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Intestinal ischemia

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https://www.readbyqxmd.com/read/29777839/-mesenteric-steal-physiology-as-a-cause-of-claudication-and-chronic-mesenteric-ischemia
#1
Aleem K Mirza, J Michael Bacharach
Aortoiliac occlusive disease (AOID) results in varying degrees of pelvic and lower extremity arterial insufficiency. Treatment approach has evolved and endovascular therapies are being successfully reported for high-grade lesion. However, Trans Atlantic Inter-Society Consensus (TASC) D often necessitates open revascularization. Disease limited to the infrarenal segment does not typically affect intestinal perfusion in the absence of visceral aortic or mesenteric vessel involvement. Chronic mesenteric ischemia most commonly occurs due to atherosclerotic disease of two or three of the mesenteric vessels...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29776790/-modern-treatment-of-mesenteric-ischemia
#2
Alexandre Nuzzo, Audrey Huguet, Olivier Corcos
Acute mesenteric ischemia is a highly morbid affliction which requires urgent care. Acute mesenteric ischemia consists in an ischemia injury of the small bowel, secondary to vascular insufficiency, either occlusive (thrombosis, embolism, arterial, venous) or non-occlusive (low flow or vasospasm). Given that the superior mesenteric artery supplies the small bowel as well as the right part of the colon, any ischemic process involving the right colon should be considered an acute mesenteric ischemia until proven otherwise...
May 15, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29771572/inhibition-of-ubiquitin-activating-enzyme-protects-against-organ-injury-after-intestinal-ischemia-reperfusion
#3
Shingo Matsuo, Andrew Chaung, Deanna Liou, Ping Wang, Weng-Lang Yang
Intestinal ischemia-reperfusion (I/R) occurs in various clinical settings, such as transplantation, acute mesenteric arterial occlusion, trauma and shock. I/R injury causes severe systemic inflammation, leading to multiple organ dysfunction associated with high mortality. The ubiquitin proteasome pathway has been indicated in the regulation of inflammation, particularly through NF-κB signaling pathway. PYR-41 is a small molecular compound that selectively inhibits ubiquitin-activating enzyme E1. A mouse model of intestinal I/R injury by clamping the superior mesenteric artery for 45 minutes was performed to evaluate the effect of PYR-41 treatment on organ injury and inflammation...
May 17, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29770885/does-near-infrared-nir-fluorescence-angiography-modify-operative-strategy-during-emergency-procedures
#4
Emilie Liot, Michela Assalino, Nicolas Christian Buchs, Boris Schiltz, Jonathan Douissard, Philippe Morel, Frédéric Ris
INTRODUCTION: Bowel viability can be difficult to evaluate during emergency surgery. Near-infrared (NIR) fluorescence angiography allows an intraoperative assessment of organ perfusion during elective surgery and might help to evaluate intestinal perfusion during emergency procedures. The aim of this study was to assess if NIR modified operative strategy during emergency surgery. MATERIALS AND METHODS: From July 2014 to December 2015, we prospectively evaluated all consecutive patients, who had NIR assessment during emergency surgery...
May 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29767265/knockdown-of-tnf%C3%A2-%C3%AE-alleviates-acute-lung-injury-in-rats-with-intestinal-ischemia-and-reperfusion-injury-by-upregulating-il%C3%A2-10-expression
#5
Zhen Yang, Xue-Rong Zhang, Qiong Zhao, Sheng-Lan Wang, Liu-Lin Xiong, Piao Zhang, Bing Yuan, Zi-Bing Zhang, Shu-Yuan Fan, Ting-Hua Wang, Yun-Hui Zhang
Intestinal ischemia and reperfusion (II/R) injury often triggers severe injury in remote organs, with the lungs being considered the main target. Excessive elevation of proinflammatory cytokines is a major contributor in the occurrence and development of II/R‑induced acute lung injury (ALI). Therefore, the present study aimed to investigate whether blocking tumor necrosis factor‑α (TNF‑α) expression could protect the lungs from injury following II/R, and to explore the possible underlying mechanism involving interleukin‑10 (IL‑10)...
