keyword
MENU ▼
Read by QxMD icon Read
search

Diagnostic reasoning

keyword
https://www.readbyqxmd.com/read/29050189/-clinical-features-and-treatments-of-retrocorneal-fungal-infection
#1
J Cheng, H L Zhai, J Y Wang, L X Xie
Objective: To evaluate the clinical features of retrocorneal fungal infection and the therapeutic effects. Methods: This was a retrospective, noncomparative study of nine patients with retrocorneal fungal infection and an intact corneal epithelium treated at Qingdao Eye Hospital. The history, clinical features, diagnostic methods, pathogens and therapeutic effects were analyzed. Results: Five patients had a history of trauma by plant, two had a non-plant injury, and two had unidentified reasons. The duration between the initial onset and the first visit to our hospital was 7...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29048178/the-uncertainty-of-psychological-and-psychiatric-diagnoses
#2
Andreas Mokros, Elmar Habermeyer, Helmut Küchenhoff
Psychiatric and psychological diagnoses are imperfect. Unlike somatic medicine, most psychological and psychiatric phenomena have no gold standard to establish their presence beyond reasonable doubt. Consequently, prevalence estimates are based on the average agreement of imperfect evaluators. Küchenhoff, Augustin, and Kunz (2012) provided a statistical method for estimating confidence intervals of the prevalence based on the well-known kappa coefficient of interrater agreement. We expand this method and derive confidence intervals for the probability of a diagnosis being true (i...
October 19, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/29047769/performance-of-photomultipliers-in-the-context-of-laser-induced-incandescence
#3
Raphael Mansmann, Thomas Dreier, Christof Schulz
Photomultiplier tubes (PMTs) are widely used as detectors for laser-induced incandescence (LII), a diagnostics method for gas-borne particles that requires signal detection over a large dynamic range with nanosecond time resolution around the signal peak. Especially when more than one PMT is used (i.e., for pyrometric temperature measurements) even small deviations from the linear detector response can lead to significant errors. Reasons for non-linearity observed in other PMT measurement techniques are summarized and strategies to identify non-linear PMT operation in LII are outlined...
October 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047032/rethinking-skin-lesion-segmentation-in-a-convolutional-classifier
#4
Jack Burdick, Oge Marques, Janet Weinthal, Borko Furht
Melanoma is a fatal form of skin cancer when left undiagnosed. Computer-aided diagnosis systems powered by convolutional neural networks (CNNs) can improve diagnostic accuracy and save lives. CNNs have been successfully used in both skin lesion segmentation and classification. For reasons heretofore unclear, previous works have found image segmentation to be, conflictingly, both detrimental and beneficial to skin lesion classification. We investigate the effect of expanding the segmentation border to include pixels surrounding the target lesion...
October 18, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29046760/an-atypical-subacute-presentation-of-posterior-reversible-encephalopathy-syndrome
#5
Eseosa Bazuaye-Ekwuyasi, Robert Dobbin Chow, Sarah Schmalzle
Posterior reversible encephalopathy syndrome (PRES) characteristically presents with rapid onset of headache, seizure, encephalopathy, and visual changes, along with evidence of parieto-occipital vasogenic edema on magnetic resonance imaging. We describe the case of a 41-year-old female with a protracted presentation of two of the four classic PRES symptoms, which were not immediately recognized as PRES due to the presence of multiple other comorbidities and reasons for encephalopathy. This case highlights the possibility of atypical presentations of PRES and the diagnostic challenges in making this clinical diagnosis when competing diagnoses are present...
October 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29046002/-optimal-diagnostics-and-therapy-for-microvascular-angina-pectoris
#6
Peter Ong, Udo Sechtem
Patients with microvascular angina are characterized by angina pectoris with proof of myocardial ischemia in the absence of any relevant epicardial stenosis and without myocardial disease (type 1 coronary microvascular dysfunction according to Crea and Camici). Structural and functional alterations of the coronary microvessels (diameter < 500 µm) are the reason for this phenomenon. Frequently such alterations are associated with cardiovascular risk factors. Patients with angina pectoris without epicardial stenoses represent for 10 - 50 % of all patients undergoing coronary angiography depending on the clinical presentation...
