing significant morbidity and mortality. Aside from local injury, intestinal ischemia-reperfusion can result in remote organ damage, particularly in the lungs. Cold-inducible RNA-binding protein (CIRP) was identified as a novel inflammatory mediator. We hypothesized that a deficiency in CIRP would protect the lungs during intestinal ischemia-reperfusion injury. METHODS: Intestinal ischemia was induced in adult male C57BL/6 wild-type and CIRP knock-out (CIRP(-/-)) mice via clamping of the superior mesenteric artery for 60 minutes...
July 11, 2017: Surgery
https://www.readbyqxmd.com/read/28704542/conventional-alpha-beta-%C3%AE-%C3%AE-t-cells-do-not-contribute-to-acute-intestinal-ischemia-reperfusion-injury-in-mice
#10
Yi Yu, Xiaoyan Feng, Gertrud Vieten, Stephanie Dippel, Tawan Imvised, Faikah Gueler, Benno M Ure, Jochen F Kuebler, Christian Klemann
PURPOSE: Ischemia-reperfusion injury (IRI) is associated with significant patient mortality and morbidity. The complex cascade of IRI is incompletely understood, but inflammation is known to be a key mediator. In addition to the predominant innate immune responses, previous research has also indicated that αβ T cells contribute to IRI in various organ models. The aim of this study was to clarify the role αβ T cells play in IRI to the gut. METHODS: Adult wild-type (WT) and αβ T cell-deficient mice were subjected to acute intestinal IRI with 30min ischemia followed by 4h reperfusion...
2017: PloS One
https://www.readbyqxmd.com/read/28700968/retrocecal-hernia-preoperatively-diagnosed-by-computed-tomography-a-case-report
#11
Shingo Ito, Ryohei Takeda, Ritsuo Kokubo, Yoshio Sakai, Hirokazu Matsuzawa, Kiichi Sugimoto, Makoto Takahashi, Yutaka Kojima, Michitoshi Goto, Yuichi Tomiki, Kazuhiro Sakamoto
INTRODUCTION: Retrocecal hernia is a rare type of pericecal hernia. Because it is difficult to diagnose preoperatively, it is often treated with emergency operation. CASE PRESENTATION: An 83-year-old male patient experienced sudden abdominal pain. Marked small bowel dilatation and intestinal obstruction were detected by abdominal computed tomography (CT). An enhanced CT scan also revealed a trapped cluster of small bowel loops behind the cecum and ascending colon...
June 28, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28700411/role-of-autophagy-and-its-molecular-mechanisms-in-mice-intestinal-tract-after-severe-burn
#12
DuanY Zhang, Wei Qiu, PeiS Jin, Peng Wang, Yong Sun
BACKGROUND: Severe burn can lead to hypoxia/ischemia of intestinal mucosa. Autophagy is the process of intracellular degradation, which is essential for cell survival under stresses such as hypoxia/ischemia and nutrient deprivation. The present study was designed to investigate whether there were changes in intestinal autophagy after severe burn in mice and further to explore the effect and molecular mechanisms of autophagy on intestinal injury. METHODS: This study includes three experiments...
July 12, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28695234/pre-and-neonatal-imaging-of-gastrointestinal-complications-in-congenital-diaphragmatic-hernia
#13
REVIEW
Katharina Minkner, Leonor Alamo
The initial outcome in infants with congenital diaphragmatic hernia is mainly related to the associated lung hypoplasia. However, these patients frequently present with additional gastrointestinal pathology that also influences their quality of life and final prognosis. Congenital gastrointestinal anomalies are often observed and the displacement of the liver, the stomach and/or the intestines into the thorax may cause distortion of the vascular axis of these organs, increasing the risk of congestion and/or ischemia...
July 10, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28691670/non-occlusive-mesenteric-ischemia-nomi-in-parkinson-s-disease-case-report
#14
G Salamone, C Raspanti, L Licari, N Falco, G Rotolo, G Augello, G Melfa, G Gulotta
Non-occlusive mesenteric ischemia (NOMI) is a severe pathological condition characterized by signs and symptoms of bowel obstruction, intestinal necrosis resulting from acute and/or chronic inadequate blood perfusion, in the absence of an organic vascular obstruction detectable by imaging techniques. A 64 years old man case with a history of Parkinson's disease in high-functioning levodopa treatment is presented. Clinical and radiological signs of intestinal obstruction were observed. He underwent surgical operation with total colectomy and terminal ileostomy for generalized secondary peritonitis due to perforation of sigmoid colon...