May 14, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29760544/ischemia-reperfusion-injury-in-porcine-intestine-viability-assessment
#6
Runar J Strand-Amundsen, Henrik M Reims, Finn P Reinholt, Tom E Ruud, Runkuan Yang, Jan O Høgetveit, Tor I Tønnessen
AIM: To investigate viability assessment of segmental small bowel ischemia/reperfusion in a porcine model. METHODS: In 15 pigs, five or six 30-cm segments of jejunum were simultaneously made ischemic by clamping the mesenteric arteries and veins for 1 to 16 h. Reperfusion was initiated after different intervals of ischemia (1-8 h) and subsequently monitored for 5-15 h. The intestinal segments were regularly photographed and assessed visually and by palpation. Intraluminal lactate and glycerol concentrations were measured by microdialysis, and samples were collected for light microscopy and transmission electron microscopy...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29743484/released-mitochondrial-dna-following-intestinal-ischemia-reperfusion-induces-the-inflammatory-response-and-gut-barrier-dysfunction
#7
Qiongyuan Hu, Huajian Ren, Jianan Ren, Qinjie Liu, Jie Wu, Xiuwen Wu, Guanwei Li, Gefei Wang, Guosheng Gu, Kun Guo, Zhiwu Hong, Song Liu, Jieshou Li
Ischemia-reperfusion (I/R) injury is a challenging clinical problem, especially injuries involving the gastrointestinal tract. Mitochondrial DNA (mtDNA) is released upon cell death and stress, and can induce the inflammatory response. We aimed to investigate the role of mtDNA in the pathogenesis of intestinal I/R. Intestinal I/R model was established with clamping of the superior mesenteric artery, and IEC-6 cells were incubated under hypoxia/reoxygenation (H/R) conditions to simulate I/R injury. Using in vitro models, H/R up-regulated oxidative stress, disrupted mitochondrial activity and the mitochondrial membrane potential, induced apoptosis and elevated the mtDNA levels in the supernatant of intestinal epithelial cells, and the co-culture of mtDNA with human primary dendritic cells significantly elevated TLR9-MyD88 expression and enhanced the production of inflammatory cytokines and chemokines...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29735031/endoscopic-follow-up-of-intestinal-transplant-recipients
#8
REVIEW
Robert E Carroll
The growing population of intestinal transplant recipients present a unique challenge to the gastroenterologists responsible for their support and evaluation. Improvements in patient and graft survival are largely attributed to surgical advancements, refined antirejection therapy, and enhanced endoscopic surveillance protocols that better perceive rejection and other complications. This article reviews the endoscopic management and interventions provided for transplant recipients at the University of Illinois Hospital with complications, such as acute rejection, ischemia, bleeding, fistula, post-transplant lymphoproliferative disorder, and gastroparesis...
June 2018: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/29721632/acute-lower-limb-ischemia-and-intestinal-necrosis-due-to-arterial-tumor-embolism-from-advanced-lung-cancer-a-case-report-and-literature-review
#9
Sayuri Togo, Terutoshi Yamaoka, Kazutoyo Morita, Kazuomi Iwasa, Yukihiko Aoyagi, Yumi Oshiro, Takatoshi Fujishita, Hideki Yokoyama, Takashi Matsui, Takashi Nishizaki
BACKGROUND: Arterial tumor embolism (ATE) is a rare but life-threating complication. PRESENTATION OF CASE: A 55-year-old man with acute lower-limb ischemia was referred to our hospital after endovascular intervention failed and underwent above-the-knee amputation for severe limb necrosis. On postoperative day 8, he developed small bowel necrosis and underwent resection. Histopathological examination of the resected bowel revealed that the submucosal arterial emboli were positive for the markers of squamous cells...