October 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29044505/diagnostic-pathology-of-early-systemic-cancer-erbb2-gene-amplification-in-single-disseminated-cancer-cells-determines-patient-survival-in-operable-esophageal-cancer
#7
Martin Hoffmann, Sophie Pasch, Thomas Schamberger, Matthias Maneck, Birte Möhlendick, Sarah Schumacher, Gero Brockhoff, Wolfram Trudo Knoefel, Jakob Izbicki, Bernhard Polzer, Nikolas H Stoecklein, Christoph A Klein
Early metastatic dissemination and evolution of disseminated cancer cells (DCCs) outside the primary tumor is one reason for the failure of adjuvant therapies because it generates molecular geno- and phenotypes different from primary tumors which still underlie therapy decisions. Since ERBB2 amplification in esophageal DCCs but not in primary tumor cells predict outcome, we aimed to establish an assay with diagnostic reliability for single DCCs or circulating tumor cells (CTCs). For this we evaluated copy number alterations of more than 600 single DCCs from multiple cancer types to define reference regions suitable for quantification of target regions, such as ERBB2...
October 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29041975/extreme-precipitation-and-emergency-room-visits-for-influenza-in-massachusetts-a-case-crossover-analysis
#8
Genee S Smith, Kyle P Messier, James L Crooks, Timothy J Wade, Cynthia J Lin, Elizabeth D Hilborn
BACKGROUND: Influenza peaks during the wintertime in temperate regions and during the annual rainy season in tropical regions - however reasons for the observed differences in disease ecology are poorly understood. We hypothesize that episodes of extreme precipitation also result in increased influenza in the Northeastern United States, but this association is not readily apparent, as no defined 'rainy season' occurs. Our objective was to evaluate the association between extreme precipitation (≥ 99th percentile) events and risk of emergency room (ER) visit for influenza in Massachusetts during 2002-2008...
October 17, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29041924/the-value-of-repeat-radial-probe-endobronchial-ultrasound-guided-transbronchial-biopsy-after-initial-non-diagnostic-results-in-patients-with-peripheral-pulmonary-lesions
#9
Chun-Ta Huang, Yi-Ju Tsai, Chao-Chi Ho, Chong-Jen Yu
BACKGROUND: Radial-probe endobronchial ultrasound (rEBUS)-guided transbronchial biopsy (TBB) is invaluable in the diagnosis of peripheral pulmonary lesions (PPLs); however, in certain instances, the procedure has to be repeated because of initial non-diagnostic procedure(s). Little if any literature has been published on this issue. Therefore, the aim of this study was to investigate the utility of repeat rEBUS-guided TBB in achieving a definitive diagnosis of PPLs. METHODS: All patients who underwent rEBUS-guided TBB of PPLs at National Taiwan University Hospital between 2011 and 2015 and had a repeat procedure after non-diagnostic initial procedures were identified as the study subjects...
October 17, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29037477/mutational-analysis-of-foot-and-mouth-disease-virus-nonstructural-polyprotein-3ab-coding-region-to-design-a-negative-marker-virus
#10
Mukesh Bhatt, Jajati K Mohapatra, Laxmi K Pandey, Nihar N Mohanty, Biswajit Das, Bikash R Prusty, Bramhadev Pattnaik
Inactivated purified whole virus vaccines are used for control of foot and mouth disease (FMD). ELISAs detecting antibodies to the nonstructural proteins (NSP), a marker of infection, are primarily used to differentiate FMD virus (FMDV) infected from vaccinated animals (DIVA). However, such DIVA assays have a limitation to their specificity since residual NSPs present in the relatively impure vaccines are suspected to induce an NSP-antibody response in the repeatedly vaccinated animals. Epitope-deleted negative marker vaccine strategy seems to have an advantage over the conventional vaccines in identifying the infected animals with accuracy...