March 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28688516/pancreas-transplantation-advantages-of-a-retroperitoneal-graft-position
#15
Joana Ferrer, Víctor Molina, Ramón Rull, Miguel Ángel López-Boado, Santiago Sánchez, Rocío García, Ma José Ricart, Pedro Ventura-Aguiar, Ángeles García-Criado, Enric Esmatjes, Josep Fuster, Juan Carlos Garcia-Valdecasas
INTRODUCTION: In the 50 years since the first pancreas transplant performed at the University of Minnesota, the surgical techniques employed have undergone many modifications. Techniques such as retroperitoneal graft placement have further improved the ability to reproduce the physiology of the «native» pancreas. We herein present our experience of a modified technique for pancreatic transplant, with the organ placed into a fully retroperitoneal position with systemic venous and enteric drainage of the graft by duodeno-duodenostomy...
July 5, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28683785/mesenteric-cysts-and-mesenteric-venous-thrombosis-leading-to-intestinal-necrosis-in-pregnancy-managed-with-laparotomy-a-case-report-and-review-of-the-literature
#16
Aris Giannos, Sofoklis Stavrou, Nikolaos Goumalatsos, George Fragkoulidis, Eleni Chra, Dimitrios Argiropoulos, Dimitrios Loutradis, Peter Drakakis
BACKGROUND: Mesenteric cyst is a rare clinical entity especially in pregnancy; therefore, few cases have been reported in the literature. The standard method of their treatment is surgical excision either with laparotomy or laparoscopy. In addition, mesenteric vein thrombosis is a rare and life-threatening condition in pregnancy and needs immediate treatment because it can lead to intestinal necrotic ischemia. This is the first report of the coexistence of mesenteric cysts and mesenteric vein thrombosis during gestation...
July 7, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28677408/delayed-sigmoid-ischemic-rupture-following-open-repair-abdominal-aortic-aneurysm
#17
Thomas Kotsis, Panagitsa Christoforou, Nikolaos Asaloumidis, Ioannis Papaconstantinou
Colon ischemia following aortic reconstruction is a severe complication with an incidence of 1% to 2% of the operated patients; this infrequent complication will be lethal for nearly half of these patients. Commonly, colon ischemia may be an intraoperative observation or an early postoperative finding. However, in the case presented here, sigmoid rupture and small and large intestine communication was revealed 3 months following repair of the abdominal aorta. A 71-year-old man, following open repair of an abdominal aortic aneurysm, went home on the fifth postoperative day...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28675281/-diagnostic-and-treatment-of-mesenteric-ischemia
#18
Cristina Parliteanu, Mathilde Gavillet, Olivier Gié, Pierre Bize, Michel H Maillard
Mesenteric ischemia results from acute or chronic blood flow reduction in the mesenteric arterial or venous vascular supply. This is usually due to an embolus, thrombosis or intestinal hypoperfusion. Radiologic and / or endoscopic imaging and histology allow for diagnosis in high-risk patients with suggestive clinical symptoms and signs. Treatment aims at preventing multi-organ failure through medical treatment, saving intestinal integrity and resecting necrotic bowel segments. Rapid and multidisciplinary management is key in order to optimize treatment and avoid long-term debilitating consequences...
August 31, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28672923/terlipressin-protects-intestinal-epithelial-cells-against-oxygen-glucose-deprivation-re-oxygenation-injury-via-the-phosphatidylinositol-3-kinase-pathway
#19
Zi-Meng Liu, Xu-Yu Zhang, Juan Chen, Jian-Tong Shen, Zhi-Yi Jiang, Xiang-Dong Guan
Intestinal ischemia/reperfusion (I/R) injury is associated with a high morbidity and mortality. Vasopressin is administered to critically ill patients with potential intestinal I/R. However, the impacts of vasopressin on intestinal epithelia under ischemic/anoxic conditions remain unclear. The aim of the present study was to evaluate the effects of terlipressin, a highly selective vasopressin V1 receptor agonist, on oxygen and glucose deprivation/re-oxygenation (OGD/R)-induced damage in intestinal epithelial cells (IEC-6)...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28666685/antioxidant-potential-of-himanthalia-elongata-for-protection-against-ischemia-reperfusion-injury-in-the-small-bowel
#20
Mariola Belda-Antolí, Carolina Padrón-Sanz, Dolores Cejalvo-Lapeña, Beatriz Prieto-Moure, Jose Miguel Lloris-Cejalvo, Jose Miguel Lloris-Carsí
BACKGROUND: Seaweed has been associated with the prevention and/or treatment of various diseases related to oxidative stress because of its antioxidant activity. We investigated the protective potential of extract of Himanthalia elongata against ischemia-reperfusion (I/R) injury in the intestine of rats. METHODS: Seventy-two (72) male Wistar albino rats were randomly assigned into 12 groups as follows: sham, I/R only, I/R plus vehicle at 3 time points, and I/R plus extract at 3 time points...
June 27, 2017: Surgery
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