May 2, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29718879/methamphetamine-consumption-and-life-threatening-abdominal-complications-a-case-report
#10
Xiaojing Zou, Haiyan Huang, Le Yang, Hong Liu, Yongfeng Li, Qin Xia, Shiying Yuan, Shanglong Yao
RATIONALE: Methamphetamine (METH) abuse is increasing rapidly all over the world and becoming a significant public health concern in China. However, abdominal complications secondary to METH abuse are usually overlooked. We describe an unusual case of gangrenous cholecystitis and small intestinal ischemia due to METH abuse. PATIENT CONCERNS: In this report, a 44-year-old male patient with abdominal pain and hematochezia has a history of crystal meth abuse. DIAGNOSIS: The patient was diagnosed as septic shock, paralytic ileus, gangrenous cholecystitis, and small intestinal ischemia due to METH abuse based on computed tomography (CT) scan, endoscopy examination, laparotomy, and pathology...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29718225/clinical-use-of-patency-capsule-a-comprehensive-review-of-the-literature
#11
Ioannis V Mitselos, Konstantinos Katsanos, Epameinondas V Tsianos, Rami Eliakim, Dimitrios Christodoulou
The patency capsule is a radiopaque, dissolvable diagnostic tool, similar in shape and size to small bowel capsule endoscopes. It was developed to offer a simple, safe, efficient, and accurate evaluation of small bowel functional patency. Although unable to provide direct visual information regarding the presence and location of strictures, masses, or luminal narrowing of the small bowel, a successful patency test minimizes the risk of retention and allows the safe administration of a capsule endoscope. However, its use entails a low risk of potentially harmful adverse events, which in their majority are indolent and resolve spontaneously...
April 28, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29712987/author-correction-role-of-irhom2-in-intestinal-ischemia-reperfusion-mediated-acute-lung-injury
#12
Jee Hyun Kim, Jihye Kim, Jaeyoung Chun, Changhyun Lee, Jong Pil Im, Joo Sung Kim
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29710463/a-comprehensive-review-on-regulatory-effects-of-crocin-on-ischemia-reperfusion-injury-in-multiple-organs
#13
REVIEW
Ghaidafeh Akbari, Seyyed Ali Mard, Ali Veisi
Ischemia-reperfusion (I/R) injury affects o2 -dependent organs including liver, kidneys, heart, brain, and intestine. I/R injury is described as the cellular injury in an organ caused by ischemia and then further aggravated during the reperfusion due to intracellular alterations. It is a process that happens in clinical settings such as organ transplantation, reperfusion after thrombolytic therapy, and coronary angioplasty. Crocus sativus L. known as saffron used in folk medicine for its beneficial effects...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29706629/targeting-the-mir-665-3p-atg4b-autophagy-axis-relieves-inflammation-and-apoptosis-in-intestinal-ischemia-reperfusion
#14
Zhenlu Li, Guangzhi Wang, Dongcheng Feng, Guo Zu, Yang Li, Xue Shi, Yan Zhao, Huirong Jing, Shili Ning, Weidong Le, Jihong Yao, Xiaofeng Tian
Autophagy is an essential cytoprotective response against pathologic stresses that selectively degrades damaged cellular components. Impaired autophagy contributes to organ injury in multiple diseases, including ischemia/reperfusion (I/R), but the exact mechanism by which impaired autophagy is regulated remains unclear. Several researchers have demonstrated that microRNAs (miRNAs) negatively regulate autophagy by targeting autophagy-related genes (ATGs). Therefore, the effect of ATG-related miRNAs on I/R remains a promising research avenue...
April 30, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29702489/what-s-new-in-short-bowel-syndrome
#15
Lore Billiauws, Olivier Corcos, Francisca Joly
PURPOSE OF REVIEW: Short bowel syndrome (SBS) is a rare disease but with many complications due to intestinal failure, parenteral nutrition and underlying disease. A better prevention, comprehension and treatment could improve the outcome of these patients. RECENT FINDINGS: Recent studies have been published on acute intestinal failure, first cause of SBS, and gives us strategy to avoid extended intestinal resection and thus SBS. There has been progress in the comprehension of intestinal adaptation, characterized by improvements in intestinal absorption, changes on hormonal secretion, development of a hyperphagia and dysbiosis of the gut microbiota...