October 14, 2017: Virus Research
https://www.readbyqxmd.com/read/29034129/sebaceous-carcinoma-in-situ-as-a-concept-and-diagnostic-entity
#11
Miglena K Komforti, Masoud Asgari, Sheng Chen
Although carcinoma in situ has been accepted as a well-established concept and diagnostic category, for reasons unknown sebaceous carcinoma in situ has not been recognized yet in general pathology or dermatopathology. Such lesions have always been misinterpreted as either benign neoplasm or sebaceous carcinoma. In the present essay, we provide a convincing account supporting sebaceous carcinoma in situ as a valid concept and diagnostic entity via critical literature review and histopathological assessment and illustration...
July 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29033893/shortcomings-in-the-current-amyotrophic-lateral-sclerosis-trials-and-potential-solutions-for-improvement
#12
REVIEW
Nakul Katyal, Raghav Govindarajan
Amyotrophic lateral sclerosis (ALS) is a clinically progressive neurodegenerative syndrome predominantly affecting motor neurons and their associated tracts. Riluzole and edaravone are the only FDA certified drugs for treating ALS. Over the past two decades, almost all clinical trials aiming to develop a successful therapeutic strategy for this disease have failed. Genetic complexity, inadequate animal models, poor clinical trial design, lack of sensitive biomarkers, and diagnostic delays are some of the potential reasons limiting any significant development in ALS clinical trials...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29031628/ultrasound-and-the-complete-urologist-part-1-methodology
#13
Eugene M Fine
Computed tomography (CT) scanning is considered as the imaging study of choice for asymptomatic microhematuria according to the American Urological Association guidelines. For those patients with persistence of microhematuria after a negative initial examination, the guidelines suggest repeating the evaluation including CT scanning within 3 to 5 years. However, the cost and risk involved for utilizing this technology going forward is an issue, especially when the yield of finding significant pathology on subsequent imaging studies is exceedingly low...
October 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29026761/postherpetic-neuralgia-diabetic-neuropathy-and-trigeminal-neuralgia-chronic-peripheral-neuropathic-pain-in-58-480-rural-italian-primary-care-patients
#14
Nicola Buono, Hans Thulesius, Ferdinando Petrazzuoli, Elena Castelli, Marco Cambielli
INTRODUCTION: Chronic peripheral neuropathic pain (CPNP) is a condition due to peripheral nervous system diseases or injury, but its prevalence is unknown in Italian primary care. AIM: The aim of this study is to assess the prevalence of CPNP in a rural primary care area in Northern Italy. MATERIALS AND METHODS: A multicenter audit study was carried out in a rural area in Northern Italy with 113 participating general practitioners (GPs) seeing 58,480 patients >18 years during 3 months...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29024518/cd5-b-lymphoproliferative-disorder-with-subsequent-development-of-plasma-cell-leukaemia-diagnostic-and-aetiologic-reasoning
#15
Evdoxia Gounari, Georgia Kaiafa, Triantafyllia Koletsa, Vasiliki Tsavdaridou, Ioannis Kostopoulos, Lilian Toptsi, Lemonia Skoura
BACKGROUND: Plasma cell myeloma (PCM) has been sporadically reported to occur simultaneously or subsequently to mature B lymphoproliferative disorders (LPDs), predominantly chronic lymphocytic leukaemia (CLL). METHODS: We describe the clinical and laboratory findings of a 69-year-old male patient who developed plasma cell leukaemia (PCL) 8 years after an initial diagnosis of a low stage CD5+ B LPD and 3 years after treatment for LPD. RESULTS: The transition from a clinically indolent B LPD to an aggressive PCM was documented by bone marrow (BM) biopsy, while flow cytometric (FC) immunophenotyping conferred additional information by disclosing the co-existence of both disorders in BM and the presence of abnormal monotypic PCs in peripheral blood above PCL levels...