April 26, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29682115/selection-and-determination-of-treatment-for-the-spontaneous-isolated-dissection-of-the-superior-mesenteric-artery
#16
Zaiqiang Yu, Norihiro Kondo, Mari Chiyoya, Yasuyuki Suzuki, Ikuo Fukuda
Objective : This study aimed to clarify the selection and determination of appropriate treatment for acute symptomatic spontaneous isolated dissection of the superior mesenteric artery (SIDSMA). Methods : Data from 10 consecutive patients, who were diagnosed with symptomatic SIDSMA using computed tomography angiography and were managed in our hospital from January 2010 to October 2015, were retrospectively collected and analyzed. Results : There were nine males and one female; mean patient age was 50.3 (range, 35-64) years...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29678610/nrf2-protects-against-acute-lung-injury-and-inflammation-by-modulating-tlr4-and-akt-signaling
#17
Jia Yan, Jingjie Li, Lei Zhang, Yu Sun, Jue Jiang, Yan Huang, Hui Xu, Hong Jiang, Rong Hu
Lung injury, which is associated with systemic inflammatory responses, is a common problem with significant morbidity and mortality. Here, we examined the involvement of toll-like receptor 4 (TLR4) and nuclear factor erythroid 2-related factor 2 (Nrf2) on intestinal ischemia-reperfusion (I/R)-induced lung injury in vivo and in vitro. Analysis of lung tissues in Nrf2-knockout mice by western blotting, immunohistochemistry, and TUNEL assay, and analysis of bronchoalveolar lavage fluid showed that Nrf2 deficiency upregulated TLR4, enhanced I/R-induced lung injury, apoptosis, inflammation, and autophagy, and increased the I/R-induced inactivation of Akt...
April 17, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29673584/a-30-minutes-supraceliac-aortic-clamping-in-the-rat-causes-death-due-to-an-inflammatory-response-and-pulmonary-lesions
#18
Antoine Monnot, Anaïs Dumesnil, Sylvanie Renet, Marie Laurence Roquet, Vincent Richard, Didier Plissonnier
BACKGROUND: The treatment of thoraco-abdominal aortic aneurysms through an open approach has general and pulmonary consequences of multiple etiologies. Our assumption was that the supraceliac aortic clamping needed for this operation causes a systemic inflammatory response associated with a pulmonary attack. MATERIAL AND METHODS: We developed a model of 30 min supraceliac aortic clamping in Wistar rats weighing 300 g. After 90 min of reperfusion the rats were sacrificed...
April 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29666717/aortic-dissection-presenting-as-septic-shock-a-case-report-and-literature-review
#19
Jing Feng, Rui Liu, Sai Ma, Changkui Cao, Wei Zhang, Yang Zhao, Shinan Nie
Acute aortic dissection is a life-threatening clinical emergency, which mostly occurs in aged patients and presents with sharp chest pain. In this paper, we reported a case of acute aortic dissection, which induced septic shock in a young woman, without typical chest pain. The septic shock was possibly due to the bacterial translocation caused by aortic dissection-induced intestinal ischemia and intestinal epithelial barrier dysfunction. Our case appeared as the first case report of aortic dissection presenting as septic shock...
2018: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/29658495/internal-hernia-following-robotic-assisted-pancreaticoduodenectomy
#20
Kai Qin, Zhichong Wu, Jiabin Jin, Baiyong Shen, Chenghong Peng
BACKGROUND Robotic assisted pancreaticoduodenectomy (RPD) is reported to be safe and feasible. Internal hernia (IH) after RPD is a serious but rarely reported complication. MATERIAL AND METHODS We retrospectively reviewed data of 231 patients who underwent RPD from October 2010 to December 2016. The incidence, symptoms, time of presentation, and outcome were investigated. RESULTS Five patients (2.6%) were diagnosed with IH. Significant correlation (P<0.001) between IH and transverse mesocolon defect was confirmed...
April 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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