October 10, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29024119/automatic-segmentation-of-the-puborectalis-muscle-in-3d-transperineal-ultrasound
#16
Frieda van den Noort, Anique T M Grob, Cornelis H Slump, Carl H van der Vaart, Marijn van Stralen
OBJECTIVES: The introduction of 3D analysis of the puborectalis muscle, for diagnostic purposes, into daily practice is hindered by the need for appropriate training of the observers. Automatic 3D segmentation of the puborectalis muscle in 3D transperineal ultrasound may aid to its adaption in clinical practice. METHOD: A manual 3D segmentation protocol was developed to segment the puborectalis muscle. The data of 20 women, in their first trimester of pregnancy, was used to validate the reproducibility of this protocol...
October 11, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29021108/effects-of-a-multifaceted-implementation-intervention-to-increase-utilization-of-pharmacological-treatments-for-alcohol-use-disorders-in-the-us-veterans-health-administration
#17
Alex H S Harris, Randall Brown, Michael Dawes, Eric Dieperink, Donald Hugh Myrick, Heather Gerould, Todd H Wagner, Jennifer P Wisdom, Hildi J Hagedorn
Over 16 million Americans meet diagnostic criteria for alcohol use disorder (AUD), but only 7.8% of them receive formal treatment each year. Safe and effective pharmacological treatments for AUD exist; however, they are rarely prescribed. Therefore, we developed and pilot tested a multifaceted implementation intervention to improve consideration and receipt of effective pharmacologic treatments for AUD, focusing on primary care settings where patients have the most frequent contact with healthcare systems. The intervention included training of local providers to serve as champions and a website for primary care providers that included educational materials, a case-finding dashboard, and contact information for local and national clinical experts...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29018927/whole-body-magnetic-resonance-in-indolent-lymphomas-under-watchful-waiting-the-time-is-now
#18
EDITORIAL
Massimo Galia, Domenico Albano, Corrado Tarella, Caterina Patti, Luca Maria Sconfienza, Antonino Mulè, Pierpaolo Alongi, Massimo Midiri, Roberto Lagalla
ᅟ: The indolent non-Hodgkin lymphomas (i-NHLs) are characterised by 'indolent' clinical behaviour with slow growth and prolonged natural history. The watchful waiting (WW) strategy is a frequently employed treatment option in these patients. This implies a strict monitoring by imaging examinations, including 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) and CT. A major concern is radiation exposure due to regularly monitoring by conventional imaging procedures. Several studies have demonstrated the reliability of whole-body magnetic resonance imaging (WB-MRI) for lymphoma staging...
October 10, 2017: European Radiology
https://www.readbyqxmd.com/read/29017439/the-expression-of-pdcd4-in-patients-with-missed-abortion-and-its-clinical-significance
#19
Yue Li, Xihong Liu, Yingshun Sun, Yanping Liu, Lu Wan, Lining Zhang, Zhenghui Fang, Zengtao Wei, Xiaoyan Wang
Missed abortion is a special form of spontaneous abortion and its incidence shows a rising trend. Immunological factor is one of the most common reasons. Tumor suppressor gene programmed cell death 4 ( PDCD4) also participates in some immune-mediated inflammation, such as atherosclerosis, and so on, but the role of PDCD4 in missed abortion remains unclear. Here, the expression of PDCD4 was detected in decidual and chorionic tissues, as well as peripheral blood mononuclear cells from patients with missed abortion and healthy controls using quantitative real-time polymerase chain reaction (qRT-PCR), Western blot, and immunohistochemistry...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28994807/dry-film-photoresist-based-electrochemical-microfluidic-biosensor-platform-device-fabrication-on-chip-assay-preparation-and-system-operation
#20
Richard Bruch, André Kling, Gerald A Urban, Can Dincer
In recent years, biomarker diagnostics became an indispensable tool for the diagnosis of human disease, especially for the point-of-care diagnostics. An easy-to-use and low-cost sensor platform is highly desired to measure various types of analytes (e.g., biomarkers, hormones, and drugs) quantitatively and specifically. For this reason, dry film photoresist technology - enabling cheap, facile, and high-throughput fabrication - was used to manufacture the microfluidic biosensor presented here. Depending on the bioassay used afterwards, the versatile platform is capable of detecting various types of biomolecules...
September 19, 2017: Journal of Visualized Experiments: JoVE
keyword
keyword
10409
